CYMBALTA Reviews (DULOXETINE)

Average Rating: 2.7 (2745 Ratings)

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 ANTIDEPRESSANTS

 Type: Rx Drug

  

CYMBALTA  (DULOXETINE):  Duloxetine is used to treat depression and anxiety. In addition, duloxetine is used to help relieve nerve pain (peripheral neuropathy) in people with diabetes or ongoing pain due to medical conditions such as arthritis, chronic back pain, or fibromyalgia (a condition that causes widespread pain). Duloxetine may improve your mood, sleep, appetite, and energy level, and decrease nervousness. It can also decrease pain due to certain medical conditions. Duloxetine is known as a serotonin-norepinephrine reuptake inhibitor (SNRI). This medication works by helping to restore the balance of certain natural substances (serotonin and norepinephrine) in the brain.   FDA Approval Date: 2004-08-03 (Sources: U.S. Centers for Medicare Services, FDA)

  

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Key to Ratings: 1=LOW (I would not recommend taking this medicine.)
5=HIGH (this medicine cured me or helped me a great deal.)

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More on CYMBALTA: Reviews Summary  |  Drug Safety Information

RATING  REASONSIDE EFFECTS FOR CYMBALTACOMMENTSSEXAGEDURATION/
DOSAGE
DATE ADDED
 
 3  Depression Left eye stays dilated (Anisocoria), blurry vision, difficultly reading close at 30 mg dose. Less problematic at 15 mg (half doses) while still some benefits. (I have light body weight.) Typical sexual side effects 4 hours after taking. I loved the tingling and tickling feelings and numbness that relieves pain. Relief from depression started at twice the duration after sexual side effects (only 8 hours) but mood benefits increased after a few days of consistent use. M 40 7 days
30 mg 1X day
12/26/2022
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 2  depresia I write ir Lithuanian language. As nezinau ar mano savijauta yra nuo Cymbaltos vartojimo.As jauciu kiekviena diena galvos skausma virsuje galvos centre,spengia ausyse,kiekviena diena skauda krutine,sokineja kraujo spaudimas,sirdies ritmo sutrikimai ir ttttttttt..... as bandau mazinti Cymbalta vartojima nuo 60mg ,kiekviena diena nuimu po 7 granules,jau pasiekiau 30mg simptomai nesikeicia,sergu kiekviena diena.as tikiuosi man pageres jei pavyks man nutraukti vartojima Cymbaltos.As pavargau sirgti kiekviena diena-sunku... M 40 8 months
60 1X day
5/29/2022
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 2  Depression It doesn’t work and it causes anger, violent dreams Withdrawals are hell M 21 2 months
60
11/19/2019
 2  Anxiety depression & pain in neck, Terrible sweats,memory lost,confusion, mean person!!!!!! The sweats bother me the most.Help with the pain,I looked like a race horse that just lost a race !!!!!!!!!!!!!!!!!!!!!!!!!!!! M 66 2 years
60 1X day
5/21/2015
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 2  Depression Initial side effects: insomnia, headaches, spaced out, constipation, dry mouth. Persistent effects: lowered motivation, loss of sexual interest and function. This is the second time I have tried Duloxetine. First trial was for 5 weeks and was unsatisfactory. This second trial has been much the same. For a while it seemed like I was improving, but over the last week or so I have sunk back to how I was before beginning the drug. In fact I am worse because this drug, like most serotonin dominant drugs, saps what little motivation I have left. I just have no interest or desire to do anything and this is much worse than before starting. The drug also failed to alleviate my bad memory and other cognitive impairment problems. There seems like no point continuing any more. I would like to give it a couple more weeks but am really sick of the way it makes me feel. I should point out that most drugs don't seem to work for me any more. M 34 6 weeks
60mg 1X day
2/12/2016
 2  Depression Insomnia, exhaustion, tense (jaw clenching), spaced-out, hot-flashes, chills, headache, mild nausea, urinary hesitancy. The pharmacist told me it could take 2-4 weeks to realize the benefit of this drug. However, it took only one day to realize the collection of disturbing side-effects. With an impending family vacation, I had to stop the medication as I didn't want to be a Disneyland zombie. It took about 4 days after ceasing the med to finally feel like myself again. Trying Deplin next. M 56 2 days
30 1X day
4/5/2016
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 2  Depression and Fibromyalgia Major difficulty having an Orgasm (this could be considered good or bad. Good, because one can perform Sex for a long, long time. Bad, because one can never get the satisfaction of completing the act.) I stopped Cymbalta for six months and went on Viibryd. I also began the type 2 Diabetes drug, an injectable, called Victoza. I was on Victoza for a year when I read that Cymbalta was now being used for Fibromyalgia. So I took one to see if it would help. 7 hours later I became so nauseous I had to run to my bathroom to vomit - I ended up puking for 15 minutes straight until I had the dry heaves. I thought perhaps I had a stomach bug so I put off taking the Cymbalta for a few days. 5 daysllater I took another Cymbalta. Sure enough 7 hours later I was running to my bathroom to puke my guts up once again. It had to be the Cymbalta /Victoza combination that made me sick. A year passed and I went to a new Rheumatologist. He recommended that I begin taking Cymbalt While I was taking Cymbalta it did seem to help my depression, but it sure did not help, nor alleviate, any of my Fibromyalgia symptoms. Also, it seemed to lose its effectiveness after I took it for some time. M 58 2 years
60 mg 1X day
6/27/2014
 2  Depression and pain On and off sweats, nausea, jittery, eyes feel like they are over focusing, dizzy. Horrible side affects but made me more tollarable to life, unfortunately I'm stopping this crap before I freak out. M 29 1 days
60mg
4/17/2014
 2  depression Increased urination; nausea; high blood pressure (165/110); being highly emotional; feeling "flat"; more anxiety; and tired during the day. I started at 30 mg and my blood pressure increased - then gradually increased dosage to 60 mg and blood pressure rose even more (pulse rate increased to around 115); also take with 15 mg of generic Adderall XR (so I can't tell which medication is causing which side effects); I really don't care for it as I have low motivation and energy on it; also, I am extremely tired (even with the Adderall) - this may be due to the interruption in sleep it causes at night. M 34 25 days
1/19/2010
 2  Bipolar depression, GAD Am still awaiting an antidepressant effect. Meanwhile have felt more depressed and generally slowed down: anorexia, tiredness, slower talking, slower walking, constipation. Other early side-effects have been headaches, irritable watery eyes (improving), hair loss (persisting), anxiety, akathisia, no motivation (worse), reduced libido. Appearing to friends/family/nurses as flat and looking more depressed. Anorexia is severe. Hoping that I'm through the *2-week wall*! We'll see.. M 56 14 days
60mg 1X day
10/3/2014
 2  Bipolar 1, Depresssion, GAD My doc doubled dose to treat depression but while it has helped slightly I remain feeling flat and anergic. ZERO LIBIDO!!! Sexual performance atrocious > feeds depression. Prolactin higher. Hair thinning persists. No motivation, flat-lining, hypersomnolence. Urinary hesitancy. This drug has made me LESS productive. M 56 3 months
60 MG 2X day
12/26/2014
 2  depression, anxiety inability to orgasm, dry mouth, weird yawning, jaw trembling, mild weight gain, increased migraines, crying at the drop of a hat, tired after taking pills, mild constipation, very dark stool i'm taking 60mg in addition to 300mg of Welbutrin. Several of the symptoms (jaw trembling, yawing, and crying) have diminished somewhat, while others have gotten worse. I have been unable to maintain and erection or achieve orgasm with my partner which has increased my level of anxiety. Thankfully he is in the medical profession and completely understands. The weird yawning and jaw trembling was intense in the beginning and was VERY reminiscent of taking Ecstasy pills back in my 20s. I've also put on about 10 pounds. I'm going to ask my doctor to take me off of Cymbalta at my next appointment. M 39 2 months
1/2/2010
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 2  Depression, peripheral Neuropathy Tired. Always tired. The first 6 months on Cymbalta were crazy. The pain in my legs subsided but I couldn't achieve an orgasim for almost the whole 6 months. Now that I've been taking 60mg for about 2 years I'm emotionally flat. Easy to shrug off anything important. Pain in my legs came back a year ago worse than ever. I ran out of pills on Tuesday. The mail order pharmacy was too slow to get the order out. Today's Friday. Started getting a headache Wednesday, didn't think anything of it. My ears started ringing loudly yesterday and today it hurts to look at the computer screen. Funny thing is when I got out of bed this morning the first thing I noticed was that the pain in the bottoms of my feet was gone. Funny reading about the brain zaps. I wouldn't have known to describe them that way. It's like a rush of blood being sprayed towards my ears from the inside. Colors are more vivid. More detail. I just got my shipment today and I don't think I am going to take it anymore. M 50 2 years
10/2/2009
 2  Depression I have been on it only 3 weeks so this may be too early but wanted to look up other's results. I have had only 2 full nights sleep since and once I wake cannot get back to sleep other than a nap shortly after waking. I did not get it for joint pain but it appears lessened. Crawly, tingling skin, short term within an hour of taking it. Sweats and change in body odour. Had Tinitus before but was very low and is louder now. *TREMENDOUS lack of energy which is getting slightly better with time. M 59 20 days
8/23/2009
 2  anxiety, depression, sleep, pain None that I can see I have been on 30mg for 5 days now and I feel a little better and sleep a some now but but not what I expected I have called my doctor to see what is next since I am in no way happy with the results so far M 49 5 days
7/17/2009
 2  Depression/Generalized Anxiety Dizziness, Mild-moderate Nausea,Episodes of anger over minor events, VIVID Nightmares, Brain "zaps" if you miss a dose. I have taken both Cymbalta & Lexapro for Anxiety. I must say that I was better overall on Lexapro. This medication has done very little for me. It was 1 month of misery to go through withdrawal from Lexapro. Lord only knows how bad Cymbalta withdrawal will be... M 43 2 months
7/2/2009
 2  Seizures / Anxiety / Migraines In March 2009 I woke up paralyzed on the left side of my body after going to bed with a migraine. I was first put on 30mg of Cymbalta back in November of 2008, upped to 60mg & now 120mg per day. Since then I have been having seizures, numbness on the left side of my entire body, I feel like I am shaking all over, I have daily panic attacks, all my joints are killing me, especially my hands. I cant sleep, although I feel as though I want to sleep constantly, I have bouts of diarrhea & constipation. I have constant dry mouth, SEVERE chapped lips & thirst. I cant think straight, & I have no emotions other than wanting to be left alone. I have pushed everyone out of my life. My doctor added Lamictal to the mix and now I am having more seizures than ever before and I cant stop throwing up. He seemed to think upping the Cymbalta would help but I don't know if I can take any more of this. I cant stop crying & I can barely stand to care for my children. They keep upping my dosage thinking it will help, but I think its going to be the death of me... M 37 8 months
6/26/2009
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 2  depression heavy sweating I thought it was great for 5 months, and then it just stopped working. I went from 60mg to 120mg and there was no lift. I am now on effexor xr. A female friend had the same experience after 3 months. M 66 5 months
7/8/2009
 2  Social anxiety. Depression. Extreme perspiration. Difficulty urinating. Insomnia. Erectile dysfunction. Libido mostly absent. Why did I even bother? M 34 1 months
7/14/2009
 2  depression, anxiety, panic attacks nausea constipation hypersensitivity My doctor started me on this drug at a 60mg dose. Over time it was increased to 90mg. I was recently told that 90mg was not recommended even for adults and that it was strange to see such a high dosage. I was told this by a different doctor who I visited after being out of school for a week and a half due to strange symptoms. M 15 10 months
5/11/2009

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