DEPO-PROVERA Reviews (MEDROXYPROGESTERONE ACETATE)

Average Rating: 2.1 (2471 Ratings)

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 ESTROGENS PROGESTINS ANTINEOPLASTICS

 Type: Rx Drug

  

DEPO-PROVERA  (MEDROXYPROGESTERONE ACETATE):  This medication is used to treat certain types of cancer (such as uterine cancer, kidney cancer). Medroxyprogesterone is like a natural hormone called progesterone made by the body. It is usually used with or after other treatments (such as radiation, surgery). Medroxyprogesterone may prevent or slow the worsening of the cancer and decrease pain and other symptoms.    (Sources: U.S. Centers for Medicare Services, FDA)

  

Results are sorted by Age from youngest to oldest (reviews with no age reported listed first).

Key to Ratings: 1=LOW (I would not recommend taking this medicine.)
5=HIGH (this medicine cured me or helped me a great deal.)

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More on DEPO-PROVERA: Reviews Summary  |  Drug Safety Information

RATING  REASONSIDE EFFECTS FOR DEPO-PROVERACOMMENTSSEXAGEDURATION/
DOSAGE
DATE ADDED
 
 1  birth control severe loss of libido, mood swings, anger, more acne, weight gain (7-14lb), painful sex, vaginal dryness I have been off depo jab for 6 weeks now and am on the mini pill instead, after complaining about side effects to Dr. My libido is back to normal and I am not experiencing pain during sex. My skin is clearer and I feel calmer and am not experiencing the sudden mood swings. F 35 15 months
1X O
5/11/2011
 1  To decrease period flow and pain! Irritable, bloating, daily dark brown/black blood, no sex drive, but when my husband and I do have sex its PAINFUL, lower back pain, joint pain in my knees and hands, headaches, weight gain, mood swings, nausea, and increased hair loss… After I had my 6th child I got my tubes tied. About a year after I had my son, I noticed that my periods, although they came regularly, cause me much pain with alot of clotting. Five months ago I decided to get the shot to slow down/ lighten my periods with the shot and I have had nothing but problems. I constantly feel sick, my lower back hurts, my entire abdomen always feels like I have been punched, always feels like I am PMS'ing, my hands and knees always hurt, daily headaches, sleepless nights from either sweating or nightmares, very moody which is NOT normal for me, ABSOLUTELY NO SEX DRIVE (my poor husband), I always feel shakey and nervous, more pimples than normal, my ovary hurts on a daily basis, and my hips feel like they are out of place. Needless to say, I am not getting the 3rd injection. I am scared that these side effects wont go away or will take a long time to. I will NEVER get the shot again. I will just have to deal with the painful periods. To those of you with no side effects, consider yourselves lucky and I hope that you never have to experience what so many of us are going through. F 35 5 months
3X O
3/21/2011
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 1  birth control depression, anger, irrational behaviour, uncontrollable emotions, paranoia, constant crying, weight gain, I BEG YOU NOT TO TAKE IT. There are thousands of women who are totally happy on it. But if you are one of the unlucky ones, the effects could be severe. It's not worth it. I didn't even realize how bad it was getting because half the time I felt totally normal & at times I can be a little intense and blamed it on myself. I went from being a generally happy person to being so negative. I was moody & would cry uncosolably. I was me sad for no reason, angry, and totally irrational. I couldn't handle any pressure. If the smallest thing went wrong I'd fly off the handle. I became a little paranoid and combatitive. Then I started feeling depressed, as though I was a bad person for behaving so badly. I started to take everything out on my boyfriend, who finally left me after 5 months. IT'S NOT WORTH THE RISK F 35 5 months
1X day
2/24/2012
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 1  painful periods nausea, diarria, loss of appetite, no sex drive, bleeding non-stop for a month, tired, sad I was debating on getting the second shot because the dr. says my body just needs to get used to the drug and side effects will go away...reading others issues helped me decide no on my next shot. I'd rather have painful periods and end up pregnant than deal with this any longer. F 35 3 months
1X day
3/10/2010
 1  birth control constant hunger, extreme irritability even rage, felt like having constant PMS I already have problems with depression. I'm bipolar and have a movement disorder. So it took me awhile to put all of the pieces together. I couldn't figure out why everything was going so badly all of a sudden when my medication had been keeping me stable for a long time. Then I saw these comments abou the sde effects. I feel better knowing it's not just me. I can't believe my doctor gave me this shot. I will not take another one. I just hope this works through my bod quickly. F 35 2 months
1X O
1/23/2011
 1  birth control nausea, headaches, fatigue, bleeding I only got 1 shot under the insistance of the dr. after having a very premature baby. 6 months later I have bee bleeding nonstop for 7 weeks with constant nausea. So hard to care for my family like this. Those who are so happy with depo....wait until you try to stop taking it. F 35
1X O
1/17/2011
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 1  birth control fast weight gain, Bloating (which led to the feeling of unhappiness and discomfort). After 2+ months of taking it I decided that It would be my last and instead use other birth control methods. The Bloating and the really quick weight gain made me very unhappy and worry about my look. I am petite size person but within 2+ months I moved 2 sizes up. I am not pregnant but wear maternity clothes! I was not advised about the appetite increase and the bloating. I am thankful that I God willing in 2 weeks I will be freed from the depo and its ill effects. I had no mood swings or any type of depression and had no period and no spotting so far. I would advice those who decide to take the depo shot to mind their eating habits and be a gym member. But if you can use other birth control then avoid the depo. F 35 3 months
1X O
12/27/2010
 1  endo and abnormal bleeding Morning sickness and early weight gain and long periods. I only got one shot because it is awful. Doctor told me irregular bleeding could be a side effect. 2 week long periods are quite annoying. Morning sickness and early weight gain, and people asking if I am pregnant. Have been coming off for 2 months and have gained more weight, more 2 week periods, no more sex drive or even opportunities with 2 week periods coming every 21 days. I was very fit, still eat better than most, but have to buy bigger clothes because of a lousy shot. F 35 3 months
1X O
9/22/2010
 1  to prevent pregnancy Within a few weeks of my first shot, I felt different; depressed, tired, bloated, spotty, hair loss, weight gain, lack of libido, irritable...these symptoms all worsened as time went on. After my 4th shot, I didn't go back for more as I'd had enough, as had my hubby. We were also hoping to increase our family by having another baby. I had my last shot in June 2011, it took over a year for my cycle to return, even now its not regular (anything from 4-8weeks cycle) and I've still not conceived. I totally regret getting the shot, it just seemed a good idea as I can not use the pull and the coil made me bleed heavily. The Dr says give it time, he knows we can conceive as we have 3 children already....but time is running out for me... F 35 4 times
6/21/2013
 1  Birth control I had 2 shots, 3 months apart. Lost hair like someone having chemo. Bleeding for 11 months!!! Lost weight, sex drive, horrendous mood swings, this shot is a nightmare! Everyone reacts differently to a medication. But I would read about it first and beware of first symptoms. I was naive and trusted my doc who said my symptoms were going away after 2nd hot. Boy I was wrong! F 35 6 months
1X O
10/28/2012
 1  birth control Immediate loss of libido. Depression with no previous history. Loss of menses after two months. Sweating and increased body odor. Increase in breast size and after a year I began having breast discharge. It is very true that the side effects of this drug are down played. Usually when a drug states that there may be side effects they are usually rare. There is a 10% chance of depression or loss of libido. One in ten people! They use this drug in men for the purpose of decreasing their libido! This is a bad drug!!! F 35 2 years
8/4/2004
 1  birth control suicidality, dissociation, horrible, horrible, horrible. lay in bed for two straight weeks crying. just awful stuff. Depo is a nightmare, or at least it was for me. I got on it because of the appeal of ease of use and infrequent periods. I got one shot and it took me six months before I felt like I was back to normal, or because I got a period again. I did suffer from depression before taking it, and took the antidepressant Lexapro, which controlled my depressive symptoms quite well. Even though I continued to take Lexapro while on Depo, the depression came back worse than ever. One day I walked into the bathroom and swallowed every pill in the medicine cabinet and woke up three days later in the ICU. I am CERTAIN this never would have happened without the Depo. I felt like it took away my brain. I really cannot begin to explain what a nightmare this medication was for me. If you have ANY history of depression, DO NOT take it. F 35 3 months
11/11/2006
 1  control for menstrual disorder I went to the doctor to regulate my. Because it's been going on for years now that I've been having a mental disorder that has been causing me to have anemia due to heavy loads of blood so she told me if I smoke before going on any contraceptive to regulate my period I said I was smoking Vapors she said that she could not give me any pills that it could cause blood clots in my system mixed with nicotine that the best option would be depo shot so it's been 8 days now now that I just got to. Really heavy I feel terrible very depressed hot flashes not hungry I've been drinking gallons and gallons of water for like 9 days very dizzy I even got a blister how to tip of my lip.very sick I feel like I have a tremendous flu I've sweat the whole bed do not take this shot got out of the shower and still sweating I guess this shot is cleansing my system of all the toxins that the cigarette smoke has cost meI hope it will be for the better after all F 35 10 days
30
3/28/2016
Email
 1  birth control Over 2000 ratings and a 2.1 average should tell you all you need to know. Most people are effected badly by this TERRIBLE SHOT! It effectively ruined my life. I had my last shot 3 years ago and still am a shell of the person I used to be. Chronically weak bones and bone pain, fibromyalgia, no energy, I can barely muster enough energy to take care of my children anymore and had to quit my job. In pain daily because of this poison. Wish I did more research instead of blindly trusting my doctor. I am not sure if I will ever feel normal again F 35
1X day
1/1/2022
 1  Prevent Pregnancy Worst decision I ever made and truly wish I had done more research. My friend has been using the shot for years with no problems I thought why not?! Well for starters, I'm a highly sensitive person and should have known how bad the side effects would be. It literally made me crazy. Mood swings, lashing out, no impulse control whatsoever, periods of being dead inside and feeling nothing. It's like someone else has taken over my body. I cry for any and all reasons and once it starts there is no stopping it. Suicidal thoughts.. Who knows about sex drive because I've completely destroyed my relationship. Went to doctor and hormones are completely out of sorts.. Elevated estrogen, low progesterone, elevated cortisol which is essential to managing anxiety. Started taking prenatal vitamins, Omega-3, Turmeric to try and balance hormones F 35 0 days
1 1X O
5/11/2021
 1  Hormone imbalance Anxiety, sadness , painful boobs, hip pain , back pain, muscle pain , headaches, shaking hands & weight loss! My 1st and last injection never ever again! I'm on week 5 of 12 and I cannot wait to get this poison out my body! F 35 3 months
1X O
4/19/2023
 5  My husband and I didn’t want to have Little to no period, Sex drive was fine. Injection site sore for the first day or so. Would definitely use it again no painful Object to get in the way of great love. Later 3 months avoided at least 3 chances of babies ... F 36 1 days
11/18/2019
 5  control heavy periods weight gain i was on this medication for over 5 years and it was fantastic -no periods, no mood swing, no painful swollen breasts. Went off due to concerns about my weight ( am about 20kg overweight) and skin sensitivity from the steroids in depo. am SERIOUSLY considering going back on it, my breasts are SO SORE AND SWOLLEN I can barely move !! F 36 8 years
10/14/2007
 5  endometriosis I am a little moody and have had a little vaginal dryness, The 1st couple of days after the shot, I have mild headaches, but they go away. It has been a blessing so far. No periods since I started, so no cramps! It affects everyone differently. I feel bad for the women who have had such a terrible time on it. For me it is wonderful. My doc told me when I started that it is an appetite stimulant so I needed to be careful and monitor what I ate. I did this and found that I was able to control cravings and I have lost 8 pounds, so weight gain is not a definite side effect. Don't be scared off! After reading some of the negative experiences, I almost was. Individual people have individual side effects. F 36 4 months
1X AN
12/19/2010
 5  endometroius Loved it Dr said I had to go off because 10 years was too long. Now I am back on the pill did not have peroids for 10 years got it back the first month full force. I have endometroius and depo kept it in check. I want my Depo back I hate the pill every day and periods hurt and what a mess. I can't even wear a tampon anymore it hurt. I have to get used to all this stuff again. anyone else out there on depo for over 10 years? my dr would maybe let me go back on if we have information on others on the drug for that long too. F 36 10 years
3/28/2009

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