COMPAZINE Reviews (PROCHLORPERAZINE MALEATE)

Average Rating: 1.2 (501 Ratings)

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 ANTIPSYCHOTICS ANTIMANICS VERTIGO MOTION SICKNESS VOMITING

 Type: Brand name discontinued; available as generic

  

COMPAZINE  (PROCHLORPERAZINE MALEATE):  This medication is used to treat severe nausea and vomiting from certain causes (for example, after surgery or cancer treatment). Prochlorperazine belongs to a class of drugs known as phenothiazines. This medication is not recommended for use in children younger than 2 years or in children going through surgery.    (Sources: U.S. Centers for Medicare Services, FDA)

  

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Key to Ratings: 1=LOW (I would not recommend taking this medicine.)
5=HIGH (this medicine cured me or helped me a great deal.)

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More on COMPAZINE: Reviews Summary  |  Drug Safety Information

RATING  REASONSIDE EFFECTS FOR COMPAZINECOMMENTSSEXAGEDURATION/
DOSAGE
DATE ADDED
 
 1  Nausea I was given 5mg Compazine through IV at hospital for nausea. I immediately started panicking terribly, felt like I was going to lose my mind. Wanted to rip out my IV. Wanted to run. Went nuts shaking and panicking for hours till they discharged me. Went home and it got worse. Utter abject terror for the next few days and now 5 days later having it on and off. Nausea, panic, dizziness. Hot flashes. Can't sit still, can't sleep, sore muscles,,sore throat. UTTER PANIC> Worse at night. When will this end?? Seriously, I've been researching for days now and everyone seems to get over it after 2-3 days, I'm going on day 5 and I'm NOT okay,, if anyone has any advice or can tell me when it may subside please feel free to email me. Worst thing I've ever lived through. This drug should be banned. F 41 1 days
12/21/2009
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 5  Severe migraines drowsiness Compazine in IV form works the best. The pills work well too but take a little longer to kick in. No anxiety or fear experienced as others here describe. Nothing else seems to work for me. F 40 3 years
12/20/2009
 1  nausea from pain medication Extreme anxiety/panic attack, severe fatigue, extreme muscle aches, very irritable, unable to concentrate, irrational, suicidal thoughts I actually felt terrible but had a very important meeting to go to where I needed to drive for about 45 minutes on a scary (under normal circumstances) highway. I couldn't make it there. I pulled over onto the shoulder (never did that before in my life except for 2 times when I had a flat tire). I couldn't understand what was happening to me. I wanted to call 911 but called my husband instead. I was unable to breath normally and was in a full panic attack. He somehow got me to get back onto the highway and get off at the next exit. I drove to a pharmacy (don't even know how I got there). I took my blood pressure 151/105. I usually have low blood pressure. I don't know how I even sat in the blood pressure chair. I was in such bad shape but no one in the pharmacy even noticed. I waited in the car with unbelievable aches and feeling like I was going to crawl out of my skin and into my skin- makes no sense. My husband had to pick me up and take me home. It was the worst thing in the world. I had NO IDEA! I will never ever take compazine again. I wish I could wear a bracelet to say I can't tolerate this drug. I would rather be nauseaus and throw up a bucket of vomit than to feel that way again! F 49 1 times
12/3/2009
 1  Migraine, Nausea felt very jittery, paranoid, had to leave the ER because I felt so scared which is not me. felt like I was crawling out of my skin. I would never take this medicine again. F 46 1 days
11/16/2009
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 1  Chemo Anti nausa med 12 hours after taking this drug my jaw began to widen uncontrolably, For the first half hour I tried to shake it off but it became more and more uncontrollable. My entire head began to pull to the side and I began to drool. We called the er and they thought I might have had an anurisam, wich put me into a state of sheer panic, thinking that I would spend the rest of my life like this. THe pulling became more sever and I became very angry and irrational, wich is not my personality at all. When we got to the ER, a doctor correctly diagnosed me and I was given 2 shots of benidryl and 2 of valium. It worked almost instantly and I was ok. Would not recommend, not worth the side effects. M 24 60 days
11/13/2009
 1  Nausea 12 hours after I was given Compazine IVP, my neck, jaw and face muscles were involuntarily moving. My neck was twisting to the side and my jaw was clenched to the side. It got to the point were I could not control any movement from my shoulders up [ I couldn't even blink my eyes]. This was extremely painful...I ended up in the ER. I also felt like i was jumping out of my skin. I was unable to sit still for anything! The doctors told me that this type of reaction does not run in families, but my aunt has gotten it also. Be very careful when taking this medication! F 21 1 times
11/13/2009
 1  nausea I had two seizures after being given this IV. My heart rate went down to 34 and my blood pressure was undetectable. I was agitated, had neck spasms, clenching of teeth, and almost died. I had to be medi-flighted to a large hosptial after being given this medicine at our local hospital. Why is this still on the market, and why woould any doctor in his right mind ever use it? DON'T TAKE THIS MEDICINE-IT ALMOST KILLED ME! F 54 1 days
11/11/2009
 1  migraine and nausea I was given this twice after being taken to the ER during panic attacks. The panic attacks triggered my migraine, and for that they gave me compazine. It was the worst experience of my life. I felt like I was paralyzed. I could not move my body because I was so exhausted, but no matter how hard I tried, I could not fall asleep. I had to wake up my two best friends who had taken me home to carry me to the bathroom. It took about 12 hours for the feeling to go away, but it was the worst 12 hours of my life. Do not take this drug. It was terrible F 20 1 days
11/1/2009
 1  Migraine cocktail. Severe Anxiety, paranoia, muscle lock ups, inability to sit still, muscle pain and rapid heartbeat. I have never in my life have had such a bad reaction to a drug than what I had with Compazine. I received the medication through IV along with benadryl to treat a severe migraine that landed me in the ER. If I would have known the utter hell I would go through, I would have chosen a thousand migraines. From the moment they injected me I started feeling spaced out. This turned into EXTREME anxiety and I couldn't stop moving. My heart rate went above 140 bpm and stayed there for about 9 hours. This medication is MISERABLE, please, weigh your options before you receive Compazine. M 23 1 times
11/1/2009
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 1  vertigo, headache It was given to me through an IV line, within seconds I couldn't breath, my heart fluttered and I felt extreme agitation and panic. It has been two weeks since I was given that drug and I have not been the same. I cannot sleep at night and wake up after only an hour with my heart fluttering, nausea and severe anxiety. I go through the days with anxiety and heart pounding. It's destroyed my ability to relax and get a good night sleep. I would not wish this drug on my worst enemy. DO NOT TAKE. Also, I've complained to the FDA Medwatch. Everyone who has a bad reaction should complain, maybe it will finally be banned. Don't take this drug!!!! M 39 1 times
10/28/2009
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 1  migraine severe muscle spasms, anxiety, and inability to sit still I've never had an allergic reaction to anything before so this was terrifying. A few hours after I was given the medication in the hospital, my mouth started to pucker up and then twist into a grimace uncontrollably. The next day, I was unable to sit still and kept getting up, taking a few steps and then sitting back down. I wanted to rip my IV out. My face looked like a mask and I felt like my jaw was going to snap and my teeth were going to shatter. My jaw was out of alignment and I was unable to open my mouth. My legs started shaking and my entire left side went stiff. My head rolled back and I had severe spasms in my neck. Finally one of my doctors diagnosed it as EPS and gave me IV Benadryl. Within 15 minutes, the symptoms were gone. F 15 2 days
10/22/2009
 1  extreme nausea Flashing lights when I closed my eyes, tounge was twitching so hard it was hurting, kept holding my breath, felt like I could get no air This by far was the scariest experience of my life. I also have a panic disorder which at first made it hard to figure out what was going on. Was at ER for flu symptoms and they gave me compazine in my IV, then released me. Within minutes I felt the scariest panic attack of my life, my stomach was on fire and I could not sit still. Heart started to race. As we were driving home my tounge began to twist violently, so hard it was hurting. Then I suddenly kept holding my breath for sometimes 45 seconds at a time, I could not control. Went immediately back to ER, just gave me two benadryl and send me home, where all night long I could not sleep. the holding breath stopped but still felt like I couldn't get air fully in my lungs. I thought I was dying and I lay there for 8 hours before I called 911 and went back to ER. 4 weeks later my throat still feels like like some pressure, will NEVER EVER take again. really made my anxiety disorder worse and scared of happeneing again. F 32 1 days
9/25/2009
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 1  Post surgery from Joint replacement The worst experience of my life...I had outpatient surgery at 3pm,& was home by 8pm. Got home, layed in bed & my legs started twitching out of control & I had the most panicky, wanting to jump out of my skin feeling. I thought it was a panic attack & took 2 Vistarils & 2 Xanaxes, I was scared to death & thought I was dying, called 911, ambulance came,paramedics thought it was a panic attack & and drove me Slowly to the hospital (not where I had surgery).. I felt like jumping out of my skin, jittery,wanted to pull the Iv out,would have happily shot myself in the head to escape that horrible crazy feeling. The Dr's thought I had od'd on drugs & told me if I didn't quit crying for help I would be sent to a psychiatric hospital.. refused to treat me. Had CAT scan & said I had blood clot that made me crazy, gave me Coumadin. I paced the hospital room all night, ripped my IV out& bled everywhere.All I got was Xanax -didn't help. By am they said This drug is dangerous. Had I been alone at home I probably would have comitted suicide. They should have just let me be nauseous. F 44 1 days
9/3/2009
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 2  nausea/chemotherapy I could not become comfortable or go to sleep while I was on this drug. When I finally could go to sleep I had the most bizarre, disurbing dreams I've ever experienced. By the end of every dream I had came to the conclusion that someone had slipped me a strong hallucinagin. I know "it's just a dream", but how weird does a series of dreams have to be for your mind to justify every time that you can't possibly be sober in them. I am actually still afraid to sleep because of this Doubtful of it's effectiveness, definitely not worth the side effects for me. M 17 6 days
8/30/2009
 1  kidney inection floating, falling, jittery, heebie jibbies, severe dry mouth, major fatigued, tortured, skin-crawling, heart racing,blood pressure high, chilled, tense,scared I went to E.R. was diagnosed with severe kidney infection with blood in urine. I had nausea and vomitting earlier and had been given to start an iv with fluids, zofran (to control throwing up), and an anti-inflamatory shot of toradol. The throwing up had completely stopped but I was still in great pain so I was given an iv shot of only 9% morphine, compazine, and a little benadryl. I could feel the pain medicine working for about 5 min. and then it hit me and I was scared for my life. There isn't really a way to describe it I started feeling as if I was at the top of a roller coaster when it gets your belly and you never seem to plane back out. I became aggitated, jittery, my skin was crawling from inside out and I had a severe dry mouth. I immediately couldn't find the nurse button so I started caling for my nurse but I couldn't hardly speak it was gibbersih and I sounded like I was having a seizure and my heart was beating out of my chest. The nurse came in and just kept saying your ok sweetie I promise you are ok, as she began putting me on the ekg and affixed the sticky monitor pads all over me. I thought if I am ok why are you doing this? She said I am just hooking you up to the monitor you are having a reaction to the compazine we see it all the time don't worry there is a cure and kept talking and yes like everyone else I wanted to pull the iv's out but didn't. We gave the shot with Benedryl maybe not enough I don't know but there is a drug to counteract these effects F 38 1 days
8/30/2009
 1  chemo nausea Did not help nausea at all. Made me feel even worse, kind of unstable and buzzy. Been on chemo for 1 1/2 years. Try this drug every once in a while for my nausea thinking that maybe this time it will work. Never does. F 37 6 times
8/6/2009
 1  migraine This medicine is a nightmare. I came to the hospital with a blood pressure averaging 190 over 110 for some time as well as a migrane. Morphine was administered intraveneously followed by an intravenous administration of compazine. This medicine gave me delerium, ataxia, tremors, as well as a large increase of jittery energy. The nurses were not helpful whatsoever. Fortunately, the physician overheard my cries for help and then administere diphenhydramine invtravenously. 3 different medicines were administered intraveneously in total; the morphine and compazine interacted with each other in a negative manner. To my understanding, compazine is a beta blocker while morphine works on mu (opiod) receptors. No doctor in their right mind should use compazine to treat nausea caused by opiods, synethetic or non-synthetic. Additionally, I did not make any complaints regarding nausea post morphine administration. This medicine ought to be taken off the market. Why is compazine still on the market??? F 48 1 days
7/4/2009
 1  Migraine I came to the ER after experiencing strange vision problems which were apparently related to a migraine. I was given compazine intravenously and immediately the back of my neck felt hot and I was filled with horrible dread. I had an indescribable feeling that everything -even talking- was "too hard"- I couldn't even call my husband to let him know I had been to the hospital. It was a feeling similar to apathy but somehow worse. I was unbearably restless while simultaneously exhausted. Feelings of fear and anxiety were overwhelming. I was terrified the feelings would last forever. This was absolutely the worst experience of my life. I experienced severe side effects for about 3 days after my one dose of compazine and did not feel like myself for a full week. I never had anxiety attacks before but now after several months have had several. I am a small person (95 lbs) but was given a standard dose size. I was given benadryl to counteract my reaction but I didn't notice that it helped at all. I wish I could give this drug a "0" rating. F 30 1 days
7/1/2009
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 1  Migraine I went to the ER with one of the worst migraines i have ever had! they gave me compazine to help the nausea, within 20 minutes i felt very jittery and anxious, i remember wanting to rip the IV out and go home. I wanted to have the migraine over that feeling, which is saying ALOT because it was an awful migraine!!! the side effects lasted for days, and i felt like i was going insane, it was the worst feeling of my life. DO NOT EVER GET THIS DRUG!! F 18 1 times
6/27/2009
 1  Nausea I felt like I was literally going insane. This stuff had me trying to pull my i.v. out of my arm. Makes you feel very aggravated & uncomfortable. Couldn't find peace of mind no matter what I did. Lasted entire day and is still in my system more than 24 hours later. Makes you feel jittery and anxious. I DO NOT recommend this to anyone. My best friend said she had the same reaction to this medication F 18 1 days
6/16/2009

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