COMPAZINE Reviews (PROCHLORPERAZINE MALEATE)Average Rating: 1.2 (504 Ratings)Filter ResultsCompare COMPAZINE with similar:
Type: Brand name discontinued; available as generic
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Results are sorted by Date added. Key to Ratings: 1=LOW (I would not recommend taking this medicine.) Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 |
More on COMPAZINE: Reviews Summary | FDA Adverse Event Summary
| RATING | REASON | SIDE EFFECTS FOR COMPAZINE | COMMENTS | SEX | AGE | DURATION/ DOSAGE | DATE ADDED |
| 1 | Nausea | I felt like I was losing my mind, thought this might be the experience people really have when they lose their minds. Scary. I sometimes believe this drug was guilty for me to experience decades of restless leg syndrome. Echoing so many posts here, this drug should be FDA level banned - globally. | I highly recommend NO to anyone given option to take/use. This happened several years ago, I'm simply re-entering to keep my post clear and current - to hopefully warn others of the extreme danger. | M | 50 | 1 days 1X day | 2/20/2026 | 1 | Acute Migraine | I went to the local hospital's ER for a migraine. I'm writing this review 15 years later, but I still remember everything, to this day. They gave this medication along with several others, in a migraine cocktail. I swear not after a few minutes after the medication was injected via IV to me, it was one of the worst experiences in my life. I have no idea how this medication is not banned in the USA, yet the world. After those couple of minutes, I went into an extreme panicky state. I could not sit still. I felt like I was going crazy. I had trouble distinguishing between reality and my thoughts. As everyone else has stated, I literally wanted to rip out the IV they put in and run out of the hospital. I made them discharge me ASAP. I could not drive, so my mother picked me up from the hospital. I felt like I couldn't be alone, so I asked her if I could stay with her. When I got to her place, I still felt the same. The only thing I could do was take a bath to try and relax and then lay in a bed in try to relax/sleep. It helped a little, but not much. This uncontrollable feeling was with me for days. It finally went away after about a week or two. I would say that the feeling lessened after a couple of days. I will never take this medication again in my life. I've told all of my doctors and medical charts to list this as a medication I am allergic to. I would never give it to my family members. I wouldn't even give this to my worst enemy. It's like a form of torture? **IF ANYO | Whoever invented this medication or recommends this to their patients should have their medical license taken away. | M | 33 | 1 days Hell IDK 1X day | 7/10/2025 | 1 | Nausea | This happened a long time ago but wanted to add to my story in case they decide to bring the drug back. In 2003 I was given an injection of Compazine. A couple hours later, both of my eyes were uncontrollable. It made my eyes look up to the right and would not go back to normal. When my husband at the time drove me to the hospital they gave me benadryl which made my eyes go back to normal in about 1 minute. The doc said that it effected my ocular nerve telling my body I was having a stroke. Scary AF! Thank you! | F | 43 | 2 days 1X day | 10/13/2024 | 1 | Migraine | This medication turned my entire world upside down. It immediately gave me severe dpdr, akathisia, tremors, etc. I thought I was going insane. It got better for about two weeks, but then it all came back and worse. Feels like all of my subconscious thoughts suddenly became conscious and constant - racing and looping. Can't focus, can't sit still. Everything feels unreal. Was given this for a migraine instead of running three tests I asked for. This was in February 2023. | I have been suffering from iotrogenic injury symptoms for 8 months now. The derealization/depersonalization, insomnia, and mental and physical akathisia are the worst and I don't get a break from them. It feels like it's permanent. If anyone has struggled with these symptoms for a while after the Compazine, but has healed, please email me. I could use all hope I can get that this will eventually go away. I have a son who is counting on me to get better. I can't live like this indefinitely. | F | 33 | 1 days 10mg IV 1X day | 9/26/2023 | 1 | Head ache ,vomiting | Short of breath can't stand up without being tired palpitation of the heart dizziness been hospitalized for two nights ran all kind of tests on me and still can't figure out what's wrong with me | F | 26 | 0 days 1X day | 9/12/2023 | 1 | Migraine | I was given IV compazine and toradol for a migraine. This was the absolute worst experience I have ever had with a medication. Like the other comments I literally wanted to rip my IV out and run out of the hospital. They couldn't discharge me soon enough. When I went home all I could try to do was sleep until the med wore off. Worst experience ever. | 23 | 1 days 1X day | 9/12/2023 | 1 | Thunderclap Headache | I went into anaphylactic shock within 30 seconds of this medication being administered. They had to give me epinephrine and Ativan to make it stop. I kept trying to scream but could not do so. | I have heard many stories about Compazine and other dopamine blockers that are used as anti emetics. This was by far the worst one I have been given. Even worse than Reglan and Droperidol. I have recently learned I am allergic to all three. Along with every other phenothiazine. I have not been the same since they gave it to me. I have nightmares about it. Insomnia beyond belief. Panic attacks that have become more common. If you ever have the opportunity to get this drug, I would warn you to decline. | F | 21 | 1 days 10mg 1X day | 7/24/2023 | 1 | Nausea | I went to the ER for some stomach pain and nausea, wish I never went. I would have much rather handled it at home than go through what I went through. As soon as I was given this medication, I could not sit still, I wanted to pull out my iv and run out of the hospital. I was pacing around with my iv still hooked up looking for a nurse to get discharged asap. Worst feeling of my life, even after I went home I didn't feel like my normal self for weeks. I couldn't be alone I constantly needed someone around to comfort me because I really thought I was losing my mind. This medication should be banned, it's horrible! I am scared of taking any kind of medication or supplement because of this traumatizing experience. | F | 26 | 1 days 1X day | 3/20/2023 | 1 | Migraine | I was give the drug in the er and the hellish night begun. It was like going crazy. Hot and cold shaking and shear panic. I actually went to the bathroom in er to rip off the masked I had to wear because I felt trapped. Had to force myself back to the room so I could be sent home with "the jitters" now hate that phrase. I pass a night with the inability to sleep.breaking into hot sweat only to follow violent spell of cold and shaking. I could not eat even though hungry the panic made it feel like I was choking on any food I tried.passed a horrible night/day seriously panic about having to go back to the hospital. And the endless need to escape myself. | Never had anything like the problem I had that night. No one should have to go through that. Especially for a migraine. I would have traded the migraine lasting for weeks instead of one night of that stuff | F | 37 | 1 days 1X day | 3/15/2023 | 1 | Vomiting | Lost my memory, thought I was going crazy. | F | 58 | 0 days 30 1X day | 2/12/2023 | 1 | Nausea | I was 16 years old and had been admitted to the ER because I had sever nausea that lasted months to the point where I couldn't eat and only weighed 89 pounds. The doctor gave me compazine to help the nausea go away so I can eat. Compazine did nothing for my nausea, instead on day two of taking the medication I began to have conscious seizures. I couldn't control my body movements, I kept twisting my limbs and back uncontrollably before snapping back and twisting again in uncontrollable painful positions. When I made it to the hospital I heard the intercom ding above my head which made me look up but as I was seizing it made my eyes snap back and forth pushing painfully far up Into my head. The doctors at the ER didn't know what was wrong with me so they sent me to another hospital in the twin cities by ambulance. The entire time from home to the twin cities I was having a conscious seizure, when I got to the hospital in the city's they gave me benadryl and eventually my seizures subsided and I Bagan to get better. I have never had a good memory since that happened in my life. I seem to continually be having trouble with focus and have had tremors ever since this happened to me. I really don't know what to do or who to talk to. This drug has seriously effected my life, I'm 25 now almost 26 and as much as I thought things would clear up with time they really haven't.. | This is a horrible drug, the name brand is now discontinued in the US though I think the people who experienced side effects deserve some sort of compensation. After doing more research into this drug it had horrible results when tested by the FDA yet some how got approved anyway. | F | 16 | 2 days 2X day | 12/11/2022 | 1 | severe migraine | went to the er for a severe migraine and was given toradol and zofran in a migraine cocktail. it didn't help much so they gave me compazine after. what no one told me was that this would send my anxiety sky high. i called my mom screaming for her to pick me up, shaking, but no tears. i thought i was going completely crazy. I went back and forth to the bathroom just to gain reality. I ended up being discharged and on the way home my eyes kept going into the back of my head. I went in the house and fell into a deep sleep. It's been 2 days and now I cannot sleep however, the anxiety and headache is gone. I'm just really restless but i'm trying to solve this by still going on about my regular daily schedule. DONT BE LIKE ME. RESEARCH BEFORE YOU LET THEM INJECT YOU WITH SOMETHING!!! | DONT TAKE THIS MED. | F | 19 | 1 days 1X day | 7/20/2022 | 1 | I was given it in a migraine cockta | I'm not sure this was the exact drug used in my iv at the hospital, it included benedryl and another possibly toridol. Immediately, I sat bolt up and said this is bad vertigo, i had to hang on to the rails and the dizziness wouldn't stop, not just a little either, like spinning, then i couldn't swallow and felt major anxiety for about an hour and 1/2, and my head kept rushing really weird. By the time they came in with morphine I said, "No! After what just happened I'm scared to try anything". They gave me 1/2 and i felt calmer, but didn't take the rest. After I got my footing, went back home still with a migraine. 1/2 mg of ativan they prescribed helped along with otc tylenol and otc aleve. But. around 24 hrs later, during the night after that experience, i woke up and my throat felt funny, and I couldn't swallow again. I heated up my herbal tea and trickled it down till i could swallow again. I would Not recommend a migraine cocktail. It was a terrifying experience. My headache is still here, but after how horrifying that was I'll nurse the migraine myself. I also tested positive for Covid while there, and I have been vaxinated and then boosted several months ago. I wear my mask everywhere and still got it. It's the cause of the migraine I've had for 2 weeks. So think hard before you let them try a migraine cocktail. It was the worst thing ever. | 59 | 0 days Don't know 1X O | 2/2/2022 | 1 | Migraines and head pressure | Went to the ER for headaches and head pressure. Was given this medication along with Benadryl as a migraine cocktail. I wish I never took it, I am in worse shape than when I went in. | Just like tons of other comments, I am extremely restless and cannot go to sleep. Took melatonin and Benadryl and still cannot sleep and I am pacing around my house. Just an overall sense of feeling DRUGGED. NEVER take this drug, I wish I never did. If you are reading this after you have taken it, my condolences. Goodluck. | M | 25 | 1 days 1X day | 2/1/2022 | 1 | Head pressure and dizziness | Severe anxiety, long term muscle twitching, long term panic attack | This has got to be a form of torture. I don't understand how this stuff is even legal. I went the the ER because I thought I was having a stroke. They told me it was a migraine and gave me a migraine cocktail. This was 7 weeks ago and my life has never been the same. As soon as they have it to my I freaked out and I grinned without doing it myself. They have me Benadryl which just made me sure tired. A day and a half later I started having these weird twitches all over my body including my face. It has made a slight improvement, but still there. I am praying and hoping that this goes away. If you have anything that can help please email me! | F | 35 | 1 days 1X day | 1/13/2022 | 1 | severe abdominal pain | was given this drug iv then given iv dilaiudid. was really jittery. came home and had horrible dreams, excessive sweating. I have literally walked over 3 miles inside of my house today and it's been 24hrs. when will this end? | F | 40 | 1 days 10 1X day | 11/15/2021 | 1 | Migraines | Anxious, the need to walk/run, irritable, and ready to just leave the hospital | This is the worst drug to give anyone. my heart felt like it was going to beat out of my chest. I was so scared and I couldn't stop freaking out. My advice after feeling like this, take two Benadryls…yes two! and wait it out breathe in and out. Worst drug ever. | F | 22 | 1 days Not sure 1X day | 11/2/2021 | 1 | Migraine w nausea | I felt absolutely out of control. Minutes after getting the migraine IV mix of Toradol, Compazine, Benadryl, and some steroid, I was in full blown panic attack. Wanted to rip my IV out and NEEDED to leave the ER. I felt terrified and could barely speak or breathe. I was shaking uncontrollably. It took hours to get to sleep at home and took a couple ativans to try and help me. It's the next day now and I still feel horrible and way off. | Be careful. | F | 30 | 1 days IV 1X day | 10/23/2021 | 5 | Nausea due to anxiety | I can't live without this medicine. It's the only thing that helps my severe nausea which is usually brought on by anxiety attacks. It also helps to calm my nerves but I don't know if that's psychological. Either way I carry it everywhere. I also use the 3mg buccastem version which acts a bit quicker. | Takes between 30 and 60 mins to work | F | 40 | 12 months 5mg 2X W | 10/13/2021 | 1 | Nausea, Headache | I went to the emergency room for vomiting and headache while I was going through Covid, I had already taken 8 mg of sublingual Zofran at home and it did nothing, the hospital administered another 8 mg of Zofran via IV port, it did nothing, so they been administered Compazine. I knew something wasn't right I thought maybe I was just agitated because I was there too long but having read these other reviews I am certain I am also one of those that had a severe reaction to this medication, I did think something was going on because I was calm sick couldn't move I was very ill with Covid, and within five minutes of receiving this via IV port, I was so agitated I was jerking and pushing agitated I wanted to pull my IV out was yanking my pulse ox off, One of the worst experiences that I have ever had with a drug as far as agitation goes. Do not I repeat do not take this medication it is horrible. | Never take this medication!!!! More needs to be done about the medical facilities using this drug so frequently. | F | 36 | 1 days 30 1X day | 8/23/2021 |
COMPAZINE (PROCHLORPERAZINE MALEATE): This medication is used to treat severe nausea and vomiting from certain causes (for example, after surgery or cancer treatment). Prochlorperazine belongs to a class of drugs known as phenothiazines. This medication is not recommended for use in children younger than 2 years or in children going through surgery. (Sources: U.S. Centers for Medicare Services, FDA)