COMPAZINE Reviews (PROCHLORPERAZINE MALEATE)

Average Rating: 1.2 (501 Ratings)

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 ANTIPSYCHOTICS ANTIMANICS VERTIGO MOTION SICKNESS VOMITING

 Type: Brand name discontinued; available as generic

  

COMPAZINE  (PROCHLORPERAZINE MALEATE):  This medication is used to treat severe nausea and vomiting from certain causes (for example, after surgery or cancer treatment). Prochlorperazine belongs to a class of drugs known as phenothiazines. This medication is not recommended for use in children younger than 2 years or in children going through surgery.    (Sources: U.S. Centers for Medicare Services, FDA)

  

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Key to Ratings: 1=LOW (I would not recommend taking this medicine.)
5=HIGH (this medicine cured me or helped me a great deal.)

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More on COMPAZINE: Reviews Summary  |  Drug Safety Information

RATING  REASONSIDE EFFECTS FOR COMPAZINECOMMENTSSEXAGEDURATION/
DOSAGE
DATE ADDED
 
 1  Nausia Control Extreamly restless. Like others here I felt like I was going insane. I couldn't sit still and actually started biting people. They gave me a small 25mg dose of Benadryl to help ease the side effects but it wasn't enough. The doctor wouldn't let me have any more so they pretty much just tied me to my hospital bed and let me thrash around for next 6 hrs or so. Related drugs such as Reaglan have the same effect. In the 25 years I've been batteling cancer though they have come a long ways from the barbaric dark ages of Compazine. Modern medicine such as Anzamet and others help a lot more and have far less agravating side effects. M 30 3 times
11/28/2006
 4  Nausea from chemotherapy Lethargy and a vague feeling of being "out of it," similar to my shipboard experience with dramimine. I am taking it only as needed rather than as a regular maintenance dose. I believe that this site gives an exaggerated opinion of Compazine's side effects because people with bad experiences are more likely to post a rating than people with good experiences. This is why I am rating the drug to try to "level the playing field." It is so widely prescribed, there is no way it is < 2. M 62 2 months
11/21/2006
 1  headache with nausea Absolute and pure terror. My dosage was via intravenous, and the crawling sensation with extreme restlessness made me think I was actually going insane. I have actually thought many times since then that my experience might be what it would be like to suddenly go insane. ANY DOCTOR OR HEALTHCARE PROFESSIONAL should be immediately prepared to issue counteraction against this drug in the event that the patient has a reaction. I unequivocally believe this drug could cause immediate suicidal tendencies. This is the only drug that I am aware of that I am totally resistant to. M 43 1 days
11/1/2006
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 1  vomiting severe painful muscle spasm, throat swollen and closed, couldn't speak, jaw pinned to shoulder and stuck to that side, paralyzed on half of body diagnosed with mono after months of fatigue and fevers, given compazine to help stop the daily vomiting, within a day my throat started swelling up and i went to the e.r. where they were going to take out my tonsils, as i was there it got worse where i spoke like kermit the frog and my jaw spasmed and i couldn't get it off my left shoulder and half my body paralyzed up, a million doctors came in and they flushed my whole system with saline and gave me benedryl and steroids, it happened again to a lesser degree a day later and i didn't feel the spasms completely stop for at least a month. scary. F 25 2 days
10/23/2006
 1  Nausea I was given an IV of compazine in the ER for severe nausea caused by the Flu. With 20 min of the IV, I began to feel like my skin was crawling. This feeling slowly intensified until I felt like my body was trying break out of my skin. My cogitive functions became depressed and I generally felt like I was in hell, not being able to feel comfortable in any position. My limbs felt like they were moving at 100 mi/hr despite the fact that I was lying still wondering what the hell was going on. The doctors did not recognize that I was having problems with this medicine. This feeling lasting with great intensity for around 3 hours. the only word to describe this feeling was torture. You feel as if you are loosing your mind entirely. M 29 1 days
10/11/2006
 1  Nausea related to surgery Back, shoulder, jaw spasms, toungue and throat swelling, convulsions. Uncontrollable and painful. My mouth was wired shut while I had this reaction to compazine. Three days out of major reconstructive surgery. I could not breath at all and almost suffocated. I was rushed to the ER where the hospital staff were confused and didn't know what my problem was. They had to call my doctor to open my mouth so that I could breath. Don't take this medicine, there's lots of other anti-nausea drugs out there. F 18 2 days
8/21/2006
 5  Nausea Sometimes drowsy It works great. I got a dose of 30 from my doctor for when I get nauseuous and Im taking Prevacid. Im not actually taking compazine.. im taking a knock-off. and im glad by looking at those other comments! I dont know what id do if that happened to me! I get panic attacks when im naseous.. and im a bit of a hypocodriact. Ha. F 15 3 weeks
5/12/2006
 1  vomiting My daughter, age 15 took compazine for 2 days for vomiting. She suddenly took on characteristics that a stroke patient would have; she could barely talk, her head was to one side, she clenched her jaw, had the shakes.... We ended up calling 911 and she was taken to the hospital by ambulance and given a huge dose of benadryl This is a very dangereous drug. No one should take it after witnessing a 15 year old go through what my daughter did. F 15 2 days
3/16/2006
 1  migraine nausea akathesia.... The worst feeling in the world. I was begging god to bring back the migraine. I felt as I was gonna crawl out of my skin. Very restless couldn't sit still. The first time I just thought it was me freaking out, the 2nd time I begged for benadryl ( had this reaction with inapsine too) the doc said I didn't need it. Any one who has been through this knows the hell it is. The feeling lasted from about 8:30 pm to 4:00 pm the next day. DO NOT TAKE THIS. If you do before hand talk to ur doc and see if you do have this reaction if you can get benadryl. F 25 2 times
2/21/2006
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 1  malaria- nausea I took the drug when i was 16 and had malaria from a trip to Nigeria. I ended up like most of the people here..in the ER due to the muscle spasms that led to a seizure. I DO NOT RECCOMEND THIS DRUG TO ANYONE.. They say that 1 in 500 react that severely to the drug. Never having any allergies, I never thought it would be me. Be careful when taking this drug..I used to twitch time to time from it. and as time went on it stopped (months). F 22 1 weeks
2/11/2006
 1  nausea from kidney infection Immediate feelings of terror and feelings of numbness swept rapidly through my body. I felt as if I had been poisoned and was going to die. Became intolerant of noise and had feelings of uncontrollable rage. I became severely agitated and, paranoid, thinking that the nurse who gave me the drug was trying to kill me. Violent urges and a feeling of being completely out of control. Strange hallucinatory effect of seeing what looked like tiny traintracks on my ex's skin. This drug was given to me intravenously in a hospital without my consent. I had a kidney infection and was pretty sick. My ex insisted that I go to the ermergency room. The staff assumed that the infection must have been making me feel nauseous but I actually did not feel sick to my stomach at all. I even told staff this when they asked if I had any nausea symptoms. I told them I did not, so what did they do- they ignored what I said and shot a dose right into my IV! F 28 1 days
12/27/2005
 1  nausea following surgery Heart arrhythmia for a few hours I was given Compazine twice at age 21 (2nd time against my will) and both times suffered a allergic reaction. M 30 2 days
12/12/2005
 1  vomiting and stomach upset I don't have allergies to much of anything, so this was a strange experience. I was prescribed compazine while in the ER for vomiting and diahrrea. I had been pretty sick and had passed out due to dehydration. I don't remember if they gave me any compazine at the hospital, but I did take one on my own the next day at home. Anyway, a few hours later I slowly noticed that I couldn't form my words correctly - I was slurring my speech and had a lisp. It was strange, so I didn't mention it to anyone and just didn't say much out of embarrassment. I thought maybe I was tired. But it got worse and within a few hours, my lower jaw had slowly pulled itself over to one side of my face. By the time I got to the ER, the lower half of my face was contorted very violently and painfully where I felt as though the tendons were tearing. I could feel my tongue pulling back in my mouth - It was all uncontrollable and terrifying but luckily I was near the ER and the staff recognized what was happening righ F 21 1 days
11/22/2005
 1  Nausea My eyes felt like they were going to pop out of their eyesockets, my heart pounded a hundred miles a minute and I had a terrible headache. My nausea came back even worse than before. My face looked like a mask. I have a co worker who had the same type of side effects. THIS STUFF IS BAD NEWS When I woke up in the morning I felt wonderful. I was full of energy. The nausea was gone. But then the trouble started...I could not sit still. I went outside & built an obstacle course of garage sale finds in a parking lot while a group of people watched. My ex asked why I was fidgeting. I told him I felt really nervous and that my head was twisting to one side on its own. He thought I was kidding. We called my doctor to see what we needed to do. They acted like it was no big deal and that the doc would call me back. My ex drove me to the hospital. A lady in the ER asked me if I had a concussion because of the way my head was twisted. I told the nurse I had taken 2 pills of Compazine (one the night before and another that morning). They gave me Benadryl and kept me over the weekend. The nurse said she had taken it and that it made her arms and legs spasm. They also said I should never take Reglan for any reason. When I went for a follow up with my doc he was SWEATING BULLETS. I F 31 2 days
10/20/2005
 1  Nausea 1. face, neck, eye and tongue spasms 2. nausea 3. headache 4. pounding heart 5. mask looking face 6. nervousness 7. psychotic behavior When I woke up in the morning I felt wonderful. I was full of energy. The nausea was gone. But then the trouble started...I could not sit still. I went outside & built an obstacle course of garage sale finds in a parking lot while a group of people watched. My ex asked why I was fidgeting. I told him I felt really nervous and that my head was twisting to one side on its own. He thought I was kidding. My eyes felt like they were going to pop out of their eyesockets, my heart pounded a hundred miles a minute and I had a terrible headache. My nausea came back even worse than before. My face looked like a mask. We called my doctor to see what we needed to do. They acted like it was no big deal and that the doc would call me back. My ex drove me to the hospital. A lady in the ER asked me if I had a concussion because of the way my head was twisted. I told the nurse I had taken 2 pills of Compazine (one the night before and another that morning). They gave me Benadryl and kept me over t F 31 2 days
10/20/2005
 2  Nausea I had a very bad reaction to compazine, and I see that others here had the same problem. It's called akathesia. I felt like I couldn't sit still and that I was going to explode out of my skin. I could feel the blood pumping in my skull. The ER gave me IV benadryl, which helped immediately. Two doctors, a general practitioner and a gastroenterologist, insisted the symptoms I described could not be caused by compazine. They smiled and nodded and were patronizing to the crazy person. Believing them, I took it again, had an even worse reaction, and wound up in the ER again. The ER doctor told me I was experiencing a known reaction to compazine and said that the sensation was unbearable. (She actually looked at me and said F 42 3 times
7/11/2005
 1  Nausea from dental surgery The first time I used this, I was fine. It was in pill form but it was years ago. The second time was for dental surgery which was very painful. About one minute after using the suppository, my whole body started to go rigid and stiffen up. I was alone at the time and had never had anything like that happen before---so I thought I was dying. I passed out, waking about an hour later feeling alright. Very scary. Have never used again. F 32 1 days
6/9/2005
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 1  To prevent nausia from codene Muscle Spasms! It was the worst. I couldn't talk, I was drooling, my legs and my arms would stiffen up. I had gotten my tonsils taken out. In the past I would get really nauseous from codeine. My doctor prescribed me compazine. It said to take every 6 hours and I took it every 12. I had to be rushed to the hospital because I seriously looked like I was someone who had been crippled for life. Honestly I looked like a special needs child god forbid. My parents thought it was a reaction from the codeine. At the hospital they did blood work and the doctor had no idea what was wrong with me. Finally one of the head nurses came over to me and realized I was on compazine. She had seen that reaction once before. It had to be the scariest thing ever. The number one side effect is muscle spasms. On the bottle they put a sticker may cause blurred vision. Crazy! F 18 4 days
1/3/2005
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 4  nasea and vomiting None. I was sick from a bad case of the flu and vomiting in the hospital and compazine helped. < Don't know why I didn't feel any bad side effects off compazine ? unlike other antipsychotics. It didn't even feel like it was an antipsychotic there was no annoying stagnance. M 23 1 days
11/5/2004
 5  diziness none 83 2 months
8/28/2004

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