FEMARA Reviews (LETROZOLE)

Average Rating: 2.5 (1087 Ratings)

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 HORMONAL BIOLOGICAL RESPONSE MODIFIERS AROMATASE INHIBITORS

 Type: Rx Drug

  

FEMARA  (LETROZOLE):  This medication is used to treat certain types of breast cancer (such as hormone-receptor-positive breast cancer) in women after menopause. Letrozole is also used to help prevent the cancer from returning. Some breast cancers are made to grow faster by a natural hormone called estrogen. Letrozole decreases the amount of estrogen the body makes and helps to slow or reverse the growth of these breast cancers.   FDA Approval Date: 1997-07-25 (Sources: U.S. Centers for Medicare Services, FDA)

  

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Key to Ratings: 1=LOW (I would not recommend taking this medicine.)
5=HIGH (this medicine cured me or helped me a great deal.)

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RATING  REASONSIDE EFFECTS FOR FEMARACOMMENTSSEXAGEDURATION/
DOSAGE
DATE ADDED
 
 4  prevent another BC recurrence I took Tamoxifen for 2 months and had a recurrence. Started Femara and no side effects for 5 months. Now I have chronic joint pain, feet, knees, wrists, elbows, shoulder, achy fingers, lower-mid back pain and hips. It's better once I get moving with my day. Some headaches. Vaginal dryness and low libido. Some dizziness and upset stomach. Weight gain. I feel like I'm 20 years older. My doctor tells me it's either Femara or another course of chemo. My husband wants me to endure the discomfort; take ibuprofen to get some sleep. He believes if taking Femarai will keep me alive longer then it's worth the pain. I wish there was something else with less side effects. F 42 9 months
2/20/2006
 2  after 5 ys of tamoxifin for BCancer I have been on femara since mid June 05 and have suffered from joint pain since July 05. It is especially painful in my hip, leg ,knee and sometimes lower back. I also notice more pain in my hands. I wake up at least 2-3 times a night with the pain. I am taking naproxin for pain and have tried physical therapy. Neither have offered any relief. I am considering stopping the drug to increase my quality of life. I used to exercise regularly, but I can not now because of the pain. F 54 7 months
2/19/2006
 2  Breast cancer Hair loss, 40lb. weight gain,cant walk on my feet in the morning they hurt, muscle and joint pain,double copel tunnel without a reason for it.cold to my bones all the time,trouble making decissions. depressed. I need something else. F 1 years
2/19/2006
 3  Breast camcer Frequent clear vaginal discharge. I had the same experience with tamoxifen except when I was taking tamoxifen the discharge felt like it was burning. In addition I had two types of vaginits two weeks after I started tamoxifen. My doctor said the infections were probably due to change in the PH balance caused by tamoxifen. I am hoping that with Femara the discharge will diminish with time. The are the first two medicines that have caused a bad reaction in me. I am determined to continue taking Femara as long as the side effects are controllable. F 67 8 days
2/15/2006
 3  6-yr post BC after tamoxifen Aches a 3 on a 1-5 scale in arms/legs/hips, feet/fingers very stiff, knees have deteriorated significantly in 8 months, tired a lot. Odd shooting pains in chest muscles and feet. It has not been so bad that I would immediatly stop taking it since the numbers for preventing recurrences are so good (all three sisters have had BC), but if there were a better alternative, I'd consider it seriously. I feel old at 44. I am getting physically weaker since I can't exercise. F 44 8 months
2/13/2006
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 2  breast cancer Swollen hands, weight gain, claw finger, breakdown of cartilage in knees. M 55 1 years
2/3/2006
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 3  Breast Cancer Chronic bone/joint pain in chest area: neck, ribs, back and shoulders. Weight gain - 20+ lbs in 9 months! Vaginal dryness and loss of libido. I was a marathon runner with a sex life and now I walk like a 90 old lady....and I won't even discuss the other issue! Started with Arimidex which caused severe headaches. Switched to Femara which got rid of the headaches but brought on the ever increasing bone and joint pain and other side effects. Given my cancer diagnosis I can live like a 90 year old woman or gamble on the cancer killing me. I am going to stick it out a little longer and see what happens. F 57 12 months
1/31/2006
 3  Infertility headaches, weight gain, still not pregnant F 34 5 months
1/31/2006
 2  to prevent return of breast cancer WEIGHT GAIN, joint pain, depression, massive sweating once off femara, I dieted off the weight but it seems to creep up more easily now, within a few weeks of stopping the drug my mood returned to happy, sweating subsided and aches and pains went away. 50 3 days
1/20/2006
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 4  Post breast cancer >5yrs tamoxifen 15 pound weight gain within first 3 months despite usual regular excercise and lifetime (46 years) of being thin without diets. I have never had to diet and watch weight until now); also significant daily joint pain, especially feet and hands first thing in the morning, and feet, hands, knees, elbows and shoulders throughout the day, and significant but intermittant fluid retention. 5 years of Tamoxifen and now 8 months of Femara have keeped me cancer free, side affects are worth that for sure! F 46 8 months
1/1/2006
 4  Prevent Breast Cancer Weight gain, some joint pain, raised cholesterol, caused mild osteopenia Taken as a follow up to 5 years of Tamoxafin. Suppose it's worth the side effects if it prevents the return of the cancer. F 55 18 months
1/1/2006
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 3  infertility Hot flashes, more emotional Easy drug to take, side effects weren't too bad, once I got used to them. It worked well the first cycle and helped me have a healthy 28 day cycle, 2nd month it did not. Will try again this month! F 38 2 months
12/30/2005
 2  for prevention of breast can return Joint,bone and muscle pain especially in wrists,thumbs,legs and feet. Bones in feet even have burning feeling. Weight gain and extreme fatigue. Rise in liver enzyme ALK. After five yeras of Tamoxifen switched to Femara. Hot flashes better but other side effect more severe. F 54 1.5 years
12/23/2005
 3  Breast cancer Hair loss, weight gain, hot flashes F 52 2 years
12/10/2005
 2  Stage 1 breast cancer Joint pain and weight gain. There are days I can't walk very well because I'm afraid I'll fall over and break something. Hair loss but not too much. Depressed a lot because I have trouble with mobility which I didn't have before. I started the drug at my oncologist's request and gave it fair time but not any more I'm sure it's a good drug but not for me. Quality of life is important for me. F 63 15 months
12/9/2005
 1  Breast cancer - 5 yrs on Tamoxifen no problem with Tamoxifen, except hot flashes--now have swollen stiff hands, "claw hand" on right, triggering of index and middle finger on right, wrist pain. Feet hurt at night; cannot sit still unless I take Ibuprophen. Wt. gain, hair loss and some balance problems--feel "off kilter" the hot flashes w/ Tamoxifen were not as debilitating as this. There must be something better F 65 7 months
12/6/2005
 3  breast cancer Switched from Tamoxifen after three years out to Arimidex and lost my quality of life. Onc switched me to Femara...have had surgery for right middle finger trigger and carpal tunnel on right wrist (I do no repetitive movement) and overall joint pain esp. in hands, feet, and lower back. Now have basal joint arthritis on left thumb, and don't sleep unless I take a pill. Hair goes through periods of extreme falling out. They can put a man on the moon...can't they come up with something that doesn't hurt more than the disease? F 56 2 years
12/4/2005
 5  Infertility If there were any they were not obvious as I cannot recall any. The half life of Femara is substantially shorter than that of Clomid which is important to me. I have taken 7.5mg/day for 5 days of my cycle. F 36
11/30/2005
 1  breast cancer stage one reoccurence triger thumb feet hurt especially at night I feel 100 years old when I get up in the morning joint pain . I have always had very thick hair and yes it has thinnned a little but that I can live with. I asked my doctor to change medicine. He prescibed aromasin but from what I read those side effects are just as bad as femara if not worse. I am considering going off of it at times due to the pain but I don't want another reoccurence so right now I stay in pain. Yoga and tai chi loosen me up some. F 57 15 months
11/26/2005
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 2  breast cancer I've been taking Femara for 5 months and my symptoms only became pronounced very recently. My body aches all over, my hip joints are unusually stiff till I get going, my hair has thinned, my scalp itches, I have become extremely fatigued for no apparent reason. I hope the side effects are temporary or that at least I can learn to live with them so that I can continue to take the drug. F 52 5 months
11/21/2005
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