DEPO-PROVERA Reviews (MEDROXYPROGESTERONE ACETATE)

Average Rating: 2.1 (2471 Ratings)

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 ESTROGENS PROGESTINS ANTINEOPLASTICS

 Type: Rx Drug

  

DEPO-PROVERA  (MEDROXYPROGESTERONE ACETATE):  This medication is used to treat certain types of cancer (such as uterine cancer, kidney cancer). Medroxyprogesterone is like a natural hormone called progesterone made by the body. It is usually used with or after other treatments (such as radiation, surgery). Medroxyprogesterone may prevent or slow the worsening of the cancer and decrease pain and other symptoms.    (Sources: U.S. Centers for Medicare Services, FDA)

  

Results are sorted by Age from youngest to oldest (reviews with no age reported listed first).

Key to Ratings: 1=LOW (I would not recommend taking this medicine.)
5=HIGH (this medicine cured me or helped me a great deal.)

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More on DEPO-PROVERA: Reviews Summary  |  Drug Safety Information

RATING  REASONSIDE EFFECTS FOR DEPO-PROVERACOMMENTSSEXAGEDURATION/
DOSAGE
DATE ADDED
 
 1  Birth Control Numbness, to the point of where I thought I had neuropathic symptoms as in diabetes, SEVERE back and abdominal pain, moodiness, ZERO sex drive and no vaginal lubrication when I do "suffer through" sexual intercourse with my husband! My doctor would not prescribe me birth control pills due to a family history of hypertension and my age. She suggested this and gave me a positive report for the drug. I have not bled once since the shot a month ago, but boy have I struggled with everything else this drug brings! I will not be returning for any more shots, which concerns me since coming off of this sounds like an exercise in horror! At this rate, I will risk getting pregnant before taking this again! Children are a blessing anyhow! F 41 4 weeks
5/6/2009
 1  Contraceptive Weight Gain, constant bleeding, constant feeling like I have a yeast infection, painful intercourse. DO NOT TAKE THIS SHOT! IT WILL RUIN YOUR LIFE! F 41 1 times
3/10/2009
 1  Birth control I bled on the progesterone only pill. My dr gave me the shot informing me I won't get a period anymore on the shot. 1st month good. Now I'm bleeding every day for 9 days with no promises of ending. I am working overtime to pay for the tampons and pads. Not worth it for pregnancy because I can't have sex with all the bleeding. I'm not happy at all. F 41 40 days
1X day
9/7/2020
Email
 1  Birth Control No period since starting. No noticeable side effects for first 2-3 years then began getting increasingly unwell with extreme fatigue. I would not recommend to be on this birth control for more than 2-3 years. Very appealing not having a period but i believe looking back over the four years i was on Depo i started having unusual health problems starting with abnormal pap smear, neck pain/stiffness and tingling/numbness in hand. then when i reached the 3 yr mark i began having hearth palpitations, dizziness and a constant gurgling/rumbling in my stomach. This then developed into food intolerances and IBS. I also suffered from reflux, indigestion and felt sick every time i ate resulting in a 12kg weight loss over about 8 months. Numerous testing and Doctors couldn't find anything wrong and didn't suggest i should go off the Depo. even after i questioned if I've been on it too long. I decide myself to stop my last injection due 4 weeks ago and am now starting to feel like myself again. I DO NOT RECOMMENED FROM PERSONAL EXPERIENCE TO TAKE THIS DRUG AT ALL OR NO LONGER THAN THE RECOMMENDED 2 YEARS. I had never suffered any of these side effects before DEPO !!! F 41 4 years
1X AN
5/26/2016
 1  Uterine Fibroids I got the depo-provera injection for the first time 1 month ago (April 28, 2023) and it will be my last. I now have really bad nervousness, anxiety and insomnia. My life has changed since I got the shot. I cannot sleep and I barely eat from the anxiety. I have lost 12 lbs in 1 month. When I try to get some sleep I wake up out of nowhere shaking with severe heart palpitations. I do not recommend this injection at all!!!!! It has ruined my life. I was only told about the weight gain but never any other side effects. I am praying that these side effects go away soon. F 41 3 months
30MG 1X day
5/27/2023
Email

Patient History
 5  breast pain and tenderness no period, lower sex drive, possible loss of bone density I started depo for birth control while breastfeeding and happily discovered that it relieved me of the nearly constant breast pain that I had had for 3 weeks of every month since my early 20's. They used to hurt whether or not I was on birth control. I seem to be the only person on this site with this situation. I have been very happy with depo, but I am going to stop soon to protect my bones. I do worry that my breasts will hurt again like before. I don't know if my periods will return as I now have hot flashes and have started menopause. Depo seems not to have affected my weight nearly as much as my exercise and diet do--my weight has varied by 12 lbs. up or down in 9 years. F 42 9 years
6/27/2007
 5  birth control none love it F 42 2 years
1X O
7/18/2011
 5  Birth Control Occasional spotting if I am overdue for needle. I have no period at all and it has been extremely effective as birth control F 42 19 days
3/20/2007
 5  Birth Control Occasional spotting if I am overdue for needle. I have no period at all and it has been extremely effective as birth control F 42 19 years
3/20/2007
 4  birth control/stop heavy cycle no cycle so no cramps, head aches and irritability Started taking after my 10year old son was born and never seemed to have a problem except for occasional break through bleeding (clots). Came off around 4 1/2 years ago to have my three year old daughter, took me around 5 months to start having regular cycles again and then 6 months to get pregnant-which was probable pretty good considering my age and the depo. Went back on the depo at my 6weeks postpartum appt. Having break though bleeding again, and since learning that oseoporosis runs in my family I am starting to get really concerned about that side affect. I am gettting a bone scan as soon as possible and hoping that all my years of walking walking walking (weight bearing exercise) will be in my favor. If the scan does show damage I will stop the depo and if I have to, will just opt for a partial historectomy to stop the heavy cycles. My mother was also anemic from heavy cycles. F 42 10 years
8/31/2007
 2  Birth Control Hair loss due to dryness, weight gain, muscle and joint pain. Extreme decrease in sex drive. No period (that was the only plus!) It prevented pregnancy, but I think I experienced depression and mood swings. I took the shot for almost 5 years and the symptoms grew more and more yearly. I stopped taking the shot and the syptoms slowly disappeared. F 42 5 days
7/8/2006
 1  birth control constant bleeding, uterine lining never returned to normal, extreme anxiety, panic attacks, depression My doctor insisted this was the only suitable birth control and told me the only side effect was a good one: that I'd stop getting my period. It concerned me. I wasn't told of any other side effect possibilities. When I ended up bleeding for the full 3 months I was told the bleeding would stop if I took another shot. I had been set on refusing another shot and only went to the clinic to find out what to do about the bleeding. They convinced me another shot was the best cure. After six months of non-stop bleeding I returned and they claimed that excessive bleeding was not a known side effect. It's been 7 yrs since the shot and my periods have never returned to normal. Anxiety and panic attacks: I used to be "zen" calm. Nothing got me riled. I got along with everyone, even people I didn't like. About 3 wks after my first shot I started flying off the handle over simple things. I was yelling at my child on a near daily basis. The panic attacks started shortly into the second shot. I have tried to take herbs and supplements to stabilise my moods but still have to explain to people when I'm having an attack so they don't take it personally. The depression went away after about a month of the last shot. I've gotten better at identifying when it's me and not them. This drug is horrible. It could have wrecked my life. It could have turned me into a "revolving door" drug user if I had chosen to keep trusting the doctors. 7 years later, I still can't say F 42 6 months
2X O
9/4/2012
Email
 1  birth control I have a history of depression,anxiety and ptsd. I was given the Depo shot in June 2012, in September I took my 2nd shot. I didn't know at the time but I finally figured it out what Depo did to me. I was severely depression to the point of cutting myself and other self harm, I was very suicidal almost psychotic at times, I was anxious nervous and eventually lost my job and became so scatter brained and reluctant to leave the house. I gained weight had headaches, rapid heart flutters, pimples and moody /irritable. November 11th I was due for my third shot but refused it because about 3 weeks before it was due, my mental health improved and I counted back when my "breakdown" started and realized it correlated to the time I started the Depo shot. It was the worst 6 months of my life that I, my children and boyfriend had to endure. I almost went to inpatient treatment because of the depression...Make sure you educate yourself, its not for everyone... F 42 6 months
1X day
11/20/2012
Email
 1  Essure procedure precaution Extreme fatigue and back pain. Bleeding dark then heavy then spotting then heavy. I'm a marathoner and triathlete. I will never take this again!!!! Doctor said 1 SHOT WOULDNT CAUSE ANY PROBLEMS...it did. I know my body and this shot is bad news. Stay away from it. F 42 3 months
6/15/2012
 1  birth control exhaustion, severe muscle pain, weight gain Ive always been strong and able to physically do a lot. Had no clue my exhaustion and muscle pain could be related to depo - those symptoms I wasnt warned about - but starting checking online today about the prescriptions I take and what others are saying. Found all of this info and started realizing my muscle and exhaustion issues started shortly after my first shot. I started waking up with serious neck cramps until one day I couldnt lift my head off the pillow, crawled out of bed and it took 2 weeks with a chiropracter to straighten it out. Started seeing a massage therapist because of ongoing back muscle problems, and the pain starting moving down into my leg muscles lately. I am so glad youve all shared your experiences, as Im going to NOT have any more depo shots and hope my symptoms disappear with time. I am afraid of what the first couple of months off depo will be like, however, after reading all of your accounts. Hopefully others will find this info early as well and a F 42 2 times
3/25/2006
 1  birth control This stuff is bad. You gain a bunch of weight and unlike what they tell you, it takes longer to get your period back. Really jacks around with your hormones. If I could go back in time, I would not take it again. The side effects are understated. F 42 1 years
1X AN
1/15/2012
Email
 1   This stuff ruin my relationship with my girlfriend stay away from it you will be sorry later M 42 1 years
1
11/21/2011
 1  yes continious bleeding. My Doctor never metioned this side effect. F 42 40 days
1X day
11/14/2010
 1  Preparation for Essure procedure Severe mood swings, exhuastion, sore breasts, crying for no reason, nausea, digestive problems, irregular periods, weight gain, weakness, dizziness, loss of libido I only took this shot to prepare for having the Essure procedure done. The procedure went perfectly and I've had no side effects from that. But although I had the shot in early June, I am STILL feeling horrible. I have been so emotional and sad, feeling depressed all the time. I've had moments of extreme panic and I can't explain why I feel that way. I've been nauseous and sick feeling all the time now. My breasts are so tender. I have been absolutely uninterested in sex at all. I feel creepy-crawly feelings under my skin at times. I feel achy occasionally. I thought I was going crazy and I was seriously considering seeing a psychiatrist for the depression and then I found all these web sites talking about the side effects of going off the shot. I will never, ever let the doctor give this to me again. I am SO mad that I had to do it, but at least now I know I'm not going crazy. I will never let my daughter get this either. It's a really dangerous drug. F 42 3 months
1X day
10/17/2010
Email
 1  Birth-Control Depression, anxiety, weight gain So I have hesitated to post this but I realize if I stay silent it will not benefit anyone. I had Depo-Provera injected into my body in 1994 after my first child and once the symptoms began I stopped taking it; basically I only received one dosage. However this is such a toxic medication that I suffer to this day with problems that were created by taking just that one dose. The best I have felt since then was when I was being treated by a Naturopathic Physician. She took the time to listen to EXACTLY what I was complaining about and then compared by complaints with my lab work and treated me accordingly. I thank God for her and for the treatment plan she placed me on. Depo was never mentioned and yet through her LISTENING she was able to hit the target. I was not 100% certain about the problems I have experienced since 1994 being related to the Depo until I found this website. Ladies there is EXTREME danger to your body now and way into the future if you take this drug. Figure out a better birth control method. F 42 3 months
Unkonwn 1X day
2/23/2011
Email

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