CYMBALTA Reviews (DULOXETINE)

Average Rating: 2.7 (2745 Ratings)

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 ANTIDEPRESSANTS

 Type: Rx Drug

  

CYMBALTA  (DULOXETINE):  Duloxetine is used to treat depression and anxiety. In addition, duloxetine is used to help relieve nerve pain (peripheral neuropathy) in people with diabetes or ongoing pain due to medical conditions such as arthritis, chronic back pain, or fibromyalgia (a condition that causes widespread pain). Duloxetine may improve your mood, sleep, appetite, and energy level, and decrease nervousness. It can also decrease pain due to certain medical conditions. Duloxetine is known as a serotonin-norepinephrine reuptake inhibitor (SNRI). This medication works by helping to restore the balance of certain natural substances (serotonin and norepinephrine) in the brain.   FDA Approval Date: 2004-08-03 (Sources: U.S. Centers for Medicare Services, FDA)

  

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Key to Ratings: 1=LOW (I would not recommend taking this medicine.)
5=HIGH (this medicine cured me or helped me a great deal.)

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More on CYMBALTA: Reviews Summary  |  Drug Safety Information

RATING  REASONSIDE EFFECTS FOR CYMBALTACOMMENTSSEXAGEDURATION/
DOSAGE
DATE ADDED
 
 4  depression/anxiety The first week on 30 mg.I experienced terrible nausea,flu-like symptoms,chills,lightheadness,extreme fatigue and insomnia.My doctor says that this usually goes away after the 2nd week and that many give up on it because of the symptoms. I can tell emotionally that I am feeling a little brighter. F 47 1 weeks
3/28/2006
 4  mild depression SEVERE night sweats and increased sweating during the day, and somewhat difficult (but not impossible) to reach orgasm. I had intense headaches for the first 3 days of taking Cymbalta, but then the depression "fog" cleared and I felt much less weighed down by my thoughts. During the first few months of taking Cymbalta (30 mg) I used to wake up at least 2X during the night to change pajamas & sheets/bedding due to intense sweating & was losing lots of sleep. Now I don't wake up until morning but I am soaked with sweat. Overall, I have felt more like myself & much less depressed, but occassionally when I experience a setback, I don't dwell as much on my sad thoughts. Both my therapist & psychiatrist are extremely puzzled by the instense sweating, as though they're hearing of this side effect for the first time. F 36 8 months
10/26/2006
 4  60 MG I have gone from 30 to 60 mg in the last two weeks; I think it helps pain, depression and anxiety. My BIGGEST complaint, is overheating; sweating.l Will that get better! F 62 60 days
8/17/2006
 4  anxiety/depression weight loss (good thing), nightmares, sweating. I have a new symptom and that is when I start to fall asleep I go into an instance panic attack or something. I feel I stand lay still and my stomach is crawling. Has anyone else had that problem? F 62 6 months
2/19/2007
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 4  depression and chronic pain. Some insomnia, but nothing that can't be cured with a sleep aid. Also, decreased appetite, weight loss (a good thing!), vivid dreams, increased sex drive with intense, almost painful orgasms. This is the first med that has HELPED with my depression and chronic pain. I was started at 30mg and bumped up to 60mg after 1.5 months. It has almost eliminated my anxiety. I don't fly off the handle. I FEEL HUMAN!!! I am consistantly losing weight and I'm really not complaining about the increase in my sex drive! LOVE IT! F 29 4 months
1/30/2007
 4  depression 1 or 2 days a week I am really weepy where I feel like I need a good cry w/o anything particular occurring each week. Some marital probs may contribute. Palpitations if I have a drink or two. Previously taken Zoloft for 10+ yrs & Wellbutrin for 5. Now Cymbalta w/Wellbutrin seem to have helped my outlook & stability. F 50 1 months
2/21/2007
 4  Depression/ Anxiety SWEATING, dizziness with missed dose, leg nervousness, weight loss initially. Slight forgetfulness or difficulty concentrating. Less side effects than Effexor but just as effective if not more. Definitely took me off the emotional roller-coaster I was on from PMS. F 42 6 months
9/12/2006
 4  bipolar and borderline personality the first SE i noticed was substential sleep difficulty, then weight gain and recently an alarming hair loss, although this may also be due to Dekapote which i also take. i've been on Cymbalta for 10 weeks now, and am very very pleased with it's anti-depressant effect; this, after failure of almost all existing anti-depressants and ECT treatment to grant relief from severe depression and very poor functioning. F 53 10 weeks
10/18/2005
 4  mild depression, anxiety, pain some brief spells of nausea, restless legs and vivid dreaming at first and when upping dose, low sex drive increased energy apathy Love it/hate it! Definately reduces fibro pain. energizing at first then decreases. I'm more patient, less negative, calmer but my give a darn is broken and I can't even imagine why folks would want to have sex. Makes me a bit withdrawn. F 37 10 months
10/10/2005
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 4  chronic pain and mild depression I wake up in a cold sweat. Soaked. 60 mg. at night. No more negative thoughts. Happy Days instead of sad days. Better relationships with my friends and family F 78
2/19/2007
 4  depression On 90 mg I had sweating at night so that my clothes are drenched, somtimes multiple times at night. I also have had a lot of gas and some constipation. On 60 mg, I was irritated with my boyfriend when he wasn't being irritating at all. On the whole, this drug has helped very much. The side effects for me are less than for Effexor. F 23 2 months
2/7/2007
 4  Panic Attacks/Depression The first few days insomina, after that I felt very tired all the time. Long Delay before orgasm. Loss of Libido I have been on 150 mg of Effexor for about 8 months. Was experiencing loss of sexual function, delayed orgasm. In the past many years ago I tried Zoloft & Prozac and had the same effect. My shrink felt maybe by switching to Cymbalta my libido would come back. It's too early to tell I have only been on it for one week at 30 mg's along with 37.5 & 75 Effexor. He is weening me from Effexor to Cymbalta. I really havent had any different side effect other than the fact I feel a bit more tired, maybe it will ease up as time goes on. I also take 0.05 klonopin for anxiety. When I go for my next visit I am sure he will adjust by taking more of the Effexor away not sure if he will increase the Cymbalta. I feel like I have gained so much weight with all theses anti-depressants, but I guess it beats having panic attacks and not wanting to go out of the house and enjoy life. I do have alot of extra added stress in my life right now. I am a student, mother, wife, and work part-tim F 42 1 days
12/28/2005
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 4  depression/anxiety consipation, weight gain 20#, delayed orgasm, daytime sleepiness, vivid dreams helps with depression well but am worried about withdrawal if and when I stop it. When will wt gain stop? F 51 16 months
1/3/2006
 4  back pain, mild depression loss of appetite, diarreah, nausia, feeling wired at night, trouble falling asleep first 2 days, bad taste in my mouth and urge to yawn all the time even though I felt pretty wired and alert. I feel good, but the more I read about the withdrawal symptoms, the more scared I am. I called my dr. today to find out more about BRAIN ZAPS, and am waiting to hear back. My mood has improved, I feel good- relaxed, even tempered and am not dwelling on things like usually, and today my back pain is improved, I feel less nautious when I take in the AM with food. My doc recommended taking for a year. . . but I'm not up for that if the withdrawal symptoms are as bad as I've read. F 26 4 days
1/5/2007
 4  GAD and Depression I was so tired the first few days I started this I stayed home from work for two days because I couldn't stay awake. I slept for hours and hours. The first few days I would yawn constantly, it was a weird fake yawn but I felt compelled to do it. Also the first couple of nights while sleeping I would clench my jaw to the point when I woke up and started with the yawning it hurt. My pupils are huge were co-workers and friends have noticed and asked "What are you on?" Currently I'm still very tired all the time, I'm constantly trying to figure out how I can fit naps into my day, or sleep in longer in the morning, going to bed earlier. I used to be very active (anxiety) I could never sit still, I hated to sit down and watch a TV show or Movie. Now I rather stay in on the weekends and watch TV and nap. This was kind of nice at 1st but now I'm getting worried. I'm tired all the time, I can nap during the day but at night I wake up almost every hour tossing and turning and bad nigh Aside from being tired all the time and conspiring to sneak in naps through out the day, Cymbalta has helped greatly with my GAD and depression. My anxiety was on the verge of ruining my relationship with my boyfriend of 3 years but now things are great. I feel very secure, like a weight has been lifted off my shoulders. I'm independent and free from my repetitive and negative thought process. It's very refreshing. I do have a harder time reaching orgasm but I find intercourse to feel 100 times better. I just hope the tiredness goes away and that soon I will sleep at night. F 29 1 months
12/27/2006
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 4  Depression Insomnia at night, drowsiness during the day, difficult to orgasm I'm taking 60mg and it has helped with my depression. It has also made it nearly impossible to orgasm, which really bothers my. I also have a big problem with insomnia on this medication, whether I take it at night or in the morning. I like that this med does not cause weight gain like Lexapro did for me, but I hope these side effects go away soon. F 21 6 weeks
6/26/2006
 4  Depression, arthritis pain I came onto the site to see if anyone else had experienced an increase in appetite on this drug. I have noticed a marked increase in appetite since reaching my 60mgs dosage (not good). After reading other reviews - the night sweats!!! At least I know I'm not alone with that - thought I was going into early menopause! I have taken Lexapro and Prozac in the past with numerous side effects; very minimal with Cymbalta. There isn't a drastic change to my mood, however I'm able to problem solve and actually live life now!! I had been experiencing a lot of pain due to RA and OA and this is GONE!!! Very happy with this drug overall. F 32 2 months
11/23/2006
 4  Depression Sexual side effects, severe lack of motivation, headaches. Seemed to work great initially, then in a few months I was depressed but dismissed it because it had seemed to work so well. F 49 1 years
2/20/2006
 4  severe chronic depression inability to orgasm, dry mouth, vivid dreams, extreme night sweats This med stopped the harrowing bout of depression and suicidal obsessions. I take 90mg, which is an ungodly high dose and is probably eating my liver. Sex isn't much fun without being able to orgasm, but at least the night sweats keep any prospective partners away F 39 3 months
4/9/2006
 4  Neuropathy Tired at first and a little nauseated. Always eat something first before taking Cymbalta. Some dizziness at first. Started on 30mg. Have lost 16 lbs. since February which I really needed to lose after being on Neurontin, Lamectal and Ponstel since December. I will never go on Neurontin and Lamectal again. I'm abit more spunky than I used to be. The Dr. increased me to 60mg. a day after about 3 weeks. That seemed to help me alot. Noticed after about 2 weeks that not only the pain and burning in my legs disappeared but also the pain I had been having with Cervical Spondylosis has subsided too. I've been suffering with that since 1996. Its nice not to get up in pain every day. All I have to do now is find a job that I'm happy with again as my boss has been a first class pain in the butt since all this started in October 2005. F 48 2 months
4/15/2006

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