PRISTIQ Reviews (DESVENLAFAXINE SUCCINATE)

Average Rating: 2.8 (628 Ratings)

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 ANTIDEPRESSANTS

 Type: Rx Drug

  

PRISTIQ  (DESVENLAFAXINE SUCCINATE):  Desvenlafaxine is used to treat depression. It may improve your mood, feelings of well-being, and energy level. Desvenlafaxine is known as a serotonin-norepinephrine reuptake inhibitor (SNRI). It works by helping to restore the balance of certain natural substances (serotonin and norepinephrine) in the brain.   FDA Approval Date: 2008-02-29 (Sources: U.S. Centers for Medicare Services, FDA)

  

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Key to Ratings: 1=LOW (I would not recommend taking this medicine.)
5=HIGH (this medicine cured me or helped me a great deal.)

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RATING  REASONSIDE EFFECTS FOR PRISTIQCOMMENTSSEXAGEDURATION/
DOSAGE
DATE ADDED
 
 1  depression/anxiety nausea, inability to concentrate(forgetting names, words very embarrassing), extreme jaw clenching(asleep or awake), headaches, irritability- turning into extreme anger at light speed, weight gain, restlessness, unable to wind down, sex drive has tanked I have been on Lexapro for 3 yrs, needed to swap due to drug not really working for me anymore, OMG!!! I have only been on this drug for 5 days and I am soooooo coming off of it right now, I HATE IT!! Severe iritability, turning to full blown temper within minutes ( I was NOT like this before!!!!!), jaw clenching that lead to severe headaches, basically I was not myself. I know what everyone says about giving your meds a chance to work but this sucks big ones and my whole life is suffering. My kids are scared of me!!!!! I might fly off the handle for no reason.....thats no way to live. This drug is not for me. I am not even talking to my gp about it, I just know this is the right thing for me to do. You make up your own mind!!!!!! F 37 5 days
1/1/2010
 1  Brain wave disorder--seritonin drop Severe constipation-totally blocked upper intestine--pain level resembling long-term stage 3 labor. Magnesium citrate, enemas, laxatives did not work. It took a tube procedure to unblock the upper intestine and it occurred two more times until discovered that the Pristiq casing which does not digest but goes through your system as a small sponge the size of a small marshmellow was the culprit in blocking my upper intestine. When taken off the medication cold and quickly, I went through severe withdrawal--severe vertigo, nausea, shakes, sweats, flu like symtoms and feelings of passing out along with crying spells. I still have a bit of hissing in my head and shakes which should subside within the next few days. This is by far the worst medication I have ever taken. I do not usually experience much in the way of side effects and the ones I do have been mild. I took the lowest dosage available. I can't understand why an extended release pill was not placed in a dissolable capsule I have been on low dose medication for 20 years. When I become ammuned, I have been switched to other medications. Pristiq was the medication from hell. Within six weeks I found myself in the ER three times for a blocked upper intestine. Magnesium citrate and enemas did not work. It took an very invasive procedure to unblock the upper intestine. The pain was as intense as 3rd stage labor. It took three visits to ER with morphine to reduce to pain and lots of colon cleansing to release the blockage. Pristiq is a hard tablet with a casing that swells up like a sponge about the size of a marshmellow that is supposed to be released through your colon. Mine blocked it entirely. It took magnesium citrate, enemas, a tube intervension and then 64 ounces of Go Lightly to finally release all these casings from my upper intestine. Then I had to go off medication and went through the most severe withdrawal with severe vertigo where I could not even move my eyes from side to side, shakes, sweats, flu like symtoms. It took four to five days to return my system to somewhat normal. I still have some hissing in my head and shakes which I hope will eventually subside. I am, in general, a very healthly person with no colon issues and no health issues. I would never recommend this medication to anyone after the last three weeks of pain and withdrawal I have had to experience. I have taken probably seven different medications over the past 20 years and never have had side effects F 58 60 days
12/30/2009
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 1  Depression and OCD Severe depression, suicidal thoughts and mania Was on Prozac and switched to 50mg Pristiq. The first week of transition between the 2 drugs was great!!!! However, it only lasted a WEEK! My Dr. continued to raise my dosage in an effort to get me back to how I felt the first week however I never got there. He increased me to 200mg (saying that he had some patients on as much as 300mg). He agreed to reduce me back down after seeing worsening results. Though this was a slow transition, I still had severe withdrawal symptoms such as suicidal thoughts, severe depression, worthlessness, mania, etc. As a last ditch effort to feel normal again I opted to go holistic. I also have ADHD and purchased the book "Prescription for Nutritional Healing”(at GNC) to learn more about how to treat ADHD naturally but later realized that Anxiety, Depression, Manic Depression and even Schizophrenia were listed in the book. The book is user friendly and list out the vitamins that you should and should not take and the reason why. It also lists the essential foods that should be eaten and avoided. Example: It states wheat should be omitted completely because it has been linked to depressive disorders. Luckily, I was told of Psychiatrist who also prescribes vitamins (because it helps the body absorb the meds) to assist me in weaning off Pristiq. He mentioned that Pristiq could cause mania. Not good for me because I already had those tendencies. There is question as to whether or not I have a mild case of bipolar however the F 35 6 months
12/22/2009
 4  depression, anxiety migraine, occasional nausea, dizziness Began with 25 and then 50mg to mitigate Lexapro withdrawal. Side effects ended as I adjusted to the medication. M 26 2 months
12/21/2009
 1  Depression and anxiety Anxiety symptoms worsened and became unbearable... I was paralyzed with anxiety while taking this med. My depression worsened and I became suicidal, had to be hospitalized. Anorgasmia and loss of libido was troublesome as well. I was taken off Pristiq gradually and began Luvox about a week and a half ago... doing VERY well now with the Luvox, not much anxiety at all anymore and my libido is back/no more anorgasmia, feeling hopeful and getting back into life now. M 37 2 months
12/21/2009
 4  Depression I had almost every side effect for the first week. After 35 days, the one remaining side effect is blurred vision. It is quite alarming and I am debating whether I should stop the drug. I have had almost every other SSRI, and this one is by far the most effective. And, other SSRI's had side effects that forced me to stop. None however caused blurred vision. I am hoping that this condition improves because I do not have any other options in the drug world. F 56 35 days
12/18/2009
 3  Severe Depression Weight gain, lethargy, short temper/anxious, if I miss a dose within 4 hours I'm feeling nauseous, dizzy, sick like I'm dying. Lexapro lost its efficacy so I was switched to Pristiq. I'm severe bi-polar and take Lamical also. Initially Pristiq lifted my mood, allowed me to be happy with what was, positive outlook, the doom and gloom was lifted and I felt so much better than I had in years. Unfortunately, I'm not feeling that way now and feeling the side effects. I'm most concerned about the weight gain! F 47 9 months
12/16/2009
 2  Anxiety, OCD, Depression Nausea, jittery hands and legs, headache, body aches, weakness, loss of appetite, groggy in the mornings. Increasing anxious thoughts. I wouldn't recommend this med. I'm taking 50mg and it seems each day the nausea and headache feelings gets stronger. I thought I was getting the flu but come to find out it's the med. F 28 5 weeks
12/16/2009
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 1  Depression I would have chosen 0 for a rating - but it was not available... Chest Pain, Hallucination, Paranoia, High Blood Pressure, Depression, EXTREME Anxiety, Panic, Crying, Laughter - Like coming off a meth or cocaine bender - but worse. I had the worst manic day2 in 19 years on 3 days with this drug. Choosing between prestiq and suicide would be very easy. I made it through with my support system and a extra doses of xanax. I'm glad this drug works for some - but before embarking - READ THE SIDE EFFECTS. It didn't work for me!!! After the effects of pristiq wore off, I felt peaceful, relieved and ready for some good sleep. Depression seemed like a walk in the park compared to this drug - better suited for use in military torture. M 53 3 days
12/14/2009
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 4  Depression, Severe Anxiety Drowsiness, Problems focusing . . . both lasted about three weeks, then lessened. I do not notice either anymore. I moved to this after my insurance dropped Cymbalta. Pristiq seems to be working sufficiently [in conjunction with other medications]. However they cannot singularly do with Cymbalta did. F 22 4 months
12/13/2009
 4  Depression 50mg - none; 100mg - only on day two but started feeling slight effects after just a few hours of day one. Feeling tired and a lack of energy. Seems like a lot of people are saying that some of their side effects lifted after a week or two. I hope that's the case for me. 50mg helped alot at first (switching from Paxil 30mg which pooped out) then seemed to gradually not help as much. Hopefully the 100mg will hold longer. M 32 9 months
12/12/2009
 3  depression dialated pupils, severe anxiety, insomnia,mild sexual disfunction depression has improved, havent had anymore suicidal thoughts but gained a lot of anxiety, i never had it before taking pristiq. if im late on my dose i get headaches. staying on med, hoping side effects go away. glad suicidal thoughts are gone. M 25 5 days
12/7/2009
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 2  Depression Sleeping all the time , no will to do any-thing , didn't feel like even taking a bath!! Better since I stopped taking it, I only took it for 2 1/2 weeks. Man , what a nightmare. I think this might work for some-one , but not the general population of depressed ( and I mean depressed , like it's life for us , dawl , type folks ) F 42 18 days
12/2/2009
 4  depression & anxiety slight headache for the first few days and low energy. Things are better now. I've tried so many antidepressants, but Pristiq has been working wonders for me! I feel happier and more positive and my energy is coming back. The only thing that gets me a little nervous is... what if this medication stops working and I'm back to my old sad self again? I have to stop thinking that way. Thanks Pristiq!! F 43 3 weeks
12/1/2009
 4  depression Hair loss, trouble sleeping, hot flashes, night sweats, jaw clenching Been taking for about 6 months. My benefits from the drug have been good but the hair loss and jaw clenching is starting to bother me. I have been on other anti-depressants before which didn't seem to help the depression as well as Pristiq. Will probably talk with my doctor about the side effects and see if there is another drup I can take. I didn't realize that alot of the issues I have been having are probably side effects to Pristiq until I started reading the comments on this site. F 53 6 months
11/30/2009
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 1  Depression, insomnia High blood pressure, palpitation, ringing in my ears (tinnitus), dizzines, extreme pain in my joints, dry mouth, apathy, hot flushes I took Pristiq for a week in conjunction with Cymbalta to wean myself off Cymbalta. At the time I thought it was working great, because I could finally fall asleep and stay asleep all night. So, I told the Dr. that this might finally work!! Boy was I wrong!! After discontinuing Cymbalta my problems began. See the Side Effects I had. I have been off for a week and my ears are still ringing so BAD I just hate it!! Still have somewhat high blood pressure (never had problems with my blood pressure before). I hope these symptoms will go away. And now unfortunately my insomnia is back. I think they ought to outlaw this medication. F 62 30 days
11/25/2009
 5  DEPRESSION, ANXIETY The first 2 weeks I noticed sexual side effects, but only a few hours after I took it. Less hungry, more thirsty. Nausea was a problem for about 2 weeks, gone now. The best thing about this medication is that all the side effects have either disappeared or leveled off for me. My anxiety is greatly curbed and depression is much less severe too. I'm able to concentrate on things better and I have more energy. My family has noticed that my temper rarely flares like it used to. Overall the results are great. F 47 3 months
11/23/2009
 3  anxiety/depression I was nauseated for the first week- I dont know-I dont notice anything- I think I get a little more irritated more easily? I know this takes awhile to get into yoursystem, but I am still not noticing any difference in mood or energy or anything. I am still awfully down and depressed and am really just waiting for something to happen. I have tried a thousand other things. I was really hoping for a boost in energy, but havent noticed anything. And it is hard for me to get up in the morning. My body is always tired. I hope it works well for you. M 32 2 weeks
11/22/2009
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 2  ocd severe constipation It didn't help my symptoms much F 25 3 months
11/20/2009
 2  GAD- General Anxiety Disorder a little dizzy when getting to standing position, gas, constipation. More major side effects is waking after several hours, and sexual dysfunction(Anorgasmia) M 65 8 days
11/19/2009
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