DEPO-PROVERA Reviews (MEDROXYPROGESTERONE ACETATE)

Average Rating: 2.1 (2471 Ratings)

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 ESTROGENS PROGESTINS ANTINEOPLASTICS

 Type: Rx Drug

  

DEPO-PROVERA  (MEDROXYPROGESTERONE ACETATE):  This medication is used to treat certain types of cancer (such as uterine cancer, kidney cancer). Medroxyprogesterone is like a natural hormone called progesterone made by the body. It is usually used with or after other treatments (such as radiation, surgery). Medroxyprogesterone may prevent or slow the worsening of the cancer and decrease pain and other symptoms.    (Sources: U.S. Centers for Medicare Services, FDA)

  

More on DEPO-PROVERA: Reviews Summary  |  Drug Safety Information

RATING  REASONSIDE EFFECTS FOR DEPO-PROVERACOMMENTSSEXAGEDURATION/
DOSAGE
DATE ADDED
 
 4  Birth control Weight gain, severe depression and mood swings. Increased appetite, headaches. Sore breast, ill feeling right before shot is due. Feeling tired and body aches. No period but occasional spotting. The side effects of Depo are the worst I've experienced on any medication. I did not rate this medication on side effects. I rated it on the effectiveness. I have been on the shot off and on for 9 years. And the majority of the time I feel like crap and almost always feel like I'm losing my mind. But I've never gotten pregnant and I don't have a period. The weight gain and effects it has on my mental state are honestly the worst part but as of now it is doing what it's intended to do. I know you shouldn't be on this long term so maybe in the future I'll stop getting it. But the benefits outweigh the bad and I think with any medication you have to decide whether the symptoms are worth it. Not for everyone though. F 24 9 years
4/6/2016
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 3  Ovarian cyst...last option Tremendous weight gain...mood swings...digestive problems...depression..and who knows what else is from this I used this as a last alternative from severe ovarian cyst and bad side effects from BC pills...Wish I would had been more informed about what I was getting into....At the time when I was taking it I thought only side effect was weight gain until I started researching myself and realized all my other issues were actually from this...Now I have quit taking it and feel like I am a crazy person...I know there has to be help to get my body back to a normal state... F 24 9 years
1/13/2010
 3  Pregnancy Prevention numerous fainting spells, heart palpitations, loss of libido, memory loss I began taking Depo when I was 16 (in 1996) and took it faithfully for 9 years. During my teen years, I had many fainting spells and heart racing. We never related it to Depo at the time, just teenage hormones. I didn't have a period for years! I trusted the doctors that this wouldn't be problematic in the future and it was pretty nice not to have to deal with that. I got off it to get pregnant which happened within 6 months. No complications there. I have a 2 year old and a 3 year old and didn't have any problems. I breastfed both for the first year of their lives and no problems there either. I now have a terrible memory, which started in my early 20's. I'm not sure if it's directly related to the Depo, or other events, but it's there nonetheless. I haven't had any bone density tests, which I should obviously do since I was on it for nine years, so I can't comment on those effects. Overall, I don't expect any drugs to be free of side-effects. I do wish that the doctors wouldn't be so quick to give a young kid a drug that's fairly new to the market. I've included my e-mail if anyone has any questions. F 29 9 years
3/31/2009
 3  Birth Control - Stop Periods I started taking depo around the age of 16 to stop my period- it was great but i didn't take it constently only when my period would come- maybe twice a year. THEN - i got in a serious relationship and needed to take it constantly (ive been on depo for about 5yrs with 1 yr break to try ortho evra. at first i had no weight gain. I was full timer at age 21 then started the weight gain, nausea(this is serious)I'd be in the middle of eating (in which im hungry all the time) and feel like i need to throw up. Less sex drive vaginal dryness I love having no period but the weight gain, nausea and mood swings are unbearable. i weighed 115 at graduation, i didn't gain weight then probably because i was so active. when the side effects started getting worse i switched to ortho evra lost some weight was was down to 125 Ive been back on depo this last year and i now weigh 138. Im getting off and will do the patch again- Im thinking patch in the winter when i dont need to hide it and depo in the summer. F 25 9 years
12/15/2008
 3  To get rid of my periods Extreme weight gain, severe depression, headaches, bruise easily, extremely dry vagina, NO sex drive, horrible mood swings, lack of energy, leg pain and painful sex. I loved being on the depo and would have continued using it until I saw a gyno who specializes in sexual dysfunction and was told that I have a vagina of an 80yr old women. I have been married for 4yrs and have been unable to have sex due to the extreme pain. She told me about the side effects of the depo and was shocked to find out that the depo has been the cause of all of my medical problems. I am also shocked that my gyno of several years didn't realize that was the cause of my sexual pain. F 30 9 years
1X day
2/5/2011
 3  Pregnancy prevention Facial Hair, Weight Gain, Decreased Sex Drive, Moody I have been taking Depo off and on for 9 years. I have experimented with other things here and there but always go back to it. Every time I have stopped taking it my period returned right away. While taking it I never have bleeding except when my next shot is almost due. When I was younger I had no bad side effects at all. However, I am getting older now and I think it's impacting me differently. Over the last few years I have gained 20 pounds, and it's hard to get the pounds off and keep them off. I do find myself very, very, hungry sometimes for about a week at a time. I am also growing a lot of hair on my chin and will have to get laser hair removal. My sex drive is all but gone now, I have noticed that when my next shot is due my sex drive increases. I also find myself having days where every little things tics me off. It was a good friend until the last few years. I plan to discontinue using it for good. F 29 9 years
1X O
5/22/2010
 3  pregnancy Headaches, weight gain, Acne, hair breakage, moodiness, back pain, joint pain, I was on Depo for 9-10 years. I came off for 3 mths when I was 19 and I became pregnant with my son. After he was born, I started taking Depo again. I decided to come off 8 mths ago, because I have been going through a body detoxing and I didn't want any synthetic chemicals in my body. It is funny because I didn't realize any of the side effects until after I stop taking the shot. They were not severe that I would have stopped taking the shot before I did. I loved not having a period. Before the shot I weighed about 115 lbs(19) but at my highest on Depo I weighed 160 at 5'5" (29). Since I have stopped Depo, I have lost about 15 lbs in about 4 mths, and that is with eating healthier (not a diet/no exercise). One thing that stunned me was I have had acne since I was 13, so having acne as an adult really did not faze me. Then, once I stopped taking Depo, 4 to 6 months down the line my face cleared up. It was almost instantaneously. I did have A LOT of Dr. visits over the last few yrs F 30 9 years
3/14/2007
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 3  pregnancy Headaches, weight gain, Acne, hair breakage, moodiness, back pain, joint pain, I was on Depo for 9-10 years. I came off for 3 mths when I was 19 and I became pregnant with my son. After he was born, I started taking Depo again. I decided to come off 8 mths ago, because I have been going through a body detoxing and I didn't want any synthetic chemicals in my body. It is funny because I didn't realize any of the side effects until after I stop taking the shot. They were not severe that I would have stopped taking the shot before I did. I loved not having a period. Before the shot I weighed about 115 lbs(19) but at my highest on Depo I weighed 160 at 5'5" (29). Since I have stopped Depo, I have lost about 15 lbs in about 4 mths, and that is with eating healthier (not a diet/no exercise). One thing that stunned me was I have had acne since I was 13, so having acne as an adult really did not faze me. Then, once I stopped taking Depo, 4 to 6 months down the line my face cleared up. It was almost instantaneously. I did have A LOT of Dr. visits over the last few yrs F 30 9 years
3/14/2007
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 2  prevent pregnancy I started taking Depo after I had my son 9 years ago. I was off and on (mostly off) until two years ago. Since taking it regularly, I have been experiencing the following symptoms. Weight gain, lack of sexual desire,insomnia, constant headaches, hot flashes, muscle and joint pain, and anxiety and heart palpatations. After various tests returning normal, I started researching side effects for Depo and I am convinced I am one of many experiencing similar issues. It may not be bad for everyone, but I would suggest taking the time to research it. F 27 9 years
4/30/2013
 2  Horrible periods/ Endometriosis I never had weight gain, mood swings, periods, acne or any other side effects from this drug. But, 1 1/2 yrs ago I shattered my leg doing an everyday thing and all my doctors said it was a freak accident since I should not have broken it that badly (2 plates and 20 screws to put it back together to give you an idea). I asked if the Depo could have caused this and was told no; that I'm young, active, and they wouldn't worry about it causing enough bone loss to effect me in that way for another 5-10 years. Well, so much for that. I got a bone density test and am borderline osteoporosis at 33. My score was -2.1 and full blown osteoporosis is at -2.5. I of course changed doctors and was told that there is a clock ticking when you are on Depo. Usually people come off it before it does too much damage, or a bone scan will show that its time to get off, but, unfortunately my clock ran out before anyone caught it and shattered my leg to the point that it'll never be the same again. 9 years of no pain and no periods is definitely not worth the limp I'll have for the rest of my life. I didn't read thru all the stories on here, and some of those I did read touched on bone density, but just wanted to share my story to show what can happen when this shot robs your bones of what they need. If you choose to be on it, be proactive and ask for bone density test every year after the first 2 years on this drug. I wish I would have. F 33 9 years
1x 3 mos
12/28/2011
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 1  Prevent ovarian cysts, stop period Depression, kidney stones, weight gain, breakthrough bleeding (recently and has lasted for over 2 weeks now), digestive problems, low libido, anxiety, mood swings, yeast infections I started taking Depo when I was 18 to help with ovarian cysts and to stop my period.... I have not had a regular period, or any period for 9 years, except when I went off it when I was 23 because I had cervix cancer and had to have surgery, I'm not sure if the cancer was related to depo or not. Until recently reading posts about Depo, I never thought about side effects such as depression and loss of sex drive and weight gain..... But now I definitely can associate these with Depo, and I have had these symptoms for years. Over two weeks ago now, I started to spot.... It's not a period, it's started as a yeast infection, with light pink blood, that lasted 3 days, ever since its been dark brown mucus, apparently it's called breakthrough bleeding associated with any term of use of Depo..... Although Depo does have different effects on different women, I would not recommend prolonged use, I want to start having kids, and now I have to wait at least 12 months for it to clear my system before I my be fertile. I wish I had studied up on it years ago, but my Dr. Never ever said anything about it, he would just give me a yearly prescription for 4 doses a year.... Thanks for all the other posts and info! F 28 9 years
1x 3mo 1X O
2/19/2012
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 1  contraception Horrible horrible drug. Took me far too long to realize the horrible side effects. No doctor made the link. Too many problems to list. I lost my gallbladder. I am always severely sick to my stomach. Saw a gastroenterologist numerous times and had numerous tests. Many years later and finally deduced through elimination that it was the depo screwing up my whole system. I am finally off it and now suffer just as badly, along with nausea, sleeplessness, severe mood swings, backaches, headaches, dizzy spells, no sex drive, bloating, cramps, period is not back yet, hair loss... general aches and pains, general feeling of being ill from head to toe.. the list goes on. F 39 9 years
1X day
9/9/2013
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 1  Birth control OSTEOPOROSIS!!!! DO NOT TAKE THIS MEDICATION! This should be Illegal! I had Osteoporosis at age 26! I started seeing a menapause specialist for bone density issues at 26! F 27 9 years
9/6/2007
 1  birth control Low libido, joint pain, bone density loss, dental problems, headaches, fatigue, out of control eating, gained 40 lbs., depression I have been on Depo for 9 years and did not realize that the symptoms I experienced might be related to the shot. I am now facing thousands of dollars in dental work due to bone density loss, and will probably end up with osteoporosis. I am getting off Depo and will never touch it again! F 24 9 years
7/9/2007
 5  Prevent pregnancy None - all good really, a tiny weight gain but that could have been down to age/unhealthy eating. No periods, no period pains. I have been on depo for just over 10 yrs, a long time! So I thought i'd give my body a break. The only side effect I have had in coming off the drug is sore breasts, this has lasted for 4-6 weeks now but it is getting better. Maybe I will have more side effects but so far so good. My partner thinks I have been short tempered, maybe I have but i've not noticed it. F 29 10 years
8/30/2007
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 5  prevent pregnancy May have had a little weight gain. I have really had no side effects. I love it. I have no period and feel very confident about not getting pregnant F 25 10 years
5/25/2005
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 5  endometroius Loved it Dr said I had to go off because 10 years was too long. Now I am back on the pill did not have peroids for 10 years got it back the first month full force. I have endometroius and depo kept it in check. I want my Depo back I hate the pill every day and periods hurt and what a mess. I can't even wear a tampon anymore it hurt. I have to get used to all this stuff again. anyone else out there on depo for over 10 years? my dr would maybe let me go back on if we have information on others on the drug for that long too. F 36 10 years
3/28/2009
 5  contraception Only experienced a decrease in sex drive. Any estrogen based contraception causes me to experience severe vomitting, so Depo has been a life saver. F 35 10 years
11/3/2007
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 5  to not get pregnant at the begining very long periods which eventually subsided...basically been period free since..might have some spotting for a day during the time right before my shot I feel bad about all those that have had major side effects. i did have a lot of wt gain, but the convinience of the shot is worth it to me.My practitioner has not mentioned getting off of it,so was surprised to hear the comment of not being on it as long as I have, but dr makes sure I'm taking the right amount of calcium thru supplements and regular food. Starting to get vaginal dryness, but chalking that more to starting to get perimenopausal F 41 10 years
4/11/2009
 5   None F 10 years
5/7/2009

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