FEMARA Reviews (LETROZOLE)

Average Rating: 2.5 (1087 Ratings)

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 HORMONAL BIOLOGICAL RESPONSE MODIFIERS AROMATASE INHIBITORS

 Type: Rx Drug

  

FEMARA  (LETROZOLE):  This medication is used to treat certain types of breast cancer (such as hormone-receptor-positive breast cancer) in women after menopause. Letrozole is also used to help prevent the cancer from returning. Some breast cancers are made to grow faster by a natural hormone called estrogen. Letrozole decreases the amount of estrogen the body makes and helps to slow or reverse the growth of these breast cancers.   FDA Approval Date: 1997-07-25 (Sources: U.S. Centers for Medicare Services, FDA)

  

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Key to Ratings: 1=LOW (I would not recommend taking this medicine.)
5=HIGH (this medicine cured me or helped me a great deal.)

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RATING  REASONSIDE EFFECTS FOR FEMARACOMMENTSSEXAGEDURATION/
DOSAGE
DATE ADDED
 
 1  Breast Cancer I have only been on Femara for 1 month. Unbelievable how bad I feel. My energy level is terrible and the will to do even fun things is gone. My joints are so sore. Hips are the worst. I just walked 2 blocks and had to come home. I can't seem to stand up straight anymore. I have gained 6 pounds in 30 days. After reading all the comments I now know that it is best for me to stop taking Femara. I will talk to the Dr. first but I just want to feel like I did before taking this drug. F 62 30 days
5/27/2007
 1  Breast cancer Hot flashes, joint pain, muscle pain, swelling of joints, tingling toes and fingers. It took 2 weeks for the tingling to start and as time went on the joints, especially hips, shoulders, feet, knees became very sore and swollen. Like others I wonder whether this is doing permanent damage to my joints. I have gone from Femara to Tamoxifen and have been on this for about 1 month but have not noticed any difference. I am seriously considering taking myself off Tamoxifen and having quality of life. I'm 55 and feel 80. F 55 6 months
5/23/2007
 2  Breast Cancer Stage 1 Hot flashes that keep me from getting a good nights sleep, joint pains, odd shooting pains in the back of head, periodic nausea and vomiting, frequent bladder pressure and more urinating. I was on tamoxifin and arimidex. Both elevated my cholesterol very high. Had to have ovaries removed.Developed large cysts. Now, after 6 months have gut problems. Any one else? F 46 6 months
5/22/2007
 4  Breast Cancer Stage 2 no lymph node Joint pain, I blame on Femara. Vaginal dryness might just be hormonal loss from menopause (made worse by Femara). My hair is beginning to thin, but I don't see that as a common side effect on this list. Glucosamine Condroitin helps with joint pain. It was worse several months ago, but I am doing better now. I wonder if it's causing and permanent damage to my joints. I am looking forward to the day when I can stop taking it. F 53 1 years
5/19/2007
 2  Infertility I didn't feel any side effects at all while taking this medication. However, a few weeks later, I found out that I developed an ovarian cyst, which may be a side effect of this medication. Unfortunately, this means that I will have to wait on the sidelines for approx. 3 weeks in hope that the cyst resolves before starting another treatment cycle. This medication is used off label for ovarian stimulation. Its use for this indication is controversial. A Canadian study suggested there is an increased risk of congenital malformations among infants born to mothers who used this medication for ovulation induction. However, there are criticisms of this study ( in particular, the control group was comprised of normal healthy women who had infants naturally with no medical assistance; also, the half life of femara is fairly short so at least theoretically harm to a developing fetus would seem unlikely). A subsequent study comparing Femara and clomid showed no significant difference in the rate of congenital anomalies. The main benefit of Femara (vs. Clomid) seems to be fewer side effects. Whether or not you think its worth the risk of potential harm to a developing embryo is up to you to decide. F 35 5 days
5/18/2007
 1  Stage 1 bc;nodes negative I stopped the drug after 3 months due to extreme fatigue, anxiety, numbness and tingling of hands, severe dryness of skin and vaginal tissues, terrible pain in hips, knees, and ankles. Felt 90 yrs old. My Onc said he has never heard of any symptoms other than joint pain. I told him to come to this site.He said taking Femara would only prevent a new br ca by <1%. I've been off of it for 3 months. Have more energy but joint pain still terrible.My right hand numb in the AM, have trouble sleeping due to this.Why put someone through this for < 1% improvement??? F 52 3 months
5/15/2007
 2  Breast cancer Feel like I've aged 20 years in 2 months. Muscle aches, extreme dryness, constipation, edema, fatigue. Can it possibly get worse-felt better during chemo F 60 2 days
5/11/2007
 5  Leiomyosarcoma severe muscle & bone pain - especially the hips and shoulders, hot flashes, fatigue. Although the side effects are major, I am really without any other options. It beats the alternative all to pieces! F 49 3 years
5/10/2007
 4  Endometrial Stromal Sarcoma Hot flashes, elevated cholesterol, tingling in hands and feet, mild bone pain and stiffness, vaginal dryness, complete loss of libido. Side effects are bearable, especially if it is preventing a reoccurence. F 47 13 months
5/10/2007
 5  lobular breast cancer Very mild headache on day 1, occasional brief hot flushes I have not been so fit for years. Skin is good, lost weight and lead a very active lifestyle. Not sure how much is due to the drug and how much is takng care o myself better F 61 15 months
5/9/2007
 4  after bilateral mastectomy stage 1 joint pain, relieved by 3 mg prednisone daily While I'm not happy with the joint pain, it's much less bothersome with the daily prednisone. My rheumatologist suggested it (I had used it 6 months earlier when I suddenly got polymyalgia rheumatica). My oncologist said, "I've learned something," and none of my doctors is concerned about that low dosage. I'm very physically active, so being able to still hike, bike, and snowshoe has been a blessing. But my skin is crepey and dry, and I will be happy when I can go off the drug in a year and a half! F 78 3 years
5/8/2007
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 2  post tamoxifen 5 years Extreme fatigue, acute muscle and joint pain-painful swollen right knee, now bilateral trigger thumbs.Breathlessness with minimal exertion,insomnia,detrussor muscle instability,vaginitis and generally feeling extremely old and stiff.Frightened to continue taking this drug frightened not to take it.Also low white cell count following breast cancer treatment even lower now!Also raised cholesterol. F 50 9 months
5/8/2007
 1  Infertility I took this medicine at 9 pm fine until 9 am and it hit me like a train wreck. I got hot and felt dazzed. I felt nauseous, dizzy and just out of sorts. I got a very bad headache. I was so nauseous that I could not turn my head without feeling like I would throw up. I started gagging in my lab class, which was the first day of class. I had to leave and drop the class this medicine has taken over my summer plans with just one pill. I took 2.5 mg one time. I would not recommend it. I had a very bad reaction. I laid in bed for 24 hours and still feel very, very sick. F 33 1 days
5/8/2007
 1  Breast cancer Palpations. After 4 months developed burning pains in hands. Was waking me up during the night. Doctor prescribed anti inflammatory and took them for one week. But these were not working. Have claw like fingers. Swollen fingers. Wedding ring tight. Put on weight F 53 4 months
5/5/2007
 2  bc stage 3 a 6/24 nodes involved I fell like a cripple 25 pounds up, so tired, stiff and makes you wander if the whole treatment chemio and radiotion were worth of just ending as an 60 yeasr old lady sitting down(= just watching life pass by ( due to stiffnes and pain ) or just have really great years ( gambling if it will return the cancer somewhere else) Do not recomend to take it Extremely expensive, to many side effects F 43 365 days
4/29/2007
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 3  bone mets- reoccurrence thumb joint pain both hands have pain opposing my thumb to any of my fingers especially the ones further away like thumb to pinky, thumb touching ring finger...etc have heel and foot joint pain.Seems to be worse (like regular arthritis sometimes does) when its raining out. fatigue. hot flashes very frequent. sometimes lightheadedness vaginal dryness with slight but not full loss of libido (i use to have a great one now it does feel blunted. im in my 30's and had ovaries taken out as well....they are trying to wipe out all sources of estrogen...meanwhile sudden abrupt menapause is no fun especially on my joints F 35 4 months
4/27/2007
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 3  metastatic bc to bone I was on Arimidex for 6 1/2 months and switched to Femara a week ago. The side effects are not as bad on Femara. I'm starting to notice an increase in my blood pressure and my rt. hand is really stiffining up. My major concern with both drugs is a continuous low grade fever for over two weeks ranging from 99 to 99.4. My Oncologist ran usual blood tests and all in normal range. I saw my GP and he is running more involved tests and urine as well. I haven't seen any comments regarding fever from anyone. Has anyone experienced this? My e mail address is included if you care to respond. Hope to hear from someone, not just about the fever, but if you'd just like to talk, that's fine. I feel I will stay on this drug as long as possible and try to cope with the side effects. F 64 15 days
4/26/2007
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 2  Stage 1 BC Lots of pain in my hands in the a.m. and if I am sitting still for a while. I can hardly move and I am stiff. Feels like I age 30 years in the last year. Hot flashes throughout the day, always warm. F 54 1 years
4/24/2007
 4  breast cancer tiredness I have 144 tablets of Femara 2.5 mg. which I no longer can use. These are unopened bubble packets of 12 per packet. If you are interested in these, please email me. F 60 3 months
4/22/2007
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 2  BC estrogen positive Have had MRI on knee due to severe pain/Bakers Cyst and torn miniscus also higher cholesterol and irregular heart beats. My knee problem has been helped by knee exercises rather than surgery. I noted that someone else also had bakers cyst queston/ my ortopedic Dr felt femara related. F 61 25 months
4/22/2007

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