CYMBALTA Reviews (DULOXETINE)

Average Rating: 2.7 (2745 Ratings)

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 ANTIDEPRESSANTS

 Type: Rx Drug

  

CYMBALTA  (DULOXETINE):  Duloxetine is used to treat depression and anxiety. In addition, duloxetine is used to help relieve nerve pain (peripheral neuropathy) in people with diabetes or ongoing pain due to medical conditions such as arthritis, chronic back pain, or fibromyalgia (a condition that causes widespread pain). Duloxetine may improve your mood, sleep, appetite, and energy level, and decrease nervousness. It can also decrease pain due to certain medical conditions. Duloxetine is known as a serotonin-norepinephrine reuptake inhibitor (SNRI). This medication works by helping to restore the balance of certain natural substances (serotonin and norepinephrine) in the brain.   FDA Approval Date: 2004-08-03 (Sources: U.S. Centers for Medicare Services, FDA)

  

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Key to Ratings: 1=LOW (I would not recommend taking this medicine.)
5=HIGH (this medicine cured me or helped me a great deal.)

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More on CYMBALTA: Reviews Summary  |  Drug Safety Information

RATING  REASONSIDE EFFECTS FOR CYMBALTACOMMENTSSEXAGEDURATION/
DOSAGE
DATE ADDED
 
 3  Depression/Anxiety Headaches, extreme nausea, jaw clenching I have only been on Cymbalta for 2days but I am having really bad headaches in the back of my head that I have never had before. I have to concentrate on not clenching my jaw and the nausea is almost unbearable. I do not notice a difference in my moods or anxiety. Having said all this it has only been 2days. I want to at least wait out the 1st month to see if it'll get better. Anything has to be better than Lexapro. F 26 2 days
7/20/2007
 3  Fibromyalgia After initially feeling "out of it" for a time, my body adjusted and I felt fine. The side effects I've experienced include frequent stools, sweats, delayed orgasm (took forever), loss of libido, and....major weight gain. I have gained over 30 pounds in nine months, and have not changed my diet or routine. Don't much like these changes to my life. It did seem to lessen my fibro aches and pains somewhat. I have decided that I am going to the MD tomorrow and start weaning off this med. I wish I would have researched this drug more when I first started. I have never been heavy in my life and I'm sure that added weight is not doing my fibro any good. I am a little worried about the weaning process...it seems that it is not so nice. I wish that my doctor had been more forthcoming about the fact that getting off this drug can be hell. F 55 9 months
5/4/2007
 3  Chronic back pain Extreme tiredness, blurred vision, constipation, weight gain, and irritability. My neurologist suggested Cymbalta for chronic back pain. Started with ten mg's and increased to 20 mg. While there has been some pain relief the side effects are more than I care to deal with. I am planning on asking him to take me off of Cymbalta and increase my Tegretol. F 42 3 months
6/3/2007
 3  DEPRESSION After being on Cymbalta for 9 months at 60 mgms, I am experiencing "flying off the handle" side effect. The Cymbalta has controlled the depression, but any stressor in my life causes a major, irrational temper tantrum. After I calm down, I'm fine. But, I've always been a laid back person and these symptoms are not normal. I'm going to my doctor to change my antidepressant from Cymbalta to something else. F 54 9 months
7/3/2007
 3  depression/back pain/other.. well its only my 2nd day..so im tryin to be open minded.but after taking it yesterday i got really sick to my tummy..i kept running to the bathroom thinking i was goin to throw up..and im really tierd.im kind of dazing off..very spacey feeling...but i kno these are normal at first. This is my 2nd day. im scared to be takin this stuff..i have never taken an antidepressant in my life..but i figure its worth a shot to be happy..im going to give it 2 weeks..but if im still feeling this out of it and naseous i will stop. i have to admit all thses stories of side effects and withdrawls reeeally scare me.brain zaps?! i do not want that! i pray that God will give me all the good effects..i hav to wait and see.. F 21 2 days
5/10/2007
 3  Depression, Fibromyalgia At first it was wonderful. Fibromyalgia was much improved as was depression. After about 3 or 4 months it stopped working on the pain and I noticed that I was having huge problems with anxiety and anger. Similar to when I was on Prozac. Trying to go off it has been pure hell. I am suicidal and could kill my husband very easily. Absolutely no interest in sex or other activities. I've been through it before with Prozac so I'm not worried, I know it will go away. At first I thought this drug was wonderful. That was back in March. After taking it 3 or 4 months it no longer helped the fibromyalgia but continued to help the depression. I was on 30 mg twice a day. The doctor suggested upping it to 90 mg a day but I was scared to try that after reading this site. I get letters from my pharmacist whenever I haven't filled my RX on time warning me not to go off suddenly. That is not a good sign. I should have flushed it down the toilet then but it was working so well on my pain, I really hated to stop. It only worked on the pain for a couple of months. F 58 4 months
8/22/2007
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 3  anxiety, depression, menopause No side effects at first. Felt great. Lots of energy. Calmer. Took the edge off. Mild headaches. Gradually noticed fatigue returning. I think the initial bounce wore off. More pleasant to be around, but more tired. Started noticing more and more that I was feeling lightheaded, which is why I discontinued it. 20 mg. Started on antidepressants after lumpectomy & very traumatic move. A trusted phychologist helped me mourn & did me more good than pills. 20 mg. Celexa worked well for menopause, without side effects that seem to affect the entire body. (40 mg. sapped my energy) Off Cymbalta for a few months, headaches & vertigo. F 50 5 months
4/14/2007
 3  depression, anxiety Occasional dryness of mouth & constipation at first. Slept like a baby. No real mood change, but decision making became a lot easier. Rapid heart beat at times. Felt calmer, but also had less energy. Some blurriness of vision which I didn't attribute to the medicine until I went off 2 wks. ago. Mild headaches. Lightheadedness. Low dose (20 mg.) One weird side effect I had was an occasional feeling of heaviness in my calves that gradually increased and became painful, almost like the blood was pooling in my legs. Discontinued medication, using Motrin to pre-empt headaches. Still feel lightheaded now & then. Next: Wellbutrin(energy) or nothing. F 57 4 months
4/13/2007
 3  chronic pain/wegners granulomatosis uncontrollable shaking/tremors, sweaty palms, nausea, clenching of the jaw during sleep Have been on Cymbalta (30 mg) for 7 days due to chronic ear pain. Noticed difference on day 1. Felt no pain at all and experienced happier moods. However the uncontrollable shaking really scared me. Have quit this drug before things get worse. F 47 7 days
4/13/2007
 3  chronic pain/wegners granulomatosis uncontrollable shaking/tremors, sweaty palms, nausea, clenching of the jaw during sleep Have been on Cymbalta (30 mg) for 7 days due to chronic ear pain. Noticed difference on day 1. Felt no pain at all and experienced happier moods. However the uncontrollable shaking really scared me. Have quit this drug before things get worse. F 47 7 days
4/13/2007
 3  Depression and anxiety agitation, dizzy spells, yawning, fatigue, anxiety It seems to help the depression but not the anxiety, but I am willing to wait and see if this improves with time. I have lost weight and still losing. Previously on remeron which made me gain weight, even with exercise and controlled eating. I hope this works because so far no weight gain or sexual side effects. F 30 2 weeks
4/13/2007
 3  anxiety, depression extreme dry mouth, to the point where I constantly felt as if something was stuck in my throat which would in turn cause me to have an anxiety/panic attack, decreased appetite, severe insomnia Cybalta definitely helped with my depression but the side effects really took a toll on me after only a week. I had barely slept and had lost over 6 pounds within the first week because just the thought of food would make me sick to my stomach. I was constantly drinking water and had to have a bottle by my side at all times, it was just incredibly uncomfortable. F 20 3 weeks
7/24/2007
 3  depression nausea, indigestion, gas, belching, heartburn, constipation, acid reflux, stomach ache. Very good for depression, very rough on the stomach. I don't think I'll be able to continue because of the effect on my digestive system. I've been taking Gas X and Mylanta, which helps somewhat, but not enough. It figures that I would finally find a medication that works for me but makes me fart and constantly feel like I need to throw-up. F 52 7 weeks
7/24/2007
 3  Depression Insomnia, night sweats, major jaw clenching, tingling in hands and feet, urge to stretch, yawning, feel as if I am "zoning out" alot, decreased appetite Its been a week on the 30 mg and I have lost 5 pounds. I am not hungry and often remind myself its time to eat. I recently switched to taking this medication at night so that I could get some sleep. Taking it right before I go to bed has been helpful. This drug has greatly reduced my depression but I feel really paranoid at work, like others know I am taking something. The drug has also already helped me to not obsess about my ex-husband and our divorce anymore. When I am at home I get alot more things done because I am not depressed and glued to the couch. I have alot more energy. The yawning is annoying, because I am not tired. In fact, I feel wired. My doctor said that the side effects will get better. I am going to stick with it because I would rather have the side effects than deal with being so depressed all of the time. F 31 8 days
8/6/2007
 3  Depression My Dad passed away in 05. My Mom has not been able to deal with this after her 57 years of marrage. She has been taking various anti depressents. Celxa was the last one. Her dosage was increased to 40 mg and she got tremors and increased anxiety. Her MD put her on cymbalta. She has been taking it for 2 weeks. What I have noticed as her daughter and care giver is aggression. Normally even withourt drugs she is very passive. If I would call her to see if she wanted to come for dinner she would say yes no matter what time it was. Now her answer was your calling at 5 and want me for dinner I just made a sandwich. I thought it was great she had an opinion my husband took offense. The other thing where I thought she was out of character was that she was mad at a very good friend who she normally wouldn't be. She seems to be taking a stand and being angry where she normally even with out medication she is very passive and going along with the flow. I will say she isn't crying as much. F 76 10 days
6/10/2007
 3  Bipolar disorder / Depression Sexual side effects including dryness, pain, and inability to reach orgasm When I initially went on 30 mg Cymbalta daily, it worked very well for me. After a year my depression started to return and my dosage was increased to 60mg, however, I was recently married and the sexual side effects were causing problems, so I am in a transitioning period of my medications currently F 19 2 years
1/24/2007
 3  depression feeling edgy, sweaty palms, foggy head, loss of appetite just started taking cymbalta 5 days ago. I take it in the morning as it makes me feel kinda speedy. I am on 30 mg. SE are better if taken with cereal. I just want to feel more balanced and not so emotionally raw. Today I feel better, not so anxious or speedy.. time will tell, I guess. how long did it take for you to feel better? F 49 5 days
1/25/2007
 3  Depression, OCD Nausea the first couple days, difficulty orgasming the first couple weeks, beyong that NO SIDE EFFECTS I have taken Cymbalta off and on since it first came out (lost my health insurance, got it back)...when I am on it I noticed an extreme difference in myself with worrying and anger issues, it helped a lot in my job and with obsessing over other situations. Results for me were within first week. No real side effects. 60mgs daily. When I've had to go off, nothing major...some dizziness but that's it. Nothing else had worked with me for my obsessiveness ... I wanted to write Eli Lilly a thank you letter when I first started taking it. Seemed to stop working after six months in a row not sure if that is because I had increased stress or I was drinking more than usual (never a good idea to drink to much when on a med). F 33 2 years
1/14/2007
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 3  Menopause - Miled Depression Weight gain, teeth grinding/clenching & anti orgasmic I have been taken off of Cymbalta because it caused me to grind my teeth so bad that I was in a lot of pain. I think I wore the bottom of my teeth off! I also gained weight. I did have withdrawl headaches but nothing to bad. F 49 4 months
1/10/2007
 3  Depression, anxiety sleeplessness, trouble achieving orgasm, lack of appetite (to the point of being a problem), blurred/strange vision, I didn't have side effects when I took a lower dose of cymbalta, but once I switched to 60 mgs -- and stopped taking remeron, my old drug-- all the awful side effects started. I would wake up every night (literally. Even when I attempted taking some sort of sleep medication to help) at around 6 or 7 30, then not be able to fall back asleep for a good hour and a half to two hours. It was incredibly irritating and caused a lot of exhaustion on my part. I also noticed a pretty major decrease in my appetite-- this paired with my use of (prescribed) adderal meant I wasn't eating EVER-- had trouble achieving orgasm during intercourse (it took forever, absolutely forever), and towards the end, even had spots in my vision/blurred vision. The worst was that I loved how this drug made me feel mentally-- I really did-- but I just couldn't stand the physical side effects. I gave it a 3 for this reason; of course, these side effects by no means pop up in every patient, and if they don't in yo F 19 2 months
3/27/2007

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