FEMARA Reviews (LETROZOLE)

Average Rating: 2.5 (1087 Ratings)

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 HORMONAL BIOLOGICAL RESPONSE MODIFIERS AROMATASE INHIBITORS

 Type: Rx Drug

  

FEMARA  (LETROZOLE):  This medication is used to treat certain types of breast cancer (such as hormone-receptor-positive breast cancer) in women after menopause. Letrozole is also used to help prevent the cancer from returning. Some breast cancers are made to grow faster by a natural hormone called estrogen. Letrozole decreases the amount of estrogen the body makes and helps to slow or reverse the growth of these breast cancers.   FDA Approval Date: 1997-07-25 (Sources: U.S. Centers for Medicare Services, FDA)

  

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Key to Ratings: 1=LOW (I would not recommend taking this medicine.)
5=HIGH (this medicine cured me or helped me a great deal.)

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RATING  REASONSIDE EFFECTS FOR FEMARACOMMENTSSEXAGEDURATION/
DOSAGE
DATE ADDED
 
 1  Breast Cancer Horrible joint pain, hands (thumbs) feet, ankle pain to point of not able to walk at times, Back pain, severe hip pain. Now also shoulders painful. And left breast pain, well where I use to have my breast.. Memory loss,Hair thinning, Eye sight worsen. Major Depression and anxiety. Exhaustion. Legs feel like weights,,,should I go on? I was told by taking this drug instead of chemo and radiation, I would have a much better life. I was diagnoided 2 yrs ago. My life stopped when I began Femara. I have regreted it from day one.Though my onocologist insist that I must take it and fights me about it all the time. I would not recommend Femara to anyone! I have not heard of one person that has had positive experience with this drug. I agree with everyone else, quality of life means much more than years of pain and torment. F 54 2 years
1X day
7/2/2011
 4  Prevent recurrence Some joint pain, thinning hair, hot flashes I exercise every day (walking and Pilates) and that makes a MAJOR difference with the joint pain. Also, I switched to a vegan diet and that REALLY reduced the hot flashes and pain. I take melatonin at night (time release) and that has made sleeping way better. Read the book "Life Over Cancer" by Dr. Block. Changing our lifestyle is a HUGE component in keeping the cancer at bay and has made a big difference in the side effects. I'll finish up 3 more years of taking this drug. F 53 2 years
30mg 1X day
6/26/2011
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 1  Breast cancer recurrence Severe leg, ankle, hip pain. Depression. Weight gain. Hair loss. 4% bone loss. I can't sit, stand, or lie down for long without a lot of pain. Can't sleep because of the pain. Pain meds don't work and I don't want more drugs anyway. Facial hair growth. No libido and don't care about life at all. I can't believe I didn't figure this out sooner. All of my doctors, including my oncologist, ignored me about the pain. I didn't talk about depression because I thought I was being self-centered and a wuss. But it was finally the depression that led me to do some research. I've been on Femara for 5 years. No more. I won't take another pill. I will worry about the cancer returning, because I was stage 3, but I'll eat a lot of fruits and vegetables. This scares me, but I'm only 63 and I move like I'm 100. I have an 18 year old daughter and this is breaking her heart. I work full-time, long hours. Have no idea how I manage. F 63 5 years
2.5 mg 1X day
6/26/2011
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 3  Prevent recurrance - BRCA2 Noticed that my hot flashes are DECREASING - don't know how that is possible. Almost all the other side effects I went through when I had my ovaries removed after breast cancer - chemo and radiation. I assumed they were from the sudden onset of menopause at 46 yrs old. They have all subsided except the hot flashes which seem to be better but I have only been on it for 5 days. I am quite stunned at some of the dosage levels. 30mg? Really? Perhaps that is part of the problem? For brain fog - I started taking wellbutrin after the oophorectomy - took about 6 months but I feel more myself again. Yoga and walking really really really helps the stiffness and bone pain Maybe it is too soon to tell for me - how long before the side effects kick in? F 47 5 days
2 1X day
6/24/2011
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 4  To prevent recurrence Stiff feet waiking up in the morning, but smooth after walking for 5-10 minutes. . Cannot walk very far on streets unless I wear very soft soles, Cannot stand for very long. Insomnia.Some stifness in fingers. Knees hurt sometimes when walking up stairs. Body feels heavy. Sometimes hard to get out of the car and to raise up from a chair. Limbs feel weak. Memory loss - but that can come from insomnia. Less side effects this year than the three first years. I choose to continue with the medicine to hinder recurrence. Ithink changing diet has helped. a year ago I started to take 1g magnesium pr day with calsium, pluss a lot of cod roe oil, seal oil and flax seed oil,coconut oil through the day, and it has helped soften my limbs. I also eat a lot of fat fish and a lot of vegetables AND have stopped eating sugar and and wheat. Life is easier now than a year ago. F 60 4 years
2,5 1X day
6/17/2011
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 3  Stage 1, non-invasive breast cancer Terrible joint pain. Can hardly move after sitting for a while but can not stand for long periods. Mornings are the worst. Have to hold on to things to walk for the first few minutes. Feet knees and hips stiff and painful. Hips seem to tighten after I have walked for even a short distance.. Car rides longer than 15-20 minutes seem to cause a numbness in my legs with lots of pain. Hair thinning, weight gain, muscle spasms and sleeplessness also occur. Will be seeing my oncologist in 2 weeks and will talk about possibly stopping medication. I am only 59 and it is to the point where I have difficulty doing my job. Warm soaks seems to help hand stiffness in morning. Gentle stretching helps loosen joints a little. I am starting a gentle yoga class to see if that helps. F 59 0.16 months
2.5 mg 1X day
6/14/2011
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 1  breast cancer stage 1 Deep bone pain all over. The worst part was the brain fog and the strange headache that was nonstop. Anything that affects thinking to this extent can't be good. I lasted 4 months before giving up on this medication. I now have pain all the time. It is difficult to walk up and down stairs and to get in the tub. Going on it was a mistake for me. What good is being alive if you are in pain and in a fog all the time? F 60
30 mg 1X day
6/13/2011
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 1  cut risk of breast cancer recurrenc My doctor so badly wants me to take this medicine and it scares me to death. So does breast cancer recurrence. I'm reading all the side effects that everyone has, did ANYONE have a positive experience with this drug (no severe side effects)? Please let me know as the bad very much outweighs the good it seems to me. F 49 0 days
2.5 1X day
6/12/2011
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 4  to prevent breast cancer recurring slight thinning of hair on top, much bone loss to -2.9%, even while on Fosamax Other than that it was very easy & comfortable in my experience with Femara. DR wanted me to take it for 10 yrs, but because of bone loss, stopping it now at 5 yrs. Will continue Fosamax. Bit nervous about stopping though, dont want the estrogen & then the cancer to return. But the present research does have it prescribed for 5 yrs. F 58 5 years
2.5 mg 1X day
6/10/2011
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 1   destoyed my spine and my hip i can hardly walk now, i am having cortizon shots so i can go on.it helps very little, the demage is done by femara. i am alone and i have to take care of myself and it became very hard to leave with very bad pain. F 82 6 months
1X day
6/8/2011
 2  Breast Cancer Mild Hot Flashes, Extreme joint, bone and muscle pain. I started having side effects from this drug in mid March after starting in January 2011. The pain from my joints makes it hard to walk and has limited my activities. I was always very active, now I dread even going to the grocery store because of the pain. F 65 158 days
2.5 MG 1X day
6/6/2011
 1  Breast cancer Extreme fatigue, night sweats, hotflashes, dizziness, Pain in joints and muscles, Hard to walk after awaking foot and ankle pain, Hip pain when getting up after sitting, Hip pain that wakes me at night, pain in both thumbs. Can't remember simple things, poor focus and concentration, worsened anxiety and depression. Couln't stand the pain anymore, feels like I'm 90yrs old, told my oncologist and was taken off Femara 1 month ago. STILL have all of the symptoms...Seeing my doctor in the morning to decide what the next step will be. Im NOT taking anymore of that medicine! F 44 9 months
2.5 mg 1X day
6/2/2011
 2  Post Stage 2 Breast Cancer Headache, muscle aches and pains. No weight loss, feeling like I am 101, not 57. Sleepless, nights, pains in my hips, knees and elbows. Trying to exercise at the gym. This is so frustrating. I can totally idenify with the comments below. Thanks to everyone that has commented, I am talking with my husband and making an appointment with my medical oncologist. I really want to trust God on this one too! F 57 1.5 years
10 mg 1X day
5/24/2011
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 1  Post arimidex; surgery; radiation Major nausea, headache, constipation. Mentation lacking, swollen hands every morning until about noon then improves. Took me two years to lose the 12# weight gain while on Arimidex. Drugs stored in the body fat and it took 2 1/2 years before all of the side effects of armidex left my body. Now the femara is doing the same thing. Quality of life means more. No one wants to be a zombie w/all of these side effects. Spend most of my time trying to sleep to get through the day. I'm calling my medical oncologist tomorrow and report my 11 days of misery!! Life is not worth living like this....I think I'll just take my chances w/o the estrogen blockers. I'll leave it in God's hands!!! F 72 11 days
2.5mg 1X day
5/22/2011
 1  Post-surgery stage 2 Breast Cancer Apalling stifness on waking. Pain in night severe enough to wake me. Back, hip ankles, fingers and knees. I am 57 and feel 100. Have to crawl in the mornings and slide down the stairs on my bottom. Health professionals give me scare stories about stopping but it may be that I have a happier/more comfortable if shorter life F 56 2 years
2.5 1X day
5/20/2011
 3  Post Op Breast cancer stage 2 Where do I begin. When I wake in the morning I'm stiff as a board. My hand are in so much pain my hip as woken me up at least 10 times in the night because of pain. Can't move to find a better position. Absolutely no libido, I'm 51 and I feel 101. F 51 3 years
2.5 mg 1X day
5/9/2011
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 2  Stage 1 ductal cancer - no lymphnod I was taken off Femara after 1 year due high bood pressure. I was normally 116/75 and it climbed to 190/95. I had slight memory loss, was dizzy and some bone pain. Prior to this I was on Arimidex for 8 months but experienced sever joint pain, walked like I was 90 and had memory loss. Now my doctor has put me on Aromasin which I will start today. I am running out of options except to just "deal with it". F 69 1 years
30mg 1X day
5/6/2011
 1  recurrence of cancer in axilla I took it for 60 days and could not stand the crippling effect it had on my joints, back. Also sleeplessness, itching, and foggy head. I told my oncologist since there are no proven facts this keeps cancer away, I prefer quality of life. I will deal with cancer if it returns. F 61 60 days
20mg 1X day
4/29/2011
 1  Stage II breast cancer Extreme numbness and pain in hands and joints of my forefinger and thumb; pain in legs; feel like I am 100 yrs. old. I have no strength or endurance. I went off of it 2 days ago and hope to be back to "normal" soon. I believe quality of life is important and there is none with this horrible drug. I'm sure my oncologist will be unhappy with me when I see her on May 9. She needs to take it and see how she feels. It is a relatively new drug and not "tried and true" and the side effects I read about are so like my own. It scares me to think what this drug is doing to my body. F 62 3 months
20 mg 1X day
4/28/2011
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 3  ER+ lobular breast cancer I took all 3 aromatase inhabitors, first Aromasin 1/2 yr, then Femara 1/2 yr and last Arimidex for the rest of the time; 2 yrs after 2 yrs with Tamoxifen. Finished in 2009 as is the standard treatment in my country!! There were no difference between the 3 products; terrible problems as you all mention. Joint pain with arthrosis at both thumbs, dissy, hair loss/thinning, high colesterol, sleepless, headace, feel 90+++ and got skin and shape look like it too, vaginal dryness and loss of libido(and no sex life due to all the problems and pain). 1 yr after seponation my hear is better, dissyness is gone and I can again sleep, but the terrible joint pain is there still!! My libido is back but my vagina needed (as many others) to be operated on and post operative have to use hormone cream to get it to grow! I am VERY anxious now since I had high pos rating - and hope this does not lead to recurrence! I also wonder how the long term effects will be - the side effects are terrible to cop They say Femara and the 2 others are significan better and give very good survival! I wonder what the future will say about the life quality for the survivors!!! F 61 3 years
2,5 mg 1X day
4/26/2011
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