GLUCOPHAGE Reviews (METFORMIN HYDROCHLORIDE)

Average Rating: 3.4 (586 Ratings)

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 Type: Rx Drug

  

GLUCOPHAGE  (METFORMIN HYDROCHLORIDE):  Metformin is used with a proper diet and exercise program and possibly with other medications to control high blood sugar. It is used in patients with type 2 diabetes. Controlling high blood sugar helps prevent kidney damage, blindness, nerve problems, loss of limbs, and sexual function problems. Proper control of diabetes may also lessen your risk of a heart attack or stroke. Metformin works by helping to restore your body's proper response to the insulin you naturally produce. It also decreases the amount of sugar that your liver makes and that your stomach/intestines absorb.   FDA Approval Date: 1995-03-03 (Sources: U.S. Centers for Medicare Services, FDA)

  

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Key to Ratings: 1=LOW (I would not recommend taking this medicine.)
5=HIGH (this medicine cured me or helped me a great deal.)

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More on GLUCOPHAGE: Reviews Summary  |  Drug Safety Information

RATING  REASONSIDE EFFECTS FOR GLUCOPHAGECOMMENTSSEXAGEDURATION/
DOSAGE
DATE ADDED
 
 5  PCOS, Insulin resistance I have not had many side effects yet. Although I do feel a little more tired. I have not had the diarrhea or bloating as alot of others have had... I have been taking this for only 6 days now, and I have lost 7 LBS!!!! This is so exciting for me - I thought maybe 2 or 3 (because I have really been watching what I eat and drink) but 7 lbs!! This only encourages me to continue to eat healthy and take this medication, because I also feel MUCH better. F 30 6 days
10/24/2007
 3  PCOS related insulin resistance diarrhea, loose stool/undigested food in stool, gas, nausea, weight loss, increased energy Started taking metformin after years of researching what was wrong with my menstrual cycles (4cycles/year, bleeding up to 3weeks) and other related side affects (acne, carrying my weight in my abdomen, fatigue). No gyn. believed the research i presented - ended up going to an endocrinologist, who sent me for a pelvic ultrasound and did a lot of bloodwork - diagnosed with PCOS this past May - began a regimen of metformin, starting at 500mg/day, increased to 1500mg/day. I want to decrease to 1000mg as I get sick on 1500mg (loose stool with food particles in it, nausea) - have lost about 10lbs since starting (also went on weight watchers). feel more energized except when sick - don't need a nap at 3 or 4 anymore, don't seem to be craving extremes (salty/sweet). Since i'm also on Kariva (birth control pill), i'm unsure as to whether or not the PCOS is being managed, need to schedule an appt. to re-check levels, perhaps see if i will have a real menstrual cycle sans birth control. F 22 6 months
10/24/2007
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 4  PCOS Diarrhea, Less Fatigue, Some weight loss Glucophage has given me hope that I might be able to conceive and has started making my periods regular again. I was sometimes going 6 months with no period. I have now had two 45 day cycles and my last cycle was 42 so I hope they keep getting shorter! My doctor tells me it will take a few months for me to regulate. I never thought I would be so happy to have a period! I have been on the drug for a few months now and have noticed that I don't experience those days when I just want to fall asleep...I have more energy now and I find myself plucking less hairs on my face. Although I haven't really changed my diet, I have lost a few pounds. I started out taking 500mg twice a day (after breakfast and after dinner) for two weeks. I am now taking 1000mg twice a day...so 2000mg. F 30 4 months
10/20/2007
 3  infertility loss of appetite, vomiting, diarrhea, upset stomach, mild headache I'm still considered to be at the beginning stages of taking the meds. Week one began with 500mg, week two 1000mg and now I'm at 1500 mg on week three and will be at 1500mg for the duration of the time that I'm on the meds. I do not have PCOS nor diabetes, but my FSH level came high which probably explains why I haven't been able to get pregnant after almost two years of trying. I do notice my side effects improving, but for the first week I threw up every morning. The second week it was accompanied by diarrhea and other side effects here and there. I'm glad I continued because I really was hating the yucky feeling I was having and thought of quitting. Now that the problems have minimized I feel so much better that my body is getting used to it. F 30 3 weeks
10/20/2007
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 4  PCOS D/T Insulin resistance Very rare diarrhea. That is actually better than the dumping I had been having d/t my gallbladder being removed. In fact it appears my dumping has stopped since I began taking this. I haven't lost any weight but my cycle has changed and I can tell my body is acting differently. My menstrual cycle seems to be more normal and I think I am ovulating for the first time in a while, it has only been about 4 weeks though so I still need more time to know for sure. I have occasional headaches also, but rare, and rare nausea. Like twice, it was pretty severe nausea but it did pass after a few hours. Nothing I can't handle to have a healthier cycle and be able to get pregnant when we try. F 38 24 days
10/9/2007
 3  Insulin intolerance Type II Have taken for close to three weeks. Side effects from use has been, constipation, pain under my ribs in the morning on my left side (while laying down), affected my libido (couldn't get the old boy up!), fatigue, sleepiness, lose of energy in legs. Also, less craving for food. Question, is there anyone out there who has experienced glucophage affecting his/her libido, or am I the only one?! M 55 3 weeks
10/3/2007
 3  PCOS and TTC the only side effects i have had is bloating and mild headaches. only had 1 bout of the runs when i had had a high carb meal...the doc perscribed 250mg (1/2 tablet)in morning for 2 weeks, then 500mg (1 tablet) with dinner for two weeks, then 1/2 tablet with breakfast and 1 tablet with dinner for another 2 weeks and then finally one 1 tab with breakky and 1 tab with dinner. He said this will minimise side effects.... had no weight loss but am quite slim anyway 168cms (5"5) and 60kgs (132pounds).... i am feeling quite hungrey all the time though, Dont know if that is a side effect. Another thing is that after 5 days of taking the med I had brownish spotting for about 10days ??? (havent had a period in 7 months) Has anyone else experienced spotting? Hoping that it will help bring my periods back so I can ovulate and get pregnant. Just wondering how long it usually takes to start getting your periods back? Really wanting a baby without using clomid.... F 25 15 days
10/2/2007
 4  regulate blood gulcose timing of drug is critical M 67 1 years
9/27/2007
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 3  PCOS muscle and joint ache, metallic taste,SEVERE constipation, bloating and gas, weight loss and no cravings 1st week muscle and joint ache, metallic taste 2nd week SEVERE constipation, bloating and gas.Lost 5 lbs in 2 weeks no cravings no appetite F 48 2 weeks
9/25/2007
 2  possible PCOS, weight loss Mild diarrhea, lethargy, bloating I feel no difference. I feel like my stomach has increased in size and I have no energy. I was losing weight before I took the drug, now I am at a plateau. I take 1000mg at bedtime. It's been almost 4 weeks, shouldn't I be noticing a difference? Does anyone have any suggestions or feedback? F 26 3.5 weeks
9/22/2007
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 3  Insulin resistance None so far For the patient who is concerned about lactic acidosis - see following www.medsafe.govt.nz/Profs/PUarticles/5.htm F 68 15 days
9/21/2007
 5  PCOS with Insulin Resistance I haven't really noticed any side effects yet,except feeling better. I have maybe noticed some sleepiness right after I eat and have taken the med. Also thirst. I have been drinking more water and tea. I started it about 38 days into a cycle where I haven't gotten my period yet and after a week of 500mg I am spotting but I haven't had the acne that usually accompanies my periods and also I have a decrease in mood swings, even when I am usually irritable because I work nights and often don't get enough sleep I have not been dieting this past week, I have kinda trying this to see how my body works with it under my regular type of circumstances. I normally get dumping after meals due to gall bladder being taken out, but since beginning this, I actually have not had this happen. I went ahead and did my increase a couple days early to 2 tabs(to 1000mg) a day and so far so good. I've lost 3 pounds already and have been eating normally. I can say I haven't felt like eating in between meals, and feel more satisfied more quickly in general. But it's only been 1 week. I'll have to keep you posted on my progress. I am also hoping to get pregnant, although I hadn't been trying before, so I wasn't considered "infertile" but I know I wasn't ovulating all the time. I hope this helps my cycle but it's too soon to tell yet. F 38 7 days
9/19/2007
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 4  Infertility / PCOS / High Insulin Weight Loss, Diarrhea, Higher Energy Levels I've been on this for 6 weeks at the 1000mg per day dosage (two pills with the evening meal). I get diarrhea or loose stools multiple times a day, but find that I feel better on days that that is happening. On days that I don't get the diarrhea, I feel pretty lousy. It's a very noticable difference. I've lost about 25lb in these past six weeks...no other changes in my life-so it has to be the medicine. I have a healthy appetite now....not eating constantly like I was before because I ACTUALLY FEEL FULL FOR THE FIRST TIME IN MY LIFE!!! I sometimes have to remind myself or force myself to eat, and even then, I eat a small amount and am good. Too soon to tell whether my periods are becoming more regular or not... F 25 6 weeks
9/8/2007
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 3  Insulin resistance I have begun taking this medication since FOUR days to augment the Insulin shots I take. Some cramping and weakness, muscle pain. It makes me scared to think that it might give me LACTIC ACIDOSIS. Does anyone have any clue as to the occurence (per 10,000 patients) for this particular side effect? Any help will be APPRECIATED M 43 4 days
9/7/2007
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 5  PCOS/Insulin Resistance Stomach Discomfort The discomfort was mild, and went away after two weeks. Small inconvenience for being able to control my blood sugar and prevent Type II Diabetes and all the terrible complications that come along with that. F 29 2 years
8/22/2007
 4  PCOS, OBESITY, & ISULIN RESISTANCE Lots of loose stools, explosive diarrea at first, when you eat greasy food or high carbs or high sugar, you will feel like death... If you alter your diet, you feel better and look more beautiful... Skin is clearer ( *I Look Radiant...when I eat better and tough out the 1st part) ask your dr. about welchol or something like that for diarrea ( it helps me) only if you continue to avoid greasy foods... I get muscle weakness when I work out, and I have had an easier time, breaking pills in half and then gradually increasing dosages, I call my doc. to check in... and we adjust the doses based on how I'm feeling. A bit of weight loss. Need to lose 8- - 100 pounds... I'm on cafe mom... so look at PCOS support groups... I'm "wow_you_get_me"... or on myspace I am www.myspace.com/dontalkcrapaboutme (It was a weird time period I was much younger.) I love metformin's ability to minimize my worst hair and acne and cystic problems so far.... Being off of it made me realize, I have no energy and I am miserable even without it. F 24 1.5 months
8/14/2007
 5  PCOS Mild headaches I am taking this for past 11 months - two 500mg tablets per day -one in morning and one in night. Have lost 10 pounds over this period. Now getting my periods regularly.No adverse symptoms. I think the dosage should be increased gradually to avoid the symptoms. F 26 11 months
8/10/2007
 5  PCOS/Infertility/Insulin Resistance Malaise, cramping, nausea, loose stools, headaches Got pregnant very easily with first child after years of irregular periods. Took 5 years to conceive son happened with 150mg Clomid and 1500mg Glucophage.Had only a few stomach upsets. Now trying for baby #3 MAJOR stomach issues this time! After reading posts thinking it may be becasue it is generic...calling DR on Monday. No great weight loss to speak of also cardio 4x a week and weight training 2X a week so not sure if the little I have lost has anything to do with the medication. F 29 1 months
8/10/2007
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 5  
8/10/2007
 5  type II diabetes No side affects. None that other people have experienced. I have lost 20 lbs after being on this med for 7 weeks. I have a reduced appetite and have to remind myself to eat sometimes. I currently take 500mg with my evening meal. I return to the doctor in 6 weeks and will see about upping the dosage. I also have stepped up my exercise regime. Plus, the rx is free with my health plan, but is only $4 without it. What a deal! F 50 7 weeks
8/9/2007

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