DEPO-PROVERA Reviews (MEDROXYPROGESTERONE ACETATE)

Average Rating: 2.1 (2471 Ratings)

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 ESTROGENS PROGESTINS ANTINEOPLASTICS

 Type: Rx Drug

  

DEPO-PROVERA  (MEDROXYPROGESTERONE ACETATE):  This medication is used to treat certain types of cancer (such as uterine cancer, kidney cancer). Medroxyprogesterone is like a natural hormone called progesterone made by the body. It is usually used with or after other treatments (such as radiation, surgery). Medroxyprogesterone may prevent or slow the worsening of the cancer and decrease pain and other symptoms.    (Sources: U.S. Centers for Medicare Services, FDA)

  

More on DEPO-PROVERA: Reviews Summary  |  Drug Safety Information

RATING  REASONSIDE EFFECTS FOR DEPO-PROVERACOMMENTSSEXAGEDURATION/
DOSAGE
DATE ADDED
 
 1  birth control osteopenia, IBS I meant to say 12.5 years, not days. I have developed osteopenia and I am a healthy 36 year old. My mother is 60 and has normal bone density. F 36 12.5 years
10/3/2006
 5  Can't remember to take the pill weight gain or no period, hmmm... decisions, decisions... I have been on the shot for 13 years and the only reason I have not quit is because I love not having periods and I am so afraid of if and when I do stop, how my body will react to it. How long will I bleed and what other problems will I have. I have gained 50lbs but I really don't blame Depo. I am lazy and eat fast food everyday. I had lost 50lbs in my 5th year on the shot but gained it all back. I am wondering about my bones in my golden years and still am trying to find information on long term affects. Everytime I get my shot I always ask that question and I never get an answer. WHAT ARE THE LONG TERMS AFFECTS??? I guess I will know soon... F 34 13 years
1/4/2005
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 5  birth control none I lost weight on the shot. When I started taking the depo shot, there were no answers of what had happened, only things that could happen. I was 21 with two children and a not so good relationship with their dad. So, I took my chances. I did have headaches, but I'd had migraines for years before I got the shot. I am concerned now because I would like to discontinue the shot. Now that I'm older and wiser, I am afraid of what it may cause. I guess we'll see. It was due in January and I did't get it. F 34 13 years
3/5/2009
 5  it helped stop cramps hot flashes it worked for me it stop my cramps and my periods. and as an athletic person it was very helpful. stop blammimg the docters they tell u the side effects and u chose to take it. everybodys body takes the drug in a different way then others. im just glad it helped me but i will be coming off to let my body cleanse itself. F 27 13 years
5/27/2008
 5  easy form of contraceptive My side effects appeared to be bearable. Bloating, mood swings,anxiety,outburst of rage and anger. I still continued to have a period every other month and PMS every month. I had not problems with my sex drive. I didn't really suffer from weight issues. I weighed 168 when I first started and I'm 183 13 years after the fact. I did suffer sugar cravings but I had researched and depo contains an appetite suppressant. I am 37 and was diagnosed with osteopenia in Aug.06. My doctor has asked me to come off since I have been on depo for 13 years. I believe I did grieve a bit because my side effects were bearable. I can't think of a more convenient form of birth control. I did not go back for my shot this month and I have started experiencing headaches and nausea. I had a period last month and have not had one yet this month so I can start the pill. I really enjoyed the depo injection but osteoporosis runs in my family 3 generations ahead of me so my best choice is to come off the shot. After going on this website I guess I can look forward to seeing how many side effects I really suffered from. I'm confused about the women saying they were still waiting for periods to come back to normal after one or multiple years off the shot. M 37 13 years
4/17/2007
 5  Contraceptive None other than fertility took longer to return but then I was on it forever!! 13 yrs. (Started it 1990) & am 47 now (2020) It worked great for me. No periods. No side effects other than extended fertility returning (after Had come off it) F 47 13 years
150 4X O
10/24/2020
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 3  Contraception I feel like I've gotten off lucky with it, I've been on and off it for years and I'd usually just wait for my period to completely come back because it usually spots for a bit then stops after regular injections, so o would cycle it after 2 years like they recommend. I did gain weight but I train a lot and eat a lot I'm not overweight for my height I think it depends on you and if you have any health conditions. I still had a sex drive just not as extreme, lol. But I did get emotional numbness and mood wings but it's so much better for me than the pill which even though it's technically the same thing it just gave me depression, with depo I just do t feel things as much most things just go over my head which I'm grateful for with my mental health being the way it is. When I did try to come off it completely however after 10 years of being on and off I had terrible periods lasting 3 weeks sometimes very heavy as well which is unusual for me I don't know if it's to do with making the lining thicker before because I'd been on it so long, so I tried the pill then and had the bad experience and went back to the depo. I think every person I've spoken to has different experiences i think you just had to try it F 27 13 years
Unsure 3 m 1X day
10/20/2020
 1  not to get pregnant Dizziness, heart palpatations, severe stomach problems, sinus infections, weight gain, numbness, confusion, tired, lack of sex desire, insomnia, nervousness, muscle aches, night sweats, low immune, acne, loss of hair, anxiety, bloating, allergies, frequent urinaation, sugar cravings, losing my mind Gynecologist said it was fine to be taking it for 13 years...it was not fine, it is a poison. F 36 13 years
3/28/2007
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 1  Birth Control Fatigue, Mood Swings, Anxiety, Back and Body Aches, Weight Gain, Digestive Upsets, Acne, Hair Loss I started Depo Provera in Feb 1998 after the birth of my first daughter..For the first couple of years it was a micacle drug until I had my first panic attack which at the time I related to losing my father suddenly in 2001. As my moods progressively got worse my Doctor at the time suggested that I have Depo every 8 weeks..and take a daily dose of Zoloft. About 12 months ago my moods and panic got so severe that I couldn't even drive my daughter to school :-( About this time I changed doctors and the first thing discussed was the Depo and the effect it can have on mental health so in December 2010 I had my last shot EVER!! Im now undergoing extensive medical tests for hormone imbalance, pituitary and adrenal glands, blood sugars etc etc the list goes on and on...One month after my last shot was due Im slowly starting to feel a little 'normal again'. Oh and by the way I forgot to mention that I was 72 kg after my daughters birth and I now weight close to 100 kg :-( F 32 13 years
150mg 1X O
5/14/2011
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 5   some weight gain at first, reduced ovarian cyst production... ive never wanted children so i am thankful for this prevention med...easy to remember, effective, no periods for many years now, which i love! plus it greatly reduced the number of ovarian cysts i had been having. wouldnt try anything else. havent had any trouble with long term osteoporosis effects either. will continue until i dont need BC any longer. F 35 14 years
1X O
10/1/2012
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 4  birth control Gained weight but I think that had something to do with getting older because with strict diet and strict exercise I lost it.I LOVED not having a period. I also think that it decressed my sex drive also. I enjoyed not having a period.Let me correct that, when I first started the shot when I was 18 yrs old I would spot a little before getting the next shot but after the first year or so no periods. Now that I am married (3 yrs yesterday)and decided to have a child I have been off the shot for 2 yrs and still my period has not returned. If it wasn't for my husband wanting a child with me (he has two teenage boys)I would probably still be on it. I really can't say that the shot is the reason I havent gotten pregnant yet. But I can blame it for not having a period. F 34 14 years
1X O
11/4/2010
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 4  Not wanting a period/birth control None of the normal side effects, increase sweating I guess I'm one of the lucky ones. I actually love the shot and have not had any of the "normal" adverse side effects. The very first doctor that put me on the shot in 1996 told me to take at least 1000 mg of calcium a day. I did and with calcium supplements and excerise my bone density test have come back normal. I have put on a few pounds but considering I started the shot at 22 and am now 36, I attribute the small weight gain to age, not eating healthy and not excersing as much. I do sweat more and noticed the increase sweating within a year of starting the shot so I don't know if the two are related, but it makes since that they are. However, I haven't noticed anyone else mention an increase in sweating. I've had many discussions with my OBGYN regarding the shot and he has said as long as my bone density test come back fine, I can stay on the shot. F 36 14 years
1X O
6/4/2010
 3  birth control None for the first 10 years then a gradual change to include fatigue, hair loss, subclinical hypothyroid, acne, darkening and thickening facial hair, facial skin pigmenting, and slight-gradual weight gain. Absolutely loved Depo for the first ten years. I had one normal period every six months. I began to notice changes during the 11th year at a dermatologist screening where the pigment on my cheeks, nose and chin began to age spot or darken. The dermatologist attributed the change to depo and prescribed a 30 sunblock for daily use. At 40 I still have mild acne and pronounced facial hair which does not run in my family. My periods became highly irregular and I began to experience longer spotting durations. I now bleed at a low volume for 15 out of 30 days per month. I also began to experience unusual fatigue, muscle gain (my legs look like Marion Jones with little training and no Balco products) as if I were 19 again, and overall gradual but accelerating weight gain. I scored 70% on a thyroid dysfunciton test and have no doubt that my estrogen, testosterone, progesterone and thyroid are no longer normal. No bone density issues. MAKE SURE YOU GET THE THIN PREP PAP TO AVOID ANY FA F 40 14 years
1/31/2008
 5  birth control & control bleeding I guess I am very fortunate. I love the depo shot!! I have been on depo for 15 years, I have never had a single problem with it!! I did get off it briefly after having a tubal, but my irregular periods were just like they were when I was young so now once again I am back on it. I will take it forever if the Dr lets me!! F 35 15 years
8/26/2008
 5  period control / birth control none i took depo for 15 years - from the age of 15 to 30 years old. for me it was the wonder drug - i had no side effects and no period for 15 years. i maintained a weight of 100 pounds the entire time and was so happy. a year ago, my obgyn sent me for a bone density scan, and it showed that i have the bones of a 90 year-old woman - very frail and brittle. she demanded that i get off the shot immediately in order to reverse the loss. i was on the nuvaring during the last year, which has sent my weight to a whopping 150 pounds, which at 5'4" is ludicrous, considering i have gained half my previous weight and now weigh 1.5 times what i used to. i no longer recognize myself, both physically and internally - just don't feel right, don't feel like myself. i had a mirena iud inserted last week in order to get my body back to the condition it was in during the depo, so i am currently hopeful. had my doctor not refused to continue giving me this shot, i would still be on it. F 31 15 years
12/7/2009
 5  birth control weight gain (175lbs.), hairy breasts, hairy buttox, swollen feet, nail fungus, etc. i would always come to this page and be like "i'll never be another sad depo story" but look at me today. i weigh over 300lbs, my face, breasts, buttox have had an increase in hair growth. i have hair loss on my head, so i look 80 not 35. over the months my feet have become swollen and i grew nail fungi in my toes and fingers. my husband left me, and my family has disowned me. i'm just here to let all of you know, please research the birth control good before taking any. you don't want to be another ME. don't tell me i didn't warn you! F 35 15 years
10/26/2005
 4  didn't want a baby or a period no period, no craps, no mood swings On depo for 15 years… after about 2 years no more periods, no craps, no mood swings…loved it. I have gained some weight over the years but that is due to my diet and can’t blame that on the drug. I’m 5’6 started when I was 18 and weighed 120 now I’m 145. My doctor was concerned about my bone density. Had it tested last month and it was normal but due to the fact I just had a birthday and have considered the fact I might want to have a baby someday I did not get my last shot which was due March 16,2010 about a week after my shot was due started getting hot flashes and felt totally blaaaaa. The hot flashes are gone I just got some very light spotting no craps yet but have a serious lose of energy. I normally go 2 the gym 4-5 times a week and find it hard 2 drag myself there 2 plus times. I still walk my dog 3 times a day but really wanted some helpful information on how to help my body detox faster. The sooner I can get this drug totally or as much as possible out of my system and get back to my energetic self. There is a down side to everything and at 18 I could not see that thought it was the wonder drug. Now I’m not 2 sure. F 33 15 years
1X O
4/9/2010
 4  birth control slight weight gain, headaches, moodiness when time for inj. This was wonderful even with the side effects until I reached my thirties. My natural hormones changed and I became dependant on the injections to keep my energy and moods together. When it was time for my shot EVERYONE knew it. I would recommend for temporary birth control but no more than five years. F 37 15 years
4/10/2008
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 2  18yrs old. I did not want children NO PERIODS(WHICH WAS REALLY NICE). NEGATIVES: STEADY WEIGHT GAIN, DEPRESSION, ANXIETY, IRRATIONAL BEHAVIOR, VERY SHORT TEMPERED, OVERLY AGGRESSIVE, BLOATING, WATER RETENTION, GASTRO-INTESTINAL ISSUES. DURING THE 15 YRS ON DEPO I BLAMED MY SIDE EFFECTS ON EVERYTHING BUT THE DEPO,I NOW KNOW THAT I WAS IN DENIAL. I SOUGHT HELP FOR DEPRESSION & ANXIETY WITH MEDICATION & IT DIDN'T HELP. NOW THAT I'VE STOPPED, I REALIZE HOW MUCH THE DRUG AFFECTED ME. 15 YRS ON DEPO. I'VE BEEN OFF OF IT SINCE 8/08. I'M NOW HAVING PERIODS EVERY 14-16 DAYS FOR 6 DAYS. I NO LONGER HAVE THE ANXIETY AND DEPRESSION PROBLEMS I HAD, I FEEL MUCH MORE NORMAL AND RATIONAL I DON'T 'FLY OFF THE HANDLE' FOR SILLY REASONS. I HAVE YET TO LOSE THE WEIGHT THAT I GAINED WHILE ON DEPO. ONE OF MY FIRST UNDENYABLE CLUES THAT DEPO WAS THE ISSUE, WAS WHEN I STARTED GOING TO THE GYM AND WORKING OUT 2HRS A DAY 5 DAYS A WEEK FOR 6 MONTHS WITH NO WEIGHT LOSS WHAT-SO-EVER! I LOST VERY MINIMAL INCHES NOTHING SIGNIFIGANT ENOUGH TO BEGIN TO JUSTIFY THE AMOUNT OF CALORIES I WAS BURNING!! I'M IN THE 'DETOX' STAGE OF THE PROCESS NOW, INITIALLY (1ST COUPLE OF MONTHS AFTER STOPPING)I HAD SEVERE CRAMPS & BREAST TENDERNESS, I BEGAN TO START FEELING MORE 'NORMAL' WITH LESS ANXIETY & DEPRESSION. I FEEL MORE 'NORMAL' AS EACH DAY GOES BY, MY PERIODS SEEM TO BE LIGHTENING A LITTLE THE BREAST TENDERNESS IS MINIMAL BEFORE MY CYCLE AND THE CRAMPS ARE BARELY NOTICEABLE. I'M SOON GOING TO GIVE THE EXERCISE ROUTINE ANOTHER TRY. I WILL LIKELY SEEK OUT THE HELP OF AN ENDOCRINOLOGIST TO FIND OUT WHAT MY BODY IS DOING.I HOPE TO HEAR FROM ANYONE WHO HAS GONE THRU THE 'DETOX' OF DEPO AFTER BEING ON IT FOR YEARS SO THAT I HAVE AN IDEA OF ANYTHING ELSE I MIGHT HAVE TO LOOK FORWARD TO. F 35 15 years
4X O
3/31/2010
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 1  Migraines, Birth Control Extreme decrease in sex drive, bloating, feeing hungry all the time, HAIR LOSS I was on the depo for around about 15 yrs. First thought it was brill but I didn't think my bald patch or mild depression and bloating had anything to do with it. Ihad a couple of breaks but my last shout was 3 months a go. I will never have another shot ever in my life. When I comb my hair it comes out and has stopped growing. no sex drive and acne whitch I never had before. I always rooted for the Depo shots BUT It's really not worth it. Trust me F 34 15 years
12/28/2006

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