COMPAZINE Reviews (PROCHLORPERAZINE MALEATE)

Average Rating: 1.2 (504 Ratings)

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 ANTIPSYCHOTICS ANTIMANICS VERTIGO MOTION SICKNESS VOMITING

 Type: Brand name discontinued; available as generic

  

COMPAZINE  (PROCHLORPERAZINE MALEATE):  This medication is used to treat severe nausea and vomiting from certain causes (for example, after surgery or cancer treatment). Prochlorperazine belongs to a class of drugs known as phenothiazines. This medication is not recommended for use in children younger than 2 years or in children going through surgery.   (Sources: U.S. Centers for Medicare Services, FDA)

  

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Key to Ratings: 1=LOW (I would not recommend taking this medicine.)
5=HIGH (this medicine cured me or helped me a great deal.)

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RATING  REASONSIDE EFFECTS FOR COMPAZINECOMMENTSSEXAGEDURATION/
DOSAGE
DATE ADDED
 
 1  Migraine headache This has to be the worst drug on the market. I was given a Compazine cocktail for my migraine headache at the emergency room and after the doctor administered it within 30 minutes I was having a feeling of skin crawling horrible headaches vision disturbances sweats continuous shaking and I ended up with Akathisia . This has been in my system for over two weeks now and now I have to see a neurologist to see what can be done. I haven’t slept for days due to the side effects and have had continuous restlessness and anxiety that this medication has caused me. I let the ER doctor know what was going on with me because I was so weak after I was given that and they told me oh you need to leave because we have to have the bed for someone else forced me out of the ER and said oh well come out of your system within about 10 to 15 minutes. This was a bunch of BS and now I am going to seek legal counsel because this has completely ruined my life, cause me to lose 27 pounds and now I have to go through multiple blood work and test all because of this medication DON’T TAKE THIS MEDICATION AT All!!! Compazine Should be removed from the market as one of the most serious and dangerous drugs. M 26 1 times
50mg
7/8/2019
 1  Migraines/ER visit Was given Compazine in my IV as part of a migraine cocktail at the ER to help with a Migraine I had for 4 days. While the cocktail did help my migraine, I now have extreme anxiety, restlessness, and jitters. At the hospital I had a freak out and wanted to rip out the IV, the nurse had to calm me down and told me that once the saline washed it through I would feel better. I still feel anxious and like I want to just rip out of my own skin. Do not take if you don't have to!!! F 25 0 days
5/23/2019
Email
 1  Migraine Temporary insanity, restlessness, anxiety, cold sweats, suicidal thoughts I went to the ER for a pretty severe migraine. The nurse gave me a cocktail with compazine in there right before wheeling me into the room to get a CT scan. By the time I got on the table for the scan I started sweating profusely and just figured I was nervous and a little scared. When I got back to the room however I knew something was wrong. I just wanted to rip out my IV and escape! I couldn't get comfortable temperature wise ino matter what I did. I told the nurse and dr I didnt feel right and they just acted like it was no big deal. The car ride home i kept telling my wife something felt wrong, and when we got home I couldn't fall asleep at all. It took me until 10am to do so by some miracle. Day two and I still dont feel 100%. I cant wait for this crap to be out of my system. Medical staff should be trained better on this sort of side effect and more importantly they should know just how terrible it makes patients feel. I would choose death over feeling like that again it was so bad. M 34 0 days
IV
2/16/2019
Email
 1  migarine anxiety shaking all over couldn't sleep felt like I was going crazy. Do not take this drug!! F 33 1 days
1X day
12/21/2018
Email
 1  Migraine Shaking, couldn't stop moving, heart racing, insomnia even after sleeping off and on for 12 hours. F 27 1 days
11/30/2018
 1  Migraine at hospital I took my daughter to the hospital due to Migraines and they flush compazine thru IV. They usually gives her Toredol with sofran and does the trick but today they decided to add compazine to her cocktail. It was an awful idea. She started to have her muscles spamming like crazy and was having all the symptoms of dystonia.. She was twitching involuntarily and crying in pain. She was walking like a special needs person. It also cause her anxiety to be off charts and vomiting uncontrollably. I took her to another hospital and they were able to fight off the symptoms by giving her congentin. They should have stay with what works.. I'm so mad. Awful and horrible medicine.. It should be remove from the FDA. F 20 1 days
Unknown
11/12/2018
Email
 1  Given in the ER Akathisia and still affected months later, panic, anxiety, PTSD. We should all get together for a class action law suit that they are still using this and hurting so many people. Disgusting money hungry scum. F 40 1 days
1X day
10/23/2018
Email
 2  Nausea A few hours after taking the first dose, I started grinning involuntarily. It kept getting worse, and I ended up having to go to the hospital. Those were the only muscles affected. This happened in the early 1970s. I'm really suprized the medical community is still using compazine given the introduction of better nausea and migrane meds and atypical antipsychotics. M 25 1 times
10/2/2018
Email
 1  Headache post LP AKATHESIA. Irritability, inability to sit still, restlessness, anxiety, terrible horrible awful side effects. Don't take!! F 44 1 days
1X day
6/30/2018
 1  Dizziness I came into hospital with severe dizziness so doctor gave me 50mg meclazine paired with an iv of compazine. I noticed that I started to become very agitated and just wanted the nurse to come over and take my iv out. I was SO tired, but I couldn’t sleep because my body was so restless. It was SO uncomfortable. It was hard to talk or keep my eyes open, even though it was so impossible to sleep. Never again! F 29 1 days
5/12/2018
 1  Nausea Jittery, anxious, couldn’t sit still. Very jittery still, at 13 hours later. Can’t stop moving! Going crazy and wondering when it will stop! F 29 0 days
10mg IV
4/15/2018
Email
 1  Headache and nausea post concussion After I received the drug, my legs started shaking and I was crawling out of my skin. I felt freezing but hot when they tried to put a blanket on me. I thought I was just anxious due to being in the ER but when they brought me to CT I climbed out of the machine. When I told the nurse she said it was common and gave me IV benedryl which helped a little. I got home and couldn’t sit still or get comfortable for HOURS until I finally took 2 more benedryl and slept. The next day I was still very much on edge. I’d say it took 24 hours at least to get out of my system. I have compazine listed as an allergy in my medical record now. F 32 1 days
3/18/2018
 1  Headache Anxiety, scary feeling like being trapped, very rapid heart rate as soon as it was administered via IV really bad side effects F 41
1X day
3/17/2018
 1  Administered via IV for Migraine This medication is awful, and should not be used as a first choice treatment for anyone. I immediately felt pure terror and felt like I was trapped. Of course, I was left alone in an ER treatment area. I felt like I was going insane but was afraid to tell anyone what was going on, I thought I was just having a panic attack due to being at the hospital for 5 hours. I don't remember driving myself home, I immediately went to sleep to try to get rid of the panicked feeling. I woke up 6 hours later still feeling panicked and out of control. I am very upset that this medication was given to me, I had suicidal thoughts and sheer panicked feeling. It has been over 24 hours and I still don't feel right. This is a horrible medication and I wouldn't recommend it to anyone! F 38 1 days
1X day
2/27/2018
Email
 1   Agitated, uncontrollable shaking, head felt like it was weighing down, feeling of being stuck and not able to get out I went to the ER because I hit my head and thought I had a possible concussion but I didn’t go till a few days later after I had hit my head. I went to the ER three days later and they said I had a frontal sinus infection also. They gave me an IV with saline, Benadryl, and compazine. Within 10 mins I felt absolutely uncomfortable. I was super jittery and could not lay comfortably. I was holding myself from shaking uncontrollably. After my IV was done they wanted to give me a steroid injection and I refused to take it because I felt so disturbed and uncomfortable. By the time I got in the car, the lower half of my body was uncontrollably shaking. Id try so hard to stop but I couldn’t for about 9 hours straight. I felt like I was going crazy. I kept thinking to myself that I’d rather have a headache than this and I totally regretted going to the ER. I felt like I was stuck in my body and couldn’t get out. I kept trying to sleep it off but I couldn’t. I eventually took melatonin which tired me out some and laid on my stomach for about 2 hrs and I woke up with no shakes. I know for sure that I will refuse this medication for any future medical visit. It is not worth it because my headache came back anyways. Which at the time I’d rather would’ve had the headache. F 20 1 days
1/30/2018
 1  Migraine Almost immediately after the IV was started I felt a hot burning sensation. It became so intense that I had to stand up and pace. It progressively got so bad that I wanted to rip it out and escape from the hospital. I told the nurse who just laughed and said that many others had the same reaction so no worries there. I felt so panicked. As soon as my wife came I fled the hospital in a terrible state. I slept for a few hours but then woke up with raging tinnitus. The tinnitus was deafening and never stopped. I was dizzy and nauseous. I started waking up constantly at night with terror. I had none of these symptoms before. Things continued to deteriorate. When I went to emerge I weighed 150 pounds. Every month after I continued to loose weight until I fell to 112 pounds. I went to so many Drs. trying to regain some control over my life and none of them could identify what was wrong or how to help. I told my family and my wife that my decline in health was directly linked to th My son passed away on December 5, 2017. He suffered every day after receiving that medication. We really hunted everywhere for an answer to what had happened, and how to overcome the negative side effects. We are heart broken. I was the one who took him to the ER and I was present when they gave him that cocktail to ease his migraine.I wish so much that I had never taken him there. His reaction was so dramatic and obvious and we were lulled by the nurse and attending Drs. dismmissive response that we both thought it would just wear off. He has always been so healthy so we were appalled at his rapid decline. Worse was that we were not able to find any way to counter the negative side effects. No side effects were ever discussed with us and if he had known he would never have taken it. The side effects he suffered were rare but still should have been disclosed. This medication is supposed to be used for people suffering from schizophrenia and anxiety disorders. It should not be used so casually for a non psychiatric use such as a migraine. Anyone who has suffered from negative reactions from this medication should report it to the FDA. The company that manufactures this is GlaxoSmithKlyne. This drug had earlier been successfully litigated over poor manufacturing processes. In addition people who have had serious symptoms after being prescribed this drug should consider litigation, a class action suit. This is a very bad drug and needs to be removed from the market M 29 1 days
10mg 1X day
1/16/2018
Email
 1  Headach Yall, I have never in my life felt so crazy. I went to my local ER with complaints of headache that I thought was from my bp. I have no history of migraines. They tried to give me Toradol and Compazine at first but I refused Toradol because it's an NSAID and I can't take NSAIDS due to acid reflux. Walked in calm with a slight headache. After they started IV of Compazine, within minutes, I wanted the IV out. I knocked on the window and told them to take it out because it made me feel woozy. I couldn't rest, couldnt get comfy. Just wanted to go home. They released me andI went home. Had a hard time falling asleep but I finally did. Th next morning I wasnt myself. I was restless and couldn't be still. I thought something was wrong with me mentally because I didnt want my kids around me and I was thinking of hurting myself. At one point of time I was curled up in a fetal position and had convinced myself that I was going crazy. I kept thinking, it had to be the medicine, but I was scared to google the side effects because I was already jittery and panicky and didnt want to see anything that would upset me. So, finally, my kids convinced me to take a drive, and upon getting in the car, I was courageous enough to google info and landed on this forum. I thank God that I did because it saved my life! I knew it had something to do with the medicine. I read where people said that Benadryl was the counteractive drug and it is! I took 1 Benadry 25mg and 15 minutes later, was sleeping lik F 32 1 days
IV
12/29/2017
Email
 1  migraine i went to the ER for a migraine i had for a week straight the minute i told the doctor what was going on she recommended what they called a migraine cocktail.. they gave me benadryl toradol and of course COMPAZINE .. this medication i wouldnt recommend to ANYONE not even my worst enemy. this drug has taken over my life at such a young age. i was given this medication through an IV drip and the minute my nurse stuck it in my arm i was not feeeling like my self. i told him i did not like how it made me feel and none of them seemed to care. automatically i felt my heart start to rush. i got dry mouth so bad and i felt like i needed to rip the Iv out of my arm. i felt so dizzy and tired but could not sleep. i felt confused like i was falling in and out of reality and it blurred my vision so bad i couldnt really recognize my own mom. i got home and could NOT sleep. i would fall asleep for about 5 minutes then i was up then id fall asleep again and would be back up . this happened all night. this drug needs to be banned. worst thing ever!!! F 15
1X day
12/8/2017
 1  Chronic Headaches I’ve had many headache cocktails in the past two years for headaches. Compazine was coming through an IV drip, and the side effects are awful. For me, the side effects included feeling jittery, I could not stop moving and everything felt terrible. This drug is fantastic at inducing panic attacks, and thoughts about having to leave “right now”. Every time I had an IV I thought I would rather be dead. It sounds dramatic, but this drug is terrible. It brought full panic, and feeling like I was going to die if I was left alone. Even after the IV’s would end, a part of the feeling would follow me home, and I couldn’t do anything without feeling completely uncomfortable. F 15 0 days
10 MG
12/7/2017
 1  Migraine/ER visit Uncontrollable shivering; freezing cold feeling; could not sit still; severe jaw clenching Worst feeling ever. Dr put warm blankets on me but it did not help nor did Benadryl. I was given Ativan which helped tremendously to stop the shivering and shaking. F 43 1 days
12/1/2017

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