COMPAZINE Reviews (PROCHLORPERAZINE MALEATE)

Average Rating: 1.2 (501 Ratings)

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 ANTIPSYCHOTICS ANTIMANICS VERTIGO MOTION SICKNESS VOMITING

 Type: Brand name discontinued; available as generic

  

COMPAZINE  (PROCHLORPERAZINE MALEATE):  This medication is used to treat severe nausea and vomiting from certain causes (for example, after surgery or cancer treatment). Prochlorperazine belongs to a class of drugs known as phenothiazines. This medication is not recommended for use in children younger than 2 years or in children going through surgery.    (Sources: U.S. Centers for Medicare Services, FDA)

  

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Key to Ratings: 1=LOW (I would not recommend taking this medicine.)
5=HIGH (this medicine cured me or helped me a great deal.)

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More on COMPAZINE: Reviews Summary  |  Drug Safety Information

RATING  REASONSIDE EFFECTS FOR COMPAZINECOMMENTSSEXAGEDURATION/
DOSAGE
DATE ADDED
 
 1  Extreme nausea My fiancé went in to the Er a year ago for extreme pain and while he was there he was suffering from nausea the doctor wanted to give him compazine. We asked if there were any symptoms and he said no. Not five minutes after he was given the drug his legs started shaking he looked like he was going to have a seizure. He jumped out of the bed and started yelling at the doctor he nearly tried to rip the IV out. We were so afraid to give him anything else but finally they gave him Ativan to counter the compazine. He later told me he felt like he was going to jump out of his skin, he was in a panic and felt like he was going to die. The doctor later said he knew of the effects but it was so rare he had never seen it before. I am glad to hear we are not crazy. One year later he still has what we have come to call attacks on his body he has seeked therapy because we didn't know what else to do. This has changed his life drastically.please do not take Do not take you feel like you are going to die. Sysmptoms will continue for many months if not longer M 20 1 days
1X day
7/9/2012
 1  migraine awful feeling anxious, suicidal, nausea for days, all symptoms everyone has described is how i felt and still do 3 days later!!! If you know of anyway to get ride of these symptoms please help!!! F 23 1 days
shot 1X day
7/5/2012
 1  pregnancy nausea trouble swallowing, trouble breathing, locked jaw, anxiety! Do not take! F 31 1 days
1X day
7/4/2012
 1  Migraine I had horrible anxiety and felt worse after I took it. It has been 24 hours and I am still trembling. My legs shaking uncontrollably. How in the world is this stuff on the market. They hooked me up to a monitor before they gave it to me. Duh, if you are scared of a side effect that requires heart and blood pressure monitoring, then maybe its not a good idea to administer this drug! M 40
1X day
6/14/2012
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 1  Morning sickness Took this medication in rectal suppository form for nausea related to pregnancy. Dosage info on package said take 1-2 doses for nausea as needed. Took one at 4 p.m-after about hour and a half I was still throwing up so took additional dose. Was very sleepy and jittery about three hours later. Slept through night and when woke up next morning was very jittery, restless, could not sit still. Over next couple hours the feelings intensified. Heart was racing, could not stop pacing, dizzy and had blurred vision. Strange feeling of dread and I thought if there was a cliff near I could throw myself or one of my kids off it. Was terrified of hurting myself or my children. Thank god our babysitter came that day-when she left I called my husband to come from work. The effects started to subside at 2 in the afternoon but didn't go away fully for another day and a half. I had taken this medication before for nausea and had not had any problems like this. I hope the fetus is OK-very scary 38 1 days
25-50mg 1X day
6/5/2012
 1  Lightheadedness A full blown seizure. Ended up in A/E which is ER in the Uk. Not good. Reported to the FDA. F 36 4 days
30
5/22/2012
 1  migrane and throwing up Worst feeling of my life! They gave it to me in an IV with benydrl. i felt like the inside of my body was trying to get out. Cant explain the feeling but i would rather be throwing up for a month strait then ever feel that way again. When i left the ER i started driving home and had to pull over on the highway at 2AM and call my sister to come get me. I left my car is a horrible part of the city and i didnt even care becuase i ws so sick. I couldnt sleep. I could NOT get comfortable. It took about 9 or 10 hours to were off. It was torture. F 1 times
1X day
4/14/2012
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 1  MIgraine I ripped out my IV and ran out of the hospital. I went to the ER for a migraine. I was already in a lot of pain, it got rid of the migraine but soon after I got it in an IV I started moving my uncontrollably. It was the most terrifying time I've ever had. I tried to tell the nurse that I was freaking out and she just walked out and left me alone. I became so paranoid that I ripped out my IV, put my clothes back on and fled the hospital through a back door. I ran all the way to my car where my husband was waiting and he was confused. He thought I was discharged as normal and I was too scared to say anything. I got no sleep that night and still could not control my body movements. The next day I went to another ER because I honestly thought I was going out of my mind. It's been years and I'm still terrified of ERs and taking new medications because of my experience. My life was changed with this drug and I have to take zoloft for anxiety and panic attacks now. F 26 1 days
1X day
3/14/2012
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 1  Food poisoning I was given Compazine for nausea from food poisoning. Almost 20 years later I still randomly suffer from side effects. Everything around me gets extremely loud, fast and heavy feeling. It usually last between 10, and 20 min. M 8 7 days
Unsure
3/4/2012
 1  Nausea w/Sickle Cell Pain Attack Instantly I felt jittery, agitated, like I needed to run around the hospital. Only by the grace of God did I make it home alive, and had to sleep all night and all morning. I had to call in to work this morning...worst experience of my life. Felt the same way after being given Reglan...still not the same. I love my doctor, but after this experience found myself to be very very angry with him! WHY is it allowed to be given to anyone?!? F 26 1 days
not sure 1X day
2/21/2012
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 1  nausea, vomiting I became paranoid and anxious. I was actually plotting my "escape" from the ER. I was pacing and felt that I needed to run and escape. My mind was racing. I was given this medication in the ER. F 42
1X day
2/1/2012
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 1  Headache, nausea Suicidal Thoughts,Anxiety,Lasting for months Has anyone else thought about a class action lawsuit against the makers of Compazine? F 36 1 days
Not sure 1X day
1/28/2012
Email
 1  Influenza I went into a frenzy clinging to the medic and the doctor screaming MAKE IT STOP I thought I was having an Out of body experience. I was crying screaming shaking and rocking back and forth on gurney. 8 months later I am not the same. I suffer from severe panic attacks ( never had before ) And irrational thoughts of suicide and anger spurts. I am anxious all the time I now see the va for help. I don't know if anyone else has ever had long term effects but I was 100% normal great bill of health until compazine was given for Influenza in my local ER... If anyone else has long term effects from compazine AKA 2 months or more after stopping use or getting IV compazine please email me [email protected] put subject COMPAZINE REACTION F 23 1 days
i dont kno 1X day
1/17/2012
Email
 1  awful effects all the ones listed here by others I have never had compazine IV. Years ago I had pill form and do not remember any adverse effects. I just wanted to comment on what people I know have told me. Their effects are exactly the same as all of yours. I can not believe that hositals still use this medicine for nausea in this day and age. Zofran is an anti nausea that dissolves on your tongue and works wonders. I know medicines affect us all different and do not want to preach, but I have never have heard of any other drug that universally seems to be as toxic as this one. For those of you who go to ER and need something for nausea. Please discuss other options instead of compazine. As someone who suffers from anxiety, it makes me upset to hear the terror some of you suffered. Please ask if Zofran is an option. NO side effects and nausea disappears lickety split! M 42 1 days
1X day
1/6/2012
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 1  Extreme Nausea Anxiety, paranoia, jerking, suicidal, homicidal. I am 19 weeks pregnant with severe sickness and kidney stones which also caused extreme nausea. I have been given this via IV not once but three times even after I explained that I had a reaction. Benadryl did nothing... actually made the anxiety a million times worse. I ripped out my IV the last time and stabbed myself with it. Had to be knocked out with Ativan. I can't believe they give this to people. No offense but especially pregnant women. Very very dangerous. F 26 1 days
10mg
1/4/2012
Email
 1  Cluster headache While I have taken compazine orally before with no problem, the I.V. compazine for me, as well, caused such a severe panic attack I DID rip my IV out the first time because no one was at the hospital with me and they just left me in the room after administration. They got me set back up and gave me some ativan, but it was one of the worst feelings in my life. I have a pre-existing anxiety condition to begin with, so I think I am also more susceptible to this compazine-induced anxiety, but clearly others have had a terrible reaction as well. It seems to me it was a very specific panic, too... it was not only that I wanted to get out of the hospital room, I suddenly feared I would never leave. Claustrophobia also set it and the having the IV in, being "tethered" to something, made it that much worse. I might have been a little better off if I had asked to go to the bathroom and just get out of the room. Skin crawling, racing thoughts, racing heart. Really just miserable. Always taken with toridol and benadryl, and always the same awful anxiety. After this combo had been tried about 5 times (on separate visits), it never helped my headaches and I had the terrible reaction to the compazine, so now when they ask me about drug allergies I tell them while I'm not allergic to anything, I know I have that reaction to compazine, reglan, and zofran and just request in advance it not be given, or if it must, something other than benadryl be administered to curb the anxiety. M 21 1 days
1X day
12/9/2011
 1  Sever migraine/ nausea Horrible panic attack within 10 minutes. Couldn't concentrate, couldn't sit still, hard to drive home, constant restlessness. I finally fell asleep after taking some Ativan and Tylenol pm, woke up and STILL feel restless and crazy like totally not myself. I told them not to give me reglan which is in the same group of medications but had never heard of this before so if you had a bad reaction to compazine DO NOT take reglan either!! F 22 1 days
11/21/2011
 1  Migraine Skin crawling, eyes couldn't move, couldn't focus, mind racing, sick to stomach, hot flashes, list goes on and on.... F 15 1 times
1X day
11/20/2011
 2  nausea/vomiting Extremely tired and restless. I was unable to get comfortable. I felt like my soul was leaving my body. I was tired and lightheaded at the same time. 3 days later and Im experiencing constipation. I was sick from a virus, vomiting all night and unable to keep fluids down. I went to the doctor in the morning and soon after the injection I was lightheaded, excessively tired, anxious. I wanted to leave the doctors office but they ended up keeping me there for an hour and half to get test results back. It was awful. I was in bed 24 hours straight I was so tired and I kept waking up every hour feeling restless. Wish I had known more about the drug before it was injected into me. 3 days later and I still feel tired. F 24 1 days
10 1X day
11/17/2011
 1  Severe Migraine/Vomiting Severe anxiety (first time in my life). Feeling my body being exhausted and limp for 2-3 days but my mind racing the entire time. This was adminsitered with benadryl and toradol. I have never had any drug allergies before. As a chronic migraine sufferer, I highly recommend just asking for a shot of Demerol. I have no history of mental illness but after taking Compazine I had suicidal thoughts and felt crazy as hell. F 24 1 days
10mg 1X day
10/6/2011
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