CYMBALTA Reviews (DULOXETINE)

Average Rating: 2.7 (2745 Ratings)

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 ANTIDEPRESSANTS

 Type: Rx Drug

  

CYMBALTA  (DULOXETINE):  Duloxetine is used to treat depression and anxiety. In addition, duloxetine is used to help relieve nerve pain (peripheral neuropathy) in people with diabetes or ongoing pain due to medical conditions such as arthritis, chronic back pain, or fibromyalgia (a condition that causes widespread pain). Duloxetine may improve your mood, sleep, appetite, and energy level, and decrease nervousness. It can also decrease pain due to certain medical conditions. Duloxetine is known as a serotonin-norepinephrine reuptake inhibitor (SNRI). This medication works by helping to restore the balance of certain natural substances (serotonin and norepinephrine) in the brain.   FDA Approval Date: 2004-08-03 (Sources: U.S. Centers for Medicare Services, FDA)

  

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Key to Ratings: 1=LOW (I would not recommend taking this medicine.)
5=HIGH (this medicine cured me or helped me a great deal.)

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More on CYMBALTA: Reviews Summary  |  Drug Safety Information

RATING  REASONSIDE EFFECTS FOR CYMBALTACOMMENTSSEXAGEDURATION/
DOSAGE
DATE ADDED
 
 2  Depression decreased libido increased depression F 37 7 days
1/1/2010
 2  Depression and Anxiety In a constant fog, inability to concentrate, no libido, memory loss, night sweats and vivid nightmares(in the first month, stopped eventually). This particular drug did not work for me. I have been on 60mg. I just dropped to 30mg today and will be coming off of it to switch to welbutrin. I am a full time graduate student who works full time. I have never in my life had such a hard time getting motivated (even with anxiety and depression). I am constantly forgetting words and always feel like I'm in a fog. I barely remember the last 3.5 months. I would sit down to study for class and forget what I just read. I would suggest if you are starting this drug to do so when you have no important engagements going on, so that you can see how this drug effects your memory and concentration. F 26 3.5 months
12/15/2009
 2  Fibro/Myofascial pain syndrome Unable to achieve orgasm or get sexually aroused. Some mild headaches, nausea & sleeplessness initially which went away but sexual side effects were intolerable. Worked great for the pain but discontinued due to sexual side effects. I really wish companies provided more info and did more research on sexual side effects of medications on women. F 37 3.5 weeks
12/11/2009
Email
 2  depression/anxiety Felt like I had taken speed - anxiety, restlessness, insomnia, loss of appetite, felt "worked up", increased depression, probably because of sleep deprivation from the insomnia. Obviously not the drug for me! I was not willing to wait around to see whether the side effects would decrease after a while, as I have 2 young kids, a house and a job and I need to function in the mean time. F 33 5 days
12/12/2009
 2  depression/anxiety Constipation that has increased to very severe over the past 3 yrs. degestive problems, memory & problems with attention. Decreased libido I changed from paxil to cymbalta after having possible TIA or mild stoke (only a small spot showed on the Brain Scan in the right frontal lobe-Overnight I had temporary slurred speach and permanently lost part of my ability to remember). I wanted to see if changing to cymbalta helped my memory. Cymbalta is great for the depression and I felt less medicated than when I took Paxil and had a little more libido, but the memory loss problem continued and the prementioned side effects now make it necessary to try something else. Has anyone else had my constipation or other problems and if so, what have you successfully changed to? I get very depressed easily and very irratible when I skip a dose (60 mg). F 61 4 years
12/2/2009
 2  Depression I have been taking Cymbalta for about 3 years, I was taking Prozac and felt it was time for a change. But I am having trouble here lately with terrible headaches, everyday! I am wanting to get off of it. It seemed to have worked quite well at first and now it seems useless. Does anyone fill the same way? F 47 3 years
11/12/2009
 2  Depression, panic attacks F 60
30 1X day
8/2/2014
Email

Patient History
 2  Nerve Pain and Depression Hair loss, nightmares, blackouts, irrational thoughts I ended up in the hospital after having a few drinks at a party and blacking out completely. This stuff is dangerous. My hair loss still hasn't come back. F 36 2 years
60 mg 1X day
7/31/2014
 2  Fibromyalgia 8 pound weight gain, horrible clenching of my teeth Improved my mood but had no effect on my pain. F 46 21 days
60 mg 1X day
1/19/2015
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 2  bipolar 1 , chronic pain, fibromyag Nervousness, night sweats, jerking of arms, palpitations, anxiety, difficult concentrating, insomia Pharmacist thought I was having serotonin syndrome, since old med still on board. After weeks and Dr calling in nerve med and muscle jerks started I stopped and went back on old symptoms went away. Did seen to help with pain some F 54 6 weeks
60mg
1/3/2015
 2  Fibro/acute anxiety First MONTH was awful! Couldn't keep anything down, or it ran straight through me. Headaches like I had never had, even worse than migraines if that's possible. Extreme rage over nothing. 4 months later, headaches still hit with no warning. Either I "feel" nothing or I'm on the extreme far ends of the emotional spectrum. During the day I sleep, productivity way down, can't sleep at night. Joint pain is better, but muscle, lower back, and spasms have tripled. I've seen good reviews and had hoped this would finally help. I hate it. But I can't stop taking it. When I've tried (slowly taking every other day) I get diarrhea, brain zaps, and this weird sensation that my lips are going numb and I'll get these scary tingles that start on the side of my head and run through the left side of my body. Will "pulse" it only hits for 3 seconds but will hit every minute or two. The headaches are the worst though. At least with migraines there are warnings. This feels like those super intense headaches that hit right above your eye and lasts for a second or two, but these do not go away for hours. They are devastating. F 28 6 months
30mg 1X day
2/6/2015
 2  depression,aniexty,and pain I agree that it isnt really effective for me either. I feel sluggish,unmotivated,and still have depression,aniexty and pain. I need something that helps me with all those things. I was on Lexapro for 4yrs and it stopped working. I also, agree that if I stop taking the Cymbalta I feel those "brain zings" and fuziness,that is withdraw symptoms. If I dont take the medicine at the same time every day or forget a day, I will expreience withdraw and its horrible! I am going to go to a psychotrist to see if there is something else that will help me. F 34 3 months
60 mg
2/11/2015
 2  Fibromyalsia jaw clenching, increased thirst, cold shivers, Exhausted and yawning constantly but couldn't sleep well. Emotional numb feeling. F 31 4 days
30
3/10/2015
 2  Depression, anxiety, & hx of fibro weight gain (50+ pounds) high blood pressure skin problems tiny wounds would not heal for months, frequently developed into skin infections (e.g. from acne) immune system problems loss of interest in all activities loss of interest in relationships extreme fatigue wanted to sleep all the time could not feel happiness or joy continued to feel depression, have suicidal thoughts under stress Spent 2 months cutting down dose, final withdrawal off of 30 mg dose was agony emotionally and physically for weeks. Can't get over how much better I feel now off of this drug. F 42 6 years
90 mg 1X day
9/9/2013
Email
 2  Fibromyalgia Nausea all day long, pounding heart, anxious, loss of appetite. F 38 8 days
30mg 1X day
9/18/2013
 2  Depression Worked great at first but now I'm always exhausted, have a horrible non-stop ringing in my ears, feel like I have uncontrolled anger often, suicidal thoughts, feel like I'm going to explode & my restless leg syndrome is only increasing. Going to taper off, hopefully with success! F 51 6 years
60 1X day
3/2/2014
Email
 2  Migraine prevention I have bipolar II and when I was on 60 mg it caused me to have thoughts of hurting other people. I went down to 40 mg and that side effect went away, but the medicine didn't help me very much with my migraines so I went to Tizanidine which has helped a lot. F 42 60 days
40 mg 1X day
3/16/2013
Email
 2  For memory problems and anxiety Extreme tiredness, low libido Did not work for my memory problems nor my anxiety, both stayed about the same. I was on 60mg/d for a full year and then to 90 for a couple months which did nothing, so I had to wean off of it completely. Be warned that stopping Cymbalta can be very dangerous, I missed 3 doses, 3 days in a row and felt like I could have killed somebody. When I weaned off of 90mg I went to 60 and then to 30 over a course of 2 months but that is not long enough. A few days after stopping from 30mg I had very strong urges to kill myself for about a week. I knew I really didn't want to die but that didn't stop my brain from telling my body to do something about it. Luckily I have family and doctors that helped me through it. The only positive I can give this drug is that it helped me sleep when I trouble falling asleep before taking it, but it made me so sleepy that I needed a nap everyday. Now that I'm off it, I hardly ever want/need naps but my inability to fall asleep is back. F 26 1.5 years
90 1X day
6/29/2014
 2  Depression & Anxiety, Joint Pain Very Tired, the feeling of just Not wanting to do anything at all,just feeling BLA and the insane feeling of being so HOT on and off all day it's crazy it's freezing outside and I'm out there in a tank top my neighbors probley think I'm nuts..Did NOT help with my joint pain actually I feel worse I know every medication effects people differently but this definitely isn't for me.. Hopefully it works for someone else.. Good luck.. Definitely would not recommend it.. Sucks didn't help at ALL.. F 40 1 months
30mg
1/11/2016
 2  Headaches Too much pooping!!! Seemed to help with headaches initially, but not so much now. F 57 1 months
30 MG
3/22/2016

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