COMPAZINE Reviews (PROCHLORPERAZINE MALEATE)

Average Rating: 1.2 (501 Ratings)

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 ANTIPSYCHOTICS ANTIMANICS VERTIGO MOTION SICKNESS VOMITING

 Type: Brand name discontinued; available as generic

  

COMPAZINE  (PROCHLORPERAZINE MALEATE):  This medication is used to treat severe nausea and vomiting from certain causes (for example, after surgery or cancer treatment). Prochlorperazine belongs to a class of drugs known as phenothiazines. This medication is not recommended for use in children younger than 2 years or in children going through surgery.    (Sources: U.S. Centers for Medicare Services, FDA)

  

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Key to Ratings: 1=LOW (I would not recommend taking this medicine.)
5=HIGH (this medicine cured me or helped me a great deal.)

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More on COMPAZINE: Reviews Summary  |  Drug Safety Information

RATING  REASONSIDE EFFECTS FOR COMPAZINECOMMENTSSEXAGEDURATION/
DOSAGE
DATE ADDED
 
 1  Nausea/migraine After 2 minutes of having it pushed through my IV with Benedryl & toridol ,I felt a warming sensation in my chest, felt like I came up off the bed, I felt like my heart was about to beat out of my chest. Starting feeling like I couldn't breathe, Starting itching, I was very restless & went from the bed to the floor, to the bathroom, like 10 times in 2 hours. I felt like taking my IV out & going home. This is BY FAR THE WORST MEDICINE I HAVE EVER RECIEVED! I would not recommend anyone to take it! It has been 2 days since getting Compazine & I still do not feel like myself. I still feel a little skidish & I feel sick! F 30 1 days
30 1X day
7/2/2013
Email
 1  migranes This dug SUCKS!!!! I was given compazine for a severe migraine. About 5 mins later I was edgy, jittery, and could not sit still. DO NOT ever take this drug or u will suffer greatly. It should be banned!!!! M 44 1 days
20 MG
6/26/2013
Email
 1  migraine Triggered horrible anxiety my skinn was crawling I wanted to run like a crazy. Its now 3 days after receiving iv of this nasty drug and im still having nausea and anxious from this drug.. I would not give it to my worst enemy. M 29 1 days
shot
6/8/2013
 1  nausea About 15 minutes after getting compazine by IV so I could get in a CT scan I began feeling like I had to sit up. They told me I had to lay still after the Ct scan I began going to the bathroom every 10 minutes and I noticed Black lines around my eyes like I had been punched and I kept telling them to raise my feet. I began to panic and decided that I needed to pick up my kids from the YMCA. The nurses told me I was having an allergic reaction to the medication but they gave me nothing to combat this. They would not let me drive so I called a cab. I felt as if I were walking very slowly and that the world was on super speed. As I was waiting for the cab some kids were playing on the steps and I felt as if I could not talk to them. The cab driver picked me up and I told him to take me to the YMCA and that I don't know what they gave me but I am going to die tonight. When we got to the YMCA I told the cab driver to wait for me and by the time I got to the desk I could barely move. I s F 51 1 days
5 1X day
6/5/2013
 1   Had IV in hospital for food poisoning. Caused heart racing, panic, shaking, shortness of breath. Asked to be taken off the IV. They told me that Compazine cannot cause those side effects and then called the Psych Nurse. I told them to unhook the IV and I went home. I was shaking with racing heart for about 12 hours. Called a friend who is a Pharmacist and he said that it does cause that side effect in a small percentage of people. Obviously, it is on my DO NOT ADMINISTER list. F 58 1 days
IV 1X day
5/31/2013
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 1  Headache. Felt super crazy for months. anxious, paranoid, crazy, anxiety, psycho, insane, !!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!! Still feel it years later but it is diminishing. They put it in my IV. I felt so crazy but I know I am not a crazy person so I called the ER and asked WTF they gave me. Dont mess with this stuff. Put it on your allergic list. It needs to be banned and the manufacture needs to be in jail for all the suicides it has caused. I cant believe this stuff is still available. WTF M 35 1 days
IV? 1X day
5/29/2013
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 1  Nausea Taken tablet, prescribed for nausea. First day I had extreme restlessness, and a sense of unease. Second day I had to go to school, and as I was about to walk home, my head just locked in an upright position, my eyes started rolling back, and my neck was twisting, it was painful and I was scared, because I thought I was going crazy. (Wasn't aware of reactions like this)) I had to go to ED after about an hour of terrible muscle spasms and twisting and pulling. They said I had a severe drug-induced dystonic reaction. It was probably one of the worst feelings I have ever had. I think that this drug should only ever be a last resort! The side effects are terrible, and use of ondansatron etc, should be the first choice. I read that even if you take a low dose you have a 2% chance of getting a dystonic reactions. To this day I still feel unease with restlessness, and its been about 4 months since. Please be aware of the drugs you are taking, they can have serious consequences which can last a long time. F 17 1 days
3X day
5/20/2013
 1  Nausea post surgery Given through IV for nausea when I was in the hospital. After half a dose I had uncontrolable shaking that started in my legs and went to my jaw too. I immediately knew something was wrong and was given Benadryl and Adavan to counter act the effects and calm me down. It worked after about 45 minutes. Will NEVER TAKE AGAIN! Bad drug I take zofran for my chronic nause due to a stomach condition and have never had any side effects from that. F 27 1 days
1X day
4/26/2013
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 1  severe headaches As soon as Compazine and Benadryl was administered through an IV, I felt a hot feeling rush through my arms and progressed throughout my body especially in my chest and abdominal area. I remember thinking OMG please reverse this...I had the same feelings as others about wanting to run out of the room. I was high and jittery and extremely drowsy at the same time. I kept turning my head from side to side and shaking my legs. My skin had this crawling tingling feeling as if a worm was moving underneath my skin. I had a very difficult time catching my breath and my heart was beating irradically. Later that evening I had the worst leg cramps ever and had to keep stretching it out. The next day, I have chest pains and still had difficulty breathing. I asked the doctor what he was giving me and his response was "a headache medicine". I even asked what is it? Is it a receptor blocker of some sort? He did not tell me the reported side effects of this drug. I would have never allowed them to give it to me. Do NOT take this drug. It is not worth the horrible experience! F 38 1 days
4/11/2013
 1  migraines vomiting nausea Severe uncontrollable facial neck jaw movements seizure like.do not take this medicine F 33 1 days
10 mgs
2/16/2013
 4  migraine headache Note! If you are too nauseated to keep the pill form down...ask your Dr. for rectal suppository .... works quickly....Europeans take many mere via this. method as it absorbs quickly through the intestinal wall. My Dr.was surprised when I asked if it was available...as she had never heard about it. It is cheap....very cheap in comparison to the fancy migraine meed. Only problem is it must be kept in fridge...melts easily. When people tell.me of their headaches being awful and object to this suggestion....I know they are not in REAL.PAIN......Another tactic that works is to take whatever mere...wait 20 minutes.Get in shower. Point water to your head. Turn as hot as you can stand then switch to cold as you can stand then hot then cold back and forth till you cant take it any more.....this will expand and contract blood vessels and pump mere through your system. Idealnif you can go to bed and take a nap after the shower. People who object to this method because it willL mess up their hair are not in REAL PAIN.!!! These are cheap and simple tactics that can provide. relief to desparate migraine sufferers! Oh yeah....and compazine can leave me somewhat tired.....and give me a dry mouth....not bad for cheap relief. F 59 10 days
30 mg
2/1/2013
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 1  migraine Worst experience from a drug ever. Two minutes after it was put in my iv I had overwhelming feeling to just run out of the hospital. I literally ripped my iv out of my arm and struggled with the nurse to get out of room. They explained to me %it was a reaction to the medicine. 12 hours of misery felt like i just want to jump out of my own skin. Awful feeling will never take it again. F 36 1 times
1X day
1/27/2013
Email
 1  Nausia Went to ER with extreme nausea from migraine. Was given Compazine via IV. Within five minutes of having the drug administered my legs began to shake uncontrollably while my breathing began to be labored and my throat began to close. The nurse literally ran to get the doctor in charge. As I am laying there thinking I'm going to die the doctor injected Benadryl and the reaction began to immediately subside. The doctor said in all his years practicing medicine had had never seen a reaction to Compazine. He assigned a nurse to stay with me at all times during my ER stay to ensure that I was not going to have any further reactions. Like others have noted here, I continued to experience a reaction after the initial event. I had very restless legs for a solid month after the event. I understand that this drug does not cause issues in the majority of the population but for me and the others here on this ratings site it was obviously hell. Be very very careful. F 45
1X day
12/25/2012
Email
 1  Migraine nausea Uncontrollable neck movements, foot bends , anxiety . I was 19 and still suffer extreme anxiety and panic attacks. Need to take Ativan daily. It was an awful experience. F 55 2 days
Iv
12/1/2012
Email
 1  Nausea I was given Compazine through an IV in the ER. I drove myself there so after the doc gave it to me I was alone in the room. The doctor told me I may feel restless as a result. Understatement of the year! I have never been so depressed in my entire life. I wanted to rip the IV out of my arm, destroy the room and kill everyone in the hospital and then myself. I had no idea that it was a result of the Compazine because I am depressed in general. My mom showed up at the hospital because I called her to tell her I was going in earlier that evening. The moment she walked in the room I looked at her and she walked out to get the doctor. She told the nurse "something is wrong with my daughter", apparently I had crazy eyes. They gave me benadryl but I was still incredibly depressed, I didn't even want to leave the hospital I was so scared about what happened. I still suffer from extreme anxiety maybe or maybe not as a result of that. It terrified me that I could ever have thoughts lik I was surprised to see that so many other people had similar reactions. I try to joke about it now saying I "hulked out", but in reality it terrifies me. Make sure you are not alone when you take this med! F 21 1 days
1X O
10/25/2012
 1  Nausea Horrible anxiety attack. The feeling was so bad I wanted to kill myself to make it go away F 36 1 days
10 mg 2X day
10/13/2012
Email
 3  Severe Migraine I have been given Compazine through an IV about 4 times in the past year. I've had a concussion for about 10 months now and I had migraines beforehand. Now, the migraines come much more often and are extremely painful, much more so than prior to my concussion. One night, I experienced severe pain that I had never felt before. My head felt like it was about to explode because of the pain. After taking Fiorescet and Maxalt with no relief, I went to the hospital and they decided to give me Compazine. After about 30-45 minutes on the IV, I started feeling lightheaded and shortness of breath. I started hyperventilating and I felt like I just wanted to run around screaming. I demanded that the doctors take the IV out because I desperately wanted to get out of there. Once I was home, I couldn't get to sleep because I was still breathing funny. I think I had this reaction because Fiorescet was a caffeine tab and Compazine is a depressant so they were counterattacking one another. Fortunately, the medicine helped my headache so my neurologist gave me a prescription for Compazine. I find the pill doesn't result in the crazy side effects, but my legs do get restless and my toes twitch uncontrollably if I'm not hydrated. The only problems with the pill (10 mg) is that the hangover from the migraine is so intense that the headaches last for two or three days afterwards and it also causes severe drowsiness. I was surprised reading most other posts and researching after I took the F 15 1 days
IV 20-40MG
9/6/2012
Email
 5  Migraine None! Given IV with Benadryl and took my migraine away. I suffer from migraines that last 72 hours on average and this works every time! F 30 1 days
IV
8/3/2012
 1  Migraine Extreme Panic Attack, Sudden Agoraphobia, Restlessness, Shortness of Breath, Extreme Dysphoria. I was given a "Migraine Cocktail" in the ER. The IV drugs where: Benadryl, Toradol (both of which I have taken before w/o any issues) and Compazine. 3 mins after everything had been administrated, I felt this sudden onset of fear and restlessness like I have never felt before. I couldn't get comfortable, was also having shortness of breath I did everything possible to try calm my self down, and not run out of the place. I tried to describe what i was feeling to the ER Dr. but he really didn't seem to care. 10 mins later I was gratefully asleep. This drug has been probably been used interrogations; as I said everything possible to get out of there as soon as possible so I could get home and just sleep off this new nightmare of situation. M 21 1 days
1X O
7/26/2012
 1  NAUSEA I HAD A GASTRO TYPE INFECTION AND I HAD NAUSEA. THEY GAVE IT TO ME IN THE ER. I TOLD THE ATTENDANT THAT I FELT WEIRD AND JITTERY. HE BRUSHED ME OFF AND PATTED MY HEAD AND TOLD ME ID BE OK. THEY GAVE ME A PRESCRIPTION WHICH I TOOK AT HOME. MY MUSCLES BEGAN TO STIFFEN AND I COULDN'T WALK, MOVE OR MOVE MY FACIAL MUSCLES. CALLED AKATHISIA. I REQUIRED ANOTHER DRUG TO COUNTERACT IT, WHICH IT DID. I WAS NOT ABLE TO DRIVE MYSELF TO THE DOCTOR. I WAS LIVING IN A DORM AND THE RESIDENT ASSISTANT HAD TO DRIVE ME. IT SUCKED BALLS AND I HOPE NO ONE EVER TAKES THIS DRUG AGAIN. THIS DRUG IS HORRIBLE. I WONDER IF THAT MAKES ME ALLERGIC TO ALL ZINE FAMILY DRUGS.. LIKE PROMETHIZENE WHICH I NEED FOR COUGHS, BUT I'M SCARED TO TAKE ANYTHING WITH "ZINE" IN IT'S NAME. F 43
1X day
7/19/2012
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