COMPAZINE Reviews (PROCHLORPERAZINE MALEATE)

Average Rating: 1.2 (501 Ratings)

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 ANTIPSYCHOTICS ANTIMANICS VERTIGO MOTION SICKNESS VOMITING

 Type: Brand name discontinued; available as generic

  

COMPAZINE  (PROCHLORPERAZINE MALEATE):  This medication is used to treat severe nausea and vomiting from certain causes (for example, after surgery or cancer treatment). Prochlorperazine belongs to a class of drugs known as phenothiazines. This medication is not recommended for use in children younger than 2 years or in children going through surgery.    (Sources: U.S. Centers for Medicare Services, FDA)

  

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Key to Ratings: 1=LOW (I would not recommend taking this medicine.)
5=HIGH (this medicine cured me or helped me a great deal.)

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More on COMPAZINE: Reviews Summary  |  Drug Safety Information

RATING  REASONSIDE EFFECTS FOR COMPAZINECOMMENTSSEXAGEDURATION/
DOSAGE
DATE ADDED
 
 1  Sickle Cell and headache As they gave me the injection of compazine, they also gave me Benadryl. The nurse said that is would take my headache away and also ease my sickle cell pain. I've never been admistered this drug for my sickle cell crisis but didn't question it. As soon as the nurse left, my body immediately started feeling cold. The IV fluid felt like freezing water. I began feeling as though I had to move around to stay alive. I began yelling for the nurses and no one would respond. I began pacing the room, and eventually I ran out to the nurses station in tears asking them to get the medicine "out of my system". I wanted to commit suicide just to stop what I was feeling. The nurse took me back in the room and took my vitals. My heart was beating fast and I began to sweat. The nurse left to notify the doctor and she administered morphine, my normal treatment for sickle cell, and I immediately went to sleep. This was a horrible feeling. F 28 1 days
4/20/2017
Email
 1  Migraine My mom was given compazine approximately 12 hours ago and it has been a nightmare. She was extremely cold, confused, kept saying "let me go" (as in 'die'), and kept trying to get out of bed to go outside. I will be sure that have the doctors put in her file to NOT give her this ever again. This experience has been a nightmare. Do NOT recommend F 57 1 days
4/18/2017
 1  Stop nausea due to migraine headach Shortly after the comazine injection, I felt abnormal nervousness. I sat down, then I had to stand up and walk around, then I had to sit down again. My body felt restless and mentally I was starting to get worried. I fet jittery, very uncomfortable. The doctors kept me in the ER for an hour under observatioin because I also had an injection of imitrix for the migraine. They gave me a second injection of imitrix, which is according to the label. I had no problem with the imitrix and I have used it successfully since then with the package for patients that comes with a self-injector. A couple years later, when I had to go to the ER again for severe vomiting due to a migraine, I told them NOT to give me compazine. They gave me a different anti-nausea medication and I did not experience any side effects. I am very glad to hear that Compazine has been removed from the market in the USA by the FDA. How on earth this medication was approved in people who do not have a speciic psychosis is unfathomable. My first dose and only dose was given in 1998. That it took this long to have Compazine removed from the market just goes to show how ineffective the FDA is. Horrible medication. F
injection 1X day
4/14/2017
 1  Migraine Do not take this drug. I had it in the ER along with Toradol for migraine and I had the nurse stop it and take my IV out. I started having panic attacks. I was in the hospital for six days getting this under control believe me it's not worth it. I should have asked for Zofran. I regret ever going to get help that day but I was deperate for relief when my migraine med failed me at home. F 44 1 days
20
3/31/2017
 1  Migraines Don't take this crap. You will be jumpy and have a hard time sleeping. No sure when it will wear off but I took it at 9am and it is 1:50pm and still nothing. ER gave me Benadryl with it and didn't tell me the side effects. The nurse should be fired for that. This stuff is found in preworkout and that's why preworkout is dangerous. Can't even type right F 22 1 days
5
3/30/2017
 1  nausea 1. tongue swollen twice as large 2. eyes bulging and rolling 3. throat closing 4. muscles along spinal column spasmed and pulled my head as far back as it could go without breaking it off my neck 5. EXTREME TERROR (no brainer) 6. sweating profusely 7. excessively high heart rate THIS MEDICATION WAS JUST ABOUT LIFE-RUINING FOR ME. I was a kid. Thirteen years old at the time. Stomach issues and had reported nausea. Compazine was the little slice of hell they dished out to me in my IV. I have literally never been the same since that day. I have suffered chronic and severe Panic and Anxiety disorders and even Agoraphobia at one point. I am now 61. Still afraid to take ANY new drug but particularly RX drugs. I will cut the pill in half just to see if it will kill me. The doctors back then called my reaction "mini-strokes" ... even after giving me medicine to bring me around... I still had two more bouts from that one dose of the C-word ; Compazine. F 61
1X day
3/29/2017
Email
 1  Hospital I went To The Hospital Cause I Wasnt Feeling Well, Headace And Nausea, So The Doctors Gave Me An Iv "Cocktail" Once They Put The Compazine In My iv, I Had A Immediate PANIC ATTACK! I Felt Even Worse After, I Just Started Shaking, Very Cold, Anxious No Matter What I Did Nothing Work I Thought I was going to Die! IM NEVER TAKING THAT AGAIN I RATHER DIE!!!! F 24 1 days
30
3/28/2017
 1  Nausea/Migraine I was at the ER for an IV drip and Compazine and about 5 minutes after having the Compazine injected I started panicking. I was sobbing uncontrollably and it felt like I needed to crawl out of my skin. I kept telling the nurse that I needed to leave and that I wanted to die. When I got home the feeling had not passed, it didn't matter what I did - stand, sit, eat, lay down, shower, I was just very uncomfortable regardless of what I did. It triggered an absolute panic attack, I will never take it again. F 19 1 days
1X day
3/14/2017
 5  Severe Nausea No side effects I know many people do not recommend this drug which I was shocked about. I have what is called Cyclic Vomiting Syndrome and compazine is literally the only drug that stops my nausea. When I get an episode of my CVS, I have to be put on compazine and fluids both through my IV in order for me to get better. I have been hospitalized about 6 times in the past 4 years due to my condition and every time the doctors have given me reg land, zofran, benadryl etc in different cocktails and compazine is the one thing that never fails. Im really surprised to see it has not worked out for so many people. I have NEVER had the feeling of "crawling out of my skin" or any suicidal thoughts. I suppose everyone really is different. F 21 2 days
30 Mg 2X day
3/10/2017
 1  I was in er for migraine My heart rate went up to 180 F 32 1 days
30 mg
3/2/2017
 1  Migraine I suddenly felt very agitated and felt like I would pass out. I felt extremely cold and couldn't get warm. I checked my blood pressure and it dropped to 78/48. I got extremely restless legs. I thought I was dying but couldn't get off couch. NEVER again will I take this medicine! Never take this medicine! F 57 1 days
3/1/2017
 1  Migraine As soon as they gave me the migraine cocktail with compazine, I went into a full blown panic attack. I had to call for the nurse twice because they did not give me a call Button. I told them I wanted the IV taken out of my arm. They kept asking me if I was sure and I told him yes that I wanted it taken out. They said that they can give me Benadryl to counteract the medicine but I told them just to take it out that I had to leave the room. Finally, once they brought me outside I was able to calm down some and they gave me some Benadryl. I'm so glad I had someone to drive me home because I was totally out of it with the medication and did not comprehend anything that was going on. Also was jittery and had no appetite to eat. When I got home, I kept falling asleep, getting up and walking around. I couldn't even stand to watch TV for only a certain limit of time. This is the worst experience ever. I would never take this medication again. I would rather have a migraine. No one should take this medication. F 40 1 days
2/24/2017
 1  Migraine headache I began to experience severe restlessness almost immediately after the IV administration of Compazine. I was unable to sit or lie still. I, particularly, felt an overwhelming need to move my legs. I was aware I shouldn't do it but I ripped out my intravenous line and fled the emergency room without being discharged. I couldn't control the urge. People who have had a bad reaction to Compazine need to be aware the same thing may happen with other medications in its class. I had similar reactions to both Thorazine and Reglan. F 45 1 days
Unsure
12/31/2016
 1  Migrane Felt Like Dying. When they gave me this medicine they also gave me benadryl & It make me tired always but with the companzine I couldn't stay still I took my IV too the bathroom & the blood was going down thr IV the nurse was telling me something but I didn't care I just wanted too run & take the IV off , I try too sit or lay down but I couldn't I was a bad reaction & I felt like that for 5 days I hate it NEVER TAKE IT F 24 1 days
12/3/2016
Email
 1  Nausea and vomiting I began to have facial twitching that might be permanent I had trouble being still but that is going away It is a very good med but if you have side effects it is a good idea to talk to your doctor about it right away F 54 8 years
20 mg
12/1/2016
 3  Migraine The compazine made me feel somewhat disoriented and very cold. It wasn't a horrible feeling but it definitely wasn't pleasant. I was given Compazine as part of a "migraine cocktail" along with Toradol and Benadryl. It helped to greatly alleviate my migraine symptoms. F 19 1 days
11/24/2016
 1  ER visit/ headache Supra Ventricular Tachycardia I was convinced this medicine was going to kill me in the Emergency Room. I was sick, had a fever, felt light headed. I had some kind of minor virus. I never told the nurse or doctor I had a beadache, but I was young and didn't question why they wanted to give me a "headache cocktail". Within a minute of receiving a compazine and benadryl doese through my IV, I suddenly felt pure fear, and doom. I told my friend something is very wrong. My head jerked to the right, my tongue felt stiff, and my heart beat steadily went up to over 180 beats per minute. The Dr and nurse ran in, and they called for a crash cart. They gave me 2 shots to bring my heart rate back to normal. It pounded so hard I could see my chest beating up and down. I felt my heart pounding even in my nose. Finally they got me back to normal, but this episode has forever screwed me up. I started having severe anxiety and panic attacks after this. This was almost 10 years ago, and it still haunts me. These idiots need to stop giving this medicine in the ER. F 37 1 days
11/19/2016
Email
 1  migraine NEVER AGAIN DOOM AND DREAD!!! TRAPPED AND HOPELESS!!! A WARNING AT THE HOSPITAL THAT THIS KIND OF A REACTION COULD HAPPEN WOULD HAVE BEEN NICE! SUICIDAL. I was trying to figure out how to kill myself in the hospital minutes after being given this horrible drug in a IV. I freaked out and felt horror and doom and hopelessness that I can only describe as the depths of hell. I was pleading with God for relief and screaming for help. I was confused enough that I couldn't think clearly enough to explain what I was feeling to the nurses. I tried to pull my IV out and run away before the nurse gave me more benedryl. I was literally coming up with a suicide plan just to get some relief because I didn't know if I could handle the mental anguish much longer. Luckily the added benedryl knocked me out and I woke still nervous and traumatized but a hundred times better. It's been five days and I still feel some doom and dread at moments and like my regular psych meds are possibly stronger and even make me feel better at times than is typical, since having compazine five days ago. It seemed to temporarily recalibrate my baseline or how my meds effect my brain chemistry or something. I think it will get better soon but SO NOT COOL!!! I am just so glad the worst of it didn't last very long. If you decide to try this med for some Godforsaken reason take a trusted friend to watch you and support you. F 40 1 days
1X O
10/23/2016
Email
 1  Migraine,nausea Very restless feeling,super jittery I was given this when I went to the emergency room after almost passing out at work. They said I had a migraine and gave me compazine. The doctor warned me I might get jittery and feel like I wanted to leave. If it happened I was told I could have Benadryl. It helped a little but I still felt very jittery for a few days afterwards.im pretty sure my heart rate shot up for awhile also but I was pretty out if. I just know the monitor started beeping. I don't recommend anyone take this. F 26 1 days
10/23/2016
Email
 1  ER migrane cocktail Couldn't breathe,Heart palpitations,I thought I was dying and was okay with that.Every breath I took tasted like I was chewing on the tip of a Sharpie marker,I've been in a constant anxiety attack for the last few weeks. Don't ever let them getting this drug it is the most horrible thing I've ever experienced. I have to go to a Cardiologist now because I have such bad heart palpitations. I will soon see if this drug actually is going to kill me. M 32 1 days
IV 30 mg 1X O
10/14/2016

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