Average Rating: 2.8 (611 Ratings)

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 Type: Rx Drug

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Key to Ratings: 1=LOW (I would not recommend taking this medicine.)
5=HIGH (this medicine cured me or helped me a great deal.)

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 3  Depression and anxiety Brain fog, jittery, insomnia first night I was on pristiq along with lexapro and wellbutrin from 2019-2020, and then stopped all three cold turkey June 2020. Strangely, I had no withdrawal symptoms. I don't recall having any side effects from the Pristiq the first time I started it. i wanted to go back on something I was already on, and so my doctor prescribed me Pristiq. First night I had insomnia, but it's gotten better. I have some brain fog and feel jittery, just off mentally, but I feel my mood is better. The side effects could go away, and what I am feeling may not even be related to being on pristiq. M 40 3 days
50 MG 1X D
 4  Depression/anxiety symptoms Really not much serious. The doctor did raise my high blood pressure medication because Pristiq raised it. Maybe some anxiety the first few weeks but then that stopped and I actually feel that Pristiq helps my anxiety long-term. I have chronic fatigue due to atypical depression. I am tired a lot, have somatic pain, and apathy. I've found that Pristiq is great for energy. Actually I discovered that because, if I miss a dose or two, I become very drowsy. I just can't get out of bed. Then I take the Pristiq and within 4 hours I feel brand-new! So I guess I'm kind of stuck taking this drug now LOL. I tried to use fluoxetine (Prozac) to ease myself off of the Pristiq, but the withdrawal and fatigue are just terrible. I'm going to stay taking the Pristiq. M 38 6 months
100 mg
 2  Depression/anxiety Tired, no motivation, feel like I could cry at a moments notice. Libido is fine. No apetite. Dreams are vivid but not nightmares. Still going to continue on this to see if it levels out but by week 4 this isnt great. Weened off anxiety meds in the process so that could be the cause. Will wait and see.... M 42 4 weeks
50 1X D
 1  Depression Weight gain, heartburn, migraines, shakiness I had high hopes for this med to be the one to work for me. I had a dna test to see what meds my body will respond well to and which meds to stay away from. Pristiq was the only one that came up for depression. The first month or two I had extreme nausea and dizziness and I hadnt seen a difference in my depression yet. My doc wanted to go up to 50mg but I wanted to wait. The dizziness and nausea got better so I went up to 50. Before taking pristiq I was on lexapro. It didnt help at all and made me gain some weight and caused me to get acne pretty bad. My doc said I shouldnt gain weight in pristiq. Before starting anti depressants I normally weighed between 120-125. I now weigh 157. I've cut a lot out of my diet, am eating less and eating healthier and am very active but still continuing to gain weight. This is something I have never struggled with before going on anti depressants. I meet with my med doc this week and will be asking how to get off of this med. I never had heartburn or migraines and get them frequently. Almost daily my whole body is shaky and its quite uncomfortable. F 25 6 months
50mg 1X D
 1  Major Depressive/Anxiety Disorder Side effects have only increased since starting ALMOST 7 MONTHS AGO. Am now at the point my body is rejecting the pills and projectile vomiting them, haven't been able to eat barely a few pretzels a day and maybe a water bottle for a week or two now, vomiting, sweating, shaking, trembling, all the side effects plastered on the damn bottle have happened to me. I can feel the improvement in my mood I really don't wanna stop taking them but now I'm gonna have to go through the intense withdrawals because my body won't allow the pill to even start dissolving before it purges it. It knows these pills are damaging and killing my body. DO NOT. DO. NOT. TAKE THESE PILLS. I trusted the medical system and their judgement and im close to being admitted into a hospital. Being type 1 diabetic, makes everything 100 times worse. DO NOT USE F 23 100 days
50mg 1X D
 2  Depression and anxiety Extreme nausea to the point where it hurt to move or do anything other than lay in bed, constipation, loss of appetite While this medicine did improve my mood, the physical side effects are unbearable. What good is feeling great mentally if I'm physically too sick to get out of bed? F 24 33 days
50 MG 1X D
 5  Depression/Anxiety Increased sweating, weight loss I live in Quebec Canada. The Covid-19 measures, confinement, curfew at 8 pm, stores and gyms closed made my life a living hell and I tried to kill myself twice. I lost 5 of my friends because they killed themselve because of that pandemic crisis. So I went into a deep depression but Pristiq saved my life. I am able to go back to work and live my life. The gym reopened so it helps. But I have to loose the 60 pounds I took since the pandemic started. I lost 20 lbs but still have to loose. My energy is back. M 41 3 months
100 mg 1X D
 4  Menopausal depression A little jittery at first and my ears felt stuffy like I had a cold. I have tried quite a few antidepressants and these side effects are pretty mild. I was feeling low and having symptoms like PMS every day. Taking estrogen has not helped , I think because it's such a low dose . Pristiq is a good medication for depression that makes you feel slow, heavy and tired . It hasn't made me anxious. I have read some comments about withdrawals coming off this and other antidepressants. Your doctor can prescribe some medication to take for a short period of time to help with those symptoms. It really helped me getting off some migraine medication which had terrible withdrawals. One is Clonidine and the other is Hydroxyzine. I'm sure there are others , too. F 57 45 days
50 mg 1X D
 1  Anxiety Horrible dreams, sweating, felt like I drank 100 cups of coffee Talked to doctor and pharmacist and both said to just stop taking it since it's only been 2 weeks at 25mg. They both claim I should not have side effects. Wish me luck! F 48 14 days
25mg 1X D
 1  Anxiety Started pristiq at 50 mg on 11/13/20 . First 4 weeks very noticeable difference in anxiety (health) for the good. It worked, finally I feel normal I thought to myself. Well it was short lived, I noticed in the beginning I was tired, but that's to be expected on meds. Been on Zoloft it pooped out, lexapro od on 20 mg . But only med I'm on is prestiq . Lately past couple weeks it's all went downhill. I am so jittery , exhausted, my stomach and intestines hurt at times. shoulders, overall achy, it's almost a chore working all day. I get home and I'm so tired but can't sleep, have 2 kids and a wife that I don't even want to talk to or be around. And I love them so much, I'm emotional, rage for no reason. Jittery, and can't seem to sit still , just scroll through channels on the tv for hours . I do clean my house all the time, not sure if that is a bad thing but comes in part with not being able to sit still . Can't focus on anything, don't care attitude. It's a terrible drug. My body twitches for no reason, scared to drive and don't want to leave the house . Almost scared to. So dizzy , feels like there's a wall in front of my brain, blurry vision and chest tightness. Check my pulse ox and blood pressure 10 times a day Oh and the chills, can't seem to get warm. Some sweating episodes but mostly cold to the bone. Just a feel of dread , don't recommend. Please feel free to email me M 42 2 months
50 1X D
 2  Depression Severe grinding teeth, day and night. Started after several months. I took Pristiq for almost 2 years. had a lot of breakthrough symptoms. F 56 1 days
1X D
 4  Depression and anxiety Only side affect i have is constipation. Which is something i usually have no issue with. I do feel a great difference. Feeling better but hoping this constipation goes away with time. Anyone else have issue with this and what did you do to help? F 45 8 days
50mg 1X D
 5  Depression, anxiety, PTSD, ADHD My side effects: laughing, enjoying life, love exercising, more social, feeling confident, no irritability, successful in life etc... I definitely would recommend to anyone struggling. No need to struggle and be miserable when you have Pristiq. Wish I would have known about this medication years ago. I have worked in healthcare/hospital for years and Pristiq has helped me tremendously to get through such horrific times. I am now able to take great care of COVID patients without feeling so overwhelmed, anxious and depressed when I thought I had nothing left in me... if you are struggling-Pristiq may be your life changer. Highly recommend. F 40 2 months
50 1X D
 3  Bipolar 2 Nausea, lack of concentration, reduced appetite (7kg weight loss first 4 weeks), mild night sweats, anxiety and mood change Iím in the 6-8 week efficacy period. If my headspace and motivation donít change for the good will most likely wean off. Always difficult to deal with side-effects with the stresses of teaching. M 53 6 weeks
 4  GAD Panic Disorder Moderate loss of libido. Excessive sweating. Slight weight gain. Occasionally forgetfulness. SNRI that worked the best for me and still feels effective to some extent after 7 years. M 25 7 years
100 1X D
 5  Depression, anxiety Slight sexual side effects but nothing major. This medication has been a game changer! If you've tried SSRI's and haven't had success, I recommend trying Pristiq. I'm so glad my psychiatrist suggested it and that I was open to trying it. F 38 2 weeks
50 mg 1X D
 4  Clinical depression Constant heartburn Came off it for a few days and withdrawal symptoms were terrible F 74 10 years
100 MG 1X D
 1  Depression, Anxiety Brain fog, very slow reaction time, very dizzy, couldnt drive, couldnt think or make decisions, lactation and weightloss, no rem sleep, supressed my emotions, night sweats, memory loss, its like someone stuffed cottonwool in my head. I wasnt monitored on it. The doctor didnt make sure I was getting help from a therapist while taking it which should be mandatory. He even suggested I go out and drink like a normal 22 year old girl. You CAN NOT DRINK ON THIS DRUG! Worst years of my life. Also to get off it you have to spend a long time vomiting, sweating, shivering and feeling like your having a heart attack. Dont give this to young women! You might as well roofie them and send them out into the world. This is a really dangerous drug. Since being off it its like a curtain has lifted and I can think, work and my memory has come back. It also started wearing off after 4 years. F 28 7 years
100 1X D
 5  PTSD mdd,ocd and anxiety None I love this it gives me hope and I'm so happy on it I dont cry or get upset I just have so much energy and I can think clear F 39 0 days
50 1X D
 5  Depression I was told to take it in the morning but it made me so sleepy in combination with other meds that also cause sleepiness so switched to night. End of problem. Slight headaches, slightly blurred vision, very dry mouth. Itchy skin which may or may not be related to the drug. I was prescribed this because the medication I take for bipolar wasnít enough for the down side. Effexor was ineffective entirely. Within a week I was feeling better. After 30 days I havenít had a single bad episode of depression. The side effects are worth it to me. F 60 30 days
25 MG

PRISTIQ  (DESVENLAFAXINE SUCCINATE):  Desvenlafaxine is used to treat depression. It may improve your mood, feelings of well-being, and energy level. Desvenlafaxine is known as a serotonin-norepinephrine reuptake inhibitor (SNRI). It works by helping to restore the balance of certain natural substances (serotonin and norepinephrine) in the brain.   (Sources: U.S. Centers for Medicare Services, FDA)