FEMARA Reviews (LETROZOLE)

Average Rating: 2.5 (1087 Ratings)

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 HORMONAL BIOLOGICAL RESPONSE MODIFIERS AROMATASE INHIBITORS

 Type: Rx Drug

  

FEMARA  (LETROZOLE):  This medication is used to treat certain types of breast cancer (such as hormone-receptor-positive breast cancer) in women after menopause. Letrozole is also used to help prevent the cancer from returning. Some breast cancers are made to grow faster by a natural hormone called estrogen. Letrozole decreases the amount of estrogen the body makes and helps to slow or reverse the growth of these breast cancers.   FDA Approval Date: 1997-07-25 (Sources: U.S. Centers for Medicare Services, FDA)

  

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Key to Ratings: 1=LOW (I would not recommend taking this medicine.)
5=HIGH (this medicine cured me or helped me a great deal.)

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RATING  REASONSIDE EFFECTS FOR FEMARACOMMENTSSEXAGEDURATION/
DOSAGE
DATE ADDED
 
 5  Stage 2 BC, ER+ Had the joint pain and hot flashes. Took two two-week breaks in the first year just to get relief from pain. After second break, pain did not recur. The rest of my 5 years went by easily. I did have some bone loss, but had excellent bone health before starting Femara so I never had to do more than take a ton of calcium and Vit. D. Also, no head hair loss, but legs and arms became baby-bottom smooth from loss of hair on them. Since I've gone off it, I've noticed that a heart arrhythmia that was driving me crazy had suddenly gone back to its normal (before femara) once-in-a-while schedule rather than all the time. Hot flashes are worse, than when I was on femara. Not noticed any body hair regrowth, which is kind of nice. F 66 5 years
2,5 mg 1X day
5/7/2013
 2  breast cancer severe joint pain, depression, hot flashes. loss of energy, whole body aching I have been on letrozole for 1 year and it is horrible. I can hardly get out of a chair, walk, sleep, (thank god for ambien and oxy), can't bend my hands hardly walk. no energy to do anything with friends and I usually cancel. the only thing that has helped me is seeing a pain management doctor who has helped me lessen the pain so that I can atleast party live my life. Also, water aerobics is the only thing that I can do and forget about my pain for an hour. TRY IT, IT really works. I am afraid to go off for I never had chemo and stats were based on talking the Femara. My life is a mess. I thought that once you go off the side affects go away and now I am a afraid that is thisl is going to be my life. A cannot work for I cant sit, walk for long times or do anything for more than an hour...I am afraid of eventually will be living on the street. F 50 352 days
1X day
4/30/2013
Email
 3  Breast Cancer Trigger thumb, weight gain, fatigue, sleeplessness,dizzy at times, low stamina. Arthitis, twisted fingers. Does anyone know if the weight gain goes away after stopping Femara? I have gained 30 pounds since beginning my treatment. F 61 3 years
2.5mg 1X day
4/19/2013
Email
 3  2A Her2Neu+ Breast Cancer This is an update to my 8/11 post regarding debilitating bone pain, particularly in the foot, ankles and hips and my use of NeoCell brand collagen supplements. As an update to my post on my 08/?/2011 the next page over I mentioned taking NeoCell Collagen Type 1&3. I immediately felt fantastic but I noticed after several months of using it seemed to have had sort of a plateau effect. That being said, I had also became very inconsistent in using it as directed...on an empty stomach at the same time every day and sometimes forgetting to take for several days in a row. My bad. I still felt better but "stuck". It got worse when I purchased a different brand and just became miserable all over again. Fast forward and I re-invested in the NeoCell brand. This time I re-researched and purchased the Type 2 Collagen. This is specifically for bones and joint lubrication and contains hyaluronic acid. I've been on it two weeks and feel even better than the type 1 & 3 made me feel. I am also very diligent to take it as directed, on an empty stomach, immediately upon awakening every single day. After approximately 30 minutes, you are then able to take type 1 & 3. They are not to be taken together! I am using type 2 till I run out to gauge the results at which point I plan on taking the two together at the specified time intervals. The pains that I do feel now are more in line with what I felt before femara and for a woman my age and weight (I'm a big girl!). I feel "normal" again. I will update this in a few months but in the mean time, the best price seems to be directly thru NeoCell or thru Amazon. I have not seen i F 49 3 years
2.5 1X day
4/8/2013
 4  ER+ PR+ and Her2+ Breast Ca Mostly hotflashes, some joint pain....I take it at night and then take my sleeping pill so I can sleep through most of it.... F 62 2.5 years
2.5 mg 1X day
4/7/2013
 5  stage 4 recurrence of ER+/PR+ BC Multiple tumors shrank & disappeared after 6 months of drug use. Side effects included joint pain & sleeplessness, which improved after taking glucosamine/chondroitin. 2 years in got bad trigger thumbs, which resolved without intervention in 3 months. Sleeplessness has gone away; now just need more sleep (9-10 hours). After 3 1/2 years, tumors have not recurred. I consider the price paid well worth it. F 65 3.5 years
2.5 mg 1X day
4/4/2013
Email
 1  breast cancer stage 1 I am off of femara since 2011. I am now suffering with vertebra problems in the lumbar spine at many levels (l1-s1) F 66 5 years
3/20/2013
 2  Infertility While only taking for only 5 days a month, I've had bad knee, hip and thigh pain, terrible headaches and heart palpitations also hot flushes. Only on my second month still no baby! F 28 5 days
2.5mg
3/17/2013
Email
 4  BC stage2 lymph nodes clear grade 3 trigger finger, arthritis like symptoms entire body, 2 spells over last 4.5 yrs of low back pain, and recently severe itching around my neck at onset of hot flashes Repost from 3-7-10 - still cancer free at 4 yrs 8 mos - if femara is the reason then the little bit of discomfort I have had is worth it...no doubt, proper nutrition and exercise have helped me immensely...my onc is now suggesting I stay on it another 5 yrs as studies are coming in that 10 yrs use keeps the Big C at bay...I say sign me up for another bottle of femara!!! F 54 4.5 years
2.5 mg 1X day
2/19/2013
Email
 1  Post op BSO.Past history breast Ca I am reposting having been off this drug for 5 months now. Whilst on it my joints and muscles ached immensely, some days I struggled to walk, get out of the car and walk up stairs. I have been left with excrutiatingly painful feet and heels which has now been Dx by a pain specialist as idiopathic peripheral neuropathy. I have not been able to become pain free following the side effect pains brought on by this horrid poison. F 49 2 months
1X day
2/15/2013
Email
 1  BREAST CANCER STAGE 2 Estrogen Receptor Positive followed by a complete Hysterectomy. Have been off for 4 yrs on May 27, 2013 and it saddens me that this is not any better for anyone. A lot of the symptoms posted just on page one of 15 internet pages. Most seriously Bones, Joints, Muscles, Headaches, 4 additional meds a day to try to control HB but did not work. Had been walking 4 miles a day 7 days a week and could not walk a block or hardly up and down the stairs. Hands as in finger nuckles bad. Had braces for hands, knees and feet. I wanted to leave a comment again about two things I take everyday that I found out about in this blog almost 4 yrs ago and wanted to share again. Always research and read first and show to your doctor. NATURES WAY KRILL OIL, 500mgs and I take two a day. Herebs of Gold - PAIN EASE I maintain enough with just one a day and of course I take 800mgs of prescribed Ibuprofen twice a day. On top of all this I have severe issues with my back. In the search engine type in Herbs of Gold Pain Ease and read about it. proteinpower.com/drmike/inflammation/why-krill-oil/ and read the article from Dr. Michael Eades. It helped the people I found out about it from I am hoping that it will help someone else. Just had my 4 year clear mamo and the tech doing the mamo said there are a lot of women coming in with terrible sideffects of this meds. There may only be 897 ratings but so many don't know about this site. My Hearts best to everyone out there . . . Please feel free to email me anytime, Brenda F 58 4 months
.25 1X day
2/11/2013
Email
 1  breast ca stage II her2 Joint pain and stiffness in hips, back, and knees, crepey dry skin, thinning hair, ridged nails, cramps in hands, fingers, weight gain from inability to exercise due to joint pain, fatigue. Worsening symptoms of Grave's Disease. It's been almost 6 mths since I stopped Femara, but symptoms haven't abated. Quality of life plummeted. With such compromised mobility I feel like a prisoner as I've formerly been a very active person with many responsibilities. I wonder if my reaction to Femara has something to do with my autoimmune Grave's Disease, i.e. an autoimmune reaction to the anti-estrogen toxin in Femara F 72 9 months
2.5 1X day
2/4/2013
Email
 4  Breast Cancer Slight hair loss, slight memory loss, irritable, vaginal dryness, slight joint pain. I took Tamoxifen for 5 years and on recommendation of surgeon changed to Femara and was advised that protection of bone density would be less, but less chance of recurring cancer. My 10 years cancer free was March 2011 and am happy that I took the doctor's advice for this 'insurance policy' to now be free of the cancer, and drugs. After nearly 2 years since taking Femara, I am starting to notice a difference - hair growth is back to normal, less vaginal dryness (slowly nearly back to normal), however, joint pain persists and worse as I get older and post-Femara - now take Mobic anti-inflammatory tablets a few days at a time when pain at its worse. F 56 5 years
2.5mg 1X day
2/3/2013
Email
 3  her2newand estrogen positive stage Bone and joint pain, vaginal dryness, fatigue, memory problems, some weight gain I feel that the bone pain is the worst. However, if it keeps me cancer free it is worth the side effects. My onco wants me on it indefinetly. I hope the side effects don't become worse. It is difficult to exercise. F 58 1 years
2.5 MG 1X day
1/27/2013
 4  Breast Cancer Arthritis, hip pain, weight gain Has anybody else gained weight on Femara? I gain 30 pounds in the last 3 years taking Fermara. The first years was the worst, a lot of pain in hands, feet and could barely stand without pain. Now it has gotten better but I am not really sure why. I will be off of Femara (Letrolzol) in two 1 year 9 months. F 60 3 years
2.5 1X day
1/13/2013
Email
 3  Breast ca ER+/PR+/HER+ stage2 1st month pretty well, 2nd month wrist pain at time, 3rd mo well tolerated so far with some skin rash had first taken Arimidex, was horrible with joint pain, felt like 100 yrs old, then I had frozen shoulder which was fixed by 2mo therapy. Had to stop after 2mo on it. After 1mo break my onc switched me to Femara with glucosamine and Tumeric 2x/day, It works! F 51 3 months
2.5 1X day
1/2/2013
Email
 1  Stage 4 BC Hot flashes (internal thermostat broken), hair loss, weepiness, and an insidious development of pains in hips, legs, joints as well as exhaustion and a constant feeling of being overwhelmed. My question is have any other patients had herniated discs after using drug? Please reply... After 8 months, finally realized that physical side effects were from Femara. Within 2 weeks of stopping drug, had 2 herniated discs and I'm wondering if Femara didn't contribute...the aging effect of the drug may have made me susceptability to spinal injury. Please ring in if you've had an experience like this. Thank you and may God bless us all! 59 9 months
2.5 1X day
11/30/2012
Email
 3  Stage 2 Breast Cancer Sleeplessness. slight frequent headaches, initially dizziness but this has worn off. I have just read all the comments and am now very concerned about what everyone is saying. I will stay on it for now, as I do not want to have to go through this roller coaster ride with cancer again if I can help it. Blessings to all. F 56 3 weeks
1X day
11/19/2012
Email
 1  Stage IV Endometriosis Bone pain, joint pain, dizziness, blurry vision, excessive vaginal bleeding, and collapsing. I was a healthy 24 year old woman trying it for endometriosis. It crippled me in two weeks. This drug was terrible and I have nothing nice to say about it. I developed uterine polyps and I required surgery. I've dislocated my finger, busted my knee skiing, busted my hip in a car accident, broke my nose, had an earring torn from my earlobe, and had my nostril slit. The pain I felt on Femara mad everything else feel like a tickle. Femara made my bones and joints hurt so bad I was in tears. I cried once in my life because of pain. It was on Femara. Also it didn't work for my endometriosis and I need surgery for the polyps it caused. I give it a negative 100 stars. F 24 14 days
2.5 1X day
11/17/2012
 1  Stage 1 Breast Cancer Femara/ letrozole - I feel like I’m 100 years old. ---I have unbelievable aching, horrible cramping and stiffness in my joints, thighs, hips and legs; my legs and bones literally ache and it gets worse the longer I take this poison. The heels of my feet are killing me. It's extremely difficult, especially after sitting for awhile or when I first get up in the morning, it’s a struggle going up and down stairs. --- Change in hair texture and I’m shedding like Angora cat. --- Dizziness – Femara related, I’m not sure; but never had it before taking Femara. --- This is not me, I’m extremely lethargic, no motivation, exhausted, can't focus or remember things, don’t want to be around people, I don’t return phone calls or emails; I hate feeling like this. --- Osteoporosis – my doctor wanted me to start Boniva because Femara has a history of sucking the calcium out of your bones. I refuse to take Boniva, like this drug, too many ugl --- I quit taking Femara today (October 27,2012), almost 6 months to the day. My doctor wants to me start on Tamoxifen, which she says doesn’t have all these side effects and doesn’t require me to be on Boniva....we'll see. I’m checking this site for Tamoxifen and will post my comments in 6 months regarding this drug too. I will give it a try and weigh the side effects; I will quit all these drugs and take my chances if they impact my quality of life like Femara/letrozole. --- Joint, leg cramping/pains, as one review recommended, I started taking Glucosamine (1500 mg) and Chondroitin (1200 mg) around Aug. 18th I don’t see any relief. --- Change in hair texture - Two weeks ago, I started using “Just Natural Organic Hair Care – Vinegar Nutritive Rinse Cleanser” and it's been helping a lot, I really like this stuff. (www.justnaturalskincare.com) F 63 6 months
2.5 mg. 1X day
10/27/2012

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