COMPAZINE Reviews (PROCHLORPERAZINE MALEATE)

Average Rating: 1.2 (501 Ratings)

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 ANTIPSYCHOTICS ANTIMANICS VERTIGO MOTION SICKNESS VOMITING

 Type: Brand name discontinued; available as generic

  

COMPAZINE  (PROCHLORPERAZINE MALEATE):  This medication is used to treat severe nausea and vomiting from certain causes (for example, after surgery or cancer treatment). Prochlorperazine belongs to a class of drugs known as phenothiazines. This medication is not recommended for use in children younger than 2 years or in children going through surgery.    (Sources: U.S. Centers for Medicare Services, FDA)

  

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Key to Ratings: 1=LOW (I would not recommend taking this medicine.)
5=HIGH (this medicine cured me or helped me a great deal.)

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More on COMPAZINE: Reviews Summary  |  Drug Safety Information

RATING  REASONSIDE EFFECTS FOR COMPAZINECOMMENTSSEXAGEDURATION/
DOSAGE
DATE ADDED
 
 1  Migraine I was given Compazine and Benadryl through IV at the ER for a severe migraine and it was the worst experience of my life. Within 2 minutes I wanted to rip the IV out off my arm. My entire body was restless I couldn't sit still. I was pacing around the room when seconds before I was laying down relaxed, I couldn't breath and my heart was pounding. The most miserable and uncomfortable experience of my life. I screamed for the nurse that something was wrong and she said “this is normal.” They gave me zero warning this could happen. I would rather suffer through a 3 day migraine than ever have to experience that misery ever again. NEVER take this drug!!! If you go to the ER for a migraine ask what they are giving you! They gave me zero warning that this reaction could happen!!! I've taken Benadryl many times for allergies and have never had an issue so I know this reaction was caused by the Compazine. F 23 1 days
1X day
5/8/2021
 1  Post Lumbar Puncture Headache I was administered the drug in the ER due to a headache from a lumbar puncture I had a few days prior. Within 5 minutes of getting the drug, I felt like I was having a panic attack and couldn't breath. I wanted everything off of me including my blood pressure cuff, IV, shoes, etc. It's been 36 hours since I got the drug and I still feel a horrible feeling of anxiety. Do not take this drug. I know most of the people reading this message are here because they had a bad experience prior to finding this website, but don't let your family members take it either. I would rather feel nauseous and have a migraine than feel like I did after taking the medication. M 35 1 days
10 MG 1X day
4/27/2021
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 1  Migraine Was given this for a migraine along forth torodol and Benadryl. With in a 5 minutes, I felt like I was going crazy. I asked to use the bathroom and I was pacing in the bathroom. I couldnt take it anymore so when I got back to room I pulled my IV out and went home AMA. I hope this helps someone. I went back to ER and they said I was having a reaction. My foot kept trying to lift itself which was scary and uncomfortable. The ER doc gave me a shot on Benadryl and Cogentin which calmed down and stop my foot for moving. I still have the shakes in my hand I'm hoping it goes away. Has not been 24 hours yet but things are much better. They also told me to take Benadryl every 4 to 6 hours which helped get the anxiety at bay. M 37 1 days
1X day
4/15/2021
 1  Migraine within 2 minutes of my daughter getting this medication in her iv with toradol and benadryl for a migraine she wanted to rip out her iv and was begging to leave the hospital. I thought she was startled because it was the first time she had iv medication and was not expecting the medication to work so quickly and the nurse came in and got her to lay down and she fell asleep. I thought that was the end of it. I looked up the medication as I had never heard of it and was shocked to see she was not the only one with this reaction. Later she woke up at home still anxious dizzy and she is still suffering the effects a full day an a half later. I had to pick her up from school because they called and said she was shaking and crying uncontrollably in panic. This medication should be discontinued and not given due to the side effects it has especially ot to minors. My daughter is 15 and is still scared out of her mind in her own skin. This drug should be TAKEN OFF THE MARKET!!!!! F 15 1 days
1X day
4/1/2021
Email
 1  Stomach bug Dystonia and anaphylaxis Terrible medicine. Caused a dystonia and anaphylaxis reaction. My body seized up in a contorted position and my throat closed up. After epinephrine and Valium I was sent to the ICU. F 3 days
1X day
3/30/2021
 3  Oshner hospital Felt jittery and like i wanted to move but i felt sleepy also,and like i wanted take out my ive Felt like i had like silver in my mouth or lead F 31 1 days
Dont know 1X O
2/23/2021
Email
 1  Nausea headaches Feeling not like my self restlessness and not being able to sleep anxiety over the roof I went to the hospital last night for headaches gave me this medicine I was fine until I got home and started having anxiety and freaking out bad it's better than last night feeling but still feeling uneasy and like I need to flush It out my system I am on my way to the doctor now to see what they can help me with! I wish I could just drink water and flush it out my system. Has anyone started to feel better ? And if so how long did it take you ? F 28 1 days
Unknown 1X day
2/19/2021
Email
 1  Headache I was given a mix of benadryl and compazine for a bad headache at the ER and immediately once they put it in the IV I began feeling terrible. It made me anxious, jittery, like I had to move my legs, made my head feel super weird, and I felt trapped in my body. Super hard to describe but I hated it. The doctor listed it as an allergy my reaction was so bad. The feelings lessened after a few hours for the most part but my head was feeling weird for about a week after. F 20 1 days
1X day
1/24/2021
 1  Headache I was given compazine and Benadryl for severe headache and as soon as it was pushed threw the IV I felt like I was gonna die and I could barley breathe. It was so scary and I was so convinced that I was gonna die that night. I would not recommend letting them give you this combination of meds ever. I also had uncontrollable facial movements for about a week I keep puckering my checks. I was scared that would be permanent but thank the Lord it went away. F 39 1 days
20mg 1X day
12/29/2020
 1  Anti nausea Panicking attack, fast heart rate, uncontrollable shaking, excess sweating. They gave me it to prevent nausea when I was in hospital. Within minutes I started having a panic attack. Freaked out, felt like I was trapped and dying. To make matters worse, they gave me benadryl to try to stop it but within seconds my heart rate went out of control and over 165bpm. I was seconds from cardiac arrest, the scariest situation of my life. Worse part, I come home to continued panic attacks. I felt like I was going through detox. It was horrific and here I am on day 3 and still feel like crap. F 31 1 days
1X day
12/24/2020
Email
 1  Migraine Yess!! Omg !! I feel like I'm going insane. I was completely fine until I went to the hospital for a migraine and they gave me this drug. I was completely fine and have been on the verge of panicking since. I kept coming in and out while driving home. Couldn't move from my bed without feeling like I was going to pass out or die. It was the most awful thing in the world. 5 days later I cannot shake this feeling. It's better but I can't completely feel normal ! I can't even sleep without taking Ativan Don't take it please don't. F 26 1 days
? 1X day
12/13/2020
Email
 1  Migraine cocktail Horrible drug made me feel insane and still do. Super vivid dreams, but only could sleep for 1 hour before jolting awake and having to pace for hours and hours hope it ends soon so I can eat and sleep. DO NOT TAKE THIS DRUG!!!! M 22 1 days
20mg 1X day
11/25/2020
Email
 1  Migraine cocktail I went to the er and they gave me compazine and Benadryl right after I felt like I was dying couldn't sit still wants to rip my legs off I will never take this drug again worse experience in my life the only thing that helped me was the ativan they gave me F 34 1 days
1X day
11/22/2020
 1  Migraine This medicine definitely needs to be discontinued!!!! I felt like I was dying, I was given this medicine through iv yesterday at about 10am in the emergency room and I was so scared trying to drive home, I kept having visions of my uncle who recently passed. Made it home safely thanks to the good lord and prayer, once I got home it felt as if it intensified, I felt weird, legs and arms extremely jittery, nauseous and no appetite I have not eaten since monday night and it's now Wednesday at 2:21. I even called the hospital back and the nurse said these are normal side effects and that it should wear off within the next day or so! I WILL NEVER GO TO THE ER FOR ANOTHER HEADACHE!!!!! I feel worst than I felt when I initially went there for help. I wish I could do something to have this drug removed seriously!!!!!! I wish I would have googled the drug first but i am relieved to know i am not going crazy that someone else has felt this. I really wish I could start a campaign/ boycott or something because this should be illegal!!! F 36 0 days
Iv 1X day
11/11/2020
Email
 5  Nausea related to cancer treatment On my second treatment (2015) for Splenic Lymphoma I threw up Zofran. They switched me to Compazine and I had no further issues, and experienced no known side effects. It worked great for me. M 45 3 years
30 MG 1X day
11/8/2020
Email
 1  Neck pain and headache I felt like I was going to die! My blood pressure went threw the roof. I could barely speak. I became so thirsty. This went on for thirty minutes I was given this in combination with metoclopramide 10mg, ketorolac 15mg. 33 0 days
50mg 1X day
11/5/2020
Email
 1  Migraine in ER This is the worst thing that happened to me life. I went to the ER like everyone else I see in here for a migraine. They gave me toradol and compazine for my headache. Immediately after receiving this medication in the IV I started trembling uncontrollably. I told the nurse and they gave me Benadryl which lead to the worst experience of my life where I was so exhausted from the Benadryl that I couldn't move, but I was still trembling inside and couldn't tell anyone. So I was essentially stuck inside my body shaking but also unable to move. This continued for hours even after I got home. I took a bunch of Xanax and managed to sleep for a bit. Fast forward 5 months and my life is falling apart. I have developed serious panic attacks, anxiety, and trembling that does not go away. This drug has ruined my life. Never ever ever ever take this drug! F 37 1 days
Not sure 1X day
11/3/2020
Email
 1  Nausea from high dose chemotherapy Thank you for sharing your experience with this horrible drug. I thought I was the only one but then found this site and see so many others who had the same negative response to compazine that I had. Everything you described is what I felt when I was given it in my IV during high dose chemo for bone cancer. I literally wanted to jump out of the hospital window the anxiety was so bad. My sweet nurse held my hand and talked me through it as I cried until they could give me some high dose Xanax. It was terrible! F 40 1 days
IV dose 1X day
9/29/2020
Email
 1  Nausea Anaphylaxis Don't take this med! 50 0 times
30mg 1X day
9/26/2020
Email
 1  Migraine cocktail Extremely jittery can't sleep or stop moving F 42 0 days
1X day
9/25/2020

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