COMPAZINE Reviews (PROCHLORPERAZINE MALEATE)

Average Rating: 1.2 (501 Ratings)

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 ANTIPSYCHOTICS ANTIMANICS VERTIGO MOTION SICKNESS VOMITING

 Type: Brand name discontinued; available as generic

  

COMPAZINE  (PROCHLORPERAZINE MALEATE):  This medication is used to treat severe nausea and vomiting from certain causes (for example, after surgery or cancer treatment). Prochlorperazine belongs to a class of drugs known as phenothiazines. This medication is not recommended for use in children younger than 2 years or in children going through surgery.    (Sources: U.S. Centers for Medicare Services, FDA)

  

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Key to Ratings: 1=LOW (I would not recommend taking this medicine.)
5=HIGH (this medicine cured me or helped me a great deal.)

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More on COMPAZINE: Reviews Summary  |  Drug Safety Information

RATING  REASONSIDE EFFECTS FOR COMPAZINECOMMENTSSEXAGEDURATION/
DOSAGE
DATE ADDED
 
 1  Nausea / Vommitting I am pregnant and was taking up compazine for 3 days to avoid nausea, yesterday I felt dryness in mouth and unable to open, it is a kind of seizure. Went to Emergency and was given Benadryl. NOT ADVISED TO TAKE F 20 3 days
6/26/2008
 1  severe vomiting This was the most horrible experience I've ever had. Was given compazine through IV and as the nurse was administrating it I had immediate burning in my skin at the IV site. It felt like my skin was being burned from inside/out! The nurse flushed the IV site and it still continued for about 5 minutes. The drug almost immediately worked on the nausea, I have to say that! About 10 to 15 minutes later I had a horrible panic attack. I felt like my skin was crawling and I was going to die. At one point I seriously considered jumping from the hospital window. My husband was so shocked with my behavior he immediately called the nurse. They did not give me benadryl (I did take it the next day once I read this site) and these feelings continued through the night in the hospital. I did not sleep the whole night and was constantly moving and having the feeling of not being able to be still. I would never take this drug again. It was a horrible experience! I thought I was losing my mi F 35 1 days
6/25/2008
 1  migraine SEVERE anxiety, paranoia, restlessness, loss of sleep, loss of appetite, crazy dreams, couldn't sit still or get comfortable, etc. I felt like I was in hell for 3 days. I was given this drug in the ER 3 days ago, and wish I had known about its horrific side effects. I thought I would get Demurral, but assumed since I'm pregnant this was a safer option. I wasn't even GIVEN an option, they just put it into my IV without even telling me what it was or its side effects. I would have rather suffered through the migraine pain. As soon as the drug got into my system, I felt like I entered into hell. I am just now getting over the SEVERE anxiety. In the hospital I felt like I was going to FLIP OUT if I didn't get out of there. I made them discharge me without running the needed tests because I thought the room was closing in on me. I was completely paranoid, and felt that way for 2 1/2 days after. I thought I had been possessed by a demon, turns out, I was just poisoned. Compazine should be illegal. F 29 1 days
6/13/2008
 1  Migraine with Nausea Restlessness, impatience, unable to get comfortable, pacing, fidgeting, and paranoia for almost 24 hours! I received this drug when I went to the emergency room for a migraine with repeated vomiting. Although it did stop my pain and vomiting, it made me feel a little crazy for a whole day afterwards. It finally stopped when I read on this site to take Benadryl. I took 2 and fell asleep about an hour later. When I woke up after another hour, I felt mostly sane again. Thank God. I will never take this drug again. They gave me a prescription, but I threw it out. F 28 1 days
3/28/2008
 1  Alleged Migraine Increased Heart Rate, Extreme shaking, anxiety, panic, restlessness, Death sounded better to me than the torture I was experiencing! Even a day afterward, I still feel shaky and my heart is racing. I almost wanted to take my own IV out just to get out of the ER. I could not stand feeling trapped! It was the worse experience I have ever had! Thought I was going crazy. I would NEVER recommend anyone taking this med!!!!!!! F 37 1 times
3/26/2008
 1  Nausa Several days after taking compazine I began to feel an uncontrollable tightening in my neck which progressed to the rest of my body. I had no control over my body. My jaw began to clench so tight I thought I would break my own teeth and my neck made my head turn to one side. My boyfriend at the time took me to the campus health center where I began to have my muscles react in the opposite direction, my jaw opened so wide I thought it would break and my back arched. The entire experience was horrific. Benedryl finally saved me. DO NOT TAKE THIS DRUG. I am now 47 but I was given this drug when I was 21, I can't believe it is still on the market if there are this many people with this same reaction. I was lead to believe this was a rare reaction. I am interested in communicating with others who have had similar experiences with this drug. Especially anyone who had this reaction 5 or more years ago. F 47 1 days
3/23/2008
 4  Nausea/vomiting due to migraine Brief feelings of restlessness, jitteriness (I am also Bipolar and often have this kind of reaction to medications that make others drowsy). In combination with Zofran, this worked very well for me. I will continue to use it (along with Benadryl, to counteract the side effect I mentioned). F 27 1 days
3/11/2008
 1  nausea i had what they called a dystonic reaction. muscle spasms, throat swelled up, tongue swelled up, unable to move arms, stomach spasms, jaw was turned to my right and pretty much glued to my shoulder, my eyes were stuck looking out to the left, I couldn't walk and had to be carried to the car and into the ER. They say that dystonic reactions generally are not deadly, but if I hadn't been given benadryl immediately in the ER, I would have died because I'd stopped breathing about a minute before reaching the hospital I was on this medicine when I was around 14 years old or so for chronic nausea. The dosage was upped the day this occurred. I honestly don't think this medicine should be used, period. This happened about 16 years ago to me, and I still remember it clearly, and flat out refuse to take any medicine that ends in -zine because of this. F 14 1 months
1/23/2008
 5  Severe GERD with Nausea None. All those comments above mine are very scary, but it sounds like a typical allergic reaction to any medication - it doesn't make it bad. I had been dealing with frequent nausea from severe acid indestion and I panic whenever I feel like I'm going to vomit so the compazine was most welcome. It would take an average of 20 to 40 minutes to kick in and always worked. Sometimes my stomach would feel a little weird, but I didn't feel sick anymore. F 31 5 months
1/22/2008
 1  Migraine/For nausea from Dilaudid Administered via IV in the ER. Extreme Terror does not do my situation justice. I suffer from PTSD, and the staff was aware of this when treating me. I actually considered ending it-and I am a very rational person who does not drink / smoke etc. Was sure I would NEVER be sane again, and could not sit still. Felt like I was drowning. I left hospital through a window, and never signed out (obviously). I figured that if I were going insane, I wanted to be alone-forever. This drug should absolutely be banned. It was administered to me for the nausea side effects of the Dilauded I was given for a migraine. Next time, I will use a hammer for the migraine-or get street drugs. They couldn't be worse!!!! M 36 1 days
1/14/2008
 1  Nausea Restlessness, anxiety, panic, pacing, crying, sweating,fidgeting, rage, and paranoia. I was given compazine through IV when I had a sever kidney infection to control my nausea. Within 20 minutes I started having a metal break down. I could not lay down I wanted to pace the room. I tried to remove my IV from my arm. I was sweating I became extremely paranoid. Then I began crying and wanted to check myself out of the hospital because I was so restless. As I said within 20 minutes that medicine caused the worst mental problems I have ever experienced. All of this was with 1 dose and I was quickly given Adivan once my doctor realized I was having such a psychotic reaction. F 23 1 days
1/11/2008
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 1  NAUSEA This was the most horrifying experience I have had taking a medicine! My heart was going crazy, beating hard, feelings of panic, chilled all the time. could'nt concentrate, cried all the time, fear of dieing.. Called the ER was told it was out of my system, had an IV on Thursday and this is Monday... When I take the Benedryl I can "cope"... When is this going to end ? NEVER EVER take this medicine... It needs to be taken off the market !! F 48 1 times
12/31/2007
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 1  nausea from inner ear problem Parkinson type symptoms, could not blink, slurred speech, muscle spasms, right foot shaking, insomnia - no sleep for 5 days straight, could only sit for 60 seconds before having to get up and get moving, restlessness, jaw would not move - could not chew food, zombie like state, could not get in and out of bed without help, stroke like symptoms. This is a TERRIBLE drug that should not be on the market. Took this for 3 weeks to help with nausea from inner ear problem. Went to ER two weeks later with stroke symptoms, had CT scan done, said symptoms were in my head. Went to ENT Dr a week later who realized after seeing me for 5 minutes what was wrong and said it was the compazine. Had me go to the ER at the hospital next door to have a MRI of my brain. ER gave me something to try and counteract the compazine. Has been a very slow progress getting better. Speech has come back almost all the way, can blink now and turn head. This was the scariest thing I have ever gone through. There isn't anything good about this drug. If you read about it the info on this drug is scary and some of the side effects can be permanant. I don't know if I will ever be 100% again. I am used to having so much energy and now I can't even bathe myself. Why do Dr's give this to patients? Why is it on the market when the side effects can be per F 44 3 weeks
12/8/2007
 3  Surgery I was so nauseated from the pain killers after I had a tumor in my finger removed when I was 17 I needed something. My mom and my dad's sister both had spasms in their face after taking compazine but since it is a cheaper anti naseau med I decided to take it. I knew that taking benadryl would counter-act the reaction so I took it for a while but since nothing bad happened I stopped taking it. After the benadryl left my system my hands started getting tense and causing me a lot of pain where I had the surgery and I became very irritatble. Later that night my tongue suddenly wouldn't stay in my mouth and my face started to skew. I couldn't stop laughing even though I didn't think it was funny and no one believed I was serious until my back started tensing up sending my head back and my eyes rolled up into my head. This was the scariest experience I have ever had not to mention painful. My father took me to the ER where they gave me an IV with benadryl. It worked well for its purpose and I wouldn't have had any problems if I had continued using benadryl. F 18 4 days
11/26/2007
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 1  chronic nausea Locking jaw, tongue spasms, loss of facial control, feeling that tongue was swelling, difficulty breathing, panic. My daughter is 18 and has been having severe constant, chronic nausea. After trying other nausea meds for a few weeks this was tried. We never were informed about this possible reaction. My daughter came to my work in a panic from school - she was trying to tell me that her tongue was swelling and she couldn't breath! I rushed her to the car and speed off to the ER. It was 4 miles away via freeway! I was was never so scared in my life. The last 2 miles I was doing nearly 100mph - and couldn't get there fast enough! I was afraid she was going to pass out and suffocate! At the ER the doctor was exceptionally calm. He got an IV of Benadryl started immediately. He said this is a very common reaction - as a matter of fact he had another patient just down the hall with a reaction as well. He said he would NEVER percribe Compazine, but if he absolutely had to, he would require it be taken with Benedryl every time! F 18 3.5 days
11/26/2007
 5  nausea from chemotherapy minimal- maybe drowsiness, but I'm not sure how much of that was the compazine vs. the chemotherapy I liked this stuff a lot. I was really worried about severe nausea and vomiting after chemotherapy, so I took this for a few days at a time after each treatment (off and on for 5 months). I got by with just a bit of an upset stomach, but no real nausea or vomiting. F 31
11/21/2007
 1  long lasting headache This was the most awful experience of my entire life. I was given compazine via IV for a headache. I wish I just kept the headache. I couldn't figure out why they had the nurse in there monitoring me, just talking away. A while after he left I suddenly became panicked. The worst panic I have ever felt. Then I noticed smoke coming from the walls. I knew it couldn't be true, but then my sweater looked like it was on fire. Iwent over to feel it and I could see the black burns. I started to scream for someone to help me and the nurse was so mean. SHe just looked at me with irritation and said I would be fine, they would give me benadryl. SEemed like forever. I laid down and felt like I was floating up to the ceiling, literally left my body and looked down. I decided I couldn't lay down. TOld nurse to take my blood pressure. THought I was having a heart attack. Couldn't keep mind straight and ripped off the cuff. Then I thought, oh my god, they are gonna think I am crazy (a They don't tell you anything about this drug, just give it to you. Watch what they give you for nausea and headaches. Don't take it. I have done a few drugs in my younger days (even hallucinogens)-now I am much more of an adult, but it doesn't even compare. This was pure terror. I also have no psych conditions or depression and am a counselor. It was complete terror. F 34 1 days
11/1/2007
 1  nausea after knee surgery 24 hours after knee surgery I started to have nausea(couldn't even keep water down) so my doctor called in a script for compazine (10 mg) 1 tablet every 8 hours. After the first pill my nausea stopped but I took 1 more pill 8 hrs later for "good measure". I didn't feel the side effects until about 8 hours later. I could not focus, crying without reason, felt like I couldn't breath fully at times, extreme restlessness and rocking back and forth, panic like feeling, urge to move but coudln't due to knee surgery. I thought that I was experencing mental illness. The next day I was worst so my husband took me to the ER (they knew what it was before I told them that I had takened Compazine). They gave me IV Benadrly in ER, when home and took 2 Benadryl every 4 hrs for 4 days before the side effects stopped.It was a very scary experence because I thought I was mental. People should be warned about the side effects BEFORE taking this drug. F 46 2 days
10/2/2007
 1  nausea Oh my God! It was absolutly horrifying! At the time I was either 15 or 16, I had nausea so my doctor prescribed compazine to me, after like 2 days of taking it this was the reaction I had. I was with my dad at a department store and he was making me laugh and all of the sudden when I was done laughing, my face was stuck in a smile. I COULD NOT TAKE THE SMILE OFF OF MY FACE! The next thing I knew, my jaw was completly crooked, I started to panic so i asked my dad for his car keys because i was embarassed to be in public. Once in the car it started getting worse and i was crying and freaking out. and that was only the beginning from my jaw then my neck went to the side, then my tongue got stuck to the side of my mouth so i couldnt talk right. then my back started to go into a backbend my arms and fingers cramped up and were getting tucked behind me. i was dry heaving and sometimes during a dry heave my body would completly relax and then it would suddenly tighten again. this whole thing i do NOT reccoment this drug, no matter what. Id rather be nauseous any day before dealing with the side effects i experianced from taking it. F 20 2 days
8/31/2007
 1  food poisoning uncontrollable body spasms,tightness in throat,difficulty breathing,jerky body movements,jaw pinned to shoulder, slurred speech, stomach muscle spasms I was given compazine by my primay physician for nausea and vomiting for what was diagnosed as food poisoning from hamburger meat purchased at a fast food resturant. I followed the directions on the prescription and took two 10mg pills for three days. Two hours after the last pill, my neck began to go to one side, I had extreme muscle spasms in my stomach and slurred speech. A friend called my grandmother and took me to her house and she thought I had experienced a stroke. She took my blood pressure and when it was norman she started to massage my neck and body. When this did not work,she called my doctor and was told to take me to the hospital emergency room. They immediately started a drip and gave me Benadryl. I continued to spasm for a period of time and then the spasms stopped. I stayed in the ER for about three hours and was told to take Benadryl for the next two days or until I could see my primary physician. My body ached all over and I was basically disfunctional for the n M 18 3 days
8/19/2007

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