PRISTIQ Reviews (DESVENLAFAXINE SUCCINATE)

Average Rating: 2.8 (628 Ratings)

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 ANTIDEPRESSANTS

 Type: Rx Drug

  

PRISTIQ  (DESVENLAFAXINE SUCCINATE):  Desvenlafaxine is used to treat depression. It may improve your mood, feelings of well-being, and energy level. Desvenlafaxine is known as a serotonin-norepinephrine reuptake inhibitor (SNRI). It works by helping to restore the balance of certain natural substances (serotonin and norepinephrine) in the brain.   FDA Approval Date: 2008-02-29 (Sources: U.S. Centers for Medicare Services, FDA)

  

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Key to Ratings: 1=LOW (I would not recommend taking this medicine.)
5=HIGH (this medicine cured me or helped me a great deal.)

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RATING  REASONSIDE EFFECTS FOR PRISTIQCOMMENTSSEXAGEDURATION/
DOSAGE
DATE ADDED
 
 4  Depression nausea, frequent yawning, sleep issues, de-sensitized genitals Had been on Effexor years ago and had very serious withdrawal symptoms so I didn't want to take that again. Pristiq has definitely helped me with the depression (went from 50 to 100mg). The nausea and sexual side effects have gone away, but I am still yawning a lot and am CONSTANTLY fatigued. I can go to sleep without issue but I wake up all night. I can go right back to sleep, but all I'm getting is interrupted sleep-- nevertheless, I don't want to change meds because this has def helped my demeanor. CATCH 22!!!! would recommend, though. F 36 4 months
7/2/2009
 3  Depression Only been taking for 9 days and the sweating started immediately...day and night sweats! Its horrible! I do feel a little weird but nothing major...the crying has cut down some. I had been on Lexapro which I loved but apparently it wasnt getting the job done. Since Ive been taking pristiq I do find myself jittery...leg shaking always feel the need to move or do something. Ive been getting extremely irritated! And Im not getting any sleep what-so-ever. I know I should wait the drug out to give it a chance to regulate in my body but without any sleep I have terrible headaches during the day and that may be whats causing me to be so irritated...help! F 36 9 days
7/2/2009
 3  Depression Headache, nausea, dizziness, confusion. The nausea is terrible. Iam trying to give it a chance to level out but am wondering if that is going to happen. There are also times of confusion-- like once I went to pay cash and could not figure our how many bills and how much change to give. It was a huge mental block and very embarassing. I do have decreased appetite but have not lost weight (which would actually be nice). The nausea actually reminds me of the sick feeling I had when I was pregnant. Yuck! It has helped my depression greatly, so I have felt obligated to stick with it as long as I can tolerate it. Also, I recieved a card when I got the Rx,that when submitted to the pharmacy-- the company pays half the co-pay. That's a nice perk since these types of meds are expensive. I've also had headaches a lot, but I do have a history of migraines. I usually sleep off the headaches. Only time will tell if the all this is worth the side effects... F 2 months
6/30/2009
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 2  Depression & Anxiety Cognitive impairment--memory problems; word & name recall was embarrassing; lack of motivation/focus; Irritability; less social; Withdrawal symptoms on day 3 (ringing in ears, profuse sweating). Unfortunately I've had to take antidepressants for 20 years now. Pristiq was the 3rd SNRI I tried. I've tried most of the SSRIs & I always return to Paxil. It's many benefits outweigh the 2 side effects I had (lack of orgasm and constipation) Please be sure to research the difference between SSRI drugs and SNRI drugs--very important distinction--and the research states they should not be taken together! Lots of progress with antidepressants in recent years, so hang in there! F 57 9 months
6/27/2009
 1  depression i only took it for 3 weeks and a month and a half later i still have diarhea from it. F 40 3 weeks
6/25/2009
 4  depression, anxiety Nausea during the first week or so. Restless legs, vivid dreams, decreased libido, delayed orgasm. If I miss even one dose, I feel it right away. My head feels strange, like it's swirling and I feel sort of nauseous. I also have nightmares if I miss a dose. This is the first antidepressant I've taken and it seems to be helping. I am more outgoing now and more sure of myself. I have more motivation to do things. However, I do still have suicidal thoughts and sometimes severe anxiety. Despite that, Pristiq does seem to have positive effects. F 18 5 months
6/24/2009
 5  Anxiety/depression I had all of the side effects in the beginning, loss of appetite, tiredness, waking up alert at 3am, constipation, excessive night sweats, blurred vision. All of the side effects (except night sweats) dissappeared after one month, so stick with it! I was on Zoloft for one year and I never felt that great and I gained weight, it was not until I got on Pristiq did I feel normal and less anxious again. I recommend it to anyone who suffers from bad anxiety. F 35 9 months
6/23/2009
 4  depression The first day i experienced nausea and heartburn but that disappeard when I took it with a full meal. I have been on it for 6 weeks now and hands down it is the best experience I have had with anti-depressants.Naturally, I still have many other issues but I am not lying in bed crying and can now enjoy life.I have always had very bad sleeping issues and it hasnt done much to correct that. There are no side effects that interfere with daily functioing and I am very appreciative that my doctor gave me this. Originally he wanted to try me on cymbalta but felt it was over my head financally. F 47 7 weeks
6/21/2009
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 1  depression weight gain (40 pounds in 6 months) constipation; vivid dreaming; incomplete sleep; exhaustion; increased heart rate; lossof mood; affect changes; no sex drive; no desire for personal relationship; isolation; despair; crying and saddness abrupt withdrawl d/t loss of healthcare benefits; hallucinatory dreams; unsettling feeling; insomnia; leg cramps; terrible gastrointestinal disturbances; terrible nausea; irritability. I a m off 4 days now. Does anyone know how long this will last>? I thought I would take myself to the ER last night for the hallucinations and nightmares. I was on 150 mgs daily times several months, before that, effexor, before that, lexapro..........I hate all of them F 47
6/19/2009
 4  anxiety nausea in the beginning, now only side effect is sweating ALOT when i sleep i've been on almost every antidepressant out there and so far this one has worked the best for me. other than the terrible sweating at night there aren't any side effects for me. i am able to enjoy myself without constant fear of....well everything. the only problem is when i forget to take a pill i'm in BAD shape! withdraw happens the day of your first missed dose so i make sure to keep them with me all the time. F 25 1 years
6/11/2009
 2  MDD, PMDD Extreme sedation when taking it in the morning, insomnia when taking it at night. Felt zonked out most of the time. Near complete loss of libido. Blurred vision. Mild nausea and fluctuations in appetite. Heart palpitations. Constantly felt overheated, like I had a fever. I'm extremely sensitive to side effects from most of these medications. I did notice an improvement in my mood, but the side effects did not go away with time on this drug. I was encouraged by the fact that I was able to take a full dose for almost three weeks, though--I'm usually not able to stay on a quarter dose of anything more than a day or two! Also, it really did reduce the symptoms of PMDD significantly. Too bad the side effects didn't go away. F 46 18 days
6/7/2009
 4  
6/6/2009
 2  anxiety headaches, jaw clenching, hand tingling, jittery, nausea The first few days were horrible. I had horrible headaches, nausea, cold sweats, felt completely out of it and not myself and my hands were constantly tingling. I decided to give it a few more days before completely writing it off but the headaches didn't go away. The jaw clenching started and was so bad I walked around holding my mouth. Nausea would come and go but would wake up very jittery. Dr. took me off and am now trying Zoloft and doing a lot better after 3 days. F 29 11 days
6/5/2009
 3  depression rapid heartbeat, feeling dizzy/swoony. No desire for food. my dream state and waking state seem to blend - I wake from dreams and not sure they happened or I dreamed them. Was on 150mg of effexor. Now on 50mg of Pristiq for 3 weeks. The sweating side effects on effexor are gone as are sexual side effects. I've had a few instances where I get a fast heartbeat and then feel fainty/light headed. I get hungry physcially but no food really appeals to me. I think that happened in the early days of Effexor too but it went away. Energy level seems same. Still taking ambien to fall asleep every night. F 40 3 months
6/3/2009
 5  depression sweating,dilated pupils works fast! F 44 2 weeks
5/30/2009
 2  Depression No real side effects that I could pinpoint. No improvement after 6 weeks. I switched from Lexapro to see if there would be less side effects. There were less side effects but I was sliding back into depression again. I had to add 10mg of Lexapro to start feeling better again. So I have stopped taking Pristiq several days ago and back to 15mg of Lexapro which does have side effects. But still better that feeling down. M 57 6 weeks
5/30/2009
 2  Depression/Anxiety It made me very irritable I took it for two weeks and got off. It didn't help at all it just made me worse F 34 14 days
5/26/2009
 5  BiPolar Disorder sleeplessness Have been on Pristiq for 4 months in combination with Zyprexa and Seroquil. I am the most stable I have been in 10 years. I started on 100mg but was increased to 200mg which works for me. The sleeplessness is handled by taking them in the morning. F 48 4 months
5/25/2009
 4  Bipolar, Anxiety Jittery, Headaches, Constipation then diarrhea, Mood swings,Delayed Ejaculation When I started taking this I had been unmediated bi choice for 9 years, I was at a breaking point where reality had to trump my pride. I went into it with apprehension to begin with. For the first couple of weeks I was miserable, but I was miserable anyway. Stick with this, Medications have changed since the last time I was on them. It does work, and the side effects do get better. It will make sleeping a little more difficult. I still take ambien to sleep, however I had sleeping problems before the meds. 50mg was a rolercoaster ride daily, so I switched to 100mg, For the most part the switch from 50mg to 100mg was mild. All in all, a rough ride at first, but worth the wait when it started working for me. I am now looking back over the last 9 years and wishing it had been there. M 34 2 months
5/17/2009
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 2  Anxiety and Depression At 50mg, none whatsoever, including sexual. At 100mg, sedation in the evenings and delayed orgasm (although not as severe as with Effexor and no issues with erections or loss of sensation). I switched to 50mg of Pristiq after gradually reducing Effexor from 150mg. After being on 50mg for three weeks and realising that it was not benefiting me, I increased the dose to 100mg. I've now been on 100mg for 10 days and have noticed no benefit. I'm very disappointed, especially given the lack of significant side effects. I'm off to try Cymbalta next. I hope you have more success with it. M 32 4 weeks
5/17/2009

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