COMPAZINE Reviews (PROCHLORPERAZINE MALEATE)

Average Rating: 1.2 (501 Ratings)

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 ANTIPSYCHOTICS ANTIMANICS VERTIGO MOTION SICKNESS VOMITING

 Type: Brand name discontinued; available as generic

  

COMPAZINE  (PROCHLORPERAZINE MALEATE):  This medication is used to treat severe nausea and vomiting from certain causes (for example, after surgery or cancer treatment). Prochlorperazine belongs to a class of drugs known as phenothiazines. This medication is not recommended for use in children younger than 2 years or in children going through surgery.    (Sources: U.S. Centers for Medicare Services, FDA)

  

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Key to Ratings: 1=LOW (I would not recommend taking this medicine.)
5=HIGH (this medicine cured me or helped me a great deal.)

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More on COMPAZINE: Reviews Summary  |  Drug Safety Information

RATING  REASONSIDE EFFECTS FOR COMPAZINECOMMENTSSEXAGEDURATION/
DOSAGE
DATE ADDED
 
 1  Headache I received an IV push of 10 mg in about 20 seconds. I had an acute dystonic reaction. Followed by what I term 6 hours of "psychological terror". Within 90 seconds of administration, I was agitated, had trouble breathing, restless, I wanted to sleep but couldn't. I was unable to easily form sentence to let them know how physically irritated I was. They had immediately given me IV Benadryl to counter the Dystonic reaction...my body was so messed up between both medications. The nurse/ER doctor who prescribed the medication assured me that I would get great results. That the medication would help me "sleep"... NEVER take this medication for a headache or nausea. I don't recommend anyone every taking the IV form of this medication. It has horrific side effects that you have to literally wait to leave your system. I wasn't not myself for over 24 hours. I highly discourage the use of IV compazine. The ER nurse administered my dose within 20 seconds. It should have been administered across 120 seconds. In addition, the side effects were FAR WORSE than my initial headache. I was far worse off at discharge. If they attempt to give this medication to you, ASK THEM if they have personally experienced IV administration. Anyone who has would never recommend this. F 34 1 days
10 mg 1X day
7/10/2014
Email
 1  Blurred vision, one does thru IV Losing my mind, agitated, severe anxiety, wanted to kill myself, felt like this for 14 hours. I am so sorry for everyone who has gone through this. There is no real way to describe what I went thru and then to have TD as a result of this. It is so unfair. I had a similar experience years back to Reglan, but nothing like this. I really thought the nurse was given me Zofran not Compazine. :( I developed Tardive Dyskenisia as a result of one dose (10 mg) of Compazine in the ER. I begged for Benadryl and would not give me. I got 50mg of Benadryl a couple of days later, but I know I should have gotten it right away. Maybe it would have helped? It is nearly three months later and I still do not feel back to normal. I pray I will get better. I have severe muscle spasms, tongue spasms, tremors, insomnia, anxiety, depression, the list goes on and on. Some say this will go away in time, others say it is permanent. I pray that God heals me very soon so that I can go back to being a mom and wife. Please pray that his will be done. This is the most horrible thing I have ever gone thru in my life. If I could only turn back the hands of time, however, this experience has brought me closer to God and I appreciate life more. Please keep me in your prayers. Please feel free to contact me if you have any advice or if I can help you at [email protected]. These past few months have been a blur.. F 36
10mg 1X day
7/1/2014
 1  Nausea I've been administered this at the Naval hospital ER for my migraines that were so painful hey caused nausea. Every time I went they gave me this. I blew it of the first time. Got a different "cocktail" the next time I went to the ER. The third time I finally got he name of the drug. Compo or Compazine through IV was one of the worst experiences of my life. I got it three different visits and feel like I was tortured. The nurse said she knew how I felt and she tried to just sleep through the side effects and she said she would get me some more Benadryl. I felt as if I was having panics attacks and eerie skin crawling feeling. I was chilled as well. The worst part is that I had an empty stomach and I swear this prolonged the side effects to where the next day I went into the ER with a bp of 151/115. It was a horrible anxiety attack. All in all I'd say it took 3 days to lol these side effects when the ER said it should've been out of my system after six hours. Oh, the paramedic in the ambulance had the same experience and couldn't believe this was still in the market. My plan is to get witness testimony and documentation of these events and take legal action. F 26 1 days
10 MG
6/13/2014
 1  severe nausea I was given this drug for nausea accompanying kidney stones and was sent home about a day in I started to feel waves of panic I started pacing and grinding my jaw I had trouble breathing and over all felt like I was going to die it was an over whelming feeling. The symptoms decreased over the course of a week it was one of the most awful experiences of my life. FYI if you have a reaction to this you might have a slight reaction to regalan as well I have. Always ask what they are prescribing and/or putting in your IV. F 21 2 days
6/5/2014
 2  chemo Severe anxiety, muscle pain, paranoia, sore throat, and high fever-103degrees. F 51 6 months
unsure
5/27/2014
 1  Nausea I was given compazine through an IV and have not felt normal ever since. I feel crazy. Minutes after I had it I got up and couldn't stop pacing around. I felt extremely anxious and made the nurse discharge me because I was so desperate to get our of there. I thought going home would calm me down a bit but no. Nothing had worked. I can't sleep or sit still. I feel a constant need to sit up or get up and walk around. This is a horrible experience and I hope this medication is taken of the market. DO NOT TAKE THIS F 23 1 days
4/16/2014
 1  migraine It made me EXTREMELY sick, I felt like I was continuslly falling in the pit of my stomach. I went completely cold and wet. I was in pain in my chest, itching nausea and that lasted at least a day. And I still had the migraine. I was given so much med to try and counteract the effects they refused to give me anymore, and for some reason the next time I went into the ER for a migraine they wanted to give me another cocktail instead of a narcotic, anyway that cocktail made me I'll also, and they ended up giving me narcotics anyway. F 41 1 days
4/6/2014
Email
 1  nausea and vomiting I got the compazine put in by IV cause I had extreme nausea and vomiting caused by my cyclic vomiting sysdrome. I have been given alot of medicines to help with this illness. This med was the only med that caused me other problems. I still have a racing heart beat and still feeling panicked. I looked at alot of websites that might say a cure for this and almost all people that have these issues said that benadryl really helps. I tried it and it seems to help. I guess if you get these bad simptoms that you are allergic to that med. If you do have these simptoms you should consalt a doctor before taking the benadryl. M 30 2 days
4/2/2014
Email
 2  migraine- nausea Could not sit back. Kept feeling like i had to sit up. Looked at my husband to reassure me. Had to pray out loud because I thought i was going crazy. I asked about the the side effects prior to being given this med and all they said was "lethargy". What a lie!!! F 34 1 days
not sure
2/27/2014
 1  Yes prochlorperazine Feelings of pure doom. Depersonalization, derealization, leg tremors, Akathisia, terrified feeling, overwhelming anxiety, hallucinations, still feeling horrendous 8 weeks later. just started Paxil for the anxiety & panic brought on by this horrendous drug! Worst 8 weeks of my life !!!! Praying it will end soon! Was only put on this drug for dizziness!!! F 29 5 days
30 mg
2/24/2014
Email
 1   Made me crazy! Def should not be given to anyone! F 42 1 days
2/14/2014
Email
 1  migraine and nausea I was given this med along with toridol for my migraine and nausea thru my iv. Minutes later I felt like I wanted to jump out of my skin. I felt the need to jump on and off the gurney. I had all kinds of crazy thoughts running thru my head and when I did dose off I had some freaky dreams. I started thinking I was gonna die. My mind kept racing. I felt crazy and to top it off I work at the hospital I was being treated in and was really trying to not make a complete ass of myself. So I told the nurse I felt way better and I wanted to go home and rest even though my migraine was still bad. The Er doc came in and I lied and said I was fine and he sent me home. I didn't wanna tell them how I really felt because I was afraid they'd give me something else that might make it worse. I honestly thought I was gonna die. On the drive home my husband who had picked me up wanted to make a pit stop for food and I got all irrational and started crying I jus wanted to go home hoping the comfort of home would help calm my nerves but it didnt. I felt horrible and this feeling dragged on for another couple days. This all happened on NYE so I spent my new years in bed with crazy dreams and insane thoughts while I was awake. Its been almost three weeks and im still feeling anxious every now and then.I'm afraid to take any meds now in fear that I'll feel like that again. I've had a reaction similar to this from reglan but not nearly as bad as what the compazine did to me. That drug is crazy stuff! F 33 1 days
1/18/2014
 1  ER Visit for Nausea/Migraine Extreme Shakiness, Suicidal Thoughts, Dry Mouth, Uncontrollable Muscle Spasms, Anxiety, Rapid Heartbeat, Sweating Never Again. As soon as the compazine shot through my i.v. , I fell down the rabbit hole of insanity. I assumed that the compazine was a nausea medication and didn't think anything of it. For the next few hours, I lived in my own personal hell debating on how to kill myself and imagining what the inside of Satan's testicles must look like. On top of my mental breakdown, I had uncontrollable muscle spasms which just made me so thrilled. Finally, I fell asleep. My dreams were horrendous, of course. What i'm generally saying is if you don't do well on antipsychotics, don't take this drug F 20 2 days
5 MG 1X day
12/18/2013
Email
 1  Had a migraine-like headache I went to ER with a bad headache like a vice around the back of my head nurse put 10 mg of Compazine in my IV along with 25 mg of Benadryl. That made me a little sleepy but then I came out of the bed lijke a shot all wigged out!? I felt like I was dying!!! I seriously couldnt make the wierd internal sensations going through my body in waves!? I got home that night and could barely sleep at all, by morning I literally wanted tom die I even thought about taking my own life!?!?!? DO NOT EVER TAKE THIS DRUG!!!!!! M 38 1 days
10 1X day
11/19/2013
Email
 1  nausea Increase heart rate, seizures, cervical dystonia, muscle spasms in lower extremities, changes in respirations, and blood pressure. After having a Migraine and nausea for 4 days, I was giving Compazine. On day two of taking it I developed the symptoms. I went to the ER and they treated me like crap, The ER doctors stated I was having a panic attack and blamed it on stress. It wasn't until the second day of having the symptoms when my nurse practitioner found the culprit! COMPAZINE. Although I am no longer having seizures, I am still having the cervical dystonia(neck and shoulder spasmodic jerking. F 29 2 days
5mg 4X day
11/19/2013
Email
 1  nausea I went to E.R for sickle cell crisis and they always give pain med with a nasea med also so they gave me compazine i never had it before i ask the nurse to wht r u giving me cause i cant take everything. She snuck it in my i.v anyway and boy i tell you the worse feeling of my life all i remeber feeling out of my mind and body didnt knw where i was scared out of my mind i made it to a phone told my step dad to come get me made it out side laying on the ground whn he arived i said nothing but jumped in the car back seat got home ran up stairs jumped in bed just remember wanting to sleep it off i never had a panic like tht and everything around me did t seam right voices were weird. Yes i could hve died i would also like to sue whom so every made this drug pls keep me in touch im with all of u i knw how uall felt and its not right life threthging. F 42 1 days
i.v
10/28/2013
Email
 1  went to er for fever felt nauseated Nurse gave me injection via iv and didnt slowly inject it. I felt like i was dying felt like i was suffocationing and panicking..couldnt sleep for days after this injection & felt jetterish for 3 days aftrwards F 35 1 days
10/25/2013
Email
 1  Migraine They gave me a cocktail of compazine, toridol, and Benadryl via IV to treat my migraine. Never even said my nausea was very bad so I don't know why they gave me this terrible drug in the first place. Almost immediately after the injection, I felt an awful rush through my body up to my throat and all the sudden I lost all grasp on reality. I felt this overwhelming urge to kill myself and everyone around me to get off of this terrible drug. I felt it was the only way! I was sobbing and asking the nurse what was wrong and she was very rude and said to calm down- that's all! I felt like I could not understand a word anyone was saying. My muscles felt like they didn't work and I felt like my skin turned to rubber. Every breath felt like a struggle. My BP went up so high the nurses came running in and all they did was tell me to calm down again. Like I could help it! I wanted to rip the IV out and hang myself with the bed sheets! I've never felt this way in my entire life. Almost 24 hours later and I feel jittery, upset, and traumatized from the incident. I want to sue whoever made this terrible drug. I hope the effects don't ruin me forever F 20 1 days
10/3/2013
 1  nausea Horrific. Felt terrified for my life and like I needed to kill anything that moved and destroy the hospital room by room. Was so scared I threw a fit like a child. My sense of time was destroyed and the butcher at the ERsaid he figured I'd have a reaction and gave it to me anyway! Is awful a month out and I'm still fighting crippling panic attacks and anxiety, insomnia, depression. I'm using Benadryl, as per the butchers instructions, for now. It helps, but this drug has literally started fraying the edges of my sanity. F 22 1 days
1x D
9/21/2013
Email
 1  nausea after gallbladder removal was given compazine thru IV every half hour until I reached max dosage due to nausea I had after surgery --- worst mistake ever!! it literally made me crazy. it took weeks before I was back to "normal" - made my skin crawl, couldn't sit still, cried, etc. it basically triggered a weeks long anxiety attack. so scary how many people have had similar side effects. do not take! F 25 1 days
7/27/2013
Email

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