DEPO-PROVERA Reviews (MEDROXYPROGESTERONE ACETATE)

Average Rating: 2.1 (2471 Ratings)

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 ESTROGENS PROGESTINS ANTINEOPLASTICS

 Type: Rx Drug

  

DEPO-PROVERA  (MEDROXYPROGESTERONE ACETATE):  This medication is used to treat certain types of cancer (such as uterine cancer, kidney cancer). Medroxyprogesterone is like a natural hormone called progesterone made by the body. It is usually used with or after other treatments (such as radiation, surgery). Medroxyprogesterone may prevent or slow the worsening of the cancer and decrease pain and other symptoms.    (Sources: U.S. Centers for Medicare Services, FDA)

  

Results are sorted by Age from youngest to oldest (reviews with no age reported listed first).

Key to Ratings: 1=LOW (I would not recommend taking this medicine.)
5=HIGH (this medicine cured me or helped me a great deal.)

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More on DEPO-PROVERA: Reviews Summary  |  Drug Safety Information

RATING  REASONSIDE EFFECTS FOR DEPO-PROVERACOMMENTSSEXAGEDURATION/
DOSAGE
DATE ADDED
 
 1  nursing but period had returned I had my first period after the shot for a month. For the last year and half, my cycles have been horribly irregular lasting anywhere from 16 days to 60 days. My periods would last sometimes 20 days as well and I only had ONE shot. I will never do it again. I was depressed and horribly emotional. I am still having problems with my cycles and it's been 17 months since the shot. My husband and I are trying to get pregnant, but I am still having issues ovulating. F 28 1 months
3/20/2007
 1  Birth Control depression, anxiety, panic attacks, weight gain (can't get off,) acne, mood swings, no libido, irritable, and sleeplessness. I started getting the shot after my 2nd daughter. I started having all the symptoms I posted shortly there after. I delt with it for a long time, then got on meds and started therapy. A friend told me this weekend to Google patient comments. I am floored! All this time I thought I just changed after having my daughter. My husband and I have been trying to heal our relationship for months because of me and this medication. I feel horrible that I brought this on myself. The really scary thing is - I was going to put my daughter on it. Horrible - I am telling all the women I care about to research first! F 28 3 years
1X O
4/6/2011
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 1  keep from getting pregnant Headaches, weight loss, pain in my stomach. I was on the shot for 5 years w no period. I just got of off of it about 2years ago. I'm still going crazy still havin pains no sex drive at all. And when I do its hurts but I don't reccomend this to no one. I remember when I tol the doctor that I didn't want the shot anymore they told me that u shouldn't b on the shot no more then 3 years well hell I was on it for 5 years. So I'm planing to sue the hospital and depo because they new and just didn't tell me that I wa only suppose to be on it for 3 years. So if ur on the shot Get OFF IT NOW BECAUSE U WIL BE MESSED UP. F 28
1X day
6/7/2011
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 1  endometriosis/conception fine first three months after giving birth end of third after missing shot two periods two weeks apart very painful and heavy messing up my sex life my fiance left me with our baby after stating I was too emotional or angry F 28 3 months
30mg 1X O
7/31/2011
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 1  Prevent ovarian cysts, stop period Depression, kidney stones, weight gain, breakthrough bleeding (recently and has lasted for over 2 weeks now), digestive problems, low libido, anxiety, mood swings, yeast infections I started taking Depo when I was 18 to help with ovarian cysts and to stop my period.... I have not had a regular period, or any period for 9 years, except when I went off it when I was 23 because I had cervix cancer and had to have surgery, I'm not sure if the cancer was related to depo or not. Until recently reading posts about Depo, I never thought about side effects such as depression and loss of sex drive and weight gain..... But now I definitely can associate these with Depo, and I have had these symptoms for years. Over two weeks ago now, I started to spot.... It's not a period, it's started as a yeast infection, with light pink blood, that lasted 3 days, ever since its been dark brown mucus, apparently it's called breakthrough bleeding associated with any term of use of Depo..... Although Depo does have different effects on different women, I would not recommend prolonged use, I want to start having kids, and now I have to wait at least 12 months for it to clear my system before I my be fertile. I wish I had studied up on it years ago, but my Dr. Never ever said anything about it, he would just give me a yearly prescription for 4 doses a year.... Thanks for all the other posts and info! F 28 9 years
1x 3mo 1X O
2/19/2012
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 1  prevent getting pregnant I will never recomend anyone to take this mess. You feel sick everyday,mood change depression ,little sleep at night ,anxiety, headache ,ovarian cyst, dry skin ,dry mouth and dry nose ,lack of vitamin D, muscle pain and weakness,loss of appetite ,bump on private part,achne, lost of taste buds in mouth with dry throat, lost of hair ,heart palpitation ,breat tenderness,headaches and neck pain,chest pain , forget about sex life....please stay away from this poison if you love yourself F 28 1 years
12/10/2011
 1  ovarian cyst It was my hell!! Until I read these comments from other women on the depo I thought I was going crazy! I have had 7 surgeries and lost my left ovary to ovarian cyst. My doctor thought it would be good to start the depo because it would be a great chance with it stopping my periods they wouldnt return. The first shot I felt sick to my stomach and just not myself. Second shot I started to notice the same thing sick to my stomach and just not feeling well. My friends and family commented on my mood swings which I started to notice myself along with horrible back pains, my hair was falling out, acne became horrible, headaches and joint pain. Third shot sent me over the edge! I became so moody for no reason at my boyfriend or anyone who looked at me wrong. I started have anxiety attacks and thinking crazy and crying for no reason. My doctor said it didnt agree with me and started me on anxiety and depression medications. I have lost time at work.. put my family and my boyfriend through hell F 28 3 times
3X O
3/1/2010
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 1  Birth Control Absolutely No Periods, Fatigue, Hungry, some weight gain (mainly in mid- section), trouble sleeping, irritability, no energy at times, little to no sex drive. I have been on the Depo-Shot since I was 17 and in the 11th grade. Throughout my college years I, got the shot. Then I started to wonder why there was little to no more recent updated information on this drug. So I started to take a break from it because my doctor could not give me much more information on how safe it was to continue to stay on it as long as I have. In between my breaks, I would have terrible, excruciating, painful periods. They were so painful that I would have to stay in bed and cry because I was unable to move. Because of this pain, I would always return back to the shot to avoid this. In 2006, upon me graduating college, I stop the shot. I did not want to not have a back up birth control so my doctor put me on some BC pills. I started the pills as prescribed. I got so sick from the pills: sore breast where I could not put my arms down, could not sleep, I developed a rashy acne in the form of a beard on my face. From this, I had to start using Proactive and I have never had any skin problems in my life. I stopped the pills. I waited almost 6 months before I started the shot again. After the unbearable periods, I just could not bear it anymore. I started the shot again. Since this, I have been on the shot continuously. I finally decided again in May 2010, not to get the shot ever again because no one can give any answers on the prolonged safeness of this drug. After stopping the shot this past May I have not seen a period. No spotting or anything either. I F 28 10 years
1X AN
9/14/2010
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 1  regulate period, prevent pregnancy Weight gain, inability to lose weight even with extreme exercise and diet, headaches, nausea, depression, fatigue, changes in appetite (some days more some days less), spotting EVERYDAY, long light period or no period, totally absent sex drive, painful sex, acne, dizziness. I've tried my best to stay free of putting meds in my body but my very heavy period and extremely painful cramps made me disparate to regulate it. I didn't want the pill because I was working two jobs and going to school & knew I would not remember. My doc recomm Depo & I went for it not thinking much about the side-effects. Now I wish I had researched before getting my injection. Not a nice experience. I have been wondering why I was feeling all these things, why no sex drive, why painful sex for the first time in my life! Also feeling so sad and down if I have no reason to and why can't I lose weight if I am exercising like I'm in the military (not a single pound!!!!!) I know its because of this drug. This is why I didn't want to put anything in my body. This is a horrible medication and wish I could get it out of my body NOW! BUT I have to wait until its time for my next appointment so I can change my prescription. F 28 3 months
1X AN
3/3/2011
 1  contraceptive Horrible mood swings, no sex drive, and headaches. After almost 10 years on this medication i began to hear of many serious problems related to it. I worked for an OB/GYN at the time i began this medication. Like most of you i was told by the DR and the pharmacy reps that this drug was safe for long term use. Well, now we know thats not true!!!!! I recently had a bone scan done to only now find out that i have Osteopenia (the begining stages of Osteoporosis). I am only 28 years old. This is what i have to look foward to now as i age. I just wonder did they know these problems before and just failed to say like many other drugs they put on the market or were they just to cheap to do the research! Either way its careless and just pure GREED. F 28 8 years
9/26/2007
 1  birth control after 2nd child I had one depo shot at my 6 week postpartum check up after the birth of my 2nd child. My knees started aching within a week (I never had knee problems and was a runner previously). The knee pain didn't go away for over 1 year. I gained 50 pounds during that first year. From that one shot - I didn't get a period until 26 months later! It was incredibly hard to concieve again. It took another 22 months after I got a period until I started ovulating and got pregnant again - I charted my cycle and my doctor was even puzzled as well. I think it is a horrible drug! I warn everyone I know not to get the depo shot!!!! If I could do it again - I wouldn't. It changed our plans for our family. We hoped to have several children 2 years apart. I didn't think I'd have a 5 year gap between the second and third child! Get this drug off the market!!! F 28 1 times
5/10/2007
 1  Birth Control Depression, Anxiety, Nervousness, mental confusion, loss of libido, overall feeling of hopelessness I was a perfectly healthy person before starting on depo. Now I wake up every morning with anxiety and nervousness. The only time I feel good (I think) is when I am sleeping. The med has interfered with my everyday life. I can't concentrate and I can't shake this feeling of hopelessness. Definitely not continuing on this med, no more artificial hormones for me!! Doctor attributes my anxiety level to my four kids, but I wasn't like this with three kids and I felt great before starting this. F 28 9 months
6/20/2007
 1  birth control & painful periods weight gain, depression, mood swings, dizziness, no sex drive I have been on the depo shot right at a year now. I got my first shot in the hospital after giving birth to my son. My ob/gyn thinks the depo shot is great. Not having a period is fabulous, but I will no longer be getting the shot. My last one was about three weeks ago. My family doctor put me on Zoloft and Synthroid (for a new thyroid problem) but I believe both problems are linked to the Depo shot. I have a friend who gets the shot because of migranes and she loves it. My doctors should have spent more time discussing the side effects with me. The only side effect brought to my attention was the bone & calcium issue. Speak to your doctor thoroughly before getting this shot! F 28 1 days
9/30/2006
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 1  birth control Severe headaches, weight gain, irritability, severe depression, suicidal thoughts. While not having a period is nice, it isn't worth all of the other side effects. I have had only two injections so far, but I've already gained 10 pounds. This drug has nearly ruined my relationship - it destroyed my sex drive. I've had headaches since I started the shot and they have been most intense the day of and the few days following the shot. This drug has also triggered depression and suicidal thoughts. I spoke with my doctor about the lack of desire to have sex, as it was becoming an issue with my fiance. She assured me that although this is a less common side effect it should go away with the second shot. Well, the lack of sex drive hasn't gone away and to top it off my mood swings are out of control. I have been severely depressed and lately have been having suicidal thoughts. I will not be getting my next shot. F 28 5 months
12/29/2008
 1  Birth Control Method Anxiety, depression, fatigue, mood-swings, weight gain even though I regularly work out for a minimum of one hour almost every week-day (burning anywhere from 500-1000 calories per work-out), brown discharge alternating with brownish red period non-stop for 9 weeks, vaginal dryness, dis-interest in sex, racing heart right after shot and occasionally, sex is painful and I always have a muddy discharge during and after sex that grosses out my husband. After experiencing all of these side effects and doing more research on the product I have concluded that it is not a healthy option. Shame on me for not really researching prior to getting treated, but even the warnings on the packaging right from the pharmacy state that this "should only be used as a last resort method for birth control when no other method works, and it is not recommended for extended use beyond two years." Seems dangerous to me. I will not be getting another shot, and I do not recommend this method. F 28 2 times
11/10/2008
 1  birth control I have not been able to get pregnet for almost 11 years my periods haven't been normal for 11 years I can't lose weight if I do I gain it right back I just would never tell anyone who wanted more children to talk this birth control F 28 1 days
11/6/2007
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 1  Prevent Pregnancy EXTREME ANXIETY, massive mood swings, insomnia, constant spotting for 4 months The night of my first and only shot I had my first EVER panic attack. I was in and out of the Dr. office after that getting "treated" for my sudden anxiety. I was assured it wasn't the Depo. I quit going to the Dr. when he told me he couldn't help me unless I saw a psychiatrist. The anxiety was so bad I couldn't eat, sleep, or function at work. I LOST 20 pounds in the first month, I literally had to force food down. My boyfriend left me b/c I became a shell of a person, all I did was sit except for when I was pacing due to a panic attack. I would not recommend this drug to anyone! F 28 1 times
1/5/2008
 1  Birth control This form of b/c was horrible for me. I gained about 20lbs., bad acne, always moody. And on top of it I had irregular periods and severe cramps. Definitely not for me. F 28 9 months
N/A
10/6/2014
Email
 1  to prevent pregnancy after giving b Heart palpitations head aches anxiety to the extreme chest pains body aches fatigue etc... I still have not recovered and it has been over a year it has got better sometimes it is worse and taking the shot is such a big regret I would give birth a million times b4 I would consider the shot again F 28 3 months
2/4/2015
Email
 1  Birth Control Heavy bleeding 28 days, light spotting for 5 days out of every month. Pregnancy. Doc told me stick with it, bleeding would stop and go away completely. It did - when a baby moved in. F 28 1 years
30mg
7/23/2015
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