COMPAZINE Reviews (PROCHLORPERAZINE MALEATE)

Average Rating: 1.2 (501 Ratings)

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 ANTIPSYCHOTICS ANTIMANICS VERTIGO MOTION SICKNESS VOMITING

 Type: Brand name discontinued; available as generic

  

COMPAZINE  (PROCHLORPERAZINE MALEATE):  This medication is used to treat severe nausea and vomiting from certain causes (for example, after surgery or cancer treatment). Prochlorperazine belongs to a class of drugs known as phenothiazines. This medication is not recommended for use in children younger than 2 years or in children going through surgery.    (Sources: U.S. Centers for Medicare Services, FDA)

  

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Key to Ratings: 1=LOW (I would not recommend taking this medicine.)
5=HIGH (this medicine cured me or helped me a great deal.)

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More on COMPAZINE: Reviews Summary  |  Drug Safety Information

RATING  REASONSIDE EFFECTS FOR COMPAZINECOMMENTSSEXAGEDURATION/
DOSAGE
DATE ADDED
 
 1  Nausea Extreme paranoia and total loss of mind and body control I had no idea others were affected like this also. Massive paranoia. If I had the means to kill myself in the hospital, I would have. Some medical staff do not believe you can have this reaction to compazine and will give it to you anyway. I've had it happen despite my wife and I telling the staff no less that 6 times not to give it to me. M 22 1 days
1/1/2009
 1  Migraine, Fainting, Nausea jittering, I couldnt sit still muscles in neck and back tighten up throat closed up, my head was completely pulled backwards touching my backand I couldnt close my eyes, my eyelids were spazzing. I looked liked something off the exorcist! scarriest experience of my life!! It was a Tuesday I had gotten up to use the bathroom and fainted, hitting my face on the floor. later on that day I fainted for more times. so I went to the ER. When I got there they gave me Compazine through IV for the nausea I was feeling from passing out. Also gave me a Perscription for it as well. I took it for three days, I was feeling a little bit of side effects but on the third day which was Christmas I felt like I was going crazy my eyes kept on wanting to look at the ceiling i had no controll over them at all. Then my head started to fall back, so far my head was touching my back! and I couldnt move it, my throat closed up and I couldnt breath! My bestfriend rushed me the the ER were they gave me Benadryl through IV. It was the most painful and scariest experience ever! This medication should be banned FOREVER!!!!! My body still hurts! F 22 3 days
12/29/2008
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 1  Nausea and Vomiting Jumping out of my skin sensations, panic, restlessness, urge to move body, nightmarish "out there" feeling---worst experience of my life!!! I agree with those of you who wonder how this could be legal! My mom has had a bad reaction to Compazine and warned me never to use it! I went to the ER this morning to find relief from my constant vomiting, only to be given this sheerly terrifying drug! ( Even though I told them I would rather not take it!). Almost instantly, I felt really off like I was on speed or something. I couldn't find a comfortable position and felt like I was jumping out of my skin! I told everyone at the ER, but they just dismissed it as a reaction sometimes seen and sent me home. I felt terrified and weird and nobody was helping me! My husband was beside himself! We called the ER to tell them I was having the worst panic attack I have ever had in my life and the doc told me to just take some Benadryl and wait it out! Well, I now know exactly what hell feels like, and I promised God if I make it through in one piece to be kind and loving to my family for the rest of my life! I took 50 mg of B F 24 1 times
12/22/2008
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 1  Nausea & vomiting started out as jittery, really shaky, after 3 days of the occasional iv injection i started having severe face and neck spasms, throat closed up i have had allergic reactions to medications before, but nothing compared to this. I thought something was wrong after they gave it to me the first time, i felt extremely uncomfortable and couldn't sit still. I didn't think much of it, i was on a lot of different medications at the time so i thought it was a mixture of the meds. after the 3 days worth of iv injections, my face and neck started to spasm. it was the worst thing i have ever experienced. started to lose strength and control in the left side of my body. my face literally looked like it was being pulled away from my skull. after the experiencing the spasms for about an hour, my throat started to close up. whenever i tried to talk, it sounded like i had just inhaled helium. they tried to give me zanax first to relax my face, they didn't think it was the compazine. they thought i might be having a brain bleed so they were getting ready to send me for a head ct. after the zanax didn't work they gave me benedryl. in 10 second F 23 3 days
12/18/2008
 1  Nausea I was 11 or 12. They gave me pill form. At night I would have horrific nightmares...spinning in space with no way to stop. Got up, sleep walked and tried to punch holes in walls. Parents though I had bad dream. Next day, at school, had to run mile at school. Whole left side of body muscles "pulled" me to one side,, slumped over on the ground and started hallucinating. Tried to regain composure. Went to next class, taking test, became extremely anxious. People around me were speeding up like a fast-forward picture. Teacher said I stared off in space for a good 30 minutes. Don't remember this. Asked doctor what to do, he says,"Take more compazine (not joking- Kaiser.) That night, more night terrors. Also, neck and back spasms so bad I actually can hear muscle tearing. It's like someone is twisting your head and you can't stop it. Carried to ER in middle of night. Had night terror, passed out in hall trying to punch out walls again. This is night 3. Get to hospital. Doctor M 40 3 days
12/13/2008
 1  migrain/nasua Last night went to the ER for magrain. I was in so much pain I started to feel sick. The doctor said he was going to give me 10mg of compazine IV. As soon as he injected the med. I became very anxious! Wanted to tear iv out and run as far away that I could. About 10 minutes later I started to have involuntary muscle spasims!! It was the worst experience i ever had. The doc gave me 50mg of benedril to counter the med. I would not reccomend this med to anyone M 22 1 times
12/9/2008
 1  MIGRAINE I had a terrible migraine and went to the ED for tx. Usually they give me a injection of stadol and phenergan and within 20 minutes I have little to no pain and no nausea. This time there was a new ED doc there and he ordered IV compazine. It was awful! I became severely agitated and restless. I remember thinking I wanted to jerk the IV out and just go home. There was no relief of the migraine and only mild relief from the nausea. Thankfully, I did not experience the other side effects others here mentioned but I would not take it again. F 33 1 days
11/5/2008
 1  Slight nausia panic attacks I was given the drug for a little nausia. It burned when it went in, but oh well. I would have lived through that burning a hundred times over rather than go through what came next. It started out as discomfort. I couldn't get comfortable no matter which position I tried. Next, I started having bad pannic attacks which would come every minute or so. They lasted about six hours. During the six hours I was in torment. I feared everything. Eventhough I knew that there was nothing to fear, I couldn't stop being afraid. I wanted so desperately for my wife to pray for me, but I couldn't even ask her because I was so irrationally afraid. If it hadn't stopped after six hours, I would have lost my mind. I realize that "losing your mind" is a cliche, but I am dead serious. I feel I was very close to losing sanity. I would have done nearly anything to make it end. I wanted to begg for help, but I was too afraid to do so. The only thing that kept me sane was the hope that M 28 1 days
11/4/2008
 3  migraine I went to the er with the worst migraine I had ever had, crying and whimpering like a puppy...the doc gave me IV compazine, about 10 minutes after I just wanted OUT of there, felt like I was going to be there forever and just had to move around...trying to be a good girl I didn't say anything, had a terrible night and finally called er and they said they give benadryl to counter it. I literally could not sit still or stop moving and felt like a junkie in need of a fix...took 2 tsp benadryl and felt much better. I wish someone had told me that was a possible side effect...headache was bad but so was the compazine...next time I will ask them to give benadryl with IV...truly one of the worst days/nights of my life esp after 12 hours of migraine pain...at least in childbirth you get a baby at the end of it Not sure it was worth the aggravation...migraine is bad, compazine didn't get rid of it, just made it a bit more bearable and side effect was HORRIBLE F 38 1 days
11/2/2008
 1  vomitting during pregnancy Horrible, terrifying experience. i would not advise anyone to take this medication. I had to take 3 hot showers and literally lock myself in the bathroom. I was up all night with panic attacks, severe anxiety, and jittery arms,& legs. No matter how hard i tried i could not close my eyes due to spasms in my eyelid. I was minutes away from having my husband take me to the e.r. and my body finally started to calm down.12 hours later!!! Stay away from this med. F 28 1 days
10/30/2008
 5  Severe Nausea Just tired which is expected I have had this IV several times. I have also had the pills. I have never had a problem with it. Just makes me sleep which is much needed after a night of severe nausea. F 41 2 days
9/15/2008
 1  Migraine Received 4mg of Compazine in the ER for migraine. Doctor told me he wanted to try something new instead of Tordol or Demerol. IV Burned first 10 minutes. After half an hour went crazy. Could not sit still, hands flying all over, felt like I was being crushed to death by the room. Paced around wanted to yank IV out then I felt like grabbing and strangling everyone around me. Wife screamed and began sobbing. Has never seen me like this. Ataivan IV calmed me down along with Benadryl M 28 1 days
9/4/2008
 4  Intense Stomach Ache f I experienced a little tightness in my chest, a little disorientation which is expected from this type of drug. Usually I take it with my Midrin for a migrane/muscle tension headache and it works really well, it makes me feel really slowed down though and relaxed, which is a good feeling after a headache like that, I am really glad I didn't have any allergic reactions to it, I would recommend it for anyone with migranes or muscle tension headaches when there really bad. M 22 1 days
8/19/2008
 1  intestinal virus ~ 24 hours after 1st dose, started to feel jittery. My head started to twist around ala the exorcist. Could not speak, tongue swelled up, and could not walk. The muscle spasms and tongue swelling are listed as "common" side effects on other websites, however I was not warned of these very scary and life threatening side effects before taking the medication. I was only 16 at the time. F 37 1 days
8/12/2008
 1  Vomiting I went to the ER with severe vomiting, the dr. gave me an IV drip of saline and 10mg of Compazine. Within 10 mins. of the Compazine entering my system (I could feel it, it stung a bit) I had a strong urge to rip out my IV and pace the room, leave the hospital, anything to get the restless feeling to go away. I called the nurse to discharge me asap, she did but didn't recognize the symptoms. I told her I was having a bad anxiety attack, I knew I was being weird but couldn't help it. I am SO glad I found this, I thought I was going crazy. It was so scary, one minute I was grateful to be in the hospital to be getting rest and be taken care of, the next I was losing my mind. I just took 2 Benadryl, I'm feeling better tonight, but still have the slightest bit of jitteriness. F 29 1 days
8/11/2008
 1  Nasaua Tounge began to feel to big for mouth, then it twisted to side, then it began to roll back makeing me almost swallow it, muscle spasms and twitchs, lock jaw, panic attack, anixety, diffuculty breathing. I was only 13 when I was given this for nasaua & I began to feel weird in my mouth. My mom didn't believe me, but then my tounge started to enlarge bigger than my mouth,she started taking me more seriously, we drove from where we were all the way home while I endured the varying symptoms of which the worst was almost swallowing my own tounge. I was told I was having a severe reaction which doesnt happen to many but as I see here it happens to more than I thought. It was hell and I make sure every dr. knows that I'm ALLERGIC. This drug should not be given to anyone. Its benefits do not outweight the cost and it should be taken off the market. F 34 14 days
8/10/2008
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 1  vomiting This is the worst experience I've ever had. All from one dose of Compazine. My mom said the first thing I said after 15 minutes of having it was that I wanted to get out of my body. I couln't ly still in the hospital yesterday and I felt like I wanted to just jump out of a window. I haven't slept since I got it yesterday at 1:30 and I just got back from my doctor's who gave me Benadryl. This has made it more barable but I am still unable to sleep. They also gave me toridal which made me tired so needless to say it has been horrific. I feel like I'm trying to escape from myself. This website has made me feel a little better though because I know I'm not just crazy and that it will go away even though it doesnt feel like it. And on top of that,the hospital doc's are really stupid because I told them I was allergic to sulfa in medications and Compazine has that too so on top on feeling like I want to die, i have a rash on my palms and bottoms of my feet. WORST experience, Compazine F 20 1 days
8/8/2008
 1  NAUSEA, VOMITTING, SEVERE DIAREAH After a weekend of severe GI issues, I went to the ER. One of the first things they did was start and IV and give me Compazine! Instantly after recieving the medication via IV, I felt like I wanted to rip the room apart! I was resteless, angry, I couldnt concentrate, I felt like I wanted to just die! It was the most awful experience, and not even my primary care doctor told me Benedryl would help, so I suffered for two days- and I seriously thought I was losing my mind! STAY THE HECK AWAY FROM IT! Phenergan is SOO much better! F 24 2 days
8/4/2008
 1  Nausea during infusion of Orencia. Within 30 minutes of being given the IV drip I started feeling as if my bones didn't fit in my skin. I couldn't sit still, I felt trapped in my own body. I couldn't stay in one place - constantly getting up and moving around. I was jittery and anxious and unable to get comfortable. I started crying and felt very afraid. I just wanted to be home where I would be safe. I could barely drive - was so spacey. I highly advise against this medication. F 30 1 days
7/29/2008
 3  possible migraine terror, panic, claustrophobia, anxiety, fear I was given Compazine via IV during a Lake Tahoe, CA trip in mid-July 2008. I was having altitude sickness symptoms (6,300 feet). After a short time, I felt closed-in and panicked and fearful. I thought I was just being a "baby" and thought I was losing my mind. I went out in the parking lot with the IV needle still in my arm and did not want to go back inside. It took about three days to feel normal again and not afraid of being indoors. It was horrible. Nausea went away though! F 44 1 days
7/25/2008

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