FEMARA Reviews (LETROZOLE)

Average Rating: 2.5 (1087 Ratings)

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 HORMONAL BIOLOGICAL RESPONSE MODIFIERS AROMATASE INHIBITORS

 Type: Rx Drug

  

FEMARA  (LETROZOLE):  This medication is used to treat certain types of breast cancer (such as hormone-receptor-positive breast cancer) in women after menopause. Letrozole is also used to help prevent the cancer from returning. Some breast cancers are made to grow faster by a natural hormone called estrogen. Letrozole decreases the amount of estrogen the body makes and helps to slow or reverse the growth of these breast cancers.   FDA Approval Date: 1997-07-25 (Sources: U.S. Centers for Medicare Services, FDA)

  

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Key to Ratings: 1=LOW (I would not recommend taking this medicine.)
5=HIGH (this medicine cured me or helped me a great deal.)

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RATING  REASONSIDE EFFECTS FOR FEMARACOMMENTSSEXAGEDURATION/
DOSAGE
DATE ADDED
 
 2  Breat Cancer (hormone receptive) I am fed up with heatwaves, concrete feet, sensitive finger tips, headaches, and pain in bones, joints and muscles. Feel like 100 ! As 4 lymphnodes were infected, I was given Femara. I'd rather take the risk of a rezidiv and live a normal life until then. I decided to stop Femara and continue with the Mistletoe-Therapie that has helped me through 8 Chemos and 28 radiations. F 72 2 months
2/3/2008
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 4  Stage 1 Breast Cancer 2001 Have gained 10 lbs. since starting 1 Year ago. Walk like Frankenstein after getting out of bed or sitting a long time. If I have more than 2 glasses of wine, the next morning I wake extremely ill. Unbelievable headache, nausea, chills. Following my diagnosis, I had a lumpectomy, chemo and radiation. I took Tamoxifin for 5 Years followed by 1 Year on Femara. My Oncologist said I could go off Femara, but I am a little nervous to do so because of the fear of recurrance even though it is his belief that I have received the maximum benefits. If anyone has any comments on this, I would appreciate hearing from you. Also, has anyone had the same issues drinking wine? That's a real drag! F 59 1 years
1/29/2008
 3  Breast Cancer very sore joint pain. At first I felt like I was 90 years old. I have been on it now for almost 4 years. I'm too afraid to go off of it. Really bad "brain Fog" to the point I stoped talking to people because I don't want them thinking I'm crazy. I was told the reason we have this problem is a lack of estrogen. This helps us think clearly. I may be in pain, but at least I'm alive and watching my children grow up. I would hate to chose the other option. You know what I mean. I have a question for all of you. I was first diagnosed when I was 37. Radical masectomy followed with 6 months Chemo. I was placed on Femara because I tested Positive. Every where I read it say's not to take Femara if we are Pre-menopausal. This drug is only for Post-menopausal women. I'm a little concerned with this information. My doctor say's it is better for me than Tamoxafin due to the blood clots and all. I would just like to know if it's dangerous for women who are not yet menopusal like myself. I also just had a bone scan done and I showed up very dark in all of my joints. My Endro. Doctor say's I look like I have severe arthritis. I would like to hear from anyone who is on this drug and still pre-menpausal and what their doctor had to say about it. The fact that I also had thyroid cancer has me a little worried about stopping this drug. Yea I feel like crap half the time, but I'm alive. I just want to know if I will be in a wheelchair by the time I'm 60? Oh yea a F 41 4 days
1/25/2008
 4  Recurrent Breast Cancer None that I know of. I take it before I go to bed every night so that I'm sleeping while it does whatever it does. F 56 1.5 years
1/22/2008
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 2  ovulation induction headaches, hot flashes F 35 3 months
1/19/2008
 5  breast cancer Sore joints, stiff neck, increased cholesterol, lighter wallet I have been able to control all side effects sufficiently. I take Osteo BioFlex (over the counter), 2 tablets once a day, which eliminated the soreness and stiff neck. I took red yeast rice extract, 2 capsules once a day, and that lowered my cholesterol even lower than it was before taking Femara. Boy, is this drug expensive!! F 58 3 years
1/14/2008
 3  breast cancer After 5 yrs on tamoxifen the hot flashes are worse on femara. having a hard time getting the 1,500 calcium i need to take. Also bone and muscle pain.Terrible hot flashes. F 66 13 days
1/13/2008
 3  Stage II Br Ca, Recur: 9 yr later At first left leg,numbness, back pain,joint pain. Recent onset (6 mo now) of severe left hip/groin pain. MD ordered MRI with contrast to r/o bone metatasis. Femara has apparently kept my cancer away (5+ years) since second bout with breast cancer. HOWEVER.....is Femara causing other severe side effects??? My MRI showed avascular osteonecrosis which will eventually require a hip replacement. HAS ANYONE ELSE HAD THIS DIAGNOSIS (while taking) FEMARA???? F 64 5 years
1/11/2008
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 2  ovarian cancer after two and a half months the bone pain and joint pain was unbareable. Am considering trying tamoxifen again as that only added to fatique and nausia. I am very active and femara shut me down. i am currently in remission but was estrogen positive any help in manageing the pain would be welcomed F 55 3 months
1/6/2008
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 2  Brst. canc. mastectomy.first node Hair loss,pain and swelling in all joints ,weight gain in stomach area not belly ,look pregnant,numbness in four toes ,left side legs hurt ,back hurts shoulders all the way to the bottoms of feet,cant hold on to things no grip and horrific pain lifting reaching bending stooping,cant breath after going up steps or any exertion,appetite not good ,nothing sounds good ,stressed from non ability to do things i need to do.I took tamoxifen for 5 yrs. now this femara for a year,they have tried gout treatment for the pain and swelling in wrists ,did not work ,scans and mris show no reason so i assume its from the drug,I am still cancer free and thankfull but I feel terrible cant function for the pain and stiffness,I see my oncologist in less than a month i will ask if something different out there ,i have almost all symtoms of others this site,still thankfull 65 feel 95 ,,did not have all this before femara maintained normal weight during chemo and tamoxifen gained on femara I am at a loss wha The rating above is hard ,if I knew i would have all this pain i might have said no try something else ..I have went from a 7/8to a 14/16 pants mainly in my stomach feels like something growing pressing on my back ,they cant find any thing..STILL VERY THANKFULL F 65 1 years
1/6/2008
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 1  Breast Cancer Weight gain, headaches, joint and muscle pain. I have been going crazy trying to determine why I am in such pain. I keep attributing all this pain to my age, even though at this age I shouldn't feel like this. I get concerned when I know I have to walk long distances, I can't take my shirt off over my head because I can't raise my arm, my ankles, elbows, ribs are in constant pain. I have gone to my doctor and they attribute it to my weight gain (30lbs over weight) and 'in my head'. I also began to think it was me......FINALLY I realized that the only change in my life for 2 years has been the Femara. Am stopping taking it TODAY. Wished I had read the comments here a year ago. I can only pray and hope that all this is reversible as I cannot imagine living the rest of my life with such pain and discomfort. F 50 2 days
1/6/2008
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 4  Infertility Hot flashes! Dose of 2.5mg days 5-9, took the pill first thing in the am. One night I felt like I was sleeping in a tanning bed. Compared to Clomid, this is a dream...my husband no longer wants to divorce me because of my crazy mood swings! From my research it is a pretty risky drug, but no more than Clomid. The half-life is shorter, and cyst problems are less common. We'll see if it works! F 29 5 days
1/3/2008
 4  Mestatic breast cancer, 12 of 16 no Nausea, tiredness, bone pain, joint pain, hot flashes, constipation, insomnia. But it beats the alternative, so far Femara has given me a lease on life.When i was diagnosed i was given 18-24 months to live,that was in October 2004 Even tho Femara has limited my activities, and excersise, the weight gain i experienced, i now have under control with diet and lost almost 10 pounds ( slowly)The last PET Scan i had in Nov 2007 was clear and i am still in remission after being declared so in Nov 2006. I would like to hear from anyone that is a long term survivor and how they are coping with the side effects of Femara F 59 2 years
1/3/2008
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 3  BC was Stage IIC Invasive Took Tamoxifen for 2 yrs with side effects that included extreme hot flushes, nausea (like morning sickness), horrible insomnia & headaches. Switched to Aromasin for next 2 yrs and it was tolerable for the first 6 months with same side effects as Tamoxifen. Then the bone & joint pain in the outer extremities started. Couldn't get out of a bed or a seated position or do stairs without feeling like a cripple. Mornings were worse & I too had the 'claw' effect with terrible weakness in my hands. Ankles felt fragile, as though the bones would break with the slightest pressure. Once healthy libido disappeared, urogenital system dried up & cholesterol levels tripled, although no change in exercise & diet. Doctor switched me to Femara 2 months ago. After the 1st week, I actually slept for two whole nights & felt awesome! Then the side effects of the Femara kicked in & it's starting to feel the same as with the Aromasin. I'm so thankful to have found this website! Over the last few years, I've so often thought that I was the only one experiencing these awful side effects. Until diagnosis, I was very fit & worked out 5x/week - weights & cardio. I continued to work & work-out even through chemo cycles. Now I feel like a 90yr old asexual being. Chemo-induced menopause presented its own challenges but these Aromatase-Inhibitor side effects continue to affect the quality of my life. Doctors are quick to offer Rx for side effects but each Rx has its own risks & side effects. It's a domino effect & I just want to feel 'normal' again & get on with my life. It would be so different if we were dealing with a broken arm. An X-ray would show the break, time would heal the fracture & then it would be nothing but a memory. Nobody knows if these AI drugs even work on something we don't even know is or isn't there. Quality vs Quantity of life should be addressed by somebody! F 50 2 months
1/3/2008
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 3  Metastatic breast cancer. Headaches, depression, fatigue, joint pain, palpitations, low libido, insomnia and weight gain. Apparently, the Femara is working, as I am almost 10 years out, but I do have many side effects. The depression, joint pain and headaches are terrible. I am applying for disability, as I can no longer work because of all of these medical problems. It takes me 7 days to get in 40 hours of work on my job, and for the past 3 months, I haven't been able to accomplish 40 hours in 7 days. I work, lie down, work, lie down, etc. Thank God I work from home, but this is becoming increasingly impossible. F 49 3 years
12/31/2007
 2  switched after 5 years of tomoxifin cold night sweats to point of being soaked. Stiff fingers, cant grasp. F 53 2 years
12/31/2007
 1  high estrogen I have been on femara for 4 years and have had the worst time of my life. crippling pain in knee joints and shoulder and elbows. I have also developed a rare case of (ONJ) dead jaw and had many other problems. why a doctor would give me this just to control my estrogen is beyond me I'VE NEVER HAD CANCER and I'm a male.other side effects proven by tests cant absorb nutrients b12 and zinc, sudden outbursts, swollen hand and face, erectile problems, and the list goes on!!!!! If any one can help me understand why I was put on this drug knowing it's adverse sideeffects or any one can explain why I have dead jaw, my jaw is rotting away and this doesn't happen to young people at all I'm 22 and I started taking this when I was 17 this drug is the worst thing that could ever happen to me completely destroyed my life!!!!!!!!!! been off the drug for 1 year and pain is as bad as ever. M 22 4 days
12/31/2007
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 2  Breat Cancer Stage1 Muscle, joint and bone pain. It seems to get worse each month. There is not a part of my body that doesn't hurt. I feel like I'm 90. Evan my hands and feet hurt. It is very hard to loose weight. Walking is getting harder and harder. but the worst is getting up from a sitting position. I was stage one invasive ductile breat cancer. But I had a high oncotype so I was treated with ACT and then radiation. I took Arimidex for two months and had bad side effects so we decided to try Femara. It is now worse than the Arimidex: the effects came on slowly. F 61 1 years
12/27/2007
 2  breast cancer stage 1 terrible knee pain. Finally called the Dr when it hurt so much to get in and out of the car that it made me cry. Dr told me to stop meds and see him in a month. 2 weeks off med and still dragging my left leg, the knee hurts so bad. Any idea of how long it takes for med to leave your system?? F 52 4.5 months
12/26/2007
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 1  breast cancer 6 years ago I am now taking "vacation" from the drug since in addition to all of the symptoms others describe (pain, very severe) I started falling around : with no warning, just fell. Once broke a hand, I guess just a momentarily weakness in my legs. I fell 5 times in 6 weeks. My general doctor told me to stop it. I could fall in the middle of the street - and then - the issue of survival is rendered irrelevant. I am off Femara now for 7 days and my pain is virtually gone. I guess one has to be grateful for surviving but there must be a cut off point beyond which it should not be necessary to have to endure the terrible pain and discomfort. F 62 6 days
12/22/2007

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