PRISTIQ Reviews (DESVENLAFAXINE SUCCINATE)

Average Rating: 2.8 (628 Ratings)

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 ANTIDEPRESSANTS

 Type: Rx Drug

  

PRISTIQ  (DESVENLAFAXINE SUCCINATE):  Desvenlafaxine is used to treat depression. It may improve your mood, feelings of well-being, and energy level. Desvenlafaxine is known as a serotonin-norepinephrine reuptake inhibitor (SNRI). It works by helping to restore the balance of certain natural substances (serotonin and norepinephrine) in the brain.   FDA Approval Date: 2008-02-29 (Sources: U.S. Centers for Medicare Services, FDA)

  

Results are sorted by Date added.

Key to Ratings: 1=LOW (I would not recommend taking this medicine.)
5=HIGH (this medicine cured me or helped me a great deal.)

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RATING  REASONSIDE EFFECTS FOR PRISTIQCOMMENTSSEXAGEDURATION/
DOSAGE
DATE ADDED
 
 4  Major depression Within the first week: Fatigue, night sweats, nausea. Constant side effects: Delayed or impaired orgasm. Appetite slightly less. Overall, Pristiq has improved my depression but not to the point I'd like. Depressing thoughts are suppressed and anger is more easily controlled (things bother me less). DO NOT DRINK with this medication, it will make you very sick, cause vomiting and erratic behavior. F 23 3 months
8/27/2009
 3  Depression Insomnia, tired dragged-out feeling during the day, sweating at night, short-term memory problems, jittery feeling, occasional nausea/decreased apetite, slight "brain-zaps" when weaning off of it. I have tried just about every drug out there, from Imipramine to Prozac to Wellbutrin to Abilify, and most recently Pristiq. Prozac worked the best for many years, but just seemed to "fizzle out" at some point. Then began the trial and error of a series of different drugs. I would honestly give each drug a fair shake, hoping that the side effects would diminish and the antidepressant qualities would kick in. No such luck! Some made me fat, some made me sad, mad, manic, sick, sleepless, etc....you get the idea. Anyway, the Pristiq seemed at first to work, but after a few weeks and an increase in dosage I realized it wasn't helping. The strangest thing about this drug for me was trying to figure out what time of day to take it... If I took in the am, I felt zoned and tired all day; if taken at night, I had trouble sleeping. Go figure! Anyway, I gave it a "3" because it did seem to help at first, but after awhile I just started to feel more depressed. I'm off it and back to the Prozac again...for now. F 45 3 months
8/19/2009
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 5  Bipolar Depression, GAD Headache, mild nausea, and mild sexual side effects-All in the first week. Since that first week they have passed and the only side effect I have is complete relief of Depression. It has been a miracle for me. Tried everything in the book to combat my severe lows of Bipolar II. Finally my psych gave me some samples for this stuff. I was doubtful as I had tried Effexor previously to no avail. After 6 days on Pristiq I woke up feeling like a had some years ago. I am glad to say I am now in remission. M 19 15 days
8/13/2009
 5  depression Severe diarrhea that won't stop and loss of appetite. First day took it in the evening and couldn't sleep all night. I need to take it in the morning. I have no headaches. It's really too bad that I'm probably going to have to stop taking it because the diarrhea won't stop. This is the first drug that has made me feel normal, content with my life. I love how I feel but I can't stay out of the bathroom. Even Immodium doesn't work. F 57 4 weeks
8/12/2009
 2  Major depressive disorder Persistent nausea I am in Australia and consulted a marvellous institution called the Black Dog Institute who, after taking a complete history and thorough analysis told me Pristiq was the answer for me because I had damaged my liver by taking TCAs for 4 years - they are the only thing that has worked so far, except for Parnate which was a miracle but gave me terminal insomnia. The Pristiq is metabolized through the liver. The Black Dog Institute is govt funded so no reason to push Pristiq but it just didn't work. The only effect it had was constant nausea and tummy ache and perhaps an increase in depression - of a low level, persistent kind, rather than the screaming horrors, if you know what I mean. Might work for others though.They now want me to try Ritalin 5mg and working up - on day 2 and will report. F 53 3 months
8/8/2009
 5  depression, anxiety Have been on 5 anti-depressants and none have ever worked as well as Pristiq. I feel like I think I'm supposed to feel. have experienced major sweating & headaches, but benefit outweighs that. Have to take every day @ same time, cannot miss a dose. If I miss a dose I get dizzy & nauseous & irritable. F 31 8 days
8/5/2009
 2  Bipolar, chronic depression Stinging, burning, painful hands and feet. Bloating/gas. Easily aggitated. Aching joints. CONSTANT HEADACHE! After years of fighting depression and suicide with little help from Effexor I had hoped this may work. It's only been 11 days but the severe stinging and burning in my hands and feet are killing me. I'm used to the aches, pains, headaches that accompany depression and meds, however, I can't stand constantly applying lotion to my hands and feet hoping for some relief from the stinging sensation. Some discomfort may be attributed to the electric shock one experiences with Effexor withdrawal, but it was never this painful. F 43 11 days
8/4/2009
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 4  depression LOUD ringing in one ear, severe gastrointestinal distress I feel so much better after taking 100 mg for about 8 months now, but am starting to wonder if the ringing in my left ear is a side effect. The Dr says to see an ear nose and throat specialist which i did, can't find a cause for it but it's so loud and always there. Also am experiencing the worst gas and bloating of my life the last few months, i wonder if that is also a side effect as i have not changed anything else in my diet or medications. Please comment if you have experienced any of these two symptoms. F 41 8 months
8/2/2009
 1  Depression After two days I started to feel sore and week, by day 7 I looked like a Parkinson patient and was having excruciating muscle spasms. Only after one of my friends who is into pharmacology asked me what else I was taking, Elavil. She then told me to look up serotonin syndrome and stop taking the pristiq immediately and to call my doctor the next day. Apparently it can be life threatning to mix the two. F 21 9 days
7/30/2009
 5  Anxiety Without food: Headache and nautious With food- none I started on Pristiq after being off and on anti-depressants for my depression and anxiety. I was depressed only due to post-partum, but the anxiety was constant. I always had a tight feeling in my throat and could not make it stop. All day long... Pristiq is the only drug I have found to stop the tightness, but with very little side effects. The nausia is the worst... Have noticed some hair loss (when I brush)and night sweats. Other than that, I feel better than I have in several years. Feel like I'm ME again.... I recommend this.. but really, it's all on how your own personal body accepts the med. You would have to try it to see if it would help... I wouldnt go on all the comments much.. everyone is different. F 31 4 months
7/24/2009
 4  depression nausea, greatly impared orgasm Taking 50mg at night. Mood has improved. Orgasm virtually impossible though no problem with erection. I have tried many different anti-depressants over the last 40 years and only Parnate proved effective over a long period, though not recently. I am hopeful about Pristiq. M 63 3 weeks
7/23/2009
 1  depression, anxiety i have been on pristiq for two weeks. previously was on lexapro. since taking pristiq i feel as though the depression has gotten worse and having some suicidal thoughts. never had that on lexapro. also feeling more anxious, jittery, not sleeping and loss of appetite. all not good things!! i have just called my doctor and am going to talk to him about getting OFF this med as soon as possible. i would definitely not recommend it. F 60 14 days
7/22/2009
 4  anxiety at 50 mg for 6 weeks low energy. At 100 mg for 5 days serious diarrhea and feely tired enough for a nap at 5pm. went from lexapro, to cymbalta, then 50 mg of pristiq. The first 4 days felt immediately better,feeling somewhat high and joyous. Then became stable with no side affects. Felt less anxious, but not more relaxed. Started on 100 mg and for the first 5 days have had terrible diarrhea,feeling tired enough to sleep by 5 pm, and anxiety level punched up a notch to where I am becoming less anxious via signs of putting things off that are routine staying busy actions, and acting a little forgetful. I'm not sure of whether anxiety drugs can meet my expectations, but so far I am less anxious and beleiving that, to date, the results are positive enough to continue experimenting. M 60 9 weeks
7/21/2009
 5  Depression Headache, fatigue, loss of appetite. The side effects were really bad the first two weeks and then completely gone. I feel 100% better. Energy has returned and headaches are gone. F 43 10 weeks
7/20/2009
 5  Depression occasionally irritable. I was very skeptical about trying PRISTIQ because of all the negative comments about it being an "effexor retread". My experience has been that PRISTIQ is superior to effexor, in terms of side effects, and antidepressant effects. Specifically sexual side effects are minimal, and weight gain has been no issue. M 58 6 months
7/17/2009
 2  Depression/Anxiety Nausea, dizziness, fatigue, headaches, night sweats, impaired concentration, weird dreams, decreased libido, increased appetite I think I'm going crazy! Been taking this med for 3 months and have been having intermittent episodes of exreme nausea, dizziness, and fatigue. Completely debilitated during episodes. Doc prescribing this med said the symptoms would have presented in the first week and not the 3rd week. Decided to stay with it but symptoms are still occurring intermittently. Have been to other docs to test inner ear because of the dizziness and nausea...they are thinking its the Pristiq. Just started going off and feel awful...can't wait till it's out of my system to see if these problems go away. F 38 3 months
7/17/2009
 4  Depression, Anxiety, PTSD, OCD Tired throughout the day regardless of sleep hours. Within the first week I noticed a considerable difference in my level of depression. After 4 months however it seems to have lost some of its effectiveness. F 39 4 months
7/15/2009
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 3  DEPRESSION Was depressed due to problems at work.feel better but have severe insomnia.will see how it goes M 48 11 days
7/10/2009
 3  Depression Very jittery in the mornings, nervous, foggy feeling. I've only been on it 2 days so far, but I've been researching and feel like I shouldn't be on it. A lot of people taking it have severe depression, and I went to my doctor just questioning whether or not I was depressed. This medicine makes me feel nervous...maybe I need a 2nd opinion. So far the depression has not changed. F 24 2 days
7/9/2009
 4  Generalized Anxiety and Insomnia for 1 day at the beginning, I experienced slight nausea. The drug had almost no adaptive side effects. However, although the manufacturer claims the drug is weight neutral, I had a 20# weight gain even though I've maintained diet and exercise. F 57 8 months
7/8/2009

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