COMPAZINE Reviews (PROCHLORPERAZINE MALEATE)

Average Rating: 1.2 (501 Ratings)

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 ANTIPSYCHOTICS ANTIMANICS VERTIGO MOTION SICKNESS VOMITING

 Type: Brand name discontinued; available as generic

  

COMPAZINE  (PROCHLORPERAZINE MALEATE):  This medication is used to treat severe nausea and vomiting from certain causes (for example, after surgery or cancer treatment). Prochlorperazine belongs to a class of drugs known as phenothiazines. This medication is not recommended for use in children younger than 2 years or in children going through surgery.    (Sources: U.S. Centers for Medicare Services, FDA)

  

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Key to Ratings: 1=LOW (I would not recommend taking this medicine.)
5=HIGH (this medicine cured me or helped me a great deal.)

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More on COMPAZINE: Reviews Summary  |  Drug Safety Information

RATING  REASONSIDE EFFECTS FOR COMPAZINECOMMENTSSEXAGEDURATION/
DOSAGE
DATE ADDED
 
 1  Migraine and Nausea WORST DRUG EVER. Did not help my migraine, and made me want to crawl out of my skin. I was so anxious and had to keep moving my legs and arms around. Could not get comfortable in the hospital bed. I didn't realize what was the matter until I read this site.. They had to give me ativan and it helped a bunch. F 20 1 days
1X day
10/2/2011
 1  anxiéty Feels like my tongue is partially paralyzéd, clenching/grinding téeth, biting tongue in Sleep. Slurred speech. Extreme fatigue. I am currently experiencing the effects of this drug. I took it for 3 days. I slept away the first 2. The effects set in full force around day 2 or 3. Scared me badly. Went to the doc and she said to stop taking it (already did) and the effects would wear off in 48 hrs. Its been over 72 hours since i stopped and the side effects are still here.im totally freaking out. Thats why im on here at midnight. M 36 3 days
10 mg 2X day
9/28/2011
Email
 1  pregnancy nausea Severe anxiety with suicidal thoughts & desire to kill my unborn baby, combined with inability to sleep, shaking, racing heart, unclear thoughts... like a bad trip off recreational drugs Do NOT take this medication. I have never had a worse psychological reaction from any other drug in my life. I love being a mom and am looking forward to our new baby. This drug made me want to kill myself- if my roommate wasn't here I may have. VERY dangerous and no one warned me about this at all. At the hospital I wanted to rip the IV out and run home... I did not know where to attribute my feelings and assumed I was just sick of being in an ER for 5 hours. Luckily I drove home OK, and then things got much worse. What a nightmare. I am still not doing well but I took benedril today and it helped me get some restless sleep. I hope this anxiety goes away soon and I can return to normal life. F 30 1 days
1X day
9/19/2011
Email
 1  went to ER for migraine & nausia i just wish i had come across this site sooner! last sunday morning i went to ER because of my migraine and first thing they gave me was compazine and benedril , immidiately i felt like a blender was inside me , and just like everyone els said i wanted to get the heck outa there and run! 2 days have passed and iam still feeling the effects and didn't even know it was because of the drug , so i started researching and here i am! i hope this goes away soon , worst feeling ever. i still feel nervous and restless inside and can't go to sleep. i have an appointment with a great doctor today, i will post results soon. M 27 1 days
10mg 1X day
9/13/2011
Email
 1  nausea Dystonic reaction. Neck, jaw, and back all moving uncontrollably/having spasms and painful and stiff. Took one 10mg pill and started having progressing symptoms within hours. ER gave up to 100mg of IV benadryl which only slightly decreased the symptoms. Eventually IV valium stopped it fully. Never had a bad or allergic reaction to any medication or anything before in my life. One and only time I have ever needed to go to the ER. F 20 1 days
10MG 1X day
9/3/2011
 1  Chronic Nausea and Vomiting Besides the restlessness and anxiety, I experienced very unusual symptoms including a locked jaw and involuntary movements of my tongue. The first symptoms after taking this drug were subtle. I felt restless and tired at the same time. My mind was out of control, though I sensed my body was exhausted, my brain remained restless and would not allow me to sleep or rest. At this point, I didn't make the connection between these symptoms and the drug. A day or two go by and I was still taking the medication, until I realized my tongue was slightly arched toward my throat beyond my control. Still, I thought nothing of it and hoped it was just my imagination. Eventually it got to the point where it made my breathing difficult and my jaw started to act up as well. My jaw would open, again involuntarily, to the fullest extent, painfully stressing my jaw bones and muscles. Then my jaw would close shut, pressing my teeth together with a crushing force. It cycled back and forth several times and I could almost feel the drug rushing through my face as I experienced these symptoms. I finally went to the hospital and they gave me an IV of Benadryl and the symptoms faded away. By far the worst drug I have ever taken. This should be off the market, and banned universally. I was told that only a few people were allergic to this drug, and I was one of the few, but I think that's just an excuse for drug makers to extend their profit margin regardless of it's dangers. M 21 2 days
1X day
8/30/2011
Email
 1  Spinal fluid leak headache I was "jumping out of my skin". Shaky, felt I was going to die. Had no control. Can't believe I am not the only one that had the jumping out of my skin reaction after put in IV. After that horrible feeling and reading these comments, I think they should not give in IV unless they know if patient has had oral dose and was ok with it. They should also have emergency stop plan instead of nurses saying there isn't anything we can do. Has to work through your body. F 35 1 days
Unknown 1X day
8/27/2011
 1  Migrane/nausea Wow im reading all of the rating and i wished i wouldve knew about compazine before it was inserted in me =/ i went to the hospital for migrane. they told me they were going to give me compazine. Maybe after 3 minutes I began to feel anxious. I wanted to leave the hospital ASAP! After the compazine they inserted fluids through iv. I swear i felt like i wanted to rip out the iv and run out. I honestly thought the anxiety was coming from being in the hospital but when i was discharged i went home and i got an anxiety attack. I remember me shaking and having trouble breathing. This has been by far the worst feeling ever!!!!! I could not sit still and i felt as everything would annoy me. I finally took a sleep aid and slept for about 4hrs when i woke up i was feeling better BUT i did not feel like myself. The anxiety was had warn off but i could still feel the side effect. Took about 2day for me to feel completely NORMAL and MYSElF. I will definitely stay away from compazine! Made me feel the worst feeling i have ever felt in my life =/ My experience was horrible with this drug!!!! F 20 1 days
idk 1X day
8/26/2011
Email
 5  severe migraine man... i'm not quite sure what happened to me a minute ago. i was laying down sleeping.. at exactly 12:01 am. and woke up having a flashback about the night that i had to take this drug. then i couldn't sleep, so i jumped on the computer and found this site... so yes, the drug did help, but the agony that my body went through was enough to wish i had died at that time! there's no other way of explaining it... i had hot flashes as soon as the nurse put it in my iv while saying, "some patients say that their skin crawls or feel as if they're soul is leaving their bodies" WELL she was EXACTLY correct!! i looked over at my mom and said "i think i'm going to die!!!!" and couldn't stop rubbing my arms and heels on the bed frantically or turning my head from left to right rubbing the back of my head on the pillow... there's no other way to describe the feeling other than would rather have been dead at the time that it went into my body. oh yea, i also had severe temperat it works, but damn if it doesn't make you go crazy. F 26 1 times
1X day
8/25/2011
Email
 1  nausea I couldn't concentrate or see well. My neck and jaw stiffened. I drooled. I thought I was going crazy. It was a horrible experience. I was put on Valium for 2 days. F 26 2 days
1 3X day
8/23/2011
Email
 1  severe vomiting This DRUG WAS AWFUL. Exactly the same as everyone else. The hrrid symptoms lasted for almost three days and I only had one IV dose of it for severe vomiting and nausea due to an allergy to caramel coloring. Just like everyone else I felt crazy. Like I wanted to get up and run around, but then when I would get up and walk it felt like that wasn't right either. Antsy is an understatement, I just felt crazy, like my thoughts weren't my own. I do not understand how this drug is even legal. Finally, after three days of not sleeping and one meal, I finally could sense myself returning to normalcy. F 33 1 days
1X day
8/23/2011
Email
 1  Went to ER for migraine / nausea Sat straight up in the hospital bed & told my mom something was wrong and told her to get a nurse because I was shaking and jittery. My skin was crawling & I couldn't stop shaking. I felt like I had to get out of the hospital ASAP. Nurse gave me a shot of benedryl to counteract the reaction & they sent me home. Felt same symptoms the next day and went to my family doctor. He told me it affected my central nervous system that's why I felt that way and the only way to stop that shaky feeling from lasting is to take Valium (a muscle relaxer that relaxes your CNS) for 3 days, three times a day. You sleep for pretty much 3 days but it took that feeling away & I felt back to normal by the 3rd night. I would recommend phenegran for nausea! F 19 1 days
1X day
8/21/2011
Email
 1  Nausea My initial reaction was anxiety and the feeling of wanting to kill myself. I have never had anxiety or suicidal feelings before. The reaction progressed to chest pain, tachycardia (160 beats), and then unresponsiveness. They gave me Benadryl and I came out of it, but still felt anxiety. So they gave me Ativan. I went home and felt better. The next day and for the past week and half now I have had chest pain every day. I have also been anxious with hot flashes and thoughts of harming myself. I went to the ER on Thursday (8 days after being given Compazine) for chest pain and anxiety. They did an ECG and cardiac work up. Nothing was found. They gave me morphine and ativan to calm me down and sent me home. I went back to the ER yesterday (Friday) because I wanted to kill myself. They offered for me to go to a Psychiatric Hospital for a week. I told them that I really think it has to be related to the compazine reaction because this was not my normal self. They gave me Ativan and I felt li This drug is awful! It should not be allowed to be given for nausea! F 34 1 times
IV 1X O
8/6/2011
 1  I had horrible nausea I was 18 at the time. The 1st day I was really 'antsy' I couldn't get comfortable just sitting still. I was constantly shifting my body around. That lasted for 2 days & got worse as the days progressed. By the 3rd day I lost control of my neck muscles. My head felt so heavy & could not hold my head up. Or keep it from falling backwards. It then turned to a strong attack where my neck would relax & then force to back farther than it should go, it did this also turning my neck farthest to the right side twisting it very painfully beyond where it should go. My back would arch at the same time, & my tongue was completely numb, my eyes were wondering. My mother said I looked possessed. It was so painful & scary not having control. I went to the er & they gave me a shot of bennadryll, & sent me out the door before I 'calmed' down it was all a horrible experience. Will never even look at compazine, I'm highly allergic to anything in the compazine family as wel Horrible! F 27 3 days
? 2X day
8/4/2011
Email
 1  headache uncontrollable shaking, restlessness, severe anxiety, impending doom I was pregnant and complained of a headache, dizzyness, extreme fatigue, and irritability. I was given a combo of compazine and benydryl via IV drip with fluids. Immediately, I felt all of the symptoms I decribed. Never have I felt so scared in my life. I wanted to scream out for help, but the drugging effect rendered me unable to articulate how I truly felt: hopelessness. I felt like I was being tortured. The worst experience of my life. 35 1 days
unknown 1X day
7/26/2011
 1  Headache, nausea I was given this drug in the ER (combined with benadryl) because of a headache / what they thought might be a migraine. Within minutes of getting the drug I felt so anxious I couldn't stand it. I felt like I wanted to scream! I felt like I had to move my legs. I got up from my bed and kept pacing around the room. This was right before getting a spinal tap and holding still for that spinal tap was next to impossible and then I wasn't able to lay down afterwards. I was up until 4 AM (drug given around 9 PM) pacing and wanting desperately to just collapse into unconsciousness. I managed to sleep a little after taking benadryl but I still feel very jittery and uncomfortable this morning. This drug is incredibly dangerous and considering the high possibility for this side effect I think it should come with a warning or possibly be banned entirely. M 27 1 days
? 1X day
7/21/2011
 1  headache OMG. This is the worst drug EVER. OMG. I was in the ER for the migraine from hell when they decided to give me this medication. Within minutes, I wanted to beat people up and run out of that damn place. It made me FEEL schizophrenic. I wanted to LEAP out of my own skin, I had to get the hell out of that place. Sure, the headache was gone, but now, I was some raving lunatic threatening the ER staff. It made me violent, angry, and anxious-all at the same time. N E V E R again. N E V E R A G A I N F 35 1 days
1X day
7/19/2011
Email
 1  Migraine They gave it to me in my iv with benadryl to lessen the side effects,as a health care person that should have alerted me i started to feel severe anxienty like i was going jump out of my skin and die!! I felt like i was going crazy, i called my husband and wanted to leave the ER, I will never take this for anti-emitc there are better ones out there. I had to go home and take anti-anxitey pills days after now this pill is going on my Allergic to do not give me list stay away. F 34 1 days
10mg 1X day
7/17/2011
 1  headache/lightheadness i went to the hospital for a headache and feeling light headed. I was given compazine, reglan and benedryl through an iv. Within 10 mins i started feeling panicky and "wierd" i called the nurse in and told her they checked my pulse and it was 150. They said i was having an anxiety attack. I felt like ripping the iv out of my arm and after serveral minutes of asking them to take it out i did just that! I felt terrible. After about an hour i started feeling a little better but still not like myself. I went home and tried to sleep it off but could not sleep. My heart was racing and i couldnt be still. I went back to the hospital and was given ativan finally i was able to sleep. Its been 3 weeks later and im still feeling the affects of this medication. Some nights i cannot sleep without taking the ativan. I feel restless and extreme anxiety and sometimes depression. I have talked to a therapist and in a week going to get a mood stabilizer. I feel like i am going crazy some days. Dont take this medicine!!!! Its better to have a headache then to suffer from the horrible side effects of this medicine F 21 1 days
not sure 1X day
7/6/2011
 5  migraine None, worked like a charm when combined with benadryl. Standard of care is not narcotics like most of the comments would suggest. M 50 1 days
10 1X day
7/3/2011
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