CYMBALTA Reviews (DULOXETINE)

Average Rating: 2.7 (2745 Ratings)

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 ANTIDEPRESSANTS

 Type: Rx Drug

  

CYMBALTA  (DULOXETINE):  Duloxetine is used to treat depression and anxiety. In addition, duloxetine is used to help relieve nerve pain (peripheral neuropathy) in people with diabetes or ongoing pain due to medical conditions such as arthritis, chronic back pain, or fibromyalgia (a condition that causes widespread pain). Duloxetine may improve your mood, sleep, appetite, and energy level, and decrease nervousness. It can also decrease pain due to certain medical conditions. Duloxetine is known as a serotonin-norepinephrine reuptake inhibitor (SNRI). This medication works by helping to restore the balance of certain natural substances (serotonin and norepinephrine) in the brain.   FDA Approval Date: 2004-08-03 (Sources: U.S. Centers for Medicare Services, FDA)

  

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Key to Ratings: 1=LOW (I would not recommend taking this medicine.)
5=HIGH (this medicine cured me or helped me a great deal.)

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More on CYMBALTA: Reviews Summary  |  Drug Safety Information

RATING  REASONSIDE EFFECTS FOR CYMBALTACOMMENTSSEXAGEDURATION/
DOSAGE
DATE ADDED
 
 3  Major Depression & Anxiety Nausea, Dizziness, Loss of Appetite, Weight Loss, Mental Numbness, Blurry Vision. I started at 30 MG for 3 full weeks. Start of 4th week, I went up to 60 MG. I take it every morning at 8 am. After getting into work because it makes my vision very blurry. I can't see well the first 3 hours of work. But by afternoon most of the side effects go away. Only loss of appetite is all the time. I just can't eat and have no desire. F 43 4 weeks
60 MG 1X day
10/18/2014
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 3  Deprression, Fibromyalgia Weight gain, tiredness. The sweating was the worst. I was sweating constantly, I did not have to even do anything to sweat. I had to discontinue due to sweating. It took a long time for my family doctor to figure out that it was the Cymbalta causing the sweating. Doctors thought it was menopause due to my age. F 50 2 years
60mg 1X day
12/18/2014
 3  Fibromyalgia & associated symptoms Jittery, speedy, heart palpitations, accompanied with exhaustion, diarrhea & no appetite. No driving for 1 1/2 weeks. 10 pound weight loss in 2 months. 2 weeks resulted in more energy and a better attitude, reduction in IBS. Speediness subsided along with fatigue and diarrhea. No pain reduction. F 57 2 months
30 MG
11/9/2014
 3  Depression/anxiety Very foggy, unable to think straight, no motivation (no matter what the motivator), panic attacks, unable to respond to emotions of others, thinning hair, sweating (especially around head), suicidal thoughts daily with some planning, no sex drive...period, emotions feel close to surface and as if they are competing to get out, helped depression at first, but not now, very poor memory, hard to follow a task from start to finish, hard to walk straight at times, VERY short temper, hostile, aggressive behavior, easily startled by loud noise, have to tell myself to show emotions...feel totally dead inside. When this drug initially helped my depression, I was thrilled. It seemed like a Godsend. One year after taking it, I experienced an episode of ITP (immuno-thrombocytopenia purpura) and nearly died. I had 1,000 platelets when checked into the hospital and required two transfusions. Took 6 months to recover. They later discovered that this was from a medication interaction between Cymbalta and the 800mg ibuprofen I was taking for pain from a car accident. Doctor did not take me off Cymbalta, but did take me off pain medication...not especially helpful. When effectiveness tapered off, my dose was doubled to 120mg/day. I began having terrible bruises, and my fingers would get painful bruises from blood testing for diabetes. I have become more and more suicidal and am moving toward the planning stages. I can barely make it through a full day of work, and usually have a panic attack at around 2pm each day. I'm searching for an answer, but in the meantime...I'm scared. F 53 8 years
60 1X day
11/21/2014
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 3  crying, anxiety, stress ringing in ears. What the drs. thought was a yeast infection. Itching - tingling on skin. Dry skin, almost like psoriasis. Tired- had to nap every afternoon. Everything was great til the 5th yr. Started out with what we thought was a yeast infection. That lasted for 7 mos.My family Dr. treated me 2 times for a yeast infection, then sent me to a gynocologist. He told me he'd never seen a case like it & did a biopsy. All came back negative. There were months I didn't want to go anywhere because I couldn't just get up & sit down. The rash went down my inner thighs. The sad news was - You may have to just live with it & try to boost up your immune system. I tried everything from not using toilet paper (wipes instead) and acidophilis vitamins. There was a little more relief everyday. When I started getting the itching all over, that was it!!! A different dr. told me I had tinnitis 4 yrs ago & live with it. I even asak the pharmacist about any yeast infections from any meds. Finally I sat down at my computer & really investigated. There it was rash & itching on the sex parts. BINGO!!!!!! Now I check all meds side effects on many web sites. F 62 5 years
60mg. 1X day
12/12/2014
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 3  migraine, mild depression Nausea for first 2 weeks or so, complete loss of sex drive for a year on meds- for 1st 6-8 months or so any thought of sex or physical contact disgusted me from what once was a high-above average sex drive, inability to orgasm for 1st year, difficulty achieving orgrasm still, but it is possible (about half the time), Complete loss of appetite (got down to 90 lbs while on it (was originally 100 lbs)) It did help with my depression. I am only on 30 mgs. My body couldn't handle being on 60mg (the no sex drive as a newly wed and weight loss was just too much). Weight loss obviously is not typical (according to other reviews) but I am a 100 lb, petite girl to begin with. It made no difference on my migraines, in fact, it might have made them worse. I am beginning to slowly taper off by taking one every other day, but am concerned with the side effects. After one week, my only withdrawl symptom has been migraine (which was why I was on it to begin with) F 25 1.5 years
11/10/2009
 3  Anxiety,depression I have been on it for 3 days. I have tried lexapro got allergic reaction. Zoloft made me feel like I was in a dream world and very weird. I am scared of with draul but I spoke to my dr. And he said don't believe everything u hear. I'm sure this drug has helped lots of people they are just not posting because they now have a life. And for the people that say they gained weight should watch what they eat. It is a proven fact this drug does not cause weight gain. As far as withdraw, we just need to ween off super slow. Any drug is going to give side effects. I just hope I finally found something. I'm afraid of taking meds. F 26 3 days
11/4/2009
 3  Anxiety/Depression/Pain Nausea, Dizziness, muscle spasms, decrease/increase in appetite, irritability,sleepiness, difficulty or inability to orgasm. Migraines, jaw-clenching. It certainly helped to elevate my mood and make me less anxious bu the side effects are rather distracting, especially the Dizziness and Nausea and I have no energy. My pain seems to have gotten worse but it's only been three weeks so I hope that will get better. The difficulty/inability to orgasm is particularly irritating. I feel like my parts are almost numb and I seriously would probably not be able to orgasm at all if I didn't use a vibrator. I have no idea how I could naturally get one! Yet I still have sexual urges which makes it even more frustrating when I want to do it and can't enjoy it as much. I hope the side-effects will level out in time so I can fully enjoy life again! F 25 3 weeks
11/7/2009
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 3  Fibromyalgia pain & Depression I've been on 60mg Cymbalta daily for 2 years. Recently decided to increase dose slowly. Anything added to my 60mg causes red burning & itchy butterfly rash on face. This has worked well for chronic pain.Unfortunately I can't seem to take more than 60mg because I break out in serious hives on my face in the cheek and eye area. I seem to be more weepy (crying easily) during pms as well. F 41 2 years
11/15/2009
 3  Depression, Social Anxiety, I have had very few -but very noticable side effects, including but not limited to: complete exhaustion (but this was there with the depression), constipation, sick to the stomach and have had changes in eating patterns. I do feel flat (as people stated) but to me this is an improvement over mania and being all over the place. I am peeing all the time and am very very thirsty. I have also aquired a taste for alcohol which I find very odd - I am not much of a drinker anymore and it is like I am developing a problem to the point people have noticed. Even though I am exhausted, I am sleeping so much better -I fall asleep much easier and I don't wake in the middle of the night anymore. I lost five pounds the first month, which is great. I have had a increase in sex drive and my migraines have gone from 3 a week to once a month. Being flat allows me to better interact in public without the anxiety but I am still depressed while alone. I am one week into the 60's. F 37 2 months
11/25/2009
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 3  Anxiety; mild Depression 15 lbs weight gain in 7 mths; some tiredness; Major sweating to the point of embarrassment; less concentration and focus It works like a charm in the beginning for my anxiety. I am now trying to wean off this medication due to weight gain and cost. Started at 30 mg. then went to 60 mg. My doc wanted me to go to 90, but I did not want to. The doc also told me that this med was less likely to cause weight gain compared to other anti-anxiety meds - not true for me. Plus I have some muscle pain and she thought it would help that, which it did not. Trying to wean off is aweful! I ran out and had to go a day without it and had the worst day ever - brain zaps, dizziness and uneasiness. That was when I decided to ask about weaning off. My new doc has prescribed Prozac and wants me to try to wean off Cymbalta in about a week. I have been down to 30 mg. for about 2 weeks. I am going to take it slow weaning off especially after reading so many comments about side effects of weaning. I think it helps to add 20 mg of Prozac to the 30 mg Cymbalta while weaning. I hope this works for me and hope Prozac works without weight gain. F 49 8 months
11/27/2009
 3  Neuropathic pain/RSD 35 pound weight gain, Sweating, Insomnia, Sexual indifference, Dry mouth, Nausea, Agitation, It worked great for over a year allowing me much greater comfort in my thigh area in regards to the neuropathy, but the agitation reached such a level, and changed the way I felt inside, I couldn't stand myself anymore, and asked to be taken off of it. Withdrawal was pure hell. Was surprised at the level of CNS involvement, and what a vegetable I became. Also was a complete dragon for a day. Was in bed 3 days entirely due to this process. Would NEVER do this again! Luckily am working to take off weight gain, and have 13 more pounds to go, and feel much better 2 1/2 mos later! F 45 2 years
12/1/2009
 3  Depression and herpes nerve pain Adrenalin Rushes, lost 3 lbs in 2 months, nightmares (these ones really top zoloft even as I've been on all SSRI's and I had a dream about a decapitated head in my pillow, nice :)...complete loss of interest in sex and can't orgasm, pain in the left side of my body and muscle aches...on the plus side I've got more energy and I'm not panicky or depressed, just a little jittery when drinking coffee and eating too much sugar. I like this drug, other then the sexual effects and nightmares I'm only taking 30 mg a day right now of the brand name. Waiting for Canada to bring the generic over so I can drop down to 20mg as I'm a little too speedy for my liking sometimes, but at least I'm AWAKE and alert which I havent been in years. F 31 60 days
12/12/2009
 3  Depression & Nerve Pain I've only been taking Cymbalta for 3 days, but I'm already not sure about it. I took the first 2 doses at night, and I wasn't able to fall asleep for 4 hours. Then, when I finally did, I woke up within 2 hours with a massive headache. So, I decided not to take it last night and took it this morning, instead. The headache hit quicker and more intensely. Also, my mouth feels like sandpaper and I have absolutely no appetite, but that part is ok! I have lost 6 lbs already, so I can't complain about that! The headaches and insomnia are almost too much, tho. Will talk to my dr soon. I don't think I can wait to see if the side effects go away. F 33 3 days
12/14/2009
 3  Depression, anxiety Nausea, dizziness upon standing, vommiting, sleepiness/fatigue I was prescribed 30mg of Cymbalta along with Abilify to treat mild depression. Within two hours of taking this combination I felt nausea, headaches, loss of coordination/dizziness, and experienced vommiting. I slept the entire day and woke up feeling a bit displaced. That evening I was unable to sleep, although I have also been prescribed a sleep aid as well. I found myself waking up several times that evening. Day two went better, although I experinced yawning and a bit of pressure in my head. However, I felt I had a more positive attitude and desire to be productive, which I hadn't felt in some time. F 25 2 days
1/17/2010
 3  depression,anxiety Nausea, constipation, insomnia at 60 mg. I would like to hear from others. I slept fine at 20 and 40 mg. Doctor said that 60 mg is the optimal dose but I think it is too much for me becasue I am waking up several times a night. Anyone have experiences at 40 and 60 mg regarding insomnia? F 46 1 months
1/7/2010
 3  depression nausea, dizziness, headache This is my first day on Cymbalta, and after feeling nauseous and dizzy I am afraid to continue. The weird thing is that about four hours after taking it I felt calm and happier.....but still sick. I don't even know if it was because of the medicine. F 44 1 days
1/8/2010
 3  Depression, Fibro Pain, Anxiety Only major side effect was inability to achieve orgasm which I personally found intolerable. Really worked great on my general pain & depression. Had it not been for the one side effect, I'd likely have continued it indefinitely for Fibro Pain & Depression. F 37 3.5 weeks
10/23/2009
 3  Major Depression Disorder/GAD I have gained 30 lbs since I began taking this. I have never been overweight before. Also, oddly my cholesterol has jumped up over 50 points in the last year. Which can be a side effect of Cymbalta. Very sleepy all the time. Hard time focusing and if I miss dose look out... I become very irritable, not to mention I experience brain zaps similar to paxil withdrawal. Having been involved in a lawsuit with glaxosmithkline due to the effects of paxil withdrawal I am very concerned about stopping this drug. However, I am not willing to be a depressed huge woman either. The drug has helped with the depression, however the side effects are awful. If you think giving a depressed woman who has never had a weight problem, an extra 30 lbs to carry around is a good idea you would be mistaken. So mostly the weight issue is a big deal. I swear the drug makes me very, very hungry. It is quite bizarre. Also, I also just seem mostly numb which is pretty scary. I dont like feeling like that. F 30 3 days
10/29/2009
 3  menopause/hotflashes No side effects...yet. I'm a little confused as to why my doc would prescribe this drug for menopause. He said his nurse is going through the same symptoms I am going through and sent her in to talk with me. She had a full hysterectomy just like me and swears cymbalta works for her. Anyone with some advise??? Oh by the way...I have no depression or any other pain problems. F 47 1 days
10/14/2009
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