COMPAZINE Reviews (PROCHLORPERAZINE MALEATE)

Average Rating: 1.2 (501 Ratings)

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 ANTIPSYCHOTICS ANTIMANICS VERTIGO MOTION SICKNESS VOMITING

 Type: Brand name discontinued; available as generic

  

COMPAZINE  (PROCHLORPERAZINE MALEATE):  This medication is used to treat severe nausea and vomiting from certain causes (for example, after surgery or cancer treatment). Prochlorperazine belongs to a class of drugs known as phenothiazines. This medication is not recommended for use in children younger than 2 years or in children going through surgery.    (Sources: U.S. Centers for Medicare Services, FDA)

  

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Key to Ratings: 1=LOW (I would not recommend taking this medicine.)
5=HIGH (this medicine cured me or helped me a great deal.)

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More on COMPAZINE: Reviews Summary  |  Drug Safety Information

RATING  REASONSIDE EFFECTS FOR COMPAZINECOMMENTSSEXAGEDURATION/
DOSAGE
DATE ADDED
 
 1  post op my daughter had out patient surgery on her arm and was given compazine for nausea, after 2 doses she thought she was having a stroke, eyes drifting to one side and she could not center them, by the time we got to er her entire body was uncontrollable and in painful spasm, chin pressed down to chest, turned to side, arms and legs twisted and twitching and very scared. I had to take her in with a wheel chair and explain that she did not have Cerebral Palsy, a benedryl injection straightened her out in about 5 minutes. What she had was a distonic reaction. She has since had other reactions to anti-nausea meds. She had seizures and takocardia (very high heart rate/blood pressure)from an injection of Zolfran about 2 years later when she had a kidney infection and had been given pain meds causing nausea. The hospital swore that Zolfran was a completely different drug than Companzine. She was kept in the hospital in telemetry for almost a week under observation for potential heart attack and F 21 1 days
1X AN
10/2/2010
 1  Severe Migraine I thought i was going to jump out of my skin! My husband had to hold just so i could feel like i wasn't going run out the ER! I will NEVER take it again! Thought I was dying and was scared out of my mind! F 49 1 days
10 mg IV 1X day
9/29/2010
 1   I feel like I am loosing my mind and wonder if I will ever be back to normal again!.. It is a very scary feeling and I know I will never take this or Toradol ever again. I cannot believe they would actually have this out on the market.. It needs to be banned! Can you please tell me how long did it take for you to feel back to normal again? I had this on Monday and am still feeling like this today.. Its very scary.. Anything you did that helped? I am drinking Chamomile Tea because I hear it helps calm you but so far its not working.. Some people say it can take 4 days to a week to get over the symptoms.. Any ideas from anyone is greatly appreciated? F 36
1X O
9/29/2010
Email
 5  severe migraine w/nausea extremely tired, could barely keep my eyes open. After released from the hospital slept for 5 hours. I was given a shot of diloted for the pain of a migraine, after 1/2 hour and I was only feeling slightly better, I was given an IV of saline and an injection of benedryl and compozine. It was like a miracle. I did not experience any of the symptoms others have described. No ticks, no paranoia, no crawly skin, no claustrophobia. Am going to follow up with my normal Dr. about a change in my treatment to this permanently it worked so well. F 39 1 days
1X day
9/28/2010
Email
 1  Pain & nausea Extreme anxiety and panic, really horrible recurring falling feeling that I think was a panic attack, felt sure I was having a heartattack and going to die, wanting to escape Was given this in a hospital in central america. Like lots of other people have said, was the worst feeling I've ever experienced, I feel scared just thinking about it. I'm never taking this again and I recommend you don't either. I would much rather have the nausea and pain. Was given this through an IV just the once I think, not sure how much. F 24 1 days
not sure 1X day
9/25/2010
Email
 1  migraines Restlessness, jittery, twisting of the face, grimacing, neck and face spasms My son was given this medication for three days due to headaches lasting about eight months. He was admitted to the hospital and it was administered in an IV. He was discharged and on the way home when his face and neck began to spasm and his arm started to retract. My husband brought him back to the hospital where they told him this was a side effect of the medication. He was given benadryl which seems to be helping, but he has had several more episodes of his neck and face having spasms. He is 14yrs old and this is very frightening for him. The headaches have gone away, but I am just wandering how long these side effects from the medication are going to last. I am so upset that the doctor did not tell us this could happen and am afraid to think what would it have been like if he had these problems after getting home! I would not recommend this medication to anyone. I am happy the headaches are gone, but the side effects are awful! M 14 3 days
10mg 3X day
9/7/2010
 1  Post op nausea As others described ,you feel like you need to jump out of your skin, but yet I laid in my hospital bed feeling like I couldn't move. When they initially gave me the 10 mg IV my heart rate jumped up to 170 and I felt like I couldn't catch my breath. I was given 50 mg of IV benadryl and and they turned up my IV fluids, it took about 6 hours for me to start to feel normal. F 39 1 times
10 1X day
9/5/2010
 1  migraine agitation, anxiety, restlessness, weakness...I was traveling and had run out of migraine medicine Relpax. In an urgent care clinic, I was administered compazine and toradol via IV. Side effects lasted about 15 hours. Beware. F 54 1 times
10 mg 1X O
9/5/2010
 1  Pre-operatively and ER Flu FIRST: I had day (pelvic) surgery. In the Recovery Room, I felt as though I was going out of my skin. Extremely restless, panicky, depressed, desperately so. I went home but I remember thinking, what's going on.. but I was thrashing around on my bed, and couldn't express my thoughts. I was moving like a maniac, which I wasn't supposed to be doing, but I couldn't stop. I felt like I was going crazy. Gyno who did the surgery dismissed my complaint. Had no idea what I was talking about. Somehow I made it through...but then a few years later, I was in the ER with the flu and was given Compazine for the nausea. WORST EXPERIENCE OF MY LIFE. Everything about wanting to die, jump out of my skin. Unable to express myself. Felt I was in some weird slow motion, and paranoid, even. Wanted to die. I echo all the other contributors here. I honestly think I would commit suicide if I had to live that way. I wasn't given Bendadryl...I think it was ATIVAN...Is that possible? to counter the side ef NEVER AGAIN! I learned from this experience that I had been given Compazine in my IV prior to that pelvic surgery by the anesthesia team. And could have avoided the whole nightmare, much worse the second time, if only I had known what it was that had made me feel so HORRID after that surgery. Another time I insisted I NOT be given Compazine. And the nurse didn't believe me!! I stood my ground! ASK WHAT THEY GIVE YOU PRE-OP for NAUSEA. DON'T TAKE COMPAZINE. It's cheaper than ZOFRAN, and that's why they probably give it for nausea! SPEAK UP!!! F 39 1 days
? 1X day
7/27/2010
 1  Migraine Headache I had had a series of migraines, over the past week. Last night, I decided that enough was enough. They opted to give me Torodol and Compazine, in an IV. Within 10 minutes, I felt completely trapped. I felt like if I could just get the IV out and leave, things would be better. Then when I did leave, I felt trapped in the car. Then, after getting home, I realized I felt trapped in ME. I was eventually lucent enough to realize that this is a serious anxiety attack. The doctor recommends Benedryl, to counteract the anxiety. If that does not give me serious improvement by tomorrow night, I am going to go back to get Adivan, to help. I heard that it can take a few days to calm down. I felt like I couldn't lay down, or sit down, or even walk around. I felt like I was going to leap out of my skin and die. And, seriously, death was feeling like a tempting offer, just to be shed of that horrible feeling. I have never felt anything like this, and hope to never feel it again. They d Avoid this, unless nothing else has worked. A nice simple Demerol or Vicodin would have been perfectly fine. After my pain med, I already felt better. This drug was really not as all worth the agony I am STILL feeling, from the anxiety, over 24 hours later. F 35 1 days
Not Sure 1X O
7/25/2010
 5  Severe Migraine Slept for 12hrs Was passing out from migraine pain and having tremors so intense ER doc's thought I was having a seizure. Compazine 5mg/Benydril 50mg/Toradol 30mg via IV stoped the seizures and completely eliminated migraine in 8 minutes. Literal lifesaver for me. F 16
5mg IV 1X day
7/21/2010
 1  nausea for the love of God never use this drug..the second it started taking effect i thought i was losing my mind. i felt trapped. i wanted to run out of the e.r...felt like i was dying and i couldnt do anything about it. it was the scariest, most helpless, horrible feeling i have ever felt. this drug should be removed from the market! it's horrible what it does to people. F 47 1 times
1X day
7/8/2010
Email
 1  Migaine Worst, most horrible, most horrifying experience of my life. I'm 11 weeks pregnant, and hope my baby is okay. I felt like the others. I wanted OUT of the ER I wanted to rip my IV out of my arm and get out of there. I couldn't hold a normal conversation or maintain normal thoughts, I couldn't sit still. My mouth was dry as cotton and they wouldn't let me drink anything. Absolutely AWFUL. Wouldn't recommend it to anyone. It would have been nice to have been warned before hand. Also, my heart rate shot up. F 34 1 days
1X day
7/7/2010
 1  Migraine Felt like I was crawling out of my skin. Antsy, couldn't sit still. Do not take this. It got rid of the migraine but not worth the side effects. F 23 1 times
10 mg 1X O
6/27/2010
 1  Severe Nausea I was in the ER for severe nausea and dehydration. The doctor ordered and IV for hydration, Compazine for nausea and Benadryl. She failed to explain what the Benadryl was for. As soon as the IV started my hand and veins felt like they were on fire. I kept saying to my husband I had to get out, I just needed to leave the ER, I just could not stay there. I wanted to crawl out of my skin, I kept begging my husband to rip the IV out of my hand. I kept saying to him that if it didn't stop I was going to die. I never act like this, I was in so much panic and did not know why. Two hours later the doctor came in an apologized for what had happened. She told me she had seen the last few patients have the same reaction and thought the Benadryl would help me. The doctor went on to say that iT was a bad batch of Compazine. Before I left she gave me some Adivan so I would be able to sleep. It has been 5 days since and last night I was able to sleep for the first time since the ER and the extreme an AVOID TAKING THIS MED, IT IS NOT WORTH IT! F 36 1 times
IV 1X O
6/20/2010
Email
 1  Migraine Anxiety, Restlessness, Feeling like I had to tell myself to breathe(even though I had not trouble breathing). I was given Compazine along with Benadryl for a migraine headache in the hospital. I had received Compazine in the pill form before for nausea without the side effects. The IV Compazine does just what a lot of people here said it does. Makes you feel like you are going crazy, anxious, restless, etc. I actually did pull my IV out and walk out of the hospital. This was after I basically begged the nurses to do it and my wife told them I was going to pull it out but they didn't listen. Even though it isn't technically an allergic reaction wherever I go I say I am allergic to it so I don't get it again. M 25 1 days
10MG 1X day
6/20/2010
 1  Severe Headache and Nausea I was referred to the ER after visiting the Outreach Clinic for a severe headache, neck pain and nausea I was suffering. My family doctor was out on vacation, so I did what I thought I needed to do. I was first given dilaudid and zofran through my IV which helped some, but not entirely. The doctor offered more pain medicine and gave me IV Compazine with Benadryl! I have never experienced anything like this. I knew within a couple of minutes that something wasn't quite right. I felt like I had no control over my body and also felt "trapped" like other reviewers have described. I am two days out now and still feel very edgy and not myself. I plan to visit my regular doctor on Monday to make sure no permanent damage has been done by this drug. The doctor or nurse neither one explained the drug to me before giving it. I was under the impression that it was for pain relief. I didn't know it was some kind of psycho drug. I will be getting to the bottom of this and have Do not take this drug! F 38 1 days
10 MG 1X day
6/20/2010
 1  Tension headache I thought I was alone in feeling this way! I took this medication and 20 minutes later I couldn't see straight, it was like I was in a different world, I was anxious, I wanted to pull my IV out, I didn't want to look at anyone. I couldn't sleep for three days! I had to induce sleep by taking homeopathy sleeping pills. I felt hopeless like there was no point of living. I couldn't concentrate, my vision was cloudy. Imagine living like this! Like there is no point to your life. I felt like I was somebody else. This is the worst experience I've ever had in my life! I felt paranoid and I was afraid to leave my home. My muscles are all tense and they hurt. I felt trapped in my own head and I couldn't escape the thoughts I was having. I was questioning my existence and the existence of the world. I think that doctors need to warn people of these side affects before giving this medication. I will never ever take this medication again. And after all of this...I still have a headache. Before taking this medicine please try to find an alternative. No one should ever feel that way ever!! F 25 1 days
IV 1X day
6/18/2010
Email
 1  Headache This is the worst experience that I have ever had with medication! I went in to the hospital because I had a bad headache for 5 days. They gave me benadryl and compazine through an IV and within 20 minutes I began to feel weird. I felt very anxious like I just didn't want to exist! That was two days ago and I am still having problems sleeping, problems with paranoia and hopelessness. I have never felt this way in my life. My headache is gone but I would gladly deal with that instead of these odd feelings of uneasiness. I have been crying because I cannot shake this feeling. I cannot concentrate on my schoolwork and it's finals. All of my assignments are late. I feel like "What's the point of life?" "Why am I here?" I am shaky and now that I read that this medicine is an anti psychotic I am just nauseas. I just had a headache now I'm like this! Please do not take it!!!!!!! F 25 1 days
through IV 1X day
6/17/2010
 1  Headache It has been more then 12 hours since my last does of Compazine and I still can't sit still. It is the most horrible feeling ever. It took me two hours to fall asleep last night and I was exhausted. I can't even remember how I ended up falling asleep. When I woke up, I felt a little better but still extremely jittery. I am planning on taking Tylenol PM to sleep because I refuse to go through this again tonight. I don't think it's fair that this drug has this terrible side affect and the patients aren't made aware. When I get over these jitters (hopefully soon) I plan to make a full complaint and that this drug be pulled off of the market. I have a graduation to attend tomorrow and I'm afraid of even going because I'm not sure if I'll be able to sit still. DO NOT TAKE COMPAZINE IF YOU DON'T NEED TO!! IF YOU'RE FEELING NAUSEATED OR HAVE A HEADACHE MAKE SURE YOU KNOW WHAT MEDICATION THEY'RE PUTTING INTO YOUR IV!!!! F 20
Not sure 1X day
6/16/2010

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