COMPAZINE Reviews (PROCHLORPERAZINE MALEATE)

Average Rating: 1.2 (501 Ratings)

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 ANTIPSYCHOTICS ANTIMANICS VERTIGO MOTION SICKNESS VOMITING

 Type: Brand name discontinued; available as generic

  

COMPAZINE  (PROCHLORPERAZINE MALEATE):  This medication is used to treat severe nausea and vomiting from certain causes (for example, after surgery or cancer treatment). Prochlorperazine belongs to a class of drugs known as phenothiazines. This medication is not recommended for use in children younger than 2 years or in children going through surgery.    (Sources: U.S. Centers for Medicare Services, FDA)

  

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Key to Ratings: 1=LOW (I would not recommend taking this medicine.)
5=HIGH (this medicine cured me or helped me a great deal.)

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More on COMPAZINE: Reviews Summary  |  Drug Safety Information

RATING  REASONSIDE EFFECTS FOR COMPAZINECOMMENTSSEXAGEDURATION/
DOSAGE
DATE ADDED
 
 1  Nausea due to another medication I believed I'd experienced a stroke; I'm an Emergency Medical Technician and tried to evaluate myself. The entire right side of my face felt like it was in a different position yet in the mirror it looked perfectly normal. I had bizarre outbursts in my attempts to speak. The panic was a nightmare-I wanted to pace like mad but my legs were rubber. When local paramedics arrived, their assessment was a DRUG OVERDOSE! Apparently other outward symptoms were present that I was unaware of. My body was working against me and I went through hell because of it. PLEASE READ THIS! I found out Compazine is in the PHENOTHIAZINE class of medications. I cannot have ANY medications in the ENTIRE CLASS. This includes PHENERGAN and REGLAN, both of which I've been given for nausea due to migraines I suffer that send me to the hospital. I HIGHLY recommend to everyone who has posted to avoid the ENTIRE PHENOTHIAZINE CLASS! My heart goes out to all of you. F 35 4 days
20mg 1X AN
6/14/2010
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 1  Nausea and Vomiting I was given Compazine in an IV when I was in the ER. It helped with the nausea but made me feel terrible. I became extremely jittery and panicked. I felt like my skin was crawling and like I was trapped. It was the worst feeling in the world! F 29
1X day
6/5/2010
 1  abdominal pain,nausea omg, this drug is rediciulus, its day 4 and im still feeling this, i was also allergic to it and it should have been flushed out but its not!! i have bad anxiety, i want to drop out of my skin still, no sleep, i feel like someone new, everytime i look at the mirror is that me? it seems so fake. i hope this ends soon please god! i pray to you please. i warn all of you do not take this! i am only 17 and just had a panic attack and its ridiculous i want to kill myself sometimes, i hope im getting better. i think im going to go to the ER tomorrow to get benedryl again. do not take this EVER!! i warn you! this can linger in your system for weeks on months even counter eracted!! i am still having the systems and i had it may 29th and its june 2nd M 17 1 days
5-10mg 1X O
6/2/2010
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 1  nausea from chemo My wife is going through Chemotherapy so the doctors gave her a prescription for Compazine to help with nausea. She took it as directed but after the 3rd time she had a bad reaction and began to panic. She was walking around the room nervously when i came home from work saying she didnt know what to do that something was wrong. Within minutes of being there with her she started complaining about her eye sight being blurred. Minutes later her jaw began chewing on its own. A few more minutes and her whole face was frozen in a surprised look and she couldnt walk straight. Benadryl was the fix but i dont ever want to see her like that again. Even though my wife had a terrible reaction i cant condemn the drug altogether. People have bad reactions to drugs sometimes, but not everyone. My suggestion is that if your doctor prescribes this drug to you take it. It is a commonly prescribed drug, of course there are going to be negative cases. M 27 1 days
10 mg 3X day
6/1/2010
 1  ulcer relief/nausea Like a lot of you above, I also was rushed to the ER after recieving this drug. My face was twisted and lower jaw uncontrollable. I felt as if a ghost had grabbed the bottom jaw and was slamming it side to side, over and over again. I have been off the medication (I was given the benedryl and epi shots once in the ER) a few days and my jaw is still in agony. Don't risk it, look at how many people have almost died and also been in this much pain. It's not worth it. AVOID AT ALL COSTS F 23 1 days
10mg 4X day
5/24/2010
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 1  Tingling on left side of face My side effects were the same but different from these comments(Thank God)! I actually thought I had the worse case of nausea ever. About 45 minutes of being given the compazine via IV, I started getting very hot from the inside out. I started twitching in my chair. Everything inside of me said, "Get up and run out of here!" I paced for a second and then sat back down. Soon after I sat down, I had no control of my body. My head went back, my arms slumped over the chair and my legs flung out. I could hear the nurses asking me questions but I could not respond. I was mumbling but nothing came out clear. My worst was the nausea. I believe that I could handle any pain better than the nausea that I was experiencing. It was the worst feeling I had ever had. I thought I was going to die. The nurses wet some paper towels and put them on my chest and head. I cooled down some. I could hear the Dr. say, "If I were you, I would never take that medicine again". No one should ever go through what I went through. Patients don't know what they are being given. They should be warned about the side effects of medicines. But, no one should ever be given compazine. F 51 1 days
IV 1X day
5/6/2010
 1  Migraine I had my 1st and only migraine and went to the ER. They gave me Compazine, Benadryl (50 mg!), and Toradol (30 mg) intravenously and within minutes I felt a huge wave of panic and could only tell my husband, "Something's wrong! Something's not right! Get the nurse now!" I had never had anxiety problems before then so all I could tell the nurse was something was really wrong. She left and I felt like ripping the IV lines out of my arm and running out of the hospital. My whole body was twitching and I couldn't sit still for even a second. THE WORST EXPERIENCE OF MY LIFE! It felt like I was trapped inside my body fearing for my life! The nurse came back and gave me 1 mg of Ativan and within a few minutes I was knocked out, not just tired but unable to stay awake for even 30 seconds. I was so out of it I couldn't even sign my discharge papers. For the few months after that I was having random panic attacks and had to get a prescription for Ativan from my doctor to take when DO NOT TAKE IT!!! I would have loved to have just been nauseous rather than have gone through that feeling! F 27 1 days
10 mg 1X day
5/5/2010
 1  nausea i was given compazine in the emergency room several times before and once while in the hospital, early this week i was given it through an i.v. and when i got home i started feeling "weird". about 45 minutes later i started experiencing the bad side effects. i felt like i was crawling out of my skin, i had uncontrollable movements of my neck/face, i had to get up and move A LOT, i couldn't sit for more than a minute. i've had good things with compazine previously but this time, it struck me wrong. i had taken 5 mg of compazine when i got home because i did not realize that these side effects were from compazine. i've been in the emergency room 3 night in a row with anxiety because i feel as if i'm gonna have another compazine "attack". the doctor told me, NO MORE COMPAZINE FOR YOU. I WILL NEVER TAKE THIS MEDICINE AGAIN! please be aware of the BAD SIDE EFFECTS. i am very sorry for those of you that have had the same thing happen to them. for those who don't have any problems, you're lucky. F 18 1 days
5 MG 1X day
4/25/2010
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 1  Severe Nausea/Vommiting Worst feeling ever. I would much rather go through severe nausea or one of my migraines than feel like I did on compazine again. I felt like I was crawling out of my skin. I was pacing back & forth, couldn't sit still. When I tried to lay down, I couldn't stay in the same position. I became panicked & couldn't stop crying. My legs & arms were twitching unbearably!! l remember screaming "I just want to die", because I couldn't stand the miserable feeling I was going through. I called the nurse hotline, & the nurse told me it was a common side effect & it should go away within 24 hours. NO WAY was I going to suffer like that for a whole 24 hours, so I went into the ER. They gave me an IV with two meds: Benadryl & Cogentin. Within less than 5 minutes, I felt completely better. Thank God for Benadryl & Cogentin. I will never take this med again. If you're going to take this med, make sure you are aware of the SEVERE side effects and keep benadryl on hand. I think it should be pulled from the market. F 22 1 days
10 MG 2X day
4/9/2010
 1  severe nausea imbalanced IV fluids ***ACUTE DYSTONIA*** felt like my head was a balloon floating away from my body; eyes bugging out of my eye sockets; tongue movements rolling around uncontrollably; neck forcibly twisting -- awful, awful awful! I was treated with IV Benadryl (diphenhydramine). F 25 2 days
4X AN
4/6/2010
 1  Migraine-pre-eclampsia Severe tremors, muscle spasms of jaw and neck. Restlessness, panic. Was given Benedryl as an antedote and it did nothing to help. Despite 2 shots of Versed, the reaction did not stop. My Water broke during this whole ordeal and I ended up delivering my son 3 weeks early via c-section while I was having this horrific reaction to Compazine. I have recently been given Reglan with a Benedryl pre-treatment and I had a similar reaction. DO NOT take Reglan if you have reacted to this drug-they are very similar. For me, Benedryl IV also causes a milder version of this reaction. F 33 1 days
1X day
3/15/2010
 1  flu-like symptoms I started to have blurred vision, I was seeing double. My tongue swelled up, blocking my airway and making it difficult to breathe. My neck jerked to the side and I could not straighten it. I had involuntary muscle spasms, dizziness, and was drooling with a grimace look on my face. I couldn't even talk to explain the reaction I was having. All of these oddities caused extreme anxiety, paranoia, and fear. I couldn't stand the reaction because I thought I was dying and went to the ER. Please have them administer an IV of Benedryl to counteract this terrible drug. Benedryl seemed to alleviate these side effects but it was a slow and painful process. If you continue to feel this way, tell them you NEED more Benedryl to counteract this drug. It was one of the scariest experiences of my life and if you experience ANY of these side effects, NEVER take this again. F 20 3 days
2X day
3/10/2010
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 1  Migraine Muscle rigidity(especially neck and face), throbbing headache, pounding heart, restlessness panic, jitters, shakes lingering anxiety. This medication honestly made me think "this is what hell feels like". I was completely inconsolable, couldn't stop moving but had extreme drowsiness at the same time. I felt like i wanted to jump right the hell out of my body, like I was going in and out of reality. Every time I thought it was wearing off I experienced another wave of panic. The muscle rigidity was HORRIBLE in my neck, jaw, shoulders and back. In had a permanent grimace on my face. All in all worst ER experience of my life and that includes when I spiral fractured my tibia! Please please use this with caution! To all of you who experienced or are experiencing this my heart goes out to you. <3 hang in there! F 28 1 days
Not sure 1X day
3/5/2010
 1  Migraine (Concussion) The same as everyone else. Severe anxiety, felt like crawling out of my skin. Dry mouth, I could barely breath, my throat was so dry it stuck to itself. I couldn't cry, I had no tears. I panicked, attempted to rip out my IV. I couldn't swallow. Doctor refused to give me water. I had to be given potent sedative since i had originally been giving Benadryl AND Compazine.. I told the nurses I was allergic to Reglan (same family) the nurse thought I was exagerating and informed me it was an ADVERSE REACTION not an ALLERGIC reaction. Told me to take Benadryl before taking reglan. Before I knew it she was shooting me up with Benadryl, I asked why, she said just incase the Compazine had side effects since it was similar to Reglan "but better". As soon as she started pumping the Compazine in, I knew it was wrong, it burnt my veins. Reglan ALWAYS burns my veins when I get IV. Was told to NEVER take Reglan again by different hospital. Nurse REFUSED to believe me. went against my wishes and gave me something WORSE and more potent. Many individuals are inherently allergic to this medicine. That means it is NATURALLY POISONOUS. F 23 1 times
not sure 1X O
2/11/2010
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 1  Vomiting 5 min after I got compazine IV I felt like I wanted to crawl out of my skin. I am an RN in the ER. I have given this medication many times and seen reactions but never knew how bad it makes you feel. I am two days out and still feel like I have the jitters. One dose and NEVER again. F 33 1 times
1/19/2010
 1  vomiting Anaphylactic shock- blurry vision, seizures, low blood pressure, heart arrythmia, airway constriction, loss of consciousness I almost died from this medication! I was lying in an emergency room unable to see or speak and my tongue was swelling by the second blocking my airway. I could hear the er staff saying how my blood pressure was dropping. This was an experience that haunts me everyday since this happened 11 years ago. Anaphylaxis will kill you within minutes if not immediately treated. DO NOT TAKE THIS MEDICATION UNLESS YOU WANT TO KILL YOURSELF! F 31 3 days
1/14/2010
 1  Nausea I have to say I posted here recently. Posting again. I had 2 doses of Compazine and got acute akathisia. It's been almost THREE WEEKS now and I'm still suffering greatly. I had a few days of feeling back to normal. I thought it was gone. But it wasn't. Came back. The restlessness is improved a bit, but wide awake, can't sleep, go several nights in a row NO SLEEP. And EXTREME TERROR and mental agitation. Can ANYONE give me ANY hope that this will resolve soon. I see most have it a day or a few days. Sometimes 3-4 weeks. Will it end soon? Did anyone else have it linger and wax and wane like this? Please any info/hope would be so much appreciated. I'm so sorry for ANYONE who has ever gone through this :(( F 41 2 times
1/9/2010
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 1  severe morning sickness 1st trimest had no idea that others had the same reaction to this stuff that i had. i felt as A feeling a sheer terror completely took over me. I didnt actually rip the iv out of my arm, but i did run fleeting down the hall of the ER while naked wearing nothing but the open hospital gown and dragging the IV pole behind me. I was convinced that the doctors were all plotting to kill me. It was completely irrational but i couldnt convince myself that it wasnt true. I felt like the walls were closing in on me and i was trapped. It wasnt until about 3 or 4 doctors or nurses grabbed me and held me down and gave me a shot of benedryl that i began to feel better. This stuff is the worst and i'd much rather have morning sickness before i ever take that drug again. Im so frightened by the effects that whenever i go to a hospital or Dr.s office and they ask for any allergies to medications i immediately let them know that under no circumstance am i to be given Compazine!!! F 20 1 days
1/4/2010
 5  migraine Jittery, drowsy I received compazine IV in the ER F 24 1 times
12/28/2009
 1  migraine Severe apathy, muscle spasm, grimacing, extreme nausea (worse than what I was trying to cure!), dysphoria, insomnia. My reaction to this stuff was awful! I went to the ER and they knew what was up, gave me benadryl, which didn't help. I had severe problems for about 3 days, ended up having to get fluids in the ER on day 2, and lingering anxiety for quite a while after I took this. F 32 1 days
12/28/2009
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