COMPAZINE Reviews (PROCHLORPERAZINE MALEATE)

Average Rating: 1.2 (501 Ratings)

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 ANTIPSYCHOTICS ANTIMANICS VERTIGO MOTION SICKNESS VOMITING

 Type: Brand name discontinued; available as generic

  

COMPAZINE  (PROCHLORPERAZINE MALEATE):  This medication is used to treat severe nausea and vomiting from certain causes (for example, after surgery or cancer treatment). Prochlorperazine belongs to a class of drugs known as phenothiazines. This medication is not recommended for use in children younger than 2 years or in children going through surgery.    (Sources: U.S. Centers for Medicare Services, FDA)

  

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Key to Ratings: 1=LOW (I would not recommend taking this medicine.)
5=HIGH (this medicine cured me or helped me a great deal.)

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More on COMPAZINE: Reviews Summary  |  Drug Safety Information

RATING  REASONSIDE EFFECTS FOR COMPAZINECOMMENTSSEXAGEDURATION/
DOSAGE
DATE ADDED
 
 1  Diabetes Bad thing M 33 3 days
30 1X H
2/16/2020
 1  Migraine Extreme panic, suicidal thoughts, jitteriness I have never ever written a review on a medication before. I have taken many over the course of my life and for the most part, I accept that side effects are part of the package. I can tolerate even the most unpleasant ones pretty stoically. Well this is in a class of its own. I was in the ER for an atypical migraine that presented identically to a stroke. The ER doc insisted that I take the "migraine cocktail" and that it would help. I was drowsy after an hour, and half an hour after that I was fighting back the urge to claw my way out of the mri machine. I felt lightheaded from claustrophobia - which I have never had before (I've had many mris) I waited for hours to be discharged and it was all I could do to not rip the IV out of my arm. On the drive home I fantasized about throwing myself out of the car to make the feeling stop. I went home and took triple the amount of my night meds just to ensure I would be unconscious enough to hopefully sleep off the worst of it. The next day was a haze of being anxious but groggy enough to make it tolerable. I'm two days out and I still feel off but it's finally more like background noise. Still sucks. I will never ever take this drug again. I'll wait out my next stroke-like migraine before I go in this crap again. Seriously, no one should be taking this stuff. P.S. The doc that discharged me said "take benadryl to counter the slight jitteriness you might feel from the compazine" WAY TO DOWNPLAY THE SI F 34 1 days
2/15/2020
Email
 1  Migraine Given for migraine- IV. Within 10 minutes my daughter, who has a chronic illness and practically lives at the hospital with comfort and ease, came out of the bathroom talking about killing herself and saying she felt empty. She was hysterical, asking if this was some type of nightmare. She begged me to stop it, but then kept saying, don’t even bother there’s nothing you can do it’s all over now. After all of this she collapsed and fell asleep. F 11 1 days
1/18/2020
 1  Nausea I was 29 (now 53) & preparing for my wedding. I was given compazine for nausea. Wound up in the ER with what looked like convulsions or a seizure (but didn’t lose consciousness). It was so severe, they offered to get me a priest! THIS BECAME A PERMANENT CONDITION & complicated further by dystonia (recently diagnosed at MAYO Clinic as a result of that same medication). It’s been almost 24yrs and has completely altered my life & destroyed my quality of life. In April of 1996, this was not a recorded side effect of Compazine. DO NOT TAKE THIS OR ANY DERIVATIVE OF IT. F 29 1 days
12/30/2019
 1  Migraine/BP Irritable, panicked, agitated, jittery, anxious, SWEATY, not like himself I am a wife writing this for her husband because he says he doesn’t remember the things he felt or did!! (Hello, red flag number 1). As soon as they put this compazine And Benadryl in his IV, his eyes looked tired and he said he felt it. He fell asleep for a short moment, then started throwing things off of him. His pulse ox, BP cuff, his shoes and socks, then started yelling for a nurse to get in there NOW and take his IV out. It’s not like him at all to get that agitated. He was pacing around the room, kept opening and closing the door, but almost looked like he was zombified. Blank face, big red and sleepy eyes, talking out of his head... He was sweating through his clothes too, so I literally grabbed a magazine in the room and followed him around fanning him. He said over and over “I’m uncomfortable I’m uncomfortable” He started crying (not like him either) and saying he wants to go home and kept trying to leave the room. The staff just kind of laughed at him and said it was normal, just put compazine down as an allergy. He couldn’t sit still in the car ride home either. He has been sleeping since we got home, but I’m worried these feeling will not go away when he wakes up :( M 25 0 days
12/4/2019
Email
 1  Migraine Panic attack, nervousness, suicidal thoughts DO NOT TAKE THIS MEDICINE PLEASE F 34 1 days
IV
11/17/2019
 1  Nausea & Dehydration Restlessness, jittery, face twitching, eyebrows rising uncontrollably, neck turned to left & I couldn’t straighten it back I was given compazine while 3-4 months pregnant. I believe I took it earlier in the day (New Years Day). I had it in pill form or suppository. I don’t remember. Anyway, I was fine after taking it...a few hours later...however is a different story. I became extremely jittery & couldn’t see straight. Shortly after the restlessness came. I couldn’t keep still for nothing. I remember going get fireworks with my husband & dad & sitting in the backseat with my 3 year old son & not being able to keep still. I went back to my mom to eat & I couldn’t concentrate on the plate. That night I went home, my son stayed at my mom. I was exhausted & I couldn’t fall asleep for nothing...laying in bed w/ my husband who was leaving to go offshore within the next 6-8 hrs..my neck contracted to the left...I couldn’t move it any other way...& my eyes were twitching and eyebrows raising out of my control. My husband not knowing put icy hot on my neck...I called my mom who had to call my husband and tell him to get me to the ER ASAP because I was having a bad reaction to the compazine. They gave me Benadry. It helped tremendously. I don’t remember anything after. Not even the ride home! I wouldn’t recommend this to my worst enemy! Worst feeling EVER!!!!! F 21 1 days
11/12/2019
Email
 1  Migraine I had a migraine for 2 days straight. The nurse and I had established I would be taking Compazine, Toradol and Benadryl. It burned while the nurse had injected it in my IV. She stated that I would start to feel anxious but “not to” because she was monitoring me. As she left the room I called my husband and told him how I was started to feel the anxious feeling then just like a truck, it hit me. I went into a full panic attack. I hung up on my husband. I ringed for the nurse and it felt like they never came. What felt like an hour was really 5 minutes. I paced around the room, heart racing, I felt uncomfortable in my body, I felt like I was legitimately dying and that I would never see a normal day again. If you have experience with the drug shrooms or acid it seems almost alike but worse with Dystonia symptoms. My legs kept kicking. I ripped my IV out. The blood only made me more panicky. I took my gown off, put my shirt on and ran out of there with blood on my arm. I called my husband again as I did weird turning movements around in my car. I begged for him to make it stop, Only part I remember while driving home was thinking to crash into incoming traffic. I kept getting suicidal thoughts, not sure if it was due to the fact it was the medicine making me delusional or I was tired of feeling this sudden terror that hovered me. I stopped myself and I kept thinking I could run to Mexico on foot. That’s how much adrenaline and energy I felt I had in my body. I Talking about it has helped me with the trauma I went through, please talk to me about it and let’s relate. It feels nice knowing you aren’t the only one. F 18 1 days
11/5/2019
Email
 1  Migraine Five years ago I went to the ER for an excruciating migraine, and my life hasn't been the same since then. The ER doctor gave me the medication cocktail, and my life was ruined. The doctor didn't even mention it was an antipsychotic. If I would have known I would have refused. I developed severe anxiety and panic after that medication. To the point that it was hard to function. I am still dealing with it. Never had panic before this medication. I ended up being prescribed other medications to help with the severe panic that developed after Compazine. It made me completely unstable. Worst experience of my life. I have seen other people with the same issues as me, just after one dose. Compazine should be illegal! Don't ever take this medication. F 39 1 days
11/3/2019
Email
 1  Headache Restless, uncontrollable movement of my body, I thought I was going to die If YOU TAKE THIS MEDICATION YOU WILL REGRET TAKING IT, TRUST ME. At the ER soon they give it to me i totally freaked out, I start shaking like crazy, trust it will happen to you the same thing, even the nurse told I see this many times with this medication, so why they give it to people then? Is stupid, also the nurse told this happen 8 out 10 and she told that this medication touch something in your brain that make you like that, so come on, even the second day I couldn't stop moving, my legs was hurting me because I been waking around almost 9 hours non stop, this people are crazy having this on the market, M 40 1 days
10/23/2019
Email
 1  Yes I had severe anxiety felt irritable wanting to ripe my IV out. All my nurse mentioned just wait it out it will only last a few minutes. Totally wrong. Left the ER still had anxiety so I called the ER to ask what can be done for the anxiety the nurse mentioned 50mg of benadryl. It helped relieve some of anxiety and irritable symptoms to relax and sleep. I wish someone could've informed me of the side effects. Wouldn't recommend to anyone. F 51 1 days
10/11/2019
Email
 1  Migraine nausea I went in the ER because I had a migraine and I was vomiting. Told them Maxalt was all I needed instead gave me a IV with compazine and Benadryl. With in minutes I was having the worst panic attack of my life. I ripped off everything they had me hooked up too and I desperately wanted to rip out my IV. I wanted to ripp my skin off or some how get out of my body. I was cold shaking and beyond irritated. I would rather be dead. Tomorrow will be day 3. Today is day 2 I still can't stand being in my own skin and I'm in full panic mode and crying none stop. I went to my doctor she said to wait it out. Why would any one give this medication to any one. Also does any one know how long before you are able to feel normal again? Please do not take this medication and please warn others. I wouldn't wish this on my worst enemy F 34 1 days
Iv Im not
10/8/2019
Email
 1  It was given to me for headache Same as others say F 49 1 times
?
10/5/2019
 1  Nausea Panic attack , couldn’t breathe high blood pressure high pulse I felt like I was dying after receiving this via iv I came home couldn’t breathe was pacing the room tried everything. Er took me back said I was allergic 24 hours after I still don’t feel right F 27 1 days
25 mg
10/3/2019
Email
 1  migraine for 4 days Horrible pacing around the room, feeling like I wanted to rip out my IV. I felt like I was trapped in my own body. The nurses just told me to chill. I wouldnt stop moving around the hospital room like a crazy person. worst experience of my life!!!!!! They had to give me 3 doses of benadryl to make me pass out because I was insane. woke up 4 hours later a lot better but still not quite right. not a good idea F 40
1X day
9/20/2019
Email
 1  Post Concussion Symptoms/ Migraine Horrible anxiety/panic attack, uncontrollable shaking, sweating, discomfort, sudden scared and trapped feeling, paranoia I'm not the type to be dramatic, and I've never written a review in my life--but my experience with Compazine is one I had to address.. I went to the ER because I was experiencing a migraine due to a concussion I got a few days back from a sports injury. They gave me an IV with Compazine and at first I was fine and sitting there like nothing was wrong. Then ALL THE SUDDEN I got this extreme feeling of terror and feeling of being trapped. My legs were shaking uncontrollably, I was sweeting, and started crying out of no were because I was so upset and anxious. ALL I wanted to do was get the IV out of my arm and was demanding to my mom (who was in ER with me) that I have to get out of the hospital right now. I insisted that the nurse take the IV out and she looked at me like I was losing my mind. After the IV was out I started pacing around the room and kept saying "I have to get out of here". I tried to lay down to calm myself and my legs were still shaking so bad it was freaking me out. The nurse came back in to give me Benadryl and I was so paranoid about taking any other medicine given to me that I was refusing to take it, but eventually did. Fortunately it made me calm down a bit. Long story short-- I was completely fine one minute just scrolling through Twitter waiting to get my head CT, and the next I was in complete terror and felt like I was going insane. I completely agree with the other comments saying "I wanted to rip my IV out and escape". It was F 20
1X day
9/17/2019
 1  Vomiting , morning sickness Racing heart, extreme anxiety, paranoia , extremely uneasy F 47 1 days
9/4/2019
Email
 1  Migraine headache This has to be the worst drug on the market. I was given a Compazine cocktail for my migraine headache at the emergency room and after the doctor administered it within 30 minutes I was having a feeling of skin crawling horrible headaches vision disturbances sweats continuous shaking and I ended up with Akathisia . This has been in my system for over two weeks now and now I have to see a neurologist to see what can be done. I haven’t slept for days due to the side effects and have had continuous restlessness and anxiety that this medication has caused me. I let the ER doctor know what was going on with me because I was so weak after I was given that and they told me oh you need to leave because we have to have the bed for someone else forced me out of the ER and said oh well come out of your system within about 10 to 15 minutes. This was a bunch of BS and now I am going to seek legal counsel because this has completely ruined my life, cause me to lose 27 pounds and now I have to go through multiple blood work and test all because of this medication DON’T TAKE THIS MEDICATION AT All!!! Compazine Should be removed from the market as one of the most serious and dangerous drugs. M 26 1 times
50mg
7/8/2019
 1  Migraines/ER visit Was given Compazine in my IV as part of a migraine cocktail at the ER to help with a Migraine I had for 4 days. While the cocktail did help my migraine, I now have extreme anxiety, restlessness, and jitters. At the hospital I had a freak out and wanted to rip out the IV, the nurse had to calm me down and told me that once the saline washed it through I would feel better. I still feel anxious and like I want to just rip out of my own skin. Do not take if you don't have to!!! F 25 0 days
5/23/2019
Email
 1  Migraine Temporary insanity, restlessness, anxiety, cold sweats, suicidal thoughts I went to the ER for a pretty severe migraine. The nurse gave me a cocktail with compazine in there right before wheeling me into the room to get a CT scan. By the time I got on the table for the scan I started sweating profusely and just figured I was nervous and a little scared. When I got back to the room however I knew something was wrong. I just wanted to rip out my IV and escape! I couldn't get comfortable temperature wise ino matter what I did. I told the nurse and dr I didnt feel right and they just acted like it was no big deal. The car ride home i kept telling my wife something felt wrong, and when we got home I couldn't fall asleep at all. It took me until 10am to do so by some miracle. Day two and I still dont feel 100%. I cant wait for this crap to be out of my system. Medical staff should be trained better on this sort of side effect and more importantly they should know just how terrible it makes patients feel. I would choose death over feeling like that again it was so bad. M 34 0 days
IV
2/16/2019
Email

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