CYMBALTA Reviews (DULOXETINE)

Average Rating: 2.7 (2745 Ratings)

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 ANTIDEPRESSANTS

 Type: Rx Drug

  

CYMBALTA  (DULOXETINE):  Duloxetine is used to treat depression and anxiety. In addition, duloxetine is used to help relieve nerve pain (peripheral neuropathy) in people with diabetes or ongoing pain due to medical conditions such as arthritis, chronic back pain, or fibromyalgia (a condition that causes widespread pain). Duloxetine may improve your mood, sleep, appetite, and energy level, and decrease nervousness. It can also decrease pain due to certain medical conditions. Duloxetine is known as a serotonin-norepinephrine reuptake inhibitor (SNRI). This medication works by helping to restore the balance of certain natural substances (serotonin and norepinephrine) in the brain.   FDA Approval Date: 2004-08-03 (Sources: U.S. Centers for Medicare Services, FDA)

  

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Key to Ratings: 1=LOW (I would not recommend taking this medicine.)
5=HIGH (this medicine cured me or helped me a great deal.)

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More on CYMBALTA: Reviews Summary  |  Drug Safety Information

RATING  REASONSIDE EFFECTS FOR CYMBALTACOMMENTSSEXAGEDURATION/
DOSAGE
DATE ADDED
 
 1  atypical depression Intense anger, manic episodes, paranoid and grandiose delusions, change in mannerisms. I experienced a real "activating" effect early on, which I enjoyed until others starting commenting on my change in demeanor. The change continued gradually and finally became extreme enough that others began to ask me whether I was abusing "uppers." All the while, I was feeling energetic and confident, and was unable to see my actions as erratic or strange. Now after having quit, I am amazed that I could not see how different I really was on Cymbalta. The memories I have from that time period seem like the memories of another person. M 4 months
12/11/2008
 1  Mild Depression, Social Anxiety Sweating, drowsiness, heart palpitations, weird/vivid dreams, decreased sex drive I was on 60 mg. By far the worst antidepressant I've ever tried. Has not done much for me. Infact, I believe I become even more anxious while on this drug. I only get a "lift" when I first take the drug, and then I'm back to being depressed and anxious within 10 minutes. M 27 3 weeks
11/6/2008
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 1   Aweful diarrhea, reflux, Feeling of beeing stoned, yawning +- 300 times per day, tired eyes, flat emotions, dulled senses, extreme tiredness, vivid dreams, ringning ears and "charged feeling" in my head, reduced general pain, slow reflexes My pdoc put me on this stuff for serious anxiety and mild but chronic depression. First day I take it im tired and groggy within half an hour. this feeling eventaully develops into a pleasant feeling much like being STONED on marijuana. Im in lectures and yawning furiously. I cant stop yawning, my eyes are watering i want to go to sleep. I cant get any reading done, im so bombed. call my pdoc, he says take it at night. i do. get tired right away and fall alseep. i wake up at 5am feeling like im staring though my eyes from a control room in a distant galaxy. I just lie there with blurred vision, not knowing what to make of this feeling, it fast becomes extreme anxiety. My ears are ringing and i get up and stumbles around in panic. get back to bed but with my lamp on because i feel uncomfortable because of a heavy feeling of darkness. wake up late, im lethargic and late for class. spend the day at uni basically stoned. social anxiety a minimum. dont really care what i say or do, who i lo M 27 2 days
2/14/2009
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 1  PTSD FROM IRAQ WAR ***ZOMBIE, LACK OF MOTIVATION AND WORK ETHIC. NO LOVE FOR ANYTHING IN LIFE...WORSE OFF THEN BEFORE THE DRUG**** (((WITHDRAWL))) THIS IS BY FAR THE WORST DRUG TO COME OFF OF. WAY TO MANY SYMPTOMS TO LIST BUT THE BIGGEST ONE IS SUICIDAL THOUGHTS AND HURTING OTHER PEOPLE....DO NOT EVER, EVER , EVER TAKE THIS DRUG...THERE BETTER OPTIONS OUT THERE..DO YOUR RESEARCH M 29 3 years
2/11/2009
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 1  Depression Zombie-fied This drug just made me feel wiped out, too weak and sleepy to keep my eyes. I wasn't as depressed but at what cost? I couldn't drive safely or perform at work. I took myself off it after about 4 weeks. I wasted a $35 co-pay on filling a prescription but it was the cost for a lesson learned. M 57 30 days
2/3/2009
 1  muscle pain fatigue, muscle cramping M 55 4 years
1/1/2009
 1  pmdd Lethargic, unable to function and wanted to sleep all the time. M 47
7/20/2008
 1  Depression I was depressed, this medication made me suicidal. Nightmares, night sweats, severe brain zaps, restlessness. I hate this drug! I took this drug for 8 weeks and have now been off it for 8 weeks. I came close to killing myself 3 times while on it or coming off it. I'm never taking an anti-depressant again because of my experience with this "medication." M 23 8 weeks
9/5/2008
 1  Anxiety The first time I took it (within hours) I had SEVERE sweating, diarrhea, dry heaves, disorientation, tingling and dizziness. I was slumped on the floor of the bathroom dripping sweat and unable to speak clearly when the EMTs arrived. That was 2 days ago and I haven't touched it again. I'm still groggy and have slower and slightly impaired speech. All in all the experience didn't lower my anxiety much! M 52 1 days
9/12/2008
 1  Depression No relief from depression. Lethargic. Brain Fog. Weight gain. Withdrawal was awful Do your research before you start this drug. M 44 1.5 years
4/30/2008
 1  depression/anxiety vivid nightmares, apathy, bladder spasms, increased anxiety, weight gain..100 pounds, blurry vision, headaches, body tremors, night sweats, dizziness, fluid retention, tachycardia, hypertension, confusion this is by far the WORST ad i have ever taken. i am trying to do a slow taper, and i mean very slow and the withdrawal is HELL! it increased my anxiety and did nothing for my depression but i became so apathetic i didn't even care how horrible my life had become. M 31 18 months
2/21/2009
 1  Depression I have been taking it for 2 days and have had sever headaches, nausea, and feel as if I have a fever. After the first dosage I assumed i was getting sick. After the second I researched the side effects. I will not take this drug any more. M 43 2 days
4/14/2009
 1  Pain Sleepy, shaking, disoriented, stupefaction I have been on Wellbutrin for over 3 years. I started it for smoking cessation and it helped me go from nearly two packs a day to just a few a day. It also gave me energy and I had no side effects at all. No stupefaction effect that many get from drugs like Eleval and Pamlor (I took both to try to help with chronic pain – worthless. Now I wear a Fentanyl patch and the pain is well controlled and I have no side effects). I took one (1) 30mg pill and within two hours was asleep in my car because I got so tired and disoriented. I was at work at the time that I took it. Later that night, I was still groggy and my body was shaking, like I was having a low grade seizure or something. I slept on and off during the night, but was unable to go to work the next day because of the shaking and feeling of being disoriented. Your experience my be different, but if you are taking something that is working fine, don’t let a doctor “recommend” this. I won’t take this drug again and I would seriously consider not taking it if you are about to. Try Wellbutrin if you haven’t tried it. M 47 1 days
4/23/2009
 1  Depression/Fibro Anger, anger, and more anger. Turned me into a raving lunatic! Lilly's going to be in trouble for this one - it should be yanked off the shelf. I am normally so calm, people ask if I have a pulse. But I felt like bashing my fist through dry wall on this stuff. Try Cytomel - it works! M 5 days
5/9/2009
 1  Depression, anxiety Started perfect, then didn't care about anyone, or anything. didn't care about the future. didn't care when a really good friend of mine died. Started not to care about living. not a depressed feeling, but there was no good or bad in life. a zombie. kinda like drugged people you see on movies of psych wards. Started out doing exactly what i wanted from it: helping the depression, and completely getting rid of the anxieties i was having. I've taken several different antidepressants and none had worked so good so fast. i took 60 mg every morning with my adderall. Over time, i just stopped caring about anything. stopped going to class. stopped going to work. stopped working out(i ran triathlons the previous semester). stopped leaving my apartment unless absolutely necessary (pretty much just to buy food). I eventually didn't want to play World of Warcraft anymore(most addictive drug ever). I got to the point where i was barely getting out of my bed. I was a Cymbalta zombie. M 21 6 months
5/15/2009
 1  Major Depressive Disorder Perfect while on it long term, problems came when I had to stop taking it. Muscle spasms, brain zaps, irritable beyond words, nauseated, headaches. This drug works great while your on it, though it takes a week or so for your body to adjust. But DO NOT ever stop taking it lol. The withdrawals are terrible. Worse then withdrawing from narotics like methamphetamines. M 32 2 years
5/24/2009
 1  Anxiety, depression, bi-polar Night sweats, 30 lb. weight gain, worse depressive episodes than pre-medication, panic attacks, alcoholism, dissociation, psychotic episodes when increasing dosage, extreme withdrawal syptoms: brain zaps, nausea, vomiting, diarrhea. Avoid Cymbalta at all costs! Felt great for the first two months, the next two years were a nightmare of horrible depression (worse than being un-medicated), psychotic episodes brought on by increasing dosage from 60 to 90 mg, alcoholism (which had never even been remotely a problem), and went from 155 lbs. athletic and fit, to 193 lbs. and severely depressed to where I did not leave the house for four months if I wasn't working. Withdrawal symptoms are horrible, but after switching to B-complex, Omega 3's, Melatonin (to sleep), and 5-htp, I feel much, much better. No more horrifying nightmares either. M 26 2 years
5/29/2009
 1  Neuropathy - Degenerative Joint Dis Brain Zaps like a short circuit in my brain - Lithargic - Weight Gain- Incredible Anxiety - No energy - Apathy combined with fits of rage and anger - Insatiable appetite for sugar, lots of soda and chocolate -things I never ate before taking this drug - Severe Depression and an overwhelming sense of helplessness I decided to stop taking this medicine completely a week ago today. I was on 60mg and at one time twice a day. At first I got a lot of these crazy short cirucits in my brain but they've almost gone away now. I can't begin to tell you how much better I feel now. Super increased energy, more positive thoughts, sleep better and able to deal with and think a lot better like I could before taking this nasty medicine. I wasn't taking this as an anti[-depressant but a pain management aid. God help anyone that takes this medication for depression. You'll probably want to go out and kill yourself afterwards and put yourself out of your misery. I had many thoughts of suicide and helplessness and being overwhelmed on this durg and thoughts I never had before taking it. I stopped exercising and socializing and became a hermit as I felt more and more paranoid. Again things I never had previously. Best advice - Don't read all this garbage about the terrible side effects of withdraw from stopping Cymbalta. Just do it and get off the stuff and see if your side effects match those of others after you have the meds out of your body for at least a week. I can tell you in one short week I got my life back again and have the high levels of physical and mental energy I had before taking this drug. I'm relaxed and able to function like the person I had always been. Do you know our enitre waste water and now fresh water systems are so laced with anti-depressants today that many aren't safe to d M 57 2.5 years
5/27/2009
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 1  wife has stage 4 lung cancer my doctor gave me cymbalta 30 mg. 1 a day said would help with my depresion . I had thoughts of killing myself and couldnt eat or sleep,or talk to anyone wanted to stay in bed all day long. 1 week of this cured me this med.is SHIT dont take it . the goverment should ban this drug very dangerious, I never In my life wanted to kill my self M 55 4 weeks
6/11/2009
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 1  Depression Sleeping as much as 20 hours at the time, heavy sweating in the feet, never happened before. Hot and cold flashes, fever, confused and just an overall feeling that I didn't care about anyone or anything. Loss of interest in everything, even my penis has gotten smaller. I should be in the ER now because the heavy sweating and all of the other symptoms. I would not wish this drug on my worst enemy! I cannot take serotonin drugs, so what does my doctor do, put me on Cymbalta. After the first dose that caused me to sleep for over 18 hours, I did feel some better. The next day I took my second dose and slept another 18 to 20 hours, I was in such a deep sleep that my daughter banged on my house for two hours before she called the police to break in. After that fiasco, I noticed that I was feeling dizzy and my feet began sweating, my feet have never sweat before, but I took another dose and and I have been completely out of it for two days. I am hot and cold, extremely dizzy, feverish with cold shakes to being so hot that I think I am going to burst into flames. I am most likely dieing as I write this because I am to stubborn to go to the ER and my doctor is closed now. It is a Friday evening and I am trying to wait until Monday to see my doctor. No one should take this drug, I don't care how depressed you are, at least you are alive! I know some people do well, but I have seen serotonin drugs prescribed for so many things and every single person I know that has taken them have had really bad experiences. Please everyone, let serotonin drugs be a last resort, it's probably going to be mine, because I really don't know if I am going to make it! M 54 3 days
7/10/2009
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