CYMBALTA Reviews (DULOXETINE)

Average Rating: 2.7 (2745 Ratings)

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 ANTIDEPRESSANTS

 Type: Rx Drug

  

CYMBALTA  (DULOXETINE):  Duloxetine is used to treat depression and anxiety. In addition, duloxetine is used to help relieve nerve pain (peripheral neuropathy) in people with diabetes or ongoing pain due to medical conditions such as arthritis, chronic back pain, or fibromyalgia (a condition that causes widespread pain). Duloxetine may improve your mood, sleep, appetite, and energy level, and decrease nervousness. It can also decrease pain due to certain medical conditions. Duloxetine is known as a serotonin-norepinephrine reuptake inhibitor (SNRI). This medication works by helping to restore the balance of certain natural substances (serotonin and norepinephrine) in the brain.   FDA Approval Date: 2004-08-03 (Sources: U.S. Centers for Medicare Services, FDA)

  

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Key to Ratings: 1=LOW (I would not recommend taking this medicine.)
5=HIGH (this medicine cured me or helped me a great deal.)

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More on CYMBALTA: Reviews Summary  |  Drug Safety Information

RATING  REASONSIDE EFFECTS FOR CYMBALTACOMMENTSSEXAGEDURATION/
DOSAGE
DATE ADDED
 
 1  Depression and anxiety Headache, constipation, extremely bad side effects when you try to stop taking Cymbalta. Worse than any other drug I have been on. I have been on it two years, yes it does work, but you pay the price. Once I get off of this physically and mentally addicting drug, I will never take it again!!! It takes months to titrate off of it so beware!! F 52 2 years
60 mg. 1X day
8/23/2011
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 1  antidepressant I am writing this for my mother . She has been takin this drug for five years . I will say that from what i have gathed from site affects over the years . I wish i would have caught it sooner ! This drug has affected her with every site affect ,dry mouth rash seeing things . I have not got all the information i need yet !But i will say my mother is not her self anymore ! She never will be , I am doing research now !with medical records ! so i know im on the right track.I wish my mother would have never been on this drug . or zoloft prozac! If they cant diagnose somethin they give you a pill! Well to much of anthing will have its on side affect! If there is anyone out there that has been on this drug or a person taking care of someone on this drug ! I would appreciate any advise you could share with me !This is my mother i am an only child , no one but me to take care of her !i am 46 and loosing my mom in front of me day after day ! I want to see if i can help her in any way!Thank You F 64 5 years
60mg 2X day
9/12/2011
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 1  Slight depression/anxiety vomiting/nausea, dizziness, vertigo, severe stomach cramps, shaking violently,no energy, sleepy I took this drug for the first time today and within 45 minutes I was vomiting and had severe stomach cramps and was dizzy. About a half hour later I was shaking violently like I had the flu and I was freezing cold. It has been 11 hours since I have taken it and I am still very dizzy/ have vertigo and I am very tired eventhough I didn't even get out of bed all day. Earlier I couldn't walk straight at all. It is slightly better now but still very dizzy. I am not taking this again. I have wasted the entire day. I hope these effects are gone tomorrow but I doubt they will be considering how bad I still feel. F 38 1 days
30 mg 1X day
9/9/2011
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 1  Chronic pain Wow!! Here's a thought for all physicians and pharmaceutical companies. I went to see about my chronic pain due to IC and endometriosis and was at my wits end. My new doctor gave me Cymbalta to try. I took one pill!! Up all night with anxiety, feels like my skin is crawling, nausea, dizzy spells, feeling angry and no appetite!! So here's my concern. Doctors do not want to prescribe pain meds due to the side effects however they will give away this extremely expensive poison (Cymbalta) for people to try. It seems appropriate to tell all to check this med out prior to taking it. Anything with an entire page dedicated to side effects probably hasn't been tested enough. So easy to hand out a drug that causes so much stress and negative side effects shows that a doctor doesn't care or hasn't done their homework about this terrible drug! DO NOT TAKE THIS POISON!!! F 39 1 days
30 MG 1X day
9/18/2011
 1  Depression No sex drive, dry mouth, weight gain, lack of emotion, like a zombie. I have come off of Cymbalta after a year of weaning. It was horrible and I now have Atypical Trigeminal Neuralgia. Was it caused by this drug? I can't get any answers from anyone. None of the Dr's I've been to know or care to know anything about this drug. "Discontinuation Syndrome" is a known problem but the only people that care are the ones experiencing it. It's horrible and not worth it. F 53 5 years
90 1X day
9/6/2011
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 1  Chronic migraine, depression Loss of motivation, loss of energy, sleeping all the time. Weight gain - probably about 20 or 30 lbs. Not helpful for depression. The withdrawal from Cymbalta (even with a very slow taper which included opening the capsules and splitting the dose, as recommended in a 2009 FDA report) was awful and incapacitating. It took 3 months to get off of it, and those months were awful. Severe nausea, vomiting, dry heaves, sweating, regular headache every day, severe muscle cramps and pain, NIGHT TERRORS and HYPNAGOGIC HALLUCINATIONS, liver pain, severe itching and tingling, "pins and needles." The FDA report states that doctors are not properly informed (or misinformed) by Lilly about the proper tapering process, and the side effects of tapering off of this medication. My doctor thought I was nuts, but there are many online forums dedicated to support for patients coming off of Cymbalta. THIS SHOULD NOT BE NECESSARY and LILLY should INFORM DOCTORS of the DANGERS of the WITHDRAWAL from this medication. After going through similar experiences from Effexor, I will NEVER take another SNRI; I will stick with the SSRIs. F 28 2 years
60 mg 1X day
6/2/2011
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 1  Depression Was on 60 mg which gave me panic attacks and nightmares. Went down to 30 mg. Started crying every day and feeling suicidal. In the process of withdrawing from this medication which is INCAPACITATING. Diarrhea, stomach ache, dizziness, shortness of breath, extreme fatigue, headache, brain zaps, you name it, I have it. Dr. then gives me Prozac to combat withdrawal which is only working to the point where I can get out of the house now, I'm not bedridden like I was last week. Don't take this drug it's POISON. F 37 90 days
30 mg 1X day
6/7/2011
 1  Pain Management Psychotic break Combined with Lyrica - Baker Acted - horrible!!!! F 51 25 days
30 1X day
6/19/2011
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 1  Irritable Bowel Syndrome/Anxiety At the beginning, shoulder pain. Bowel changes. Constipation and then horrible diarrhea. Increase in flatulence. Over time, increased need to urinate, with flow greatly DEcreased except in the morning when it is extreme flow with extreme urgency. "Fog" feeling, definate change in short-term memory. Disconnected feeling. WEIGHT GAIN!!! Not immediate, but around month 4, was like overnight, gained 10 pounds. No change in diet, other than maybe a DECREASE with an INCREASE in physical activity. Midsection focused gain. Extreme lethargy, at points, like to the point of narcolepsy almost. Trying to wean myself off now. In the beginnigng, I think it worked GREAT! Definate change in anxiety, in a good way. I noticed a plateau-ing if not a decrease in effectiveness with an increase in side effects. An odd thing, when I first went on, I had intense right shoulder pain (I have a rotator cuff problem). As I just went down to half dosage 5 days ago, today (day 5), that intense shoulder pain is back. Feels like a pre-cursor to frozen shoulder (which I've had before). Had a BIG weight gain, 10 pounds in like 2 weeks. It literally appeared nearly overnight, and all focused on the midsection. The fatigue in the last month or two has been intense. I definately noticed a change over time, and the longer I stay on it, the worse I seem to be feeling side effects-wise. I'd rather live on Immodium than deal with this so I'm trying to wean off. I wouldn't recommend this drug to anyone. I don't think enough research has been done on it. I did also see an increase in blood pressure. I'm concerned what else it's doing to my body. F 42 5 months
50 1X day
5/23/2011
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 1  Lower back pain and arthritis I was great when I first started taking it, about a month later I lost my sex drive completely. Then about the 3rd month I was having my menstral cycle almost every day the 3rd and 4rth month I had maybe 3-4days I didn't have it, month 5th and 6th, had 2 days that I did not have it. My OBGYN said was cymbalt I had seen my doctor around the 3rd month because of my sexual drive got lost we went down to 30mgs. This is the ending of the 6th month I have stopped it cold turkey per dr since I was on the 30mgs, I am currently having Vertigo so bad that antivertigo medication is not helping went to the hospital this weekend cause i'm working on 6 days of vertigo, I can barely walk straight let alone drive. How long do i have to deal with this withdrawl? oh yeah i have lapse in memory, 30lb weight gain, swelling of both legs, and horrible leg cramps all night too. Since stopping the meds i have been a horrible mess with VERTIGO,crying and mood swings, not to mention wanting to kill myself on a I was at my wit's end with pain, Cymbalta seemed to be the wonder drug. I don't know the proper way of coming off this drug it appears from all the post there is none. At this point i'm going to loose my job because of this I have a 23 mile commute one way, and for the safety of myself and other's i can not drive with this VERTIGO i can barely sit up at times. F 37 6 months
60/30 1X day
6/27/2011
 1  Fibromyalgia Miracle drug at first, weight gain, dry mouth were acceptable for years. Knocked out about 60% of fibro pain. Thoughts of suicide and night terrors began and worsened in the last year. into 3rd week of withdrawal and it keeps getting worse. Suicide (good thing I don't own a gun), uncontrollable outbursts, sleeping all the time or can't sleep, HORRIBLE nightmares, paranoia, complete meltdowns, head pain, irritable bowl, stomach pain, hot or freezing, sweating F 61 6 years
60 1X day
6/29/2011
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 1  Depression, Anxiety, Stress, Pain Everyone imaginable. Loss of appetite, metal taste in mouth, weightloss, headache, disoriented. Worst medication to date for me. I couldn't believe the side effects and how harsh they were. I felt horrible, my mouth tasted like metal and I could not sleep for days. I was hoping it would eventually go away so I continued to take it and after the 6th day of the same intense side effects I finally had to just chunk them in the trash. Was wondering if anyone else had this bad of effects but that they did go away after a certain amount of time. I have been on wellbutrin before and the side effects were bad but did wear off after about a mont F 33 6 days
30 mg 1X day
6/27/2011
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 1  for depression Weight gain, anger issues, vision problems, suicidal thoughts, body aches, extremely tired, memory problems, dizziness and that isn't even all of them I have been off of it for a year I think I still don't feel normal I've had ongoing issues with my voice that started before I went off cymbalta. My depression is getting to the point that I'm not sure I will be able to go back to work I'm on temporary TDI. I now find myself being paranoid about several things especially medications. For me cymbalta did way more harm than good. F 59 7 years
120
3/2/2018
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 1  pain, neuropothy, etc No appetite(did not eat for foir days) vivid nightmares, no pain relief, anxiety, irritability, severe diarreaha I was only on cymbalta for 30 days.my side effects were so severe I insitisted on discontinuing it. It also counteracted with my migraine meds (maxalt) which could have caused coma/death. upon discontinuing it, I experienced major withdrawl symptoms which were never explained to me. Brain "zaps"- which feel like being electrocuted in yuor brain, and can shoot through your limbs. Even worse irritability. Crying spasms. (I have taken antidepressants in the past and NEVER gone through anythong like this!) And after 4 days I was hospitalized for a major asthma attack,. Had asthma since childhood but NEVER had to go to the ER before. Even they told me cymbalta was evil poison. I would not suggest this med to anyone who has remaining choices. I understand many here are suffering from extreme depression, but do not take this until all other options have been exhauseted. This stuff is poison.it also raises your blood pressure. Be careful. F 32 30 days
30 mg 1X day
5/17/2011
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 1  Fibromyalgia numbness on face and hands, dizzy, headache, foggy, sleepy, nausea, blurred vision, dry eyes and mouth, shaky all over Bad Stuff F 56 1 days
30 mg 1X day
5/4/2011
 1  depression loss of tenderness and empathy for others. Talked alot more, connected deeply alot less. Got alot done, lost alot of contact with people I loved. Emotional depth gone (the good and the bad). F 37 3 years
2X day
5/16/2011
 1  Anxiety brain fog, mixing up words, crazy dreams, very sleepy, loss of motivation, zoning for hours, confusion, mood swings, feeling unsteady, dizziness, always feel "lost." Careless feeling, and anti-social, memory loss, and unable to separate reality or a feeling of not being real. DO NOT TAKE CYMBALTA!!!! In the long run it will ruin you. F 22 1 years
60MG 1X day
4/7/2011
 1  Anxiety Weight gain (24 pounds in 6 months), constipation, headaches, sexual side effects My withdrawal symptoms lasted over two months. I had never been so depressed in my life. The body zaps made me sick. Some days I did not want to get out of bed. I loved this drug the first few months I was on it, but please be careful on it. It will just stop working all of a sudden and coming off of it is worse than anything you can imagine. You will have legit withdrawal symptoms similar to when a druggie comes off of hard drugs. F 31 7 months
30 mg 1X day
4/7/2011
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 1  RA Fogging, Shaking legs arms and hands. Feeling of lonleness for no reason. scared one minute fine the next. zombie like, extremely tired! This is the strangest drug i have ever taken. It takes away all the pain compeltley, too bad it makes you stupid!!! im on it right now and dont even know if i am spelling correctly. I feel like they need to do some more reascearch on it, because if you ask me IT IS DANEROUS, ANYTHING THAT HAS TO POWER TO TAKE OVER YOUR MIND , BODY, AND YOUR PERSONAILTY IN THE WAY THIS DOES (A BAD WAY) IS PIOSION!!!!!!!!!!!!!!! F*CK CYMBALTA!!!! F 21 4 days
30 MG 1X day
4/2/2011
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 1  depression and associated pain constant constipation with no relief from stool softeners, laxatives, or enemas. Weaned off to 30mg for one week then stopped totally. I experienced strong vertigo, pain in my joints, severe nausea, legs jerking at night, heavy brain fog, constant dizziness for two weeks. Now, three weeks later, still have legs jerking at night and some dizziness. I feel I took a serious poison. They "don't know" how it works to block pain. However it works to block mild pains, it must be very serious and strong since the withdrawal is severe, intense, long lasting, and affects the entire body. My doctor never warned me about the withdrawal effects. NEVER TAKE THIS POISON. F 44 2 months
60mg 1X day
3/24/2011
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