PRISTIQ Reviews (DESVENLAFAXINE SUCCINATE)

Average Rating: 2.8 (628 Ratings)

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 ANTIDEPRESSANTS

 Type: Rx Drug

  

PRISTIQ  (DESVENLAFAXINE SUCCINATE):  Desvenlafaxine is used to treat depression. It may improve your mood, feelings of well-being, and energy level. Desvenlafaxine is known as a serotonin-norepinephrine reuptake inhibitor (SNRI). It works by helping to restore the balance of certain natural substances (serotonin and norepinephrine) in the brain.   FDA Approval Date: 2008-02-29 (Sources: U.S. Centers for Medicare Services, FDA)

  

Results are sorted by Date added.

Key to Ratings: 1=LOW (I would not recommend taking this medicine.)
5=HIGH (this medicine cured me or helped me a great deal.)

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RATING  REASONSIDE EFFECTS FOR PRISTIQCOMMENTSSEXAGEDURATION/
DOSAGE
DATE ADDED
 
 5  anxiety.. tiredness, last an hour in the bed(sexual)wear-out my wife, lol , but nothing major! Low dose of effexor has worked for me in the past..but this has a different "feel".. But seems to be effective..havent been on it for very long! M 42 5 days
3/2/2009
 2  depression, anxiety I have bipolar disorder 2 and within days of taking it I had mania and then all of a sudden I dropped into depressive state.The headaches were terrible so my doctor told me to stop it and see the results.The headaches were gone but I went back to severe depression,anxiety and suicidal thoughts.The doctor told me to get back on it half a pill 25mg and try to wean off of it gradually.The HEADACHES are back.I've decided to live with the headaches until I'm off of it completely the price I have to pay not to go back to the complete despair I was feeling F 42 4 weeks
3/2/2009
 5  severe depression Nothing major. Perhaps a bit of tiredness that's probably more attributable to the depression. This drug has been wonderful for me -- especially after I went from 50 mg to 100 mg. I have taken Zoloft in years past and have noticed side effects like dry mouth. Zoloft was OK but seemed to fail me when I sunk into a major depression a year ago. For me, an SNRI seems to work better than an SSRI. I think it's VERY important for readers of these reviews to remember two things: 1) Everyone's body chemistry and needs are different and there is no magic bullet. Be patient with the drugs and wih yourself as you find the best treatment for you, and 2) Don't mistake exhaustion, loss of sex drive, or other physical symptoms for side effects of the drugs when in fact they have proven ties to the physical symptoms of depression. Be cautious not to confuse the two, which might lead you to dismiss a drug before you've given it half a chance. Seriously folks -- two days on an anti-depressant will do NADA for you. Two weeks is more like it. F 38 10 months
3/1/2009
 5  Depression, Anxiety, ADD slight nausea the first few days, and nothing since. I've tried nearly every antidepressant on the market, when I finally found Wellbutrin, but then it started to poop out on me after a little over a year, so I started Pristiq, and it was exactly what I needed to perk me up again. I felt happy again almost instantly. F 25 3 months
2/21/2009
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 2  depression and anxiety I experienced sweating, dizziness. I posted something before about pristiq. I had to stop taking it because it did not really give me the full sustained beneficial effect I had with effexor xr. It seemed it quite did not help me get out of my depression and was not doing much for my anxiety. So I went back to Effexor xr and I can see how different I feel now on Effexor, I am more optimistic, positive and focused, my anxiety is back to normal levels. I do feel the decrease libido side effect but prefer to learn to deal with it than living with depression and anxiety. One good thing about Pristig is that it had very minimal sexual side effects and not weight gain. Too bad I had to quick taking it but I am gald that Effexor works very well for me. M 37 70 days
2/16/2009
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 1   severe down mood. sweating. sexual dysfunction. no appetite. no rest. M 56 21 days
2/7/2009
 1  depression and anxiety HORRIBLE jittery, shaking, insomnia, absolutely no appetite, hard to swallow, eyeballs shaking, rigid muscles, brain weirdness HORRIBLE MED! my doc put me on this to add to the remeron that i was already on for 5 months because symptoms of depression came back and it was 2 horrible days! F 39 2 days
2/6/2009
 4  Hotflashes Constipation, no libido I was on Effexor and was hungry all the time. Also kind of irritated. I tried Pristiq and had a hard time to move to it and returned to Effexor. Then, I understood I should return to Pristiq and I am on it now for 5 months and doing great. I did have to increase the dosage to 100mg. I'm strugling tho with very strong constipation problems. Besides the hotflashes I had several pain symptons. Neck, shoulders, low back, waist, ankles... Pristiq put them away as well. I had no depression or anxiety and I keep not having. Although my hotflashes make me miserable (Pristiq did reduce them to 3 to 4 a day and turn them very mild), I am not sure if I can keep on this drug. I have no insurance and to get a 3 month dose costs me $350. This is a new drug and there is no generic for it. I heard that Maca (a supplement)helps with hotflashes besides being an aphrodisiac, or at least an energiser. I can't find tho where to go to check for interactions as Pristiq is not mentioned on the sites I went F 50 5 months
1/27/2009
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 1  Major Depression, Anxiety At 50mg I would say I had very few side effects if any. At 100mg I wanted to sleep all day and felt awful. When I cut back to 50mg, the side effects dissipated but the drug seemed to have no readily identifiable effect upon my depression or anxiety. For me, it simply didn't work. It may have contributed to weight gain but then I was also taking Lyrica at the same time, which is known for weight gain. I additionally take Oxycodone & Lyrica for chronic spinal pain/degeneration and they cause depression & anxiety that I was hoping the Pristiq would combat in conjunction with Klonopin & Ritalin. The Klonopin helps, the Ritalin helps, the Pristiq did nothing except knock me out on the 100mg dosage.... F 52 6 months
1/23/2009
 3  Depression and Anxiety I experienced headaches, anxiety and some depression I have been on pristig for over 3 months. I was on effexor XR on 112.5 mg for over 3 years for depression and anxiety. At the end of 2007 I was feeling great so my doc. and I decided to begin reducing the dosage. 2 months later I relapsed. Changed pdoc and was given Cymbalta, did not work, and now on Pristiq. I feel somehow better but still having some episodes of depression and anxiety. I was also prescribed lamictal to control the downs, which seems to work ok. I will report in a couple of months to see if there is any improvement. Effexor was an amazing drug for my condition. M 36 3 months
1/22/2009
 3  Severe depression A bit of anxiety In regard to sexual side effects, everyone has sex, knows what it is, and there's a whole lot more to life than whether you have good sex or not, such as being not depressed. I would hope that people have evolved to the point where living a productive and satisfying life means infinitely more than a good lay. Jesus christ. Grow up. F 48 4 days
1/21/2009
 1  DEPRESSION I was on for 4 days while withdrawing from Cymbalta. I had headached immediately and on day 4 had a terrible reaction. My face became swollen, my eyes closed as if I was sick. I was not sure if I was sick. I did not take the drug the next day and the whole facial thing went away. I am too scared to take it again. F 56 4 days
1/18/2009
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 4  Dysthymia Wellbutrin XL stopped working for me after 6 years. Pristiq was the third med my doc had me try, after Celexa and Cymbalta failed me. I took 50 mg Pristiq first thing in the morning. I really needed it to wake up and was pretty groggy until it kicked in about 30 minutes after taking it. I had some nausea for the first few days. I also had mouth dryness, but not as severe as on Cymbalta. My doc warned me Pristiq could make my blood pressure go up. I had my blood pressure checked at my GI doc’s office after a week on Pristiq, and it was my normal 120s over 70s. A week later (2 weeks on Pristiq), I had my BP checked again and it was mid-140’s over mid 90’s—significantly higher than normal. About a week later (3 weeks on Pristiq), my BP at my gyn’s office was 130’s over mid-80’s. Since my dysthymia wasn’t fully controlled on 50 mg daily, my psychiatrist would have raised my dose to 100 mg daily—but she was concerned about the in My dysthymia manifests as apathy, cynicism, lack of motivation, head-to-toe body, joint and muscle aches, dyspepsia/IBS, overeating, physical and mental fatigue, word retrieval difficulty, 'brain fog', insomnia, and a generally unsociable, 'bah humbug/grumpy old hag' attitude. 50 mg Pristiq did nothing for my aches and pains, but it really helped my mood, energy level, motivation and attitude. I was much more sociable, outgoing and willing to converse on Pristiq. I took more pride in my appearance; I even went shopping for clothes and experimented with different hairstyles and makeup techniques. I was more productive at work and didn’t suffer from my usual midday or mid-evening slumps. I felt happy and optimistic. I noticed no sexual side effects and no significant interaction with alcohol. At the end of the day, I felt genuinely tired and ready for bed. I slept better on Pristiq with fewer awakenings. My IBS and urinary frequency problems were greatly improved. If not F 46 4 weeks
1/17/2009
 4  anxiety, deppression and ocd Chronic tiredness, dizziness, increased anxiety and depression, suicidal thoughts and a feeling of 'out of body'. first weeks i was on pristiq was terrible, but the side effects, no matter how bad, do go away. YOU MUST STAY ON THIS DUG FOR AT LEAST 4 TO 6 WEEKS TO SEE THE BENEFITS. Unfortunately i started to plateau around the 7 week mark on 50mg, so upped it to 100mg. First week was great, best i've felt since needing the medication. Unfortunately i got some worse side effects after around 6 days. But now it seems that they're going away. M 18 10 weeks
1/11/2009
 5  severe depression loss of libido I have been taking this medicine for 3 months. I have been doing very well on it. I take 50 mg on the onset of my menstruation and then take 100 mg after I ovulate (2 weeks 50mg, 2 weeks 100mg). I was taking Effexor XR for 5 years. I started with 37.5mg and eventually ended up at 300mg. I was having a lot of problems taking such a high dose (memory loss, loss of libido, skin lesions, weight gain). I was on Effexor for such a long period of time because I was a bit out of it and didn't realize that my health problems were due to such a high dose. I went off Effexor (process of about 6 months) and was clean from the drug for 2 months. I realized my depression problem was the result of the onset of the second part of my cycle (after ovulation). Pristiq works for me without all the bad side effects of Effexor (no memory problems - I test myself with crossword puzzles, no skin problems). F 40 3 months
1/4/2009
 2  Depression Huge dilated pupils after 2 days and visual disturbances Anyone else have this?I was real psyched on this med.May try again at a later time but my eyes really bugged out.My pupils looked like flying saucers. F 37 2 days
1/2/2009
 5  depression, chronic pain None! It took about 10 days for it to start to work. I was not on any med for depression/chronic pain immediately previous to this one. Things slowly are improving further since day 10 also. I experienced no side effects or adverse effects from this med either. It is definitely helping, but I do feel I have room for improvement and hope it helps some more with both aspects it's being used for. F 44 2.5 weeks
12/26/2008
 2  pmdd Nausea, increased appetite, decreased libido, drowsiness, lack of interest in doing anything I started on 50mg and didn't feel like it was enough then upped to 100mg and had severe nausea and frequent hunger and woke up hungry too. The longer I took it the worse I felt and the worse the side effects got. I went back to my Wellbutrin and Celexa regimen. F 38 1 months
12/21/2008
 2  anxiety,depression,ocd slight headache,upset stomach(mild) have been on med a little over 2 months. not as extremely depressed however still anxious and frustrated with moderate to high depression. doctor has just added abilify to speed up effectiveness. hope it works. M 65 10 weeks
12/15/2008
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 5  Depression Tiredness..other than that nothing bad This is working pretty well for me. Only on week three but feeling a bit better after trying most AD's. F 42 3 weeks
12/5/2008

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