CYMBALTA Reviews (DULOXETINE)

Average Rating: 2.7 (2744 Ratings)

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 ANTIDEPRESSANTS

 Type: Rx Drug

  

CYMBALTA  (DULOXETINE):  Duloxetine is used to treat depression and anxiety. In addition, duloxetine is used to help relieve nerve pain (peripheral neuropathy) in people with diabetes or ongoing pain due to medical conditions such as arthritis, chronic back pain, or fibromyalgia (a condition that causes widespread pain). Duloxetine may improve your mood, sleep, appetite, and energy level, and decrease nervousness. It can also decrease pain due to certain medical conditions. Duloxetine is known as a serotonin-norepinephrine reuptake inhibitor (SNRI). This medication works by helping to restore the balance of certain natural substances (serotonin and norepinephrine) in the brain.   FDA Approval Date: 2004-08-03 (Sources: U.S. Centers for Medicare Services, FDA)

  

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Key to Ratings: 1=LOW (I would not recommend taking this medicine.)
5=HIGH (this medicine cured me or helped me a great deal.)

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More on CYMBALTA: Reviews Summary  |  Drug Safety Information

RATING  REASONSIDE EFFECTS FOR CYMBALTACOMMENTSSEXAGEDURATION/
DOSAGE
DATE ADDED
 
 4  depression anxiety PTSD OCD none but nausea very good med but very very expensive M 45 2 months
60 1X day
12/15/2011
 4  Depression muscle and joint pain I have no horrible side effects from this med. My apologies to anyone who might be offended by the following. I obtain an erection and orgasm much more slowly than before. My muscle and joint pain is almost totally gone. What depression I had has reduced alot. Situational anxiety has decreased substantially. M 51 1 months
30mg 1X day
11/17/2011
 4  stomach pain and anixiety Coming off drug I have blood shot eyes now. Dizzy. I gained 20 lbs in one year. I workout every day and I WAS in good shape. I was hungry all the time and I drank too much When I was on it I did feel more confident. I would not have decided to quit taking it if it wasn't for the weight gain. I don't think he causes weight gain but it does make you want to eat more often. I ate at 10pm every night, an extra meal. I felt like it didn't matter, so what, who cares. I was a little foggy and I did not like that either. M 47 15 months
20 1X day
7/20/2011
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 4  Treatment resistant depression A little dry mouth, headache but nothing that lasted more than 3 months. This med has worked great for me. I occasionally still have a bad day or two but that's normal for everyone. Recently, it started pooping out (depression/anxiety has come back) and I'm bummed. I also take 150 mg Lamictal to augment. Dr. has added Lexapro and will post on that after a month or so. I M 37 3 years
60 1X day
3/24/2011
 4  Post Lyme Fibromyalgia Side effects: dry eyes, sight digestive changes - constipation and occasional flights of nauseated feeling. Initially weird dreams. Lately have had increasing bouts of itching skin and tiny pimple-like eruptions feeling like insect bits at groin and underarms. My Fibro had nearly incapacitated me and this med works wonders to keep me functional and able to manage my pain at tolerable levels. I have learned NOT to miss a dose when traveling of for other reasons as this causes a revisit of pain increase. If lack of meds is coupled with other fibro-triggers such as stress or lack of sleep, I have a full fibro flare-up. So for me, this drug has been wonderful, but concerns of liver damage keep me getting regular liver studies M 58 2 years
20mg 1X day
3/6/2011
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 4  Depression and anxiety Hot flush on whole body. Unable to sleep. Dry mouth. Shaky legs, feels like weak. Cymbalta makes me feel good. I never tried other AD. The worst is the hot flush I get when I took it before I sleep. After a few hours, I will be awoke by the hot flush in my body. I don't sweat. Just inside my body. My doc ask me to change it to morning and everything is fine now. I realize if I had hot flush, I just need to sweat it out by doing some excerise. M 30 1 months
30 MG 1X day
3/13/2011
 4  Depression/Anxiety Almost impossible to reach orgasm. Felt castrated by this medication. Uplifted mood, more positive attitude were the key benefits for me. Cymbalta is the only antidepressant medication that ever helped me. The first three days of taking it were like hell, so much so that I nearly quit the medication from the very beginning. My pupils were dilated and I felt nauseous. A coworker asked if I was ok and said that I looked like I was about to puke. My doctor told me that it could take 4-6 weeks before I noticed any benefits and to give it a chance so I did. Pushed on through the first few rough days and after the first week I felt ok. It was right after the 3rd week of being on the medication that I definitely noticed a positive benefit. I found myself just being in a more positive mood all the time, which was a great improvement because just weeks before I was always in a more negative/down mood. The only side effect that I noticed was a big one - I almost couldn't have an orgasm and this caused relationship problems for my girlfriend and I. When I finally did reach orgasm (and it took alot of work) it would be a very little one. Also, the semen that came out was a very small amount and seemed almost a different color and consistency than normal. I pratically felt castrated while taking the Cymbalta. After a year of the positive benefits and uplifted mood I decided to ween off of it and have not felt the need to go back on it since. I would recommend talking to the doctor about gradually lowering the dose over a period of a couple of months. The withdrawal from quitting this medication can be absolute hell if M 34 1 years
60 1X day
4/17/2011
 4  anxiety/ depression Diarrhea at first, for the first few days, serious mood change when stoping usage. Otherwise the drug works like a charm, especialy for anxiety. Found it almost impossible to have depression thoughs. No weight gain, no brain fog- quite the opposite, no memory changes, no sexual side effects- actually the sex drive is quite up, doin it more than once daily on average. But stopping it was very hard, as the mood swings, and depression thoughts crept in without notice, had to go back on it. M 33 5 months
60 mg 1X day
5/11/2011
 4  bipollar poor sex drive, weight gain, crazy dreams and odd sleeping patterns I started on 30mg 2 weeks and than moved up 2 60mg after i had a bad time with a broken back for 2 years pryor in that 2 years i cut my self 2 shreds to help ease my back pain. Sounds dumb but was effective now 4 months on i feel fine with cymbalta. my partner has stood by me the whole but hates the lack of labeito maintaining erections and the waking up every few hours i seem 2 do now. recomend it for bipolar. M 27 4 months
60 1X day
5/10/2011
 4  GAD, OCD. insomnia (treated with low dose Risperdal), costipation, mild drowsiness, delayed eiaculation. cymbalta day by day let me know what is really GAD. a destroying disorder that does not allow u to life free. i take it in combination with Risperdal, as said, and Bupropion 100 mg daily. M 24 1 months
60 mg 1X day
10/20/2010
 4  Depression Fibromyalgia at start dry mouth& metallic taste; started clinching jaws which causes headache, tooth and gum pain & neck pain. The dry mouth is very insignificant compared to depression. For those people who do not understand why anyone would take these drugs with all the side effects YOU HAVE NEVER SUFFERED REAL DEPRESSION. It is necessary to find one with fewest side effects and everyone is different. What can you live with?? I am assuming the Cymbalta is the cause of the clinching. I had the same thing with Lexapro along with some other things. M 68 2 months
1X day
8/15/2010
 4  anxiety dry mouth, sleepiness started to not work as well after 4 years M 52 4 years
90 1X day
8/18/2010
 4  Bipolar Depression Jaw clenching, I was hospitalized at Four Winds for three weeks for depression. They put me on cymbalta. It has definitely helped tremendously with depression. I am grateful for this medication. M 20 3 months
60 mg 1X day
8/1/2010
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 4  Moderate Depression, Severe Anxiety Night sweats, constipation, taking longer to climax during sexual intercourse I am glad that I started Cymbalta before I came to this site. I have only been on Cymbalta for 10 days but I am already starting to feel so much better...I've gone years and years being depressed, sometimes severe sometimes moderately. The disheartening thing is that the people who are most likely to post on sites like this are the few that have had bad side effects. However, remember that everyone is different and out of ALL those taking this medication only 20-30% end up with severe side effects if any at all. Every person physiologically is different and processes meds such as Cymbalta differently. There is a balance...there are many who are taking this medication and have not had any side effects at all and even the ones that have, it has been worth the side effects. I am hoping that my experience with this med continues and that it gets more effective as time goes on. M 32 10 days
60 1X day
7/18/2010
 4  Depression (Dysthymia) , Anxiety Decrease in libido (not totally gone), ejaculation takes longer, morning nausea/loss of appetite, constipation, more frequent urination, excessive yawning (first two weeks), penile discharge (first week), jittery/high energy (first week), weight loss. -I also take 200 MG of Provigil twice a day for Narcolepsy. -For the first two weeks I took clonazepam for the anxiety until the Cymbalta kicked in. - So far it has worked great for me and the side effects have not become severe enough to cause an issue. I was somewhat hyper/ talkative the first week (a major shift from being extremely quiet, removed, and antisocial), but that was mostly with family members. If I eat much of anything in the morning while I still have the mild nausea I will get diarrhea, otherwise I have had some mild constipation but that usually only makes me take a little longer in the bathroom so I moved some books in there for reading (reading has always been difficult because of the lack of interest, and excessive daytime sleepiness that would cause me to fall asleep repeatedly and become disoriented). My general level of anxiety has dropped quite a bit. I still recognize some of the thoughts and feelings I had before, but they no longer keep me from being able to do things as simple as taking a walk and it is much easier to communicate. My motivation level has increased a large amount and allowed me to actually have interest in creating art (an interesting/nice feeling for someone who has gone to a Fine Arts college for the last 3 years) and in life in general. I have gained a good amount of energy throughout the day and am actually sleeping better (which is still "fragmented sleep"). - I'm going to keep watching things. M 21 1 months
60 MG 1X day
6/10/2010
Email
 4  depression, anxiety constipation, light headedness, some tingling, lightheadedness, spacyness. slight loss of libido and takes longer to ejaculate. stomach pains initially, but went away after a few days. This is my second try taking Cymbalta. I tried it 2-3 months ago and my doctor took me off due to the inability to ejaculate. However, after trying two other medications, Cymbalta had the only side effec that I could see myself coping and dealing with--so i went back on it. During this second go-around, I only take the medication at night (versus the last time i was taking it in the morning). I find this works so much better. I can ejaculate at night, but not in the morning. Maybe the drug has worn off a bit at night, not sure why. Also, the second time around, the side effects seem to be less severe than before, especially the brain zaps, this time don't notice it as much. M 41 1 weeks
30 MG 1X day
5/4/2010
 4  Social anxiety, small depression Fatigue (sleepy in the afternoon), decrease in appetite, delayed ejaculation Helps with social anxiety, doesn't really help depression. M 18 2 weeks
60 mg 1X day
4/13/2010
 4  depression anxiety side effects were a little tough at first but i was told you have to stick through it to see if it works. it takes weeks to get full benefits . i am now able to function day to day. still dont feel good all the time but it put a big dent in my problems IF YOU RATE THIS DRUG WITHOUT GIVING IT THE PROPER TIME TO WORK THEN YOU DID LISTEN TO YOUR DOCTER IF YOUR NOT WILLING TO COMMIT TO THE WEEKS IT TAKES DONT WASTE YOUR TIME AND DONT POST HERE THAT YOU TRIED IT FOR 3 DAYS AND IT DIDNT WORK!!!! i do understand that these drugs do effect people differently and have considered this before my statement here. thanks...paul M 46 6 months
60mg 1X day
5/12/2010
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 4  Severe Anxiety Orgasm problems, Decreased sensations during intercourse and loss of erection. Procrastination. No anxiety at all, did not care or worry about anything. First it took me extra time to Orgasm. My wife would have two Orgasms and then it would take me 20-30 minutes. I could not feel anything during intercourse we would have to try manual or oral methods then the orgasm was not very strong. If I masturbated sometimes I would ejaculate but feel nothing. The other problem was I seemed to be so "Happy" that I procrastinated small projects and paper work. In the past "Mild" anxiety made me successful. No anxiety really slowed me down. I have been coming off the drug but I am getting a little panicky at times and don’t want to take Clonopine either because it makes me very tired. This drug would be ideal if it was not for the Sexual issues. I felt great and could teach myself not to procrastinate. The sexual problems where terrible. M 47 4 months
1/27/2010
Email
 4  Depression, Anxiety Nausea, loss of libido, unable to orgasm, brain zaps, dizziness, concentration issues, yawning, tiredness, jaw clenching, slight insomnia First, the good. The little things that would make me depressed or sad before doesn't phase me as much. I've noticed that I recognize the situation, but the drug takes the edge off. I fall asleep easier than before. Generally, I feel more content with people and situations. I don't have thoughts of death or dying like before. Now, the bad: I got a bad stomach ache the first day but it didn't happen after the second day. The same goes for the nausea, it seems to be happening less and less the longer I am on Cymbalta. I get occasional brain zaps, but it isn't too bad to where I would stop taking it. I am able to have an erection with no problems, but not able to orgasm. I am not sure if it is the drug that makes me not too concerned with this sexual side effect as I would consider myself a very sexual person. I am hoping that in time I will be able to orgasm like before, but I don't know how long that will take. If anyone has had success or advice on this side effect please email me. I don't want this to be a permanent situation or get worse. M 41 2 weeks
30MG 1X day
2/5/2010
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