COMPAZINE Reviews (PROCHLORPERAZINE MALEATE)

Average Rating: 1.2 (501 Ratings)

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 ANTIPSYCHOTICS ANTIMANICS VERTIGO MOTION SICKNESS VOMITING

 Type: Brand name discontinued; available as generic

  

COMPAZINE  (PROCHLORPERAZINE MALEATE):  This medication is used to treat severe nausea and vomiting from certain causes (for example, after surgery or cancer treatment). Prochlorperazine belongs to a class of drugs known as phenothiazines. This medication is not recommended for use in children younger than 2 years or in children going through surgery.    (Sources: U.S. Centers for Medicare Services, FDA)

  

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Key to Ratings: 1=LOW (I would not recommend taking this medicine.)
5=HIGH (this medicine cured me or helped me a great deal.)

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More on COMPAZINE: Reviews Summary  |  Drug Safety Information

RATING  REASONSIDE EFFECTS FOR COMPAZINECOMMENTSSEXAGEDURATION/
DOSAGE
DATE ADDED
 
 1  Severe headache Everything I read I experienced and I was not advised of the side effects, I have suffered from GAD for 17 years and am sure this med only intensified the anxiety I fight to control. I was fine after they started the iv drip, I tried to nap, then I sat up panicked, I pushed the nurse bell repeatedly and yelled somethings wrong. It took all my will power to not rip out the IV and run, I was shaking, crying, TERRIFIEd all of the sudden. The nurse was nice, she held my hand and tried to soothe me. I felt trapped and just so terrified. It was 4:30 am and it took even more will power not to scream, then the full blown panic attack occurred. My heart was racing, I couldn't breathe. I never ever ever want to experience this again. It took about 20 minutes for the first panic to settle, but I was anxious to leave asap. I learned to ask about all side effects in the future. Horrible F 36 1 days
Iv 1X day
2/12/2011
 1  Anti-Nausea from Migraines Severe Paranoia/Anxiety Was taken to the emergency room for chronic migraines. I was given Compazine to counter the nausea. After knowing the side-effect of this drug, I would of rather deal with the nausea than have to deal with that paranoia feeling again. M 17 1 days
Not sure 1X day
2/11/2011
 5  control nausea drowsiness, slight leg cramping I don't know what I would have done without this drug for most of my life. I am a severe hypoglycemic due to a pancreatic disorder, and when my blood sugar drops badly, I get extremely nauseous to the point that I can't eat in order to bring up my sugar. Compazine (and the generic prochlorperazine, which is equally great) takes care of the nausea so I can eat. This drug is a lifesaver for me and I won't go anywhere without it. F 35 17 years
10 mg 1X AN
2/8/2011
 1  Headache relief in ER. Uncontrolled shaking, anxiety, overheated. Hospital gave my wife Compazine in her IV for a bad headache. Almost immediately, the side effects that are mentioned in all the other posts happened to her as well. Uncontrolled shaking in her arms and legs, a feeling of severe anxiety...wanting to pull her IV out and leave the hospital...almost begging me to get her out of there. Honestly, the scariest experience I've ever been through with someone and I've seen my share. If this drug is mentioned to you when you're in the ER, refuse it!! You're better off living with the symptoms it's supposed to take care of. F 45 1 days
Not sure 1X day
2/5/2011
 1  migraine headache/dizziness more dizziness, restlessness in legs, anxious I went to the ER for help and was never told the serious side effects of this medication.This was my first time to be given this medication and last. The side effects are very dangerous and can cause more problems than a headache in my opinion. F 59 1 days
1X day
1/28/2011
 1  Migraine This is the worst feeling I have ever experienced from a medicine! Just like the others, I felt like I was going to rip my IV out if they didn't take it out NOW. I just wanted to go home, very anxious, jittery, just wanted to get out of there quickly. Terrible feeling almost immediately after this medicine was given to me through my IV at the ER for a migraine headache. F 32
10MG 1X O
1/21/2011
 1  Migraine and vomiting THE WORST EXPERIENCE EVER!!!! OMG!~I suffer from migraines and the first time I was given Compazine at the er I went delirious…Same as all of you I experienced the worst type of anxiety…I wanted to rip my IV out…I felt like I was going insane…felt like the world was closing in and no one helped me understand why…the nurses were acting as if I was really mentally ill…I just wanted to leave the hospital and run…when I had arrived I had one of the worst headaches but was completely calm and collective…once given this medication, my mind was racing and everyone seemed like they were not even real…I was in this state for 2 days…I couldn’t sleep, eat, cry, nothing…it was the worst experience I have ever had…then for some reason praying helped me sleep…and slowly I came back to my normal self…the next time I went to the ER again for another migraine and vomiting they again gave me Compazine and immediately I started the same symptoms…I was screaming and finally a doctor told me that I might be allergic to compazine and gave me ativan to calm me down…You may think that was the last time this happened but yet again I went to the hospital for Migraine and vomiting and I told them I was allergic to compazine and im sure they ignored me because as soon as I was given meds I felt that feeling again and this time I almost past out from anxiety…about 4 nurses came in and even told me that I might need to seek a Ps F 33
1X day
1/17/2011
 1  IV for headache at ER F 43
30 1X day
1/12/2011
Email

Patient History
 2  vomiting, headache Jittery, paranoid. Wanted my IV out shortly after being administered. Desperately wanted to leave the ER. Nausea did go away but I left with a feeling of anxiety. F 34 1 days
1X day
1/3/2011
 1  nausea I felt warm all over and then felt like it was a big mistake that I was in the hospital. I started to panic and wanted to take out my IV and get out. I actually tried to convince the nurse that I could probably leave as I was "feeling so much better". I was unable to sleep the whole night and my heart was racing. I told the nurses about the side effects and they seemed to have never heard of anything like that. It was horrible and I am still having trouble staying still two days later. F 29
? 1X O
1/1/2011
 1  migraine I was given compazine in the ER and immediately felt TERRIFIED. That is the best way I can describe it. I am a normally calm person but after this, I seriously considered ripping my IVs out and running out of the hospital. I have never had such a horrible feeling of fear and anxiety. I will never allow anyone to give me this drug again. M 46
1X day
12/31/2010
 1  Migraine and Nausea in pregnancy jittery, anxious, terrified. Fiance told me I was delusional. Sleeplessness. TERRIBLE. I had convinced myself that if I ripped out my IV, I would be fine. I kept calling nurses to let me go to the bathroom, just so I could get off of the IV for a minute. Exhausted but couldn't sleep, but could barely keep my eyes open. It's been 9 hours and I still feel the residual effects. Going to try to take benadryl to get rid of the effects. I feel like it's still in my body. F 21 1 days
1X day
12/7/2010
 1  Migraine/vomiting I was admitted to the ER with a migraine and vomiting. The nurse administered compazine through the IV and almost immediately, I started asking to go home. Felt restless and agitated. Also wanted to rip my IV out. The nurse gave me two doses of benadryl and I felt better, but still continued having some of the feelings for several hours. Utterly terrifying. I have never had a reaction to anything. F 25
1X O
12/4/2010
Email
 1  Severe Migraine & Panic Attack Terrible sense of suffocation and skin-crawling anxiety. I felt like I was going to lose my mind! Very restless legs, arm hurt very badly. My abdomen was churning in pain. The doc just looked at me and smiled. Scary drug and doctor(s?) who prescribe it, it seems. Tell the FDA to take a look and put restrictions on this drug! I went to ER with TERRIBLE Migraine and Panic Attack. I couldn't breathe and was terribly scared. I rarely have headaches or this kind of anxiety. Doc waited 3 hours for unrelated medical records to be verified then injected me with Compazine and I thought I was in the twilight zone. Breathing and nausea were worse! I was suffocating. Headache persisted. I, too wanted to rip the IV out and RUN. I felt profiled and patronized. Left the ER feeling worse than how I went in. A very expensive nightmare! F 31 1 days
? IV Injec 1X day
11/30/2010
 3  Migraine Skin crawling, anxious, legs cramping. I have had this medicine before in the shot form with toradol and benadryl. The first time they gave me the shot I felt like I was going crazy I could not control myself they kept telling me to lay down and that it was going to make me drowsy and that it would make the migraine go away all that it did was intensify the migraine more and made me delirious. I felt as if I was climbing the walls. My wife was so worried watching me lay down for a moment and then jump up and walk around the room with and acting like I was crazy. This past weekend I had the cocktail again this time the doctor gave it to me in the IV form and did not give as much benedryl only about 10mg as he was going to give 50mg and I still felt anxious and cramping in my legs and skin crawling but it was no where near as bad and the migraine did intensify for a moment but the toradol and compazine kicked in and calmed it down and let my topamax do it's job. He told me the next day to take some of my esgic to knock the migraine on out and it did. M 41 1 times
30mg 1X day
11/15/2010
 1  Migraine Almost immediate total panic as if something was terribly wrong. I wanted out of my body, I had been in so much pain from migraine but this was worse because it was constant panic and fear. Approximately 2:20 pm Seen at Urgent Care for severe migraine. Migraine started Friday early morning 10/22. Had slight eye blurring (left eye)in afternoon and took 1 Frova about 4:30 pm. Headache didn’t go away 10/23 Throbbing, pain behind left eye brought me to tears and felt nauseous. Spent morning in bed until boyfriend said you should see a doctor. . Seen immediately at Urgent Care 10/23, 5 minutes after IV of 2 doses of Toradol and 1 dose of Compazine I felt an overwhelming sense that something was wrong. Was terrified and couldn’t sit still. If they hadn’t unhooked me from the IV saline bag I would have tried to take out the IV in my arm myself. Sat straight up in dark room and begged my boyfriend to get the doctor because “Something is really wrong!” Then I was up and out of my room and down the hall walking around saying “something isn’t right” like a crazy person. The Dr./nurse asked me to please try and stand against the door as they gave me 25mg of Benadryl in the IV still in my arm. I felt terrified and uncomfortable. It was horrible!!! That is all I can say to describe it. My boyfriend was concerned and the Dr. kept saying 1% of people have this reaction. Then he said 5% and finally 10% of people. He said “I’ve never experienced it but what I have been told is the person just feels like leaving.” I usually am composed and not aggressive. I didn’t want anyone to touch me. I F 38
unknown 1X day
10/25/2010
Email
 1  migraine Instant severe anxiety/panic, burning in my hand and arm. The doc came in with a doppler to listen to my baby's heart rate I told him of my reaction and he brushed me off I told him not to touch me at that time but he just kept telling me he had to so I took the doppler out of his hand and smashed it on the floor. I ripped the IV out and ran home where I couldn't stay still, I was tired from the benadryl but couldn't even lay down to sleep my throat was pretty closed up and I had a hard time breathing and swallowing. I would not advise anyone to take this drug ever for any reason. F 30 1 days
10 mg 1X day
10/21/2010
 1  headache and stomache pain All of these stories that u guys are posting on here is the same with me. I went to the ER and they gave me Benedryl and Compazine in my iv tude. I couldn't sit still, I just wanted to get out of the room. I was jittery. I had ct scans on my head that the doctors gave me but it don't show anything. They never did an ct scan on my side the areas that are bothering. Yeah my muscles hurts at times. I tried Chiropractic, Physical Therapy and see an neurologist and they don't know anything on how to help me. I feel the doctors here are so stupid!!! Yeah I put as compazine as a medicine allergy for me too. It was the worst ever feeling in my life that I experienced. This happened 2 years ago and I still have the symptoms I was in a car accident when I was younger I had an in-head closed injury and my left side of my body was paralyzed. All the symptoms has came back to me. My right side of my body is fine but my left side of my body like the edge of my back and side hurt its like a pain that moves around. It will hurt on my side and then move to my ribs and so forth. None of these doctors don't know and don't know how to help me I tried everything. This pain just irritates me. I feel like I can't do anything sometimes. It topped off of my old injury that I had. What can I do to make this horrible pain go away. So what have ur doctors help u treat ur pain? Sorry I don't remember the dosage.... F 29 1 days
30mg 1X day
10/19/2010
Email
 1  my head was hurting !!! A drug from hell!! I am still not myself.can someone help me please,it's been four weeks .will i ever be the same again...I was given this mad drug in the er. why would they do this to people Jesus why??? F 41 1 days
10 MG 1X day
10/11/2010
 1  migraine I ended up in the Er yesterday because of a horrible migraine They put in an IV and gave me compazine. My headache vanished almost instantly but then slowly the awful feelings people have wrote about started to overcome my body. I felt completely uncomfortable in my own skin. It was like the feeling you get when your legs feel restless and you can't get them comfortable except this feeling was in my whole body and last hours and hours. I wanted couldn't keep my eyes open but I couldn't sleep. I wanted to lay down but I couldn't get comfortable no matter what I tried. Finally I decided I couldn't take it anymore and called the ER where I had been seen and was told that it is acommon side effect and to take Benadryl. I took the Benadryl and a bit later I finally was able to fall asleep for a good 5 hours. When I awoke the restlessness was a bit less but not completely gone. It's been over 24 hours and I still feel it slightly. Don't feel like myself. Yesterday in the midst of i F 31 1 times
1X day
10/8/2010

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