CYMBALTA Reviews (DULOXETINE)

Average Rating: 2.7 (2744 Ratings)

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 ANTIDEPRESSANTS

 Type: Rx Drug

  

CYMBALTA  (DULOXETINE):  Duloxetine is used to treat depression and anxiety. In addition, duloxetine is used to help relieve nerve pain (peripheral neuropathy) in people with diabetes or ongoing pain due to medical conditions such as arthritis, chronic back pain, or fibromyalgia (a condition that causes widespread pain). Duloxetine may improve your mood, sleep, appetite, and energy level, and decrease nervousness. It can also decrease pain due to certain medical conditions. Duloxetine is known as a serotonin-norepinephrine reuptake inhibitor (SNRI). This medication works by helping to restore the balance of certain natural substances (serotonin and norepinephrine) in the brain.   FDA Approval Date: 2004-08-03 (Sources: U.S. Centers for Medicare Services, FDA)

  

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Key to Ratings: 1=LOW (I would not recommend taking this medicine.)
5=HIGH (this medicine cured me or helped me a great deal.)

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More on CYMBALTA: Reviews Summary  |  Drug Safety Information

RATING  REASONSIDE EFFECTS FOR CYMBALTACOMMENTSSEXAGEDURATION/
DOSAGE
DATE ADDED
 
 4  bipolar vivid dreaming, makes me feel awake...not tired (weird, huh?) was on lexapro for 2 yrs and gained 30 lbs. someone told me the cymbalta doesnt cause weight gain. so far after three weeks, i have LOST 3 pounds.........i switched right over from the lexapro. feel great. no real bad side effects. makes me feel like i have more energy. M 44 18 days
2/16/2007
 4  Major Depression and anxiety Night sweats, drowsiness I have been on Cymbalta now for 3 weeks. Started at 30mg for 2 weeks, then upped to 60 mg for 6 days and 120 mg for the last 2 days. Medicine seems to be kicking in over the last 2 days. I have been able to go without taking any Xanax for anxiety for 2 days. Also, my mood has been better. I hope this works - have been in my current episode of depression for 5 months now. Have tried 3 different medications and nothing has worked. Am cautiously optimistic about Cymbalta. If it keeps working, I will be back in a week to give it a full5 instead of just a 4 rating!? M 40 21 days
3/7/2007
 4  nerve damage low back ,foot pain very hard to wake up in the morning no sex drive 30 Mg is all I take per day has help me with my feet they do not burn are feel like pins sticking me I sleep sound but very hard to wake up I also sweat much more but worth it to me because my feet feel almost normal M 57 2 months
5/2/2007
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 4  depression Possibly dry mouth (whatever that is exactly), drowsiness for the first few weeks. Unlike the other people on here, I haven't really experienced that many side effects, or really any that are any sort of bother to me. Cymbalta has helped quite a bit (along with therapy and some life style changes) to help me get through depression. I wouldn't deter people from taking it. It definately hasn't been a miracle cure, but it hasn't been bad at all. M 21 2 months
2/13/2007
 4  Major Depression / OCD Slight drymouth, but drinking more water during the day at work. Seems to be going away. The first week I found myself yawning constantly. Honestly I started feeling better about 5-7 days after I started taking it. The level of anxiety has been reduced. Little things that have bothered me before do not seem bother me any longer. My mood is better. As each day passes, I feel like I am continuing to get better. My short term memory is suffering a little, but I think it is because of occasional clonazepam that I will take in evenings. My sleep has been more even through the night. My erections are harder for some reason, but the orgasms are harder to reach. Urinating is somewhat of a chore, but I think it is worth the feeling better in my head. I seem to wake early every morning, even if I take a sleeping aid of some sort. Dreams are a very vivid. I think the drug is worth it so far. I can't wait for results down the road. M 34 3 weeks
2/14/2007
 4  Depression Very tired for the first month, night sweats, detached, weight gain. This medicine helped my mood swings and uncontrollable crying. now people can actually tolerate me! M 24 3 months
4/5/2005
 4  Major Depression & Anxiety I am now on my fifth month taking Cymbalta after trying Lexapro (didn't work). I have had trouble sleeping, though I guess it could still be related to the depression. I fall asleep but then wake up 3 or 4 times in the night with food cravings. THe depression has improved but my moods still are not where iwant them. M 41 5 months
5/9/2005
 4  Social Anxiety First few days, I was mentally not here, zombie kinda, after a few weeks I noticed that my anxiety wasnt as bad, not even close actually, lots of yawning, appetite suppressed a bit, but not near as bad as others like lexapro. Sex drive was not here, this bad bad bad side effect went away after 2-3 weeks. Extremely impressed with cymbalta. Doc started me out on 60mg (not sure why not 30mg since im a first time user) but after a few days of my body getting used to it I was okay. I was also put on 10mg valium, these two combined have taken me from wanting to stay inside the house every day to actually wanting to be productive. I always thought everyone was staring at me, now I really dont much care if they were or werent staring. Also I had extreme intensified dreams. Never had this before, very vivid, almost beleivable dreams when I wake up. This is a side effect I enjoy. Wondering if anyone else had this same effect? M 23 30 days
10/8/2006
 4  Depression no firm erections, difficulty ejaculating, intense orgasms (nice!), dizziness, night sweats is better than Lexapro - which I was on for 2 years (20 mg.) M 60 5 months
3/23/2007
 4  Anxiety, Mild Depression Decreased Libido, difficulty in achieving an orgasm. Other than those two, much better than any anti-anxiety/depression medication I've tried in last 15 years. Cymbalta is by far the best the best of the medications I've tried, and I've tried them all. It's also has the least amount of withdrawl symptoms when tapering off as suggested. Paxil is the worst for withdrawl and I had a very hard time getting off of it. With Cymbalta, I can taper down for two weeks and the only side-effect I have is mild dizziness and "zaps", which all of these medications cause when discontinuing them. All in all, a very good medication. M 46 1.5 years
7/30/2006
 4  Depression Mild constipation, profuse sweating especially during exercise. Reduced interest in sex with some difficulty getting and maintaining an erection. I've taken Zoloft, Wellbutrin and Lexapro in the past. I'd rate Cymbalta an improvement over the others. Side effects have been less severe with Cymbalta than the other drugs. It has helped keep my mood positive and almost eliminated the physical pain. For me, the benefit has far outweighed the cost of dealing with the side effects. M 55 1 years
8/13/2006
 4  depression and chronic pain. Some insomnia, but nothing that can't be cured with a sleep aid. Also, decreased appetite, weight loss (a good thing!), vivid dreams, increased sex drive with intense, almost painful orgasms. This is the first med that has HELPED with my depression and chronic pain. I was started at 30mg and bumped up to 60mg after 1.5 months. It has almost eliminated my anxiety. I don't fly off the handle. I FEEL HUMAN!!! I am consistantly losing weight and I'm really not complaining about the increase in my sex drive! LOVE IT! M 29 4 months
1/30/2007
 4  Major Depression and DPN Felt "off" for the first couple of weeks on 30mg, evened out and got upped to 60mg. Felt generally better, but developed a slight twitch in my left foot. DO NOT SKIP A DAY!! Went two days without perscription and felt AWEFUL, worse than the nastiest hang over. Now on 90mg. I love the dreams and the weight loss 10 lbs since first dose. Sex really no different, I'm just in a better mood to do it more often. I'm even keel on this after major depressive episode, not really up, not really down. DPN not going away, still have loss of some feeling in toes. Gotta kick the typre 2. Again, I feel like road kill if I miss even one day, two days is extremely unpleasant. I have noticed a bit of blurred vision and a tendancy to smoke more. Confidence is up and I'm less likely to be overly-sensitive. I do seem to get angrier more often, instead of a depressive shut-down. I'll try 90mg for a few months and see how it works out, then I'd like to wean off of it. M 31 8 months
1/15/2007
 4  DEPRESSION inorgasmia, early morning awakening have tried a number of ssri's. i felt physically better the first day of taking the medication but began to experience sleep disturbances. noted about day 4 and since the feeling of restlessness. sex drive went capuoi which is hard. no pun intended. i still have depressed thoughts so i think that the norepinephrine reuptake is more effective for the physical symptoms than the ssri is for the depression M 40 40 days
12/28/2006
 4  bipolar yawning, yawning, yawning. Jaw seems to be sleepy, like I need to stretch my mouth and mandibles to 'awaken' them. (?). Lots of energy. Nocturnal emission. I sweat easily now, before I did not. Tad of urinary incontinence: I go, and then seconds later couple drops more need to come out. Nocturnal emission, is not only nocturnal, but at any moment of the day after urinating. Orgasm: what is that? Erection is fine, but it is a marathon to reach the end (great calorie burner). I have felt a change in my mood. I was on Lexapro and I was having severe mood swings. Cymbalta has stablized me. It is like there is this bottom floor and upper ceiling, that do not allow me to be either happy or go way down into depression. Not great to be on medication but I need it and I have felt a positive change. In control. There is a light at the end of the tunnel feeling. M 36 2 months
7/13/2006
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 4  baby blues didnt love life anymore the only side effects i experienced so far have been upset stomach which lasted about 3 days and more frequent urination. I was taking Lexapro and was extremely tired all the time it was an effort to do common things. also had delayed orgasm which has not been a problem since starting the cymbalta This has worked well for me and has given me back my life Im currently taking 30 mg of cymbalta and have noticed a slight increase in appetite but nothing that is too crazy. Nice to hear others out there have similar side effects and positives . M 28 3 months
12/23/2006
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 4  Social Anxiety and Depression nausea if taken on an empty stomach; dizziness when dose is missed; frequent night sweats Despite the uncomfortable side effects this medication has been helpful - elevated mood, better concentration, fewer physical effects from anxiety (i.e. no increased heart rate; no sweating) M 33 2.5 years
4/8/2007
 4  Anxiety, Depresion none really!.... i actually have more energy...less sexual side effects than zoloft. I started cymbalta after trying a number of ssri's....my doc then put me on 60 mg of cymbalta ..and im feeling a whole lot better. M 20 1 months
4/17/2007
 4  IBS, anxiety inability to achieve male orgasm, poor urination habits (weak stream, dribble, more frequent), fatigue. After suffering from untreated IBS for several months and going through all sorts of tests, I was given Cybalta 30MG. Overall, it helps the core IBS problems which were annoying. But the sexual and urilogical side effects are annoying too. I quit taking the drug for a month and I was feeling great for a couple of weeks, but my IBS is back in a bad way. I restarted taking Cymbalta and hopefully will regain the IBS relief I had in the past. M 44 10 months
2/11/2007
 4  Generalized Anxiety Disorder Hair loss At first, Cymbalta was a dream. I got motivated to get in shape, was getting more done, and felt better than I had in my life. Last week, however, I noticed my hairline receding and general thinness in my hair. I am going to see an internalist, but I do not have much family history of hair loss (and none at my young age at all). Also, I've plateaued with the medicine and even the increased motivation and good moods have dropped off noticeably. Also, I was sleeping better than I ever had, and I'm starting to regain my insomnia. It seems like my body has adjusted and its lost its effectiveness while causing me to lose my hair. M 24 3 months
10/20/2005

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