DEPO-PROVERA Reviews (MEDROXYPROGESTERONE ACETATE)

Average Rating: 2.1 (2471 Ratings)

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 ESTROGENS PROGESTINS ANTINEOPLASTICS

 Type: Rx Drug

  

DEPO-PROVERA  (MEDROXYPROGESTERONE ACETATE):  This medication is used to treat certain types of cancer (such as uterine cancer, kidney cancer). Medroxyprogesterone is like a natural hormone called progesterone made by the body. It is usually used with or after other treatments (such as radiation, surgery). Medroxyprogesterone may prevent or slow the worsening of the cancer and decrease pain and other symptoms.    (Sources: U.S. Centers for Medicare Services, FDA)

  

Results are sorted by Age from youngest to oldest (reviews with no age reported listed first).

Key to Ratings: 1=LOW (I would not recommend taking this medicine.)
5=HIGH (this medicine cured me or helped me a great deal.)

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More on DEPO-PROVERA: Reviews Summary  |  Drug Safety Information

RATING  REASONSIDE EFFECTS FOR DEPO-PROVERACOMMENTSSEXAGEDURATION/
DOSAGE
DATE ADDED
 
 4  birth control Gained about 20 pounds over the first 2 years. No periods aftter 6 months. No pregnancy in 10 years so very effective. No complaints while on depo, but in retrospect I have some doubts. I've been off it for about a yr, and have found that my moods and my reaction to stress are now much better but perhaps just a coincidence. F 32 10 years
9/9/2004
 3  Birth control, ovarian cyst Weight gain, decreased sex drive Love the convenience, but have gained too much weight. Stopping for the time being to see if I can take the weight off. Also, my husband is concerned about the sex drive, or lack thereof. F 32 6 months
7/3/2004
 3  nurse I haven't taken Depo. However, I can tell you that A LOT of the problems described in the No drug is great for you... it is a risk benefit thing... I think for MANY it is way better than getting pregnant, especially for their undesired offspring... F 32
11/15/2004
 3  to prevent pregnancy severe headache, bloated, tired. depression, and crazy mood swings F 32 6 months
30 1X M
8/10/2011
 3  Pregnancy prevention Non-stop bleeding, breast tenderness, mood swings I took the shot for the first time in May 2010, the first 2 weeks I was an emotional wreck, but just as soon as those symptoms came, they left, never to return again. In that 2nd week I began to bleed, and it was more than just spotting. It was thick and dark brownish in color, to the point that I had to wear tampons almost every day for the entire 1st 3 months. I suffered terrible migraines and cramps during my periods prior to getting the shot and havent had any problems since. Thank goodness. I do not miss those at all. My breast continued to be sore on and off again over the whole 3 months, but other than the constant bleeding I don't have a problem with the shot. I have experienced a decrease in appetite and actually lost 12 lbs in the first 3 months. Was going to change methods this time but heard that the bleeding can get better after the first one is over. We'll see. I just got it today. If it doesn't get better and I dont stop bleeding, then I will switch. Rather have my period one week a month than every week of every month. Did not get depressed, gain weight, develop acne, have mood swings, night sweats, low sex drive, or any other symptoms listed on here...just the bleeding. I guess I'll find out what the next 3 months have in store for me. It would be perfect if I would just stop bleeding!! F 32 3 months
1X AN
9/14/2010
 2  Birth Control Major Weight Gain I started taking the shot when I was 16. It was great for a while. No periods. I had no side effects whatsoever. It was the best thing since sliced bread. Then I got into my early 20's. Around the age of 22 I started gaining weight like crazy. I would diet, exercise. Nothing was making the weight come off. And I am a very small person. Anyway, I gained 20lbs. I was up to 145lbs. The heaviest I had EVER been. Then one day I was researching and I heard about all of the horrible weight gain stories. So....I stopped getting the shots and lo and behold, I lost every bit of that 20lbs without even trying really. My normal weight is 125lbs and I am able to stay there without much difficulty. If it weren't for the weight gain, this would be a great method because I didn't experience any of the other typical birth control side effects like I have with other things I've tried. F 32 8 years
1X AN
6/8/2011
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 2  birth control aggression, significant hair loss, bleeding, uncannily increased appetite My appetite increased so much that I could eat until I hurt and still be hungry. Despite my increasing fiber and liquids in my diet, I gained thirteen pounds in three months. The medical literature refers to appetite increase as a F 32 3 months
5/10/2004
 2  Prevent pregnancy Ive experienced lots of weight loss since ive been taking the depo over the past two years. In the past of my younger years Ive maintained my weight n picked up a few pounds. Im not liking the results this time so im going to let it go. F 32 2 years
1/30/2017
 1  birth control Bloating, stomach pain, intermittent bleeding, migraines, increased hunger, ridiculous amount of weight gain. Over 4 stone in 2 months. Tiredness. I will admit it works as a contraceptive but only because I became so fat so quickly no one wanted to have sex with me. Also my libido plummeted through the floor and has remained that way. Actually think it is cruel to put women on this drug. I basically lost the whole of my 20's to it because I was so depressed about the weight gain and loss of libido. F 32 4 months
12/5/2016
 1  Finished having children I immediately got so tired and fatigued. Sore joints all over and lost weight due to decreased appetite. Had migraines and bad stomach cramps even though I had no period. I have been off Depo now for 5 months and it has been a nightmare. I have anxiety ( which iv needed medication for), bad back pain and shoulder pain, heavy long periods and generally feeling ill. DO NOT take this drug. It is awful when on it and a bigger nightmare coming off it. Never had any issues before injected with this poison. F 32 3 months
4/28/2018
 1  Birth control Depo destroyed my health. F 32 6 months
2/7/2020
 1  Stop periods Started the depo due to Wanting to stop my periods. The first few years great but then started to put weight on. Then fluid retention, now diagnosed with lymphodemea. Started feeling really sore, tired. Now diagnosed with fibromyalgia. And now diagnosed with osteoporosis. Stomach looks pregnant, don't have a partner. Severe headaches. Get dizzy and extremely tired whilst doing nothing. Severe hot flushes. Hair is so thin I need hair extensions. Skin was bad whilst on depo but once I stopped my skin cleared up. So before starting I was a uk8. Now a uk16. Stomach looks pregnant. This is now 1 year since my last depo injection, only just starting to see my periods again. Having really bad cramps and hot flushes and headaches. Iam just hoping I can start to lose some weight now and maybe get back some energy. Please think twice about this. I was never told until 10 years of being on it I should have only been on it 2 years!!! Nurse called me a liar F 32 10 days
6/3/2020
 1  To prevent pregnancy Horrible migraine almost everyday no appetite, depressed all the time . I wake up feeling weak loss weight really bad also acne breakouts on my face no sex drive by being on depo provera is the worst thing in life . I would never take the injection again. It's so bad that I cry everyday the worst side affects ever. F 32 6 months
12/8/2016
 1  Prevent pregnancy Stomach pain, extreme fatigue, hot flashes, waking up in the middle of the night, hair loss, joint pain, sore boobs, brown discharge, bleeding off and on, dizziness, anxious all the time, heart palpitations, neuropathy, no sex drive...I don't know why I took this shot so many times. F 32 9 months
1X M
11/15/2022
 1  birth control daily headaches, spotting for weeks at a time, very low sex-drive I cannot take anything with estrogen so I thought this was my solution to condoms. The side effects are so not worth it! I cannot wait until this medication gets out of my system. F 32 3 months
10/3/2008
 1  Birth Control Bled 6 months nonstop, joint pain(hip), weight gain 35 lbs, very moody and depressed I had to take Motrin to stop the bleeding to even get a pap smear because the bleeding would not stop. My husband was so afraid for me because we kept waiting for it to stop. I gained weight in places I have never had weight. I had 2 babies and my body was never like it is now!!!I exercised twice a day and never lost a pound. 2 years later I'm still trying to lose the weight, I still have 15 lbs to go. My stomach got so bloated if I had not been bleeding every day I would have thought I was pregnant. I thought it was a good idea, so i wouldn't have to think about birth control so often. It's really tooo much medication to put in one's body at a time. Now I'm wondering what are the long term effects? I should have listened to the horror stories!! F 32 2 times
3/14/2007
 1  TO PREVENT PREGNANCY BLEEDING NON STOP 6 MONTHS, EXCESSIVE WEIGHT GAIN 40 LBS., VERY MOODY, FATIGUE F 32 2 times
3/14/2007
 1  Birth control Extreme mood changes, physical and emotional numbness, gained over 20lbs., constant headaches, loss of sex drive. My doctor did not fill me in on the serious side effects until a year later when I started to question things and he straight out came clean with me and admitted it's all due to the depo injection. I can no longer take any birth control pills due to a blood disorder and this seemed to be the safe way out for the time being. I am no longer taking the injections and now worried about long term side effects. It does seem to be a very convenient form of birth control but its risks are panning out to be more serious and I do not recommend the depo injection to anyone. I am sorry I made the decision to take the injections. F 32 1 years
9/10/2007
 1  I'm anemic Horrible migraine headaches, weight gain, (was eating ALL the time, total loss of sex drive I have been on the depo shot on and off. While on it,(the last 2 years) I was diagnosed TWICE, and had surgery for cervical cancer. The dr. said it had nothing to do with the shot, but I don't agree. I was due for my shot today, and told my doctor, I don't want it anymore. I will let you all know, what side effects I feel and how long it takes me to get my period etc. I am starting a journal today, to keep track. F 32 2 years
8/29/2005
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 1  Birth Control Fatigue, Mood Swings, Anxiety, Back and Body Aches, Weight Gain, Digestive Upsets, Acne, Hair Loss I started Depo Provera in Feb 1998 after the birth of my first daughter..For the first couple of years it was a micacle drug until I had my first panic attack which at the time I related to losing my father suddenly in 2001. As my moods progressively got worse my Doctor at the time suggested that I have Depo every 8 weeks..and take a daily dose of Zoloft. About 12 months ago my moods and panic got so severe that I couldn't even drive my daughter to school :-( About this time I changed doctors and the first thing discussed was the Depo and the effect it can have on mental health so in December 2010 I had my last shot EVER!! Im now undergoing extensive medical tests for hormone imbalance, pituitary and adrenal glands, blood sugars etc etc the list goes on and on...One month after my last shot was due Im slowly starting to feel a little 'normal again'. Oh and by the way I forgot to mention that I was 72 kg after my daughters birth and I now weight close to 100 kg :-( F 32 13 years
150mg 1X O
5/14/2011
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