GLUCOPHAGE Reviews (METFORMIN HYDROCHLORIDE)

Average Rating: 3.4 (586 Ratings)

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 Type: Rx Drug

  

GLUCOPHAGE  (METFORMIN HYDROCHLORIDE):  Metformin is used with a proper diet and exercise program and possibly with other medications to control high blood sugar. It is used in patients with type 2 diabetes. Controlling high blood sugar helps prevent kidney damage, blindness, nerve problems, loss of limbs, and sexual function problems. Proper control of diabetes may also lessen your risk of a heart attack or stroke. Metformin works by helping to restore your body's proper response to the insulin you naturally produce. It also decreases the amount of sugar that your liver makes and that your stomach/intestines absorb.   FDA Approval Date: 1995-03-03 (Sources: U.S. Centers for Medicare Services, FDA)

  

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Key to Ratings: 1=LOW (I would not recommend taking this medicine.)
5=HIGH (this medicine cured me or helped me a great deal.)

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More on GLUCOPHAGE: Reviews Summary  |  Drug Safety Information

RATING  REASONSIDE EFFECTS FOR GLUCOPHAGECOMMENTSSEXAGEDURATION/
DOSAGE
DATE ADDED
 
 3  PCOS diarrhoea (only in the first 2 days) I have started taking Metformin 5 days ago. I feel good, no apparent side effects, except maybe for some muscle pain. However, this may be caused by strenuous exercise (such as stair climbing). One of my calves has been hurting me for the past four days. Incidentally, I started exercising the day I started taking the medication, so I guess it may be the exercise. A couple of days earlier I panicked thinking of lactic acidosis... but I guess that involves generalized, not localized pain. F 35 5 days
6/25/2007
 2  insulin resistance After taking this medication for a couple of weeks I began having severe weakness in my legs, ater a month and a half I was in really bad shape and barely able to get out of a chair anymore or walk up steps. I had lost all of the strength in my legs. After going off the medication it took almost a year to get all of the strength back in my legs. F 40 1.5 months
6/24/2007
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 3  PCOS (same person as below)- none with new dosage. Now that i'm taking the 500mg slow release Glucophage only at night (3 hours after i eat dinner) i feel much better- and basically no side effects. I'm also taking 50mg of Clomid and the Chromium Picolinate as a supplement to aid with my glucose levels. Just waiting to see now if all these meds will be worth it. F 26 1 weeks
6/22/2007
 3  PCOS/infertility increased dose slowly.took only 1 pill 1st day,little nausea. 2nd day increased 2nd pill,got upset stomach and dairrhea;it lasted 3 days.increased another dose on 6th day(now 3 pills in a day)this time no upset stomach or dairrhea but got nausea,vomitting,dizzy and sleepy.felt energy the first 3 days but after vomitting feel weak. taking this med to ovulate and concieve. cant say much if it worked or not cuz its only a week but am getting all the side effects. F 29 1 weeks
6/19/2007
 4  Type II Diabetes Extreme cramping, diarrhea, fatigue, but only after my pharmacy began getting the Metformin from a different company! Although the law requires the active ingredients to be the same, the inert ingredients can vary from one company to another. Studies suggest that it may well be the "inert" ingredients that are causing the side effects. I have used Metformin for about ten years. I experienced only minor upset when I started taking it. The manufacturer of that pill was Mutual. Safeway recently switched to a different company for cost reasons and I experienced severe symptoms such as others have described. I believe it is likely to be reaction to the inert ingredients after a fellow diabetic told about that being suggested by the latest research. My experience would certainly bear that out. M 53 10 years
6/18/2007
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 1  Insulin Resistance/ excess wt. gain stomache bloating, gas, nausea I got on this medication because of insluin resistance and I had gained 18 pounds in 6 weeks. I am very active and eat healthy. I workout 6 days a week and still no weight loss after 5 weeks. Not sure what I'm doing wrong. F 32 5 weeks
6/18/2007
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 2  PCOS Cramping, Diarrhea, Nausea, Vomiting, Complete miserableness. I initially started on 1000 mg twice a day- to help with my insulin/hormone levels in hopes of becoming pregnant. After 4 horrible days-I complained about the extreme side-effects, and my doctor has now suggested taking 500mg only at night as well as an OTC Chromium Picolinate. She also talked to an endocrinologist who recommends taking Glucophage 3 hours after you eat- not immediately with food. Will update with new dosage. F 26 4 days
6/14/2007
 1  Starting insulin Resistence I am not sure if it is the glucophage but I have started Colon problems recently,intense pain in the right side below my rib cage. Has anyone had the same ? Please email me!- ALl the added risk - There has to be another way! Found this on the internet and now am very concerned:BILE ABNORMALITIES. Bile is produced by the liver, stored in the gallbladder, and secreted into the intestines in order to absorb fats into the bloodstream. One possible reason for the GI problems is that metformin reduces normal reabsorption of bile from the intestines back into the bloodstream, which causes elevated bile salt concentrations in the colon.(25) Most studies suggest that colonic bile salts cause free radical damage to DNA and may contribute to colon cancer. In addition, bile acids may stimulate cells in the colon to produce leukotriene B4 (LTB4), a highly inflammatory substance. LTB4 would be a contributor to any intestinal inflammatory condition.(28) Byproducts of bacterial action on bile salts may lead to intestinal cell damage and absorption of "foreign" molecules such as food or bacteria particles into the bloodsteam, possibly causing allergies and other immune responses. Moreover, many PCOS women have s F 33 2 months
6/13/2007
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 4  diabetes None noted. On one occasion when I delayed getting my prescription filled my blood sugar went up substantially. I also follow Dr. Bernsteins low carb diet M 67 3 years
6/7/2007
 4  PCOS Diarrhea, gas, extreme tiredness, nausea It has slowed hair growth on my face somewhat, and the side effects have gotten better. I take 500mg. 2X daily. Never take a dose too close together, because I had a horrible spell of nausea and throwing up. F 26 4 months
6/5/2007
 3  Diabetes Occasional stomach pains after eating certain foods. Occasional back pain at first. Not sure how well this worked for me. Seemed to help my blood sugar levels for the first week but after a month of taking 2000mg my sugar levels were only slightly lower than they were when I was diagnosed. M 27 3 months
6/5/2007
 5  hypoglycemia - insullin resistance some diarreah I had given up on this med when it was prescribed because of the diarreah. If you take the pill on a full stomach and you don't feel as sick. In 4 days I have lost 14 lbs and I am going to stick with this because I need to feel better. F 45 8 days
5/31/2007
 4  insulin resistance/infertility some diarrhea in fist week, some stomache cramping,loss of appetite no weight loss but no weight problem I've been taking this medication since 10/06 for about 2 months but I stopped taking it after the first two months due to the side effects I started taking it again at the end of 4/07 and I found out I was pgnt today but I don't know how safe it is to continue taking it now that I'm pregnant since I miscarried in 6/06 and I've read that it is better to be off while pgnt does anyone know any different F 42 21 days
5/31/2007
 1  Type 2 diabetes explosive uncontrollable diahreea Only used it for two days. If this is what I have to deal with to control my just-diagnosed diabetes, I'd rather go blind and have my foot amputated. M 48 2 days
5/28/2007
 2  Diabetes Muscle ache, joint pain, flatulence and diahrea I have other reasons I could have these side effects. I have Crohn's disease which is an Inflammatory Bowel disease which does cause gastro problems. I also exercise quite a bit so that could cause joint and muscle pains. I'm about to get off of it so I can see if it's the medicine that is causing my problems. F 47 6 months
5/27/2007
 4  PCOS Nausea, Diarrhea, Fatigue I took over a year ago in hopes of getting pregnant. I got pregnant within a month, continued it into my first trimester and now have a healthy beautiful baby boy. Back on it to treat PCOS and having terrible diarrhea. I'm also on birth control at this time and needing to loose 20 lbs. I've dropped 2 lbs so far in only a week. F 34 7 days
5/26/2007
 3  Insulin Resistance Morning hunger pangs, diarhhea, lately noticed extreme weakness in legs and arms. I took 500mg a day for one week, then 500mg twice a day for about two weeks when I noticed the extreme weakness. I think I have lost some weight maybe 10 lbs. I have a lot of weight to loose. My sugar and insulin levels were within normal range just slight increase from last year, low carb diet for 2 to 3 years and no weight loss. I think the weakness will pass. I hope this is the problem and can be resolved before my health suffers more extremes. F 43 23 days
5/22/2007
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 3  PCOS nausea, extremely tired all the time, headache, diarrhea, cramping,loss of appietite, dizziness, flu like symptoms I don't know if my period is regular yet. first week I lost 3pounds and it came back the next week. I don't feel seek no more. I wanted to lose 15lbs. My weight at this moment is 115. I am 4'11" so I could still lose some weight. I am reading that people are losing so much weight in just a few weeks and mine is not going down at all. Is it because I am not overweight? F 28 3 weeks
5/20/2007
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 3  PCOS nausea, extremely tired all the time, headache, diarrhea, cramping,loss of appietite, dizziness, flu like symptoms I don't know if my period is regular yet. first week I lost 3pounds and it came back the next week. I don't feel seek no more. I wanted to lose 15lbs. My weight at this moment is 115. I am 4'11" so I could still lose some weight. I am reading that people are losing so much weight in just a few weeks and mine is not going down at all. Is it because I am not overweight? F 28 3 weeks
5/20/2007
 5  PCOS Stomach upset, feeling sick, wind, I had my stomach lap banded 2001 i weighed 155kgs at the time and found I lost 40kgs within 2 years I then started putting the weight back on and didnt have a period often.... After getting married in 2004 we tried having a baby I fell pregnant 4 months later but suffered a miscarriage at 16 weeks I then didnt get my period and my weight went back up in 2005 i again fell pregnant and at 8 weeks suffered a miscarriage I saw 3 doctors who told me to loose weight and unless i had 3 miscarriages they couldnt help me.... I then found a doctor who did blood tests and looked at my ultrasounds from when I was pregnant and found i always had cyst's on my ovaries one was 1.5cms he put me on diaformin ( australian name) around Dec/Jan 2006 I also was told to go on a low GI diet.I weighed 120kgs I started having a period every 4 weeks and I lost 8kgs in 2 months and surprise surprise in April 2006 the 4th I found out i was pregnant again..... I was told to go off the diaformin and on the 23rd of D F 28 2.5 months
5/19/2007
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