COMPAZINE Reviews (PROCHLORPERAZINE MALEATE)

Average Rating: 1.2 (501 Ratings)

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 ANTIPSYCHOTICS ANTIMANICS VERTIGO MOTION SICKNESS VOMITING

 Type: Brand name discontinued; available as generic

  

COMPAZINE  (PROCHLORPERAZINE MALEATE):  This medication is used to treat severe nausea and vomiting from certain causes (for example, after surgery or cancer treatment). Prochlorperazine belongs to a class of drugs known as phenothiazines. This medication is not recommended for use in children younger than 2 years or in children going through surgery.    (Sources: U.S. Centers for Medicare Services, FDA)

  

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Key to Ratings: 1=LOW (I would not recommend taking this medicine.)
5=HIGH (this medicine cured me or helped me a great deal.)

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More on COMPAZINE: Reviews Summary  |  Drug Safety Information

RATING  REASONSIDE EFFECTS FOR COMPAZINECOMMENTSSEXAGEDURATION/
DOSAGE
DATE ADDED
 
 1  Migraine Manic suicide attacks, panic, cold and shaky, could not sit still, crying I am so glad I saw this because I just thought I was going crazy. I went to the ER on 9/14/20 for migraines. They gave me a migraine cocktail with Benadryl, toradol and compazine. One minute I was laughing and joking with the nurse and the next minute I was crawling out of my skin wanting to rip my IV out of my arm. Tossing and turning and could not sit still while crying and shaking. I asked the nurse for an anxiety med and she would not give me one. Told me "she couldn't". But then later said she would go talk to the doctor and never did. I was told to take my bag of fluids that it would help... but only after a half a bag of fluids I made the nurse take my IV out and I wanted to go home. The entire way home I wanted to crash my car or find a way to put me out of my misery. I told my family if I died that"this" was the name of the nurse and she was from Alabama. I tossed and turned and cried all night, and when I woke up I was still jittery and anxious and paced In circles for 6 hours. I went to urgent care to again ask for an anxiety medication and they told me to take 50 mg of Benadryl that it "kills" the compazine drug. After 29 hours I was unable to sleep. This drug ruined me and made me crazy. Do not recommend F 25 0 days
1X day
9/21/2020
Email
 1  Er visit- severe migraine Couldn't breathe, high anxiety, thought I was going to die. The worst feeling I have experienced in my entire life Do not take this drug. EVER F 50 0 days
IV 1X day
9/19/2020
 1  Migraines I went into the hospital last night for a severe migraine. They gave me compazine and literally 2 minutes after receiving the drug my body went all hot and I felt like the walls were closing in on me and I wanted to rip my IV out of my arm. The hospital talked me into finishing my IV fluids but I could not do it. I went home and was miserable all night. Felt like the only way I was going to get out of this was to die. do not take this drug. its awful. F 25 1 days
1X day
9/15/2020
Email
 1  nausea/vomiting seizures and full body muscle spasms I was 19 (now 48) and went to the ER with severe bladder spasms, nausea & vomiting. I received IV Compazine while there and it caused a seizure and full body muscle spasms. I stayed in ICU for several days because of this drug. It's awful!!! F
1X day
9/9/2020
 1  Nausea Felt like I was trapped in my skin, shakes, felt the walls were closing in. Was psychotic. My already severely low blood pressure dropped even more. Felt like I was going completely insane. While on Compazine, the ER doctor recommended I stay overnight in the hospital, as I had severe head injuries and I was at risk for more fainting episodes. However, all I wanted to do was get out of there. I was completely out of my mind. My service dog was with me and alerting left and right, probably because of the effects of the Compazine. I left against medical advice and it was the worst week of my life. F 19 0 days
DonT 1X day
9/8/2020
Email
 1  For headache My brother went to ER for severe headache. They gave him a shot of compazine in his IV. It didnt take long and he was complaining about not being able to breathe. Then he had a full blown panic attack. Jumped off the bed and wanted to go home now. Said he felt like the walls were closing in on him. M 60 0 days
1X day
8/26/2020
 1  Headache/dizziness This was the worst medicine I have EVER taken. The doctor did not warn me too its effects. One minute I was chatting with the nurse but as soon as she left BOOM! I got so hot! I ripped my BP cuff off and ALMOSTTTTT ripped my iv out. I called the nurse and I know I looked like a maniac asking her wtf was going on. She calmly explained that yeah, you're one of the unlucky ones. And left the room. No one came back in to check on me. I literally thought I was gonna just rip the iv out and run outta there. I screamed, kicked, paced until I felt like I could get a grip. Covered my eyes and forced myself to nap and passed out for 15 minutes immediately. I'm still feeling a bit uneasy (this was yesterday). The dr prescribed oral tablets but I WILL NOT be taking them. No way. F 33 1 days
1X day
8/23/2020
Email
 1  Headaches Went to the E.R for headaches. Nurse administrated the "migraine cocktail" and within minutes I grabbed my face and wanted to pull my I.V out of my arm. I felt suicidal and the room was getting smaller. I was in and out of it! I tried to go to sleep but I couldn't. My fiancee thought I was crazy and due to Covid I was the only person in this tiny room. My heart was racing and it felt as if I wasn't in my body. I was hallucinating and heard voices. It took days for me to feel better, even now I'm afraid and it affects me. Never ever again will I take it! F 38 1 days
1X day
8/22/2020
Email
 1  Severe nausea and vomiting I am so relieved to find that this wasn't all just in my head. So thank you all. I just got out of my 2nd hospital visit for nausea and vomiting. After they gave me iv Compazine I would get horrible anxiety, confusion, frustration and frankly just made me feel worse but staff told me it was the only one I could take aside from zofran which does not a thing for me. The 1st hospital visit was the same (both times in 1 month). I went AMA both times. And that's not me at all. I thought it was supposed to help with anxiety and vomiting and nausea....not for me! And now I know I'm not the only one. Are there any meds anyone can recomend? F 40 3 days
Regular do 4X day
8/6/2020
Email
 1  ER "migraine cocktail" 2 min onset...Restlessness/entire body, anxious, shortness of breath (Especially w/covid mask) NEVER again, my Dr moved medication to my allergic list. Taken with Toradol, benadryl and Tylenol. ER visit for severe pain from prolonged migrane. F 49 0 days
30 1X day
7/26/2020
Email
 1  Nausea Within 5 minutes I felt like I was hallucinating, yet very aware I was not. Pure terror, fear, dread, anxiety arose in me out of no where. Felt unsettled, lost, and horrible. Screaming. Crying. Unexplainable feeling. Wanted to be anywhere but there. Afterwards nurse said it could do that. Especially women under 40. Well, damn doc Highly advise against. Zoloft more tolerable. F 37 1 days
1X day
7/13/2020
Email
 1  For nausea d/t migraine WORST EXPERIENCE OF MY LIFE!!!!! I've had chronic migraines my whole life, and last year was first time I went to the ER to try to treat one (first and LAST time). They gave me Compazine, and within minutes, I began panicking but didn't know why. I heard my heart monitor beeping wayyy to fast (and I could feel my heart pumping a million beats a second it felt like!). It felt like I was in hell, my body and mind began FREAKING OUT and went into self destruction mode and I had to fight my own body from hurting myself!!! My hands kept wanting to claw my eyes out and I had to fight them from hurting myself, and I was beyond panicked (panic doesn't even come close to describing how intense it was). I became uncontrollably cold, which made the panic intensify, and ever since, I now feel panicky when I get cold and I have to calm myself down. :( Worst experience of my life! But what's worse than that, is I've never really felt like the panic fully left my system ever since. DO NOT TAKE!!!! It has the possibility of subjecting you into instant suicidal mania where you'll feel like you're in hell, you'll be uncontrollably cold, and you'll be fighting your own body from hurting itself. I'm not exaggerating, I actually almost begged the nurse to please shoot me, but I was able to stop myself from screaming that out, just as I baaarely managed to stop my body from hurting itself (my body wanted to claw my eyes out, rip my iv out, and flail violently). By far the MOST terrifying experience of my life!!!! F 36 1 days
1X day
6/20/2020
Email
 1  Migraine Sheer panic and dread, burning in my ear, elevated heart rate, dry mouth. Kept screaming for help and that something was wrong, the Benadryl didn't help at all. Only thing that saved me was Ativan. Worst experience of my life, felt like I was dying.. F 38 0 days
Unknown
6/18/2020
Email
 1  Severe migraine Extreme anxiety and jitteriness and freezing cold - took at hospital never again and Benadryl it's not safe either It's 4:17 am and I was givin this med at 4:30 pm and still have burning in legs and a little anxiety couldn't sleep this happened once before when I was admitted after my gallbladder surgery and I don't remember if they gave me compazine it's not safe I don't trust Benadryl or this drug F 20 0 days
NA
6/12/2020
 5  Extreme nausea from chemo Zofran did not work for me. Compazine was great for stopping nausea. F 55 5 days
6/4/2020
Email
 1  Nausea Taking for nausea for cancer treatments and started having the most HORRIBLE VIVID REALISTIC NIGHTMARES! Wake up heart racing and sweating. Afraid to go back to sleep. Kept dreaming of being crushed to death. Cancer is bad enough. I don't need to dream of dying too :( M 51 2 days
10 mg 3x d
4/16/2020
 5  Nausea I have bad anxiety and this drug sent it over the edge. I felt like I couldnt breathe. Still nauseated. My anxiety is horrible and I dont know what to do. The pharmacist said it would go away. Ill never take this drug again. F 51 1 days
10 mg
3/2/2020
Email
 1  Gastristis Today is 3/1/20 I was giving this medication during a e.r visit on 3/28/20 for gastrointestinal pains. I'm guessing the nurse did not want to give me morphine which I usually get. Right after I was given this medication I got extremely anxious and had bad anxiety. Could not sit still pacing the room back and forth. I was so irritated I self discharged myself out and they wanted to admit me to watch me over night. Even while still at home I cant sleep, heart racing, I have to keep moving or pacing back and forth, I'm extremely worried and nervous. I wish I was never given this medication. I do know to tell them I'm allergic from now on. F 28 1 days
E.r dosage
3/1/2020
 1  Migraine Thought I was dying. They put Benadryl then compazine in my IV and within a minute my heart started racing and I could barely breathe. I felt like my body was floating and I literally thought I was going to have a heart attack. They gave me Ativan and it slowly started to get better then I laid on the hospital bed shaking for 1/2 hour. They said oh sorry this reaction is rare !!! Id rather suffer with a migraine than ever take that again! It needs to be taken off the market!! I barely remember driving home from the hospital . TAKE IT OFF THE MARKET! F 49 1 days
2/23/2020
Email
 1  Stabbing headache I do not EVER post comments about anything but this was the worst experience of my life. I was given compazine for stabbing headache at night. At first I was fine then all of a sudden I got extremely annoyed by the cold air in the hospital. I wanted to rip out my IV and run because I felt trapped. Panic attack followed but I still drove myself home. The feelings that came later was unexplained desperation, fast heart beat, and not being able to sit still. Finally I felt like I could not breathe and had to go back to ER. They gave me Ativan twice to reverse the effects. Thanks to this drug I now deal with panic attacks which I have never had before. The fear of not being able to breathe has stuck. Why is this drug still being used seriously? F 30 1 days
2/22/2020

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