PRISTIQ Reviews (DESVENLAFAXINE SUCCINATE)

Average Rating: 2.8 (628 Ratings)

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 ANTIDEPRESSANTS

 Type: Rx Drug

  

PRISTIQ  (DESVENLAFAXINE SUCCINATE):  Desvenlafaxine is used to treat depression. It may improve your mood, feelings of well-being, and energy level. Desvenlafaxine is known as a serotonin-norepinephrine reuptake inhibitor (SNRI). It works by helping to restore the balance of certain natural substances (serotonin and norepinephrine) in the brain.   FDA Approval Date: 2008-02-29 (Sources: U.S. Centers for Medicare Services, FDA)

  

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Key to Ratings: 1=LOW (I would not recommend taking this medicine.)
5=HIGH (this medicine cured me or helped me a great deal.)

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RATING  REASONSIDE EFFECTS FOR PRISTIQCOMMENTSSEXAGEDURATION/
DOSAGE
DATE ADDED
 
 2  Depression Extreme tiredness during the day, sweating, restlessness at night, decreased libido, tingling hands, itchy scalp, vivid dreams. Diagnosed with clinical depression about 8 months ago and started on 50mg/day 6 months ago. AFter about 3 months there was still no noticeable improvement, so dr increased it to 100mg, then 150mg briefly and currently 200mg/day. No obvious improvement but the side-effects have become more evident. Plan to ease myself off it over the next month as the tiredness is making it impossible to function at work. M 43 6 months
200 1X day
3/3/2010
 1  anxiety/depression wow. i've never had blurred vision in my life, and within 24 hours of starting prestiq i couldn't see straight and literally felt like i wasn't in my own body. scariest feeling ever. The sexual side effects were the absolute WORST. ZERO sex drive what so EVER, not to mention, impossible to orgasm. i know it says you will not gain weight, but i gained 11 pounds within one month. i really wouldn't reccomend this.....try something else. stay AWAY.....far far FAR away. while it did help with the anxiety, the side effects make this medicine more harm then good. F 24 3 months
50mg 1X day
3/3/2010
 2  Depression; Anxiety Extreme irritability and anger; body aches; slight headache I was on 100mg of Zoloft for years... all of a sudden it stopped working completely for my depression (although it was still keeping my anxiety in check). Doctor was going to start me on Effexor but only had samples of Pristiq left. I have noticed a slight lift in my mood but, anxiety is more pronounced than usual and I'm so easily irritated and fly into angry rages way too easily (especially since I have a 5 month old and a 23 month old to take care of full time and work from home full time as well). I don't know if it's due to Zoloft w/drawals or if it's just not helping... I know it hasn't even been a week but, I feel desperate for the anger to stop!! Very much likely to go back to Zoloft or something else if it doesn't improve within another week. F 29 6 days
50 mg 1X day
3/2/2010
 1  depression vivid dreams, severely decreased libido (it's nonexistant now), headaches, joint pain While it did help manage my chronic depression, it has left me feeling flat. I almost don't feel present in my own life any more. It's like I am a spectator instead of a participant. I am in the process of trying a different antidepressant. M 39 8 months
50mg 1X day
2/26/2010
 5  Depression, Anxiety, Severe Fatigue Pristiq is great but I have had side effects. The first week or two of taking pristiq were a bit difficult, nausea, dizziness, tired, runs, blurry vision (but keep in mind I was swapping anti-depressents therefore some of this would have been withdrawals as well). After 6 moths the side affects have come and gone and also changed. First few months was lack of appetite , then heaps of energy which later levelled out but I do find it hard to sleep at night. mild increased appetite, hair loss, decreased sexual drive, mild overheating, mild headaches and mild ringing in the airs. My bowels also don't move as often. Good side affect is that it has cleared up my acne which seem to be a result of stress and hormones or hormones causing stress that caused acne.... So in other words I believe the Pristiq has levelled out my hormones. I was taking luvox for a number of years and swapped to Pristiq. I wish I had done that sooner... I obviously have a fair few side affects but the side effects I have listed are fairly mild. For instance yes I find it hard to sleep of a night but I feel fine in the morning so its ok... Yes I get headaches but nothing a nurofen won't fix. I was very interested to read about the hair loss and ringing in the airs as this has just started for me even though i have been taking the drug for 6 months now.... I find that the side affects come and go such as the headaches and appetite changes. In saying all I recommend Pristiq. Pristiq has done what I need it to do and that is, feel normal again. I don't have the major symptoms, that I had as a result of depression. I don't have severe fatigue anymore, I don't have severe nausea and throwing up. I don't dwell as much, don't cry and actually enjoy life and don't have to force myself to do things. My anxiety is much better and moods are much better as well as my overall confidence in myself to cope. I was very hesitate to change from Luvox to Pristiq but I am so glad I did as Luvox was just ok where as Pristiq has really made a huge improvement to my life. I will see the doctor about my hair loss and ringing in the ears even though the ringing is mild. I also want to mention that it has cleared up my acne so much that I barely have any at all. Thats a bonus side affect for me! Pristiq is worth a try. F 30 6 months
100 1X day
2/24/2010
 2  Depression/Anxiety I was only on this for three days but in that time i felt an immediate effect 45 mins after the first tablet. I was spaced out in a big way, very heavy limbs, a headache, blurry vision that made me want to blink to focus all the time and just a strange out of it feeling I got scared after 3 days of feeling so out of it, and stopped taking it. It's now been a couple of weeks and I'm still waiting to straighten up and get my clear head back. I know they're meant to take a few weeks to feel the full benefit and I think I did feel a bit more indifferent to the problems in my life on the 3rd day, in a good way, but I don't know if I'm comfortable with the way I might feel when I've got commitments at work and can't afford to be a space cadet. I've got depression and anxiety issues and never taken anything else before. I feel like I want to but I'm afraid of losing my mind or just getting on the whole med go-round thing. I think I'll try coping on my own but will maybe ask my doctor about something else M 31 3 days
50 1X day
2/22/2010
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 3  major depression/anxiety; FM Diarrhea, headaches, joint.muscle pain This medication was fantastic for the first month, then suddenly completely stopped working. Stayed on it for 2 more months and became SEVERELY depressed again. Pdoc and I agreed to go back on Effexor XR. Been on 225mg for 3 months, just upped to 300mg/day. Feeling MUCH better now. Phew! F 42 3 months
100mg 2X day
2/21/2010
 2  depression Shakiness and tremor. Handwriting looked like a 90-year old stroke victim. I reduced it to 50 (on my own) and my handwriting is almost normal. I really don't think this has done anything for my depression. Really don't think this has done anything positive for my depression. F 65 3 months
100 mg. 1X day
2/20/2010
 1  depression, anxiety rage out of nowhere & extreme irritability that started 2nd week...also was not sleeping restfully @night...would wake up with dark circles after 8-10 hours of sleep F 34 11 days
50mg 1X day
2/20/2010
 5  Depression Yawning, Delayed Ejaculation, Loss of Libido Working great and effects kicked in from day 1. I'm still amazed just how much it has changed me, going from moderate/severe depression into a place where I feel inner calm. I can't thank the drug manufacturer enough. While I do have side effects I can live with them as long as it continues to make me feel happy. It's just such a big relief not to feel crap all the time. M 27 2 weeks
100 1X day
2/16/2010
 4  depression/anxiety sexual side effects, inital loss of appetite This drug is similar to Effexor. I feel much better, more even-keeled, and can laugh. No more panic attacks. However, it flattens me out a bit and does not help with motivation. I may add an ADD med for that. Biggest concern is weight gain; and though I lost weight at first, it is too early to tell about that. F 44 21 days
50 mg 1X day
2/15/2010
 5  Depression None F 22 7 months
50mg 1X day
2/9/2010
 1  depression, Bipolar 2 I totally fell apart. I had a panic attack every day, so severe I started crying for no reason and could not leave my house. Had previously been on Effexor without these effects. I had my Pdoc put me on Lexapro instead and these effects immediately disappeared. I would avoid this med like the plague. My opinion is that it will be taken off the market in a few years. M 44 4 days
50 MG 1X day
2/7/2010
 1  Depression, anxiety, OCD 50 mg of Pristiq. Appetite under control. Libido and ability to orgasm was restored. (was on Lexapro for years, and my sex life was a joke and my waist line an even bigger joke.) Felt almost human for about a week. Then all of the sudden, I went nuts. Couldn't control my anger, my crying, or my anxiety. I don't know what caused me to snap, but week #2 on Pristiq was hell. Ultimately, my p-doc saw what a mess I was and switched my meds. If you like fantasizing about your loved ones crying over your embalmed corpse, then this is the drug for you! F 35 2 weeks
2/1/2010
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 4  GAD a very slight headache on day one, plus some insomnia. Take Alprazolam for sleep so that helped. Day two on this med and I actually feel happier and more positive. My headache yesterday was very minor, not bad enough to be bothersome. I already take sleep meds so the insomnia wasn't that bad either. So far those are my only side effects. F 44 2 days
1/27/2010
 4  Depression, Anxiety The most notable side effect is lack of interest in sex and difficulty orgasming. I'm only 25, and I have a gorgeous girlfriend, so it can be frustrating, not to mention difficult to explain to her. I did run out once and experienced SEVERE WITHDRAWAL EFFECTS. Apparently, this is not uncommon, and just by googling "Pristiq withdrawal" you can find many sites where other people have wrote about their withdrawal experiences. This is one of the only drugs that has helped my severe depression. I am not where I want to be with it yet, but it is better than the results (or lackthereof) that I have received with other drugs. F 25 3 months
1/27/2010
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 2  Depression; General Anxiety first 3-4 weeks I felt wounderful. After a full month and a half or so I started to feel worse than before. * Worsening depression * Irritability * Pounding rapid heart rate (even while resting/sleeping) * Horrible sweating * Teribble mood swings * Shaking in hands * Terrible nightmares/dreams * Difficulty waking up * Don't sleep as well as I used to * Constipation * Fatigue After finally deciding to discontinue this med I experienced... * Brief but very very frequent pulsations/"Zapping" feelings in my head * Still sweating alot * Still having strange and very scary dreams * Still hard to wake up after experiencing strange dreams ( which terrifies me even more) I've only been off of this med for 3 days now. Hopefully these terrible side effects will go away soon. I certainly would NOT reccomend this med to any one specifically within my age group. I'd much rather depend on the Lord to help me overcome my battles than to deal with these side effects. I've never felt this bad. F 22 2 months
1/27/2010
 3  depression/anxiety none. This is my first day on this medicine and I am surprised that I seem to have no side effects, not even nausea. It is too early to tell if it is helping or not. I am most concerned about weight gain, since I had that on Effexor. Supposedly this one is "cleaner," so hopefully it won't happen again. F 44 1 days
1/26/2010
 3  Fibromyalgia I have not had any side effects. I am taking this along with 450mg of Lyrica. I have had some relief from my daily pain. I was not able to get out of bed & now I'm able to get out of bed at least 3 - 4 days out of the week. F 36 2 months
1/20/2010
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 2  Depression I first started taking pristiq when I told my Gynogologist I was starting to feel down because I was going through the change and was starting to feel pretty blue and she recomemnded and prescscribed pristiq. The first 4 months taking pristiq my depression was gone completely. I could even sleep at night which was good because I couldn't sleep anymore.My dreams were very vivid which was a very cool side effect that I acually liked. The The bad side effects were intense. Headache, blured vision, iching, skin irritation under moles which started bleeding, no interest in sex and when I did have sex I had difficulty having orgasm ( which sucks) Sooo i decided to stop taking after 4 months. You would think side effects would stop but they didn't. The side effects worsened and continued for about 2 months after I stopped. I had head zings and was very dizzy. The worse thing about the whole experence is the reason I started taking prestiq,on a scale of 1-10 about a 4 rating depression.Now F 53 4 months
1/14/2010

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