PRISTIQ Reviews (DESVENLAFAXINE SUCCINATE)

Average Rating: 2.8 (628 Ratings)

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 ANTIDEPRESSANTS

 Type: Rx Drug

  

PRISTIQ  (DESVENLAFAXINE SUCCINATE):  Desvenlafaxine is used to treat depression. It may improve your mood, feelings of well-being, and energy level. Desvenlafaxine is known as a serotonin-norepinephrine reuptake inhibitor (SNRI). It works by helping to restore the balance of certain natural substances (serotonin and norepinephrine) in the brain.   FDA Approval Date: 2008-02-29 (Sources: U.S. Centers for Medicare Services, FDA)

  

Results are sorted by Date added.

Key to Ratings: 1=LOW (I would not recommend taking this medicine.)
5=HIGH (this medicine cured me or helped me a great deal.)

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RATING  REASONSIDE EFFECTS FOR PRISTIQCOMMENTSSEXAGEDURATION/
DOSAGE
DATE ADDED
 
 3  Seasonal Affective Disorder After 1 month I had gained 10 pounds - have gained a total of 20 pounds. I went through surgically induced menopause 10 years ago and had not had a hot flash since then. Since being on Pristiq, I have severe hot flashes, night sweats, headaches, and insomnia. I tried going every other day, which helped a tiny bit. Since it is getting closer to spring, I have weaned myself off of pristiq and have not had a hot flash in almost 2 weeks. I am having an extremely difficult time getting the weight off. I do food journals and exercise journals logging usualy around 6 plus hours of cardio per week and don't go over 1500 calories. I haven't lost any weight..... Hopefully my metabolism will come back. It did help with my SAD - which was crying for no reason, but the side effects, to me, were so not worth it! F 51 4 months
50 1X day
2/21/2011
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 5  depression Nothing notable 50mg. of Pristiq has changed my life. My depression has been reduced 98%. Please give it a try. It may do the same for you. Good luck. Hang in there. (I have also been taking 300mg. Lamictal for many years, the big change did come about until I took pristiq.) F 41 1.5 years
50mg 1X day
2/20/2011
 5  depression & anxiety None that I'm aware of. Except if I miss a pill. Pristiq was lterally a life save for me. I had suffered from depression on & off 12 years & MDD for 13 years. Tried too many meds to list. Nothing helped. Within a week of starting it I felt like a new person. For the first time in my life I woke up in the am & didn't cry. The "strangest" time for me was when I realized that I felt hopeful & didn't want to die! I have gained quite a bit of weight but doc says it's not from the Pristiq (?). Unfortunately there are extreme withdrawal symptons if I miss even 1 pill. "Disconnected" feeling is the worse. Barely able to function until I take another one. It's a little scary to think of how potent this drug is. Everybody's experience is different. Everybody's body is not the same. For me the amazing changes in my depression far outweight the chance of missing a pill and having side effects (I just make sure I have extras with me to take just in case). I know 2 others who have taken it and had the same great results. I know 1 other who it did nothing for & she had a scary time going off of it. F 31 14 months
100mg 1X day
2/4/2011
 5  Chronic Pain and Depression irritable, tingly, impotence, mood swings, mania, The side effects faded over time are all largely minimal. Pain has been reduced and depression faded away. I blogged about it extensively if anyone is interested. http://www.alifelesspainful.com/2011/02/pristiq-my-experience-summarized.html M 47 2 months
50 MG 1X day
2/3/2011
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 5  Depression Extreme crying spells,headaches,dizzy spells,forgetfullness, loss of apetite, lightheaded I have been on this medication for about 7 months. The reason I started taking this medication was because I was broke up with my ex fiance. We were engaged and together for 6 year. I couldn't take the pain,crying all the time,couldn't bare to even wake up in the mornings. This drug ended up being a miracle for me except for side effects. In the begininning, I always felt dizzy, I would forget things, felt trapped in my own body. It took about 2 months untill I the side effects started to go away. It only took about 2 weeks for my depression to stop. In fact not only did it take away my depression, the crying stopped, I felt alive again. I wasn't stressed out anymore. I have been a very shy and quiet person all my life and this medication has given me courage and postive thoughts I never thought I would feel. I am dating someone new now and unfornately at some point I will need to get off this drug. If I stop taking this drug for 2 days, I have severe crying spells for hours at a time and I get angry with mood swings going up and down. I am truly addicted to Prestiq and would only suggest this medication to someone who is really depressed. It's a wonderful drug but does not work for everyone. Oh yeah and another bad thing, I have completely lost my urge to have any sexual contact. F 32 7 months
30mg 1X day
2/2/2011
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 5  Anxious None that I have notice, but I have much more energy. I feel good. F 63 5 months
50mg 1X day
1/29/2011
 3  Anxiety, depression Hot flashes, slightly drowsy, trouble falling asleep I feel great for once. I haven't had any anxiety attacks, or thoughts of suicide. I finally feel normal. F 20 4 days
50 MG 1X day
1/20/2011
 2  depression severe gastric distress. I was changed to Pristiq when Prozac no longer worked. I am having my 4th severe acid reflux episode since starting Pristiq. I've had trouble swallowing food, even water at times. Have even had esophogial spasms which are quite scary. I've suspected Pristiq in recent months but only after reading other patient comments am I certain it is indeed the Pristiq. Not a good drug for people that already have gastric problems like acid reflux. F 55 8 months
1X day
1/13/2011
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 5  depression drowsy when taken in the morning - I take it at night now with no problem. dizziness when I miss a dose. I was on Wellbutrin 300mg for about 4 years and still had problems with depression and a mild eating disorder. My psychiatrist recommended I add Pristiq, and I've never been better. It gave me support as I made some much needed changes in my life... I've never been so "normal" as far as emotions, socializing, and eating go. I have no plans to get off of this - it has really saved me. F 33 1 years
50mg 1X day
1/6/2011
 1  Severe depressive disorder Sweating, nausea, decresed appatite, sexual disfunction, distrubing dreams, sucidal thoughts Currently taking with Seroquel and Hypnodorm for sleep disorder. Feeling very on edge and very anxious all the time. Work is becoming harder to complete and I've been pushing myself away from everyone. M 35 4 weeks
100 1X day
12/20/2010
 1  Depression At first, depression worsened, feelings of sadness, crying, moodiness, agitation. Those symptoms eased, except for sadness and crying, but then my ears started ringing (typically toward evening and night) - sounds like constant chirping or a faucet running at a low flow. Just awful. Have been on Zoloft (Sertraline for approximately 13 years). Doctor recommended going off Zoloft because of ED issues, and prescribed Pristiq. M 54 7 weeks
50MG 1X day
12/18/2010
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 5  severe bipolar disorder with ADD !st through 4th week, weaned off of Paxil and worked up to Pristiq 100mg. (25% change each week for both meds) 5th week (pristiq 100mg), had a headache and became quite manic, but stuck with it and now in the 6th week, I FEEL GREAT. Best side effect - hugely increased libido! I developed a very serious depression during/following menopausal hormonal changes which basically paralyzed me and left me bedridden. I have been on Paxil (60mg), Welbutrin (300-450mg) and Buspirone (60mg) for the past 10 years adding Adderall (40mg) for the last 3 years, and I have been fighting a depressed fog for the better part of that time. After a shift from Brand to generic earlier this year, I had a serious dive into the dark side, then got back on brands hoping to fix it. I stayed in the dark trying my best to make it work, but after finally realizing I couldn't get out of bed, my Doctor switched me to Pristiq, while leaving me on the Welbutrin, Buspar and Adderall. I feel better then I ever have in my entire life. It is an absolute miracle. I have lowered my Adderall dosage to 20 mg. When I am driving and doing normal activities, I feel sharper and more alert then I have for at least 10 years. AND, I don't feel like all activity is worthless anymore! ALSO, I have had difficulty achieving orgasm ALL of my life. It was like running the marathon. This week, tried and achieved orgasm within seconds. And I thought Pristiq was great before I even discovered that aspect. I wake up wanting to do things, and ABLE to do them, whereas in the past 20+ years it was a monumental struggle to do anything. I am hoping against hope this med does not stop working. It is a MIRACLE for me. F 58 6 weeks
100 mg 1X day
12/9/2010
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 1  Depression & Anxiety Extreme fatigue, increased depression, ANXIETY attacks, heart racing, mental fogginess, loss of motivation to do anything, inability to concentrate, weight gain, no sex drive, horrific withdrawl symptoms Worked well until about 6 months... then completely had the opposite effect!!!!! Increased anxiety and loss of energy/motivation to do anything! I switching back to cymbalta. Would not recommend :( F 25 6 months
50 1X day
12/3/2010
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 1  depression Drug stopped working after about 6 months. Experienced extreme agitation, anxiety, irritability. Had to get off of it. Withdrawal pretty severe. In addition, during use of drug, I had extreme swets in the morning when I took it. F 51 6 months
50mg 1X day
11/29/2010
 1  depression/anxiety constant agitation, lack of sex drive, mood swings, weight gain and symptoms of depression got ALOT worse. The withdrawal symptoms are the worst part, nausea, halluciantions, dizzyness, the list goes on. I'm on day 3 of withdrawing and i feel worse than i ever did before i took pristiq, i've had thought of self harm and suicide and am actually contemplating having myself addmited to hospital for my familys and my own safety, right now i am all sorts of crazy, the worst part is my idiotic doctor told me there were no withdrawal symptoms. DO NOT TAKE PRISTIQ! This drug is anything but pristiq, it might help with some symptoms of anxiety or depression but the side effects and withdrawal symptoms are not worth taking it. Pristiq took away my anxiety, i didn't have one panic attack while i was on it but my depression got so much worse than it had ever been before and i would get so angry alot of the time for no reason at all and with no warning, this drug has made my mental health so so so much worse than it was before i started taking it. Pristiq was the 1st antidepresant i had been on and it will be the last, there is no way in hell i'm going to take these pills that the doctors obviosly know nothing about, i'm not a guinea pig! Stay away from pristiq it will not make you better or sane, it will make you sicker and crazy as all heck! F 22 3 months
50mg 1X day
11/27/2010
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 1  situational depression Brain zaps, neck pain, fainting...(led to being hospitalized for two days with a massive amount of costly tests), hallucinations, anxiety provoking dreams, insomnia, joint pain, headaches, nausea, day and night time sweats...then the chills, memory loss, irritability. These were all side effects that I experienced while on Pristiq...Currently all of these side effects have been magnified by a zillion since I quit taking the drug cold turkey 14 days ago. I stopped after I was released from the hospital; after being admitted for having hallucinations and fainting. The medical staff were not able to determine the cause...; however...all the medical staff said it could NOT be the Pristiq! Well...I used my own judgement in determining that the probable cause WAS the Pristiq; thus, I quit taking it cold turkey the day after I was released from the hospital. I am now going thru continuing withdrawals...and looking forward to the day that I feel like "myself" again...I can deal wit This drug is POISON! Do not take it! F 57 10 months
50 mg 1X day
11/24/2010
 1  major depression night sweats, extream dry mouth, still depressed, loss of appatite dont start this drug M 40 45 days
50 mg 1X day
11/18/2010
 3  Depression anxiety and chronic pain My doctor convinced me to try anti-depressants again because I have lost another job due to chronic pain and depression. I started feeling results right away. Good and bad. I have been feeling a surge of motivation which is helping against the dissabling feelings of depression. I have never been so productive! However, since day one of taking Prestiq, I have been experiencing persisting heartburn, insomnia, inability to climax (loss of sex drive which was NEVER a problem before)and a slight increase in anxiety. (nothing like the anxiety I felt with Cymbalta-difficulty breathing)I have been taking the med in the morning. Maybe I will try to take it at bedtime. The motivation has been great but I have been experiencing severe heartburn all day long since day 1. Also, I wake up at 3AM-4AM every night since taking Prestiq! This is odd for me because I usually sleeped like a log. It's 4:30AM as I am writing this!!! Waking up with an increased heart rate. The bouts of productivity have been I would like to be able to continue this drug without the side effects because I have been laughing more, feeling more excited about life and more productive than ever! It's a toss up!!!!!! F 30 20 days
50mg 1X day
11/17/2010
 3  Depression/Anxiety Weight gain 45lbs, tired, go to gym 4 days a week No sex drive at all, If I miss a dose, I will not go out of my house, feel like a crazy person. Break out in sweats!!! My doc says we will try something else, feel like a science project!!!!! F 47 2 days
100mg 1X day
11/9/2010
 1  Depression During it's use, I could not easily distinguish any, since I was taking two other drugs for on the same days (2x Adderall for AM & noon, and 1x Clonazepam for late PM). But after I quit taking it (about only 20 days later), I experienced a major-heavy withdrawl that induced even heavier feelings of depression, anger, and distress than I ever had before. (I really can't recall the amount, but I think it was 30mg). Withdrawing from Pristiq was VERY BAD. Pristiq didn't do much for me within the 20 days that I took it, so I just stopped cold-turkey. Bad idea! About 1 day after I stopped taking Pristiq, I could not help but to feel deep despair along a worsened form of my depression. Contributions of these bad feelings were mostly because of an unwanted divorce that occurred 4 months prior to starting Pristiq. The physical withdrawl was deep crying for nearly 30mins straight, a need to curl up in the fetal position, and body trembling. During withdrawls (which recurred on 3 more days) were incidents of sudden screaming out at the top of my lungs that were of: grief, anger, despair, remorse, anguish, among others... It's scary to know that such a drug had forced these emotions and feelings out from inside of me in such an unusually powerful and quite disturbing way. I advise NOT to take Pristiq if your depression is not that bad, and to try something safer that has more history. It's better to try something that's safe and proven effective, than taking a substance that has the potential to make an already bad situation 10x worse, and that can potentially induce or increase suicidal thoughts or motives. +Your better off temporarily very sad, then forever dead. !++++ Seek safer alternatives for God's sake! M 29 20 days
30mg 1X day
11/8/2010
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