Average Rating: 3.4 (496 Ratings)

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 Type: Rx Drug

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More on PREMARIN: Reviews Summary  |  Drug Safety Information

 1  Vaginal atrophy pain postpartum Insomnia, severe depression, heart palpitations, panic attacks Only used once and had awful neurological side effects. Praying it leaves my system quickly! F 31 1 days
.5 mg 1X D
 4  Hysterectomy Migraines, headaches, weight gain, back pain, body aches, hair loss, tired throughout the day I would like to know if there is an all natural product that I can take that will help replace the hormones I need, with less side effects of Premarin. F 52 2 years
2mg 1X D
 5  Hot flashes Great at first,been taken them for 3 or 4 months but i feel i need to up the dosage, they dont seem to be working as well now. F 51 3 months
0.625 1X D
 5  Total hysterectomy aged 26yrs Nil side effects. Now aged 72 yrs gained weight. 1.25mg for 45yrs now .625mg occasionally flush at aged 72yrs. I look years younger and have no wrinkles and smooth skin... Premarin is a wonderful estrogen drug..Gynecologist says stay on it because of the long period of 46yrs..when I reduced dosage had slight side effects example flushes. 72 46 years
.625 1X D
 4  Insomnia, painful sex, urinating co I gained 5 pounds in three weeks. It did help with the insomnia. So the choice is being overweight and no sleeping. I do not know what to do. F 64 3 weeks
.625 2X W
 1  Hysterectomy Massive weight gain, enlarge breast, starting to get chest pains. This medication is made from horse urine and pregnant mares have their babies slaughter, so this medication can be made. I am getting off this medication before it kills me. Going to ER now. [email protected] F 45 1 months
0.65 1X D
 1  menopause extreme migraine daily, hair falling out and contact lens problems. Premarin is an terrible dangerous pill and causes severe migraine .Waking up with a migraine early hours in the morning , at least every second day. it took me a while before I realized that it was Premarin causing all the problems. I have been off this pill for 10 days and I haven't had a headache since .I feel so much better after I have stopped drinking this pill. F 53 67 days
30 MG 1X D
 5  Total hysterectomy-No cervix I have had to stop taking it for surgery in 9 days. My blood pressure is high, chest pain, irregular heart beat, tingling in fingers. Went to ER and they couldnt figure out what was wrong. The worse hot flashes at night now and cant sleep well. Not sure if this is because i quit the premarin cold turkey. Help!! Anyone else feel this way? How long before u felt normal?? F 38 10 years
 5  Full hysterectomy I had a full hysterectomy ( they kept my right side ovaries due to osteoporosis) Iíve been on these pills since . My hot flashes and mood swings were off the charts . Since then Iíve been diagnosed with a rare form of cancer . Itís inoperable and they have no cure . In sight . Iíve recently been reduced to 0.625 mg . Iím positive if I didnít have this drug my family and myself would not have been able to handle me and my moods . F 50 11 years
 5  Complete Hysterectomy at age 35 No side effects for 35 years. I felt wonderful. I had a DVT last March and tested positive for anticoagulant. Was advised by 3 Dr's to go off cold Turkey. It's been 3 months off premarin and I feel horrible. Chronic pain, fatigue, and all the symptoms that go along with menopause. I have not been able to work since March. I want to go back on it but scared of the risks. Please email me at with any suggestions F 65 35 years
.03 mg
 3  Severe hot flushes Took 4 weeks to finally ease my hot flushes which were occurring nearly 5 to 10 minutes apart. Persisted with the tablets over the next 4 months. However, after deciding to go off the tablets, my hot flushes reappeared after only 4 weeks. Although this medication did work, albeit after 4 weeks, it did cause serious bloating and weight gain despite the fact that I stepped up my dieting and exercise regime, seemingly it made me bigger, causing me to see a doctor to verify that it was indeed the tablets causing the weight gain. After ceasing the tablets, my weight returned to normal. For this reason I will no longer be taking the tablets. F 54 4 months
1 tab per
 5  Night sweats, restlessness, hypertension None Started with .6 but didn't work and changed Dr who gave me 1.25. My hypertension disappeared and the sweating F 46 2 years
 5  Partial Hyst.& flashes none that I noticed I get extremely hot at times when others are not. Thought it might be time to get off Premarin. After reducing amount over 5 months, am still hot and now am having hot flashes on top of it. Thyroid med. just lowered, may help, but I may have to go back on the Premarin. This drug should be considered habit forming. F 72 20 years
.625 1X D
 1  Menopausal symptoms After taking Premarin for 6 weeks my body looked as thought it had been inflated with half set jelly. It took a further 6 weeks to find out the weight gain had been caused by the Premarin. I stopped taking at the end of July 2017 and so far despite rigid dieting and exercising at the gym 3 times a week I still cannot shift the weight gain caused by the medication. I had spent the previous 3 years losing over 7 stones in weight and had an operation to remove the loose skin. I had the body I had worked so hard for, then I was given Premarin and it has all been destroyed. I am devastated and depressed with no help from Pfizer or my GP Don't take it, it will destroy your life F 65 12 weeks
 5  Total Hysterectomy at 32 After my total Hysterectomy at 32 I was placed on premarin and had no side effects at all .and have stayed at .625mg a day A couple months ago ,something started to change .. I Have these severe hot flashes ,I'm losing my hair in patches ,I'm having trouble sleeping ,very anxious,forgetful ,and depression.and irritability. since I have been fine on .625 all these years it never occurred to me until tonight I am feeling all the effects of menopause! Until this happened I was going to start weening myself off ,but now I am going to increase the dosage ! It's been exhausting and miserable ,I hope it makes me feel like I always had 💗 F 46 14 years
 5  Complete hysterectomy No effects I want to know if its causing cancer F 51 7 years
 5  complete hysterectomy none I beleive as soon as I got on them they began to work their magic and continued throughout the years. Lucky Me. Back in the day I remember when I was younger the older ladies use to call them the banana pills. Do not ask me why, maybe because mine are oblong and yellow, yet not all premarin are looking the same. Yes I have additional comments. I was suggested by physicians a few times to get off of premarin and I tried until I experienced physical pain that I didn't like and at the time I was on percocets and that didn't kill the pain. So as I continued to suffer I said enough is enough. As i went back on my Premarin the pain went away just like that, therefore I told the Dr at the time. Then once again to the next Dr and then again to the next Dr then after this many times I said enough is enough because everytime it was the same, Pain. A new Pain. Comming from not being on Premarin so Drs said my body is addicted or my body needs it and I say I don't care just give me my script I need my Drug!!!!!!!!!!!! F 67 37 years
1.25mg 1X D
 5  Total hysterectomy My history: I had hormone NEGATIVE/Her2 Positive Breast Cancer 5 1/2 years ago. During chemotherapy, my constipation was so horrific it caused a cystocele and rectocele. Nine months after I completed chemotherapy, I decided to have it repaired. My GYN told me I should just get a total hysterectomy ďwhile sheís in thereĒ because ďyou never know.Ē My genetic testing was negative and my oncologist was not concerned about ovary removal because I was hormone negative. I have regretted that decision (to remove my ovaries) daily. I once had beautiful, thick hair and nice skin. Now it is thin on top and my skin looks old and pale. My hot flashes are HORRIFIC. My quality of life HORRIBLE. I was angry, hateful and depressed. I tried Effexor, Clonidine, and multiple other medications without success. Once more research was published about my type of breast cancer, I learned that estrogen actually blocks the androgen that fueled my breast cancer. So, I was given clearance to try estradiol. I started with the oral route, switched to the patch, then to bioidentical hormones, always resulting in massive post-nasal drip, nausea, headaches, weight gain, swelling, etc. So, I suffered. I recently found this site and learned that some women tolerate Premarin much better than estradiol. So, my GYN prescribed it (with my oncologistís approval) and although itís only been a few days, I am thrilled to say, I have had minimal side effects (whereas with estradiol My quality of life was horrible and I suffered. I could have gotten past my appearance had I not endured crippling hot flashes and heat intolerance (I live in the South and can rarely go out in the heat). Praying this works (I will bump up the dosage in a couple weeks). My quality of life, and my marriage, are worth any risks. Thank you, Premarin! F 49 4 days
 3  Had a total hysterectomy Waking up often during the night, restless legs syndrome, hot feet & hands thinning hair, weight loss, I wish there was something else to take that won't have the side effects this medication has...Very worried F 60
.0625 1X D
 5  Hysterectomy (Uterus & Ovaries) None that I noticed The hysterectomy that I had no choice but to undergo force me into surgical menopause. I feel horrible I had no energy I was having hot flashes night sweats and I would gained 35 lb and 8 months. I had never weighed over 110 lb before the hysterectomy. Doc first prescribe me Estradiol as hormone replacement and it didn't help at all. I went back and my doctor prescribe me Premarin and it made a huge difference in my life. With Premarin the hot flashes, night sweats, moodiness, old feeling went away. I also lost 30 pounds within 6 months without changing my diet. It's like it made my metabolism come back to normal. Risk with Premarin are minimal no matter what they've been saying in recent years I've had friends that have been on Premarin since they were in their twenties after hysterectomy and they tried to switch them off of it and it did not go well for them either. Don't be afraid of the Premarin it will definitely make you feel better and help to get some weight off of you. F 46 2 years

PREMARIN  (ESTROGENS, CONJUGATED):  This medication is a female hormone. It is used by women to help reduce symptoms of menopause (such as hot flashes, vaginal dryness). These symptoms are caused by the body making less estrogen. If you are using this medication to treat symptoms only in and around the vagina, products applied directly inside the vagina should be considered before medications that are taken by mouth, absorbed through the skin, or injected. Certain estrogen products may also be used by women after menopause to prevent bone loss (osteoporosis). However, there are other medications (such as raloxifene, bisphosphonates including alendronate) that are also effective in preventing bone loss and may be safer. These medications should be considered for use before estrogen treatment. Certain estrogen products may also be used by men and women to treat cancers (certain types of prostate cancer, breast cancer that has spread to other parts of the body) and by women who are not able to produce enough estrogen (for example, due to hypogonadism, primary ovarian failure).   (Sources: U.S. Centers for Medicare Services, FDA)