LUPRON Reviews (LEUPROLIDE ACETATE)

Average Rating: 2.7 (853 Ratings)

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 DRUGS USED IN DISORDERS OF GROWTH HORMO HORMONAL BIOLOGICAL RESPONSE MODIFIERS

 Type: Rx Drug

  

LUPRON  (LEUPROLIDE ACETATE):  Leuprolide is used to stop early puberty (precocious puberty) in children. It helps to delay sexual development (such as growth of the breasts/testicles) and the start of menstrual periods. It also helps slow down early bone growth to increase the likelihood of reaching normal adult height. Leuprolide works by decreasing the amount of sex hormones that a child's body makes (estrogen in girls, testosterone in boys).   FDA Approval Date: 1985-04-09 (Sources: U.S. Centers for Medicare Services, FDA)

  

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Key to Ratings: 1=LOW (I would not recommend taking this medicine.)
5=HIGH (this medicine cured me or helped me a great deal.)

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RATING  REASONSIDE EFFECTS FOR LUPRONCOMMENTSSEXAGEDURATION/
DOSAGE
DATE ADDED
 
 4  Endometriosis, Polycystic Ovaries Muscle & join pain, memory loss Definitely worth it. I was in severe pain to the point of vomiting and peeing my pants before I tried Lupron. F 27 6 months
5/4/2009
 4  Endometriosis/Fertility Muscle aches in my legs after injection(goes away after a day or so) hot flashes, night sweats and minor headaches. I just had my second shot (getting them monthly) and side effects are mild. After the 1st shot the pain was much worse but it lasted only about three weeks. Now everything is great, no pain no weight gain. I do recommed drinking a lot of water and also exercise on regualr baises. If you take care of yourself and eat healthy I firmly believe that will help reduce the side effects of deppression and wieght gain. I'm actually loosing weight!! F 30 2 months
5/4/2009
 4  Prostate Cancer/surg/rad/ frequent hot flashes followed by cold flashes. Extreme fatigue, body ache legs and back, depresses or down. Tend to be emotional. Increased appetite -gained 16 pounds.Stomach often feels bloated when empty. Some stomach ache. Short term memory loss mostly since the shots. I took three shots in 08 three months apart. Last was Oct. My PSA has stayed down to .002 ever since the first shot. Last test last month. I have had prostate surgery, 4 years later 37 radiation shots, but 4 years later it came back. The Lupron has controlled the cancer to this point. I will put up with the side effects for it benefits. I had a knee replacement 90 days ago and that pain is also involved. M 72 13 months
5/1/2009
 4  Prostate cancer Fatigue, loss of libido, intense feeling of warmth in extremities My PSA level was 25 (Gleason scores of 7 and 8) three months ago. A CT scan and MRI showed lymph and bone lesions in the pelvic region. After extensive consultation with my oncologist, he prescribed Lupron to shrink the prostate and shut down testosterone production. The side effects are tolerable, just annoying, and the PSA level has dropped from 25 to 3 in a month. It is also necessary to have a baseline bone scan to monitor calcium loss and other possible chronic issues, which will mandate frequent (perhaps even monthly once the Lupron treatment ceases) blood analysis and inconvenience. After 8 months on Lupron, no further androgen ablation therapy will be used until PSA levels begin to rise again. My oncologists stresses the importance of trying to maintain as normal a life as is possible, with deliberate efforts to exercise and stay active. I no longer have to take ten Ibuprofen tablets a day to relieve the stinging lesion pain enough to sleep at night. My oncologist suggests that, while he sees no additional benefit at the present time, there are other possible treatments, including radiation and chemotherapy, that may be tried if and when the Lupron no longer adequately suppresses testosterone production. I find it quite possible to continue my daily activities with a minimum of inconvenience. I plan to participate in a clinical trial designed to determine if the administration of dutasteride (Avodart)after 8 months will lessen the need for Lupron. M 67 5 weeks
4/30/2009
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 1  Endometriosis nausea, depression, cramping, severe hot flashes. others i can't think of. horrible stuff. I did Lupron for 1 month back in December and am still suffering from occasional hot flashes. The one thing that made me stop after only one shot was the severe depression I experienced about 2-3 weeks into it. I had been diagnosised with PTSD about a year prior to this, but was on the verge of being admitted into the psych ward because of the severe depression and would not recommend this to anyone who has any history of depression at all. It has been a few months but I ruined about 4 bra's due to the excessive sweating from the hot flashes. I would rather take the pain than go through that ever again. F 27 30 days
4/29/2009
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 4  endometriomas hot flashes, insomnia, decreased pain After reading different reviews I was terrified to start Lupron as so many people had such negative things to say. Fortunately my experience was positive. My endometriomas shrank significantly and as a result I did not require surgery. My pain also decreased. Staying well hydrated helped to reduce the hot flashes. I would definitely recommend trying Lupon before agreeing to any surgery. F 35 6 months
4/25/2009
 2  Endometriosis EXREME, EXTREME Nausea-been to ER 3 times for it (Zoloft did not help me nor did Reglan) Vomiting; Insomnia; restlesness is excessive in legs and throughout; backache If anyone around the same age is going through what I am, please e-mail me. Support is needed and will be provided to you,too!!! It has been 11-12 days since my laproscopy and lupron shot! I am only 18 years old!ONLY 18. Had to take a year off of University. My life has been turned upside down, man. I hope I find relief soon, but this is kiling me, man. This shot is just so bad. its symptoms I mean. I have had my first period which were PAINFUL as heck! F 18 12 days
4/22/2009
 1  Severe bleeding and cramping I started having petit mal seizures and then had a gran mal seizure and was hospitalized. Do not take it! F 30 2 months
4/22/2009
 1  Post surgery endometriosis hot flashes, moodiness, cold sweets, depression I was given a lupron injection after having a laproscopic surgery to remove the endo. While in surgery it was discovered that I was having a tubal pregnancy and my left fallopian tube was removed. I was told after the procedure that because of the surprise tubal ligation, all the endometriosis was not removed being I had been under anestesia for 3 1/2 hours and they feared greater consequences if they didn't wrap things up. I was given the lupron without my consent (you know you sing the waver saying that the doctor can do what it must to treat you) anyway, I was told the purpose of the injection was clear up the rest of the endo that was not removed. My doctor told me that "she was amazed that I tolerated the pain of both the endo and tubal pregnancy so well, and was surprised I was able to walk." After receiving the first injection which was supposed to be re-administered after 3 months I experienced severe hot flashes, horrible cold night sweats, extreme moodiness and dispression. Even with the side effects I had decided to continue on the path my doctor had chosen for me and receive my second (and last injection) when I arrived at the doctors office for my injection, my doctor had left the practice. That was in August. I have since still experience severe endo pain. I have had a hard time finding a doctor that I trusted. Finally found a nurse practitioner who ran all kinds of test (blood, ultrasound, CT) and decided that the best route for me would be to go back F 25 3 months
4/22/2009
 4  Endo I posted on 01/27....pain at the injection site, sore muscles, hot flashes, headaches/migraines, moodiness, loss of libido, some joint pain and soreness, short-term memory loss and inability to focus, depression/anxiety (altho i have a history of both) and dry skin I posted on 01/27....My side-effects have greatly diminished since I first began Lupron and so has my endo-pain. Before, my hot flashes and mood swings were nearly constant and unbearable and my side-effects were interfering with my professional and personal lives. I have been on Lupron now for about 4 months and have another 3 months to go before re-evaluating my endo/pain. I have *almost* no pain and my hubby and I can be "intimate" again - I'm not so afraid of the pain anymore that i can live my life normally. The only effects I'm still experiencing are ocasional hot flashes, occasional moodiness, headaches and lessened libido (altho it's much better than when I first started the treatment). At this point I am going to follow-thru and hopefully will not need to get surgery!! I would recommend anyone looking to begin this treatment to research it carefully and ask lots of questions. I would also recommend getting a pregnancy test before your first injection - I was not given one (!!!) and spent several months very very concerned....I am hoping Lupron works and lasts, and that when my hubby and I are ready I will be able to have children! F 20 4.5 months
4/7/2009
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 4  Surrogate Mother I have done 3 shots.... I have had hot flashes, belly ache, loss of appetite.. (not a bad thing).. Some mild mood swings.. F 31 30 days
4/5/2009
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 4  Endometriosis Hot flashes (mostly at night), very weepy but your doctor can give you medicine if you are this way, as well as medicine for the hot flashes. If you aren't into taking prescription medicine for your moods there is an over the counter medicine from wal*mart or wherever. It is called 5-HTP and it is an erb that curbs appetite and promotes positive mood. Prepare yourself for the worst and you probably won't be disappointed. :) I wasn't upset with the overall of the drug but I was fairly warned about the symptoms so. F 19 6 months
4/5/2009
 4  Uterine Fibroids - 3 12 cm diam Mild, not unpleasant hot flashes. Significant weight gain. I took the medication for 10 months: 7 one-month doses, and one three-month dose. The hot flashes were very insignificant. The best part was absolutely no migraines and PMS and just feeling "better" overall. I did gain a significant amount of weight (23 pounds) but was reassured by my endocrinologist that this will go away once the medicine is out of my system. I will be getting a TAH in May. F 32 10 months
4/3/2009
 5  Shrink Uterine Fibroid pre-surgery mild fatigue, mild headaches I took the 1x/month shot of lupron for 4 months to shrink my very large fibroid tumor (~15-16cm) in the hopes of having laparoscopic surgery. The lupron shrunk my tumor enough to remove it laparoscopically (yay!). Turns out it was 12 cm after being shrunk! When I first saw this page before I started the lupron I was terrified. I was afraid of hot flashes and (since I have a history of hormone migraines) I was concerned I’d have a 4 month migraine. After the first shot I felt great, but a week later I ended up with a moderate migraine that lasted 5 days. I felt fine for the rest of the month other than being a little more tired than usual. I did have a mild 2-4 day migraine in months 2 and 3, but not the last month. However, after the 1st month, I could feel that it was shrinking my tumor and I had less discomfort and pain from the fibroid. One very important thing that I should mention is that my doctor also had me taking a low dose of progestin (2.5mg of Aygestin) to prevent hot flashes. I only had one incident of night sweats, so it worked. He says this is key and there is no reason for women to suffer by not having add-back therapy. Not to discount any of the experiences on this site, but wanted to let prospective lupron patients know that your experience may not be as bad as others, especially with the aygestin. ASK YOUR DOCTOR about taking progestin. F 38 4 months
4/2/2009
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 3  IVF No Side Effects Yet I am only on my forth day of Lupron 10 units a day. I have no side effects yet. Wondering when they will come. F 33 4 days
3/31/2009
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 3  endometriosis weight gain (15lbs), acne, horrible and unpredictable mood swings, hot flashes that still persist even though i have been off lupron for 3.5 years, extreme nausea (used zofran with some relief), vaginal dryness, hair thinning. F 25 6 months
3/25/2009
 3  endo/infertility/fibroids/cysts frequent headaches, swollen hands (rings are tight), WEIGHT GAIN!! of at least 12 pounds, some mood swings Just got my fourth injection today. Gained another 3 pounds for a total of 12. No period since my first injection in Dec.2008. That's been nice. Bloating/swelling in hands are worse each month. Some ovarian pain couple of days each month. I can't decide if it's all worth it. I feel pretty yucky every day (physically). The verdict is still out! F 34 4 months
3/23/2009
 1  infertility Horrible drug. Reproductive endocrinologist prescribed as part of IVF treatment. 3 months AFTER completing 1 IVF cycle with LUPRON: still have not managed to lose the 10 pounds I gained on LUPRON, although have severely restricted calorie intake, (I have never had problems losing weight in the past before LUPRON) still have some tingling in my feet and aching in knees after crouching for a while ( I never experienced this before taking LUPRON ), Condition of my hair is scraggly and poor since LUPRON, Periods for past 3 months since taking LUPRON have been on abnormal 38-day-cycle (I am normally on a 30 day cycle), I had heart palpitations right after I discontinued LUPRON If you value your health and your sanity, DO NOT TAKE LUPRON Its effects may NEVER wear off, and if they do wear off, it takes MONTHS for it to wear off LUPRON IS NOT NOT NOT FDA-APPROVED FOR INFERTILITY!! F 43 11 days
3/22/2009
 3  Endometriosis Very achy all over, swollen joints (cannot even wear wedding ring), acne, mood swings, tiredness, bone and muscle pain, no periods I had my first injection a month ago, and I am going in for my second this Friday. I really hope all of this eases up, because these symptoms are affecting my ability to work. F 25 4 months
3/18/2009
 4  endo slight mood swings, pain from lower back down to knees, FATIGUE i had taken the 1-month shot for 6 months a few yrs. ago with GREAT results(minimal side effects). but am currently on the 3-month shot and experiencing more problems(coincidence?). i wasn't on add back therapy the first time either. i have had a "cycle" every other week so far and it's terrible. the pain from the side effects is definitely better than the pain from my endometriosis, and i recommend it to anyone in the same situation. F 29 2.5 months
3/15/2009
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