PREMARIN Reviews (ESTROGENS, CONJUGATED)

Average Rating: 3.4 (505 Ratings)

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PREMARIN  (ESTROGENS, CONJUGATED):  This medication is a female hormone. It is used by women to help reduce symptoms of menopause (such as hot flashes, vaginal dryness). These symptoms are caused by the body making less estrogen. If you are using this medication to treat symptoms only in and around the vagina, products applied directly inside the vagina should be considered before medications that are taken by mouth, absorbed through the skin, or injected. Certain estrogen products may also be used by women after menopause to prevent bone loss (osteoporosis). However, there are other medications (such as raloxifene, bisphosphonates including alendronate) that are also effective in preventing bone loss and may be safer. These medications should be considered for use before estrogen treatment. Certain estrogen products may also be used by men and women to treat cancers (certain types of prostate cancer, breast cancer that has spread to other parts of the body) and by women who are not able to produce enough estrogen (for example, due to hypogonadism, primary ovarian failure).    (Sources: U.S. Centers for Medicare Services, FDA)

  

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Key to Ratings: 1=LOW (I would not recommend taking this medicine.)
5=HIGH (this medicine cured me or helped me a great deal.)

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More on PREMARIN: Reviews Summary  |  Drug Safety Information

RATING  REASONSIDE EFFECTS FOR PREMARINCOMMENTSSEXAGEDURATION/
DOSAGE
DATE ADDED
 
 4  total hysterectomy the one symptom that really bothers me is melasma, I had such clear skin before, now i have blotchy skin, if anyone can tell me how to get rid of melasma, please e-mail me. F 44 4 days
11/9/2007
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 5  Hysterectomy For the first few years, I gained weight, but I also ate a lot more. Occasionally, I have had problems urinating, but that goes away when I skip a day on the pill. I am 65 and have been on the drug for 22 years. My doctor wants me off of it, and I did wean myself down to 3 pills at .6 mg a week. After six months, my skin is crepey and dry. I aged 10 years in those 6 months. Last week, I resumed daily use and feel much better already. I'll probably do five days on and two off at least until I am 70. I can find NO statistical data proving a link between estrogen-only usage and breast cancer. The data is all linked to estrogen-progesterin (which I refused to take 22 years ago after reading how unfavorably the Europeans were to it even back then). I think it's human nature to blame something when we get a disease. Premarin alone may or may not cause breast cancer, but the data just isn't there in my opinion. Quality of life means something here. My breast friend got a vicious form of breast cancer at 68 and she has a complete hysterectomy and NEVER HAD HORMONE THERAPY. So who knows? F 65 22 years
10/24/2007
 1  Hysterectomy and to protect my bone Thin bone, enlarged my heart, irregular heart rate, joint, muscle pain, serve headaches, sore on my arm that would not heal, anxiety, memory problems, personality changes, panic attack, depression, pre cancer cell had to have laser treatment, masses weight gain, serve breast pain, had a knee replacement. I have an allergy to horses. I also have been told I have Fibromyalgia and I think this drug is the cause. Started taking this pill when I was 40, it was nothing but hell for me. I was told when I was in junior high school that I reacted to horses and that I should never eat horse meat, or anything that came from horses. When I started taking this drug I did not know it came from horse, I was a farm wife raising 4 kids. When I found out the doctors would not listen to me about the side effect I was having, I was on the drug about 5 years when I found out. I was on the drug for about 12 years. This drug destroyed my life. I walked on a broken foot for almost 3 years because the doctors keep saying I was protect because I was on premarin. I was refused care because of this drug. I fear I will not get medical care in the future because of this drug. The very first pill made me sick, told my Doctor and he called me a lair. M 57 12 years
10/23/2007
 1  Hystorectomy total my mom experienced the weight gain, momory loss, blurred vision, and the sadness Started taking after the surgery, for approx. 18 yrs. then found a base ball size lump in her breast wich was malignant, and matatised into her spine, brain! She is now cancer free due to radiation, and tomoxifen. I do not recommend this drug for anyone. If you are still unsure, feel free to look up the case that was just settled in Nevada how 3 women just got awarded $99 million due to taking premarin and prepro!! And some states have taken it off the market!? A few years of hot flashes, and sleepless nights are WELL worth going through ANY cancer treatments. If you have any doubts, LISTEN to your body. DO NOT TAKE THIS DRUG! F 57 18 years
10/16/2007
 1  To open cervical canal I am fully menopausal, so no hot flashes to deal with. I am inserting Premarin to make my cervical canal more accessible for colposcopy. I have had no hormone replacement therapy. I believe this medicine is affecting my predisposition for depression. I have had some challenging life circumstances lately, and I am only taking Premarin for six weeks; hopefully I am in my last week. My emotions are very affected, I feel depressed and unable to engage in work or other activities to my utmost. So I hope that this course of treatment works to make my cervix more accessible and I can quit this stuff! F 51 6 weeks
9/30/2007
 3  complete hysterectomy virtually all side effects listed by others except hair loss Had full hysterectomy including ovaries in 2003 & took Premarin right away. High blood pressure, weight gain, tired, sadness, chest pains, shortness of breath, constantly hungry, etc. (all of the side effects). Doctor just dosage to 1.25mg from .625 about 2 mths ago. My ankles started swelling 3 wks. ago. These website testimonials explain why. I will start weaning myself & hope for the best. Not looking forward to night sweats & wrinkles. Thanks everyone for sharing your stories in real language. F 52 4 years
9/13/2007
 1  early onset menopause aches in legs and feet After using Premarin for 18 months, my Pap smear came back precancerous cells. I was treated for that. Two and a half years later my mamogram showed a small tumor. There is no history of breast cancer in my family. The needle biopsy showed atypical ductal hyperplasia. I followed the required mamogram schedule. Three years later the next needle biopsy showed cancer. When the lumpectomy was run thru the lab it revealed estrogen and progestin in the same proportions as the Premarin. My surgeon asked me if I would consider quitting the hormones and my answer was not just YES, it was HELL YES! I have been hormone free for three years, feel great and my mamorgams show a marked decrease in the usual lumps and bumps. Do I think there was a connection; yes. Would I recommend HRT to anyone--NO WAY. F 57 7 years
9/8/2007
 4  Complete Hysterectomy None. I have tried other HRT and Premarin has been the best. I couldn't sleep, I lost my appetite, I had very bad headaches, hot flashes and blurred vision. Since I have been taking Premarin, I can actually sleep, the hot flashes have deminished, and I have more energy. I continue to battle with the blurred vision however. F 32 1 years
8/7/2007
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 4  Complete hysterectomy and removal o Only brittle nails and increase in breast size. I've been taking Premarin 1.25mg since the operation and I did gain 10 lbs which I have kept. For the last three years I started with leg cramps (really bad), charlie horses on my toes, my legs to the point where I wake up (have always been a deep sleeper), also charlie horses on my hips and my back to the point where I could not straighten up. This cleared when I started taking Potassium/Magnesium/Zinc. But now, when I exercise 4-5 days a week I feel achie all over. A low-feeling ache al over that will not go away. My Dr. feels I've used Premarin 1.25mg for too long and is afraid of heart problems. I feel great with this as I do not have any of the side-effects associated with this, no mood swings, no headaches, no night sweats, or vaginal dryness, no hot flashes. The only thing was an increase in memory & libido. I've never smoked, seldom drink socially, keep stomach down with exercise. I exercise 5-6 days a week. Bad cholesterol is slightly high but high in the good cholesterol. I've always looked 10-15 years younger (good genes) and I still do. Skin is not dry and still has collagen. I do drink a lot of water all day and always have, I just like it. I had a lot of tests done for the leg cramps/charlie horses, these showed high bone density, electrolytes were OK, nothing was found. I am taking Potassium with magnesium and zinc and the problem with the charlie horses seemed to go away. I do have arthritis over the thumb on both hands and on the shoulder bone but besides that I'm O F 63 18 years
8/2/2007
 5  hormone defiencincy it is wonderful F 51 15 years
7/30/2007
 1  Total Hysterectomy Abundant hair loss, dizzyness, temporary hearing loss in one ear, major short term memory loss, legs cramps, aches & body joint pain, nasty rash all over my body (originally thought it was poision ivy), weigh gain of 20+ pounds within one year, bloated feeling. Went on this drug immediately after surgery. Side effects were affecting my job. Couldn't even think straight. My long hair was falling out in handfuls. Gained 20 pounds. Quit cold turkey, now its been 2 weeks, no nasty withdrawal symptoms and feeling so much better and can remember what I did yesterday. No more HRT for me. F 54 1.5 years
7/28/2007
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 1  total hysterectomy 50 lb weight gain in 2 years, panic attacks, depression, lower back pain, dizziness, headaches, nausea, rash, nightmares, dry skin, blurred vision, memory loss. For those of you who have chronic fatigue syndrome like myself be careful it will only make things worse. I have tried 5 different HRT'S nothing works. I take 1.25 mg it's helps me to sleep thats why I take it. F 51 2 years
7/22/2007
 3  Hysterectomy Weight gain (30 kg over the years no matter what I did), bloating, belly, spare tire, leg swelling, ankle /joint pain, cramping, vaginal dryness, lack of libido. To be honest, Premarin saved my life in the beginning. The doctor didn't prescribe HRT when I had my hysterectomy and was just in my late 30s. By mid 40s I was sobbing all the time, depressed to put it mildly and totally miserable with hot flashes leaving me soaked and dripping (very embarassing). The firt few years Premarin saved my life. However as the years went on began a gradual weight gain, developed high blood pressure, extreme water retention, large belly and thinning hair. I have been off Premarin for 10 days due to the fact that I can't get it. (It has been taken off the market where I live, so imposed cold turkey big time!) I have gone on to Phytoestrogen and so far am amazed at how good I feel. My middle is shrinking on its own, I realized my ankles aren't swelling and my legs aren't hurting so badly. I am having headaches, but hopefully that will pass. Now anxious to check my blood pressure. I am hoping that will go down. All in all I feel pretty good. F 57 10 years
7/21/2007
 3  Total hysterectomy exteme hair loss, weight gain, constantly hungry, extreme joint stiffness in lower body I stopped premarin on 1, July and as of today all my side effects are still there, nothing has changed. I haev to add now , no energy and always tired. if anyone knows what to do about the hair loss email me. F 47 4 months
7/18/2007
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 3  Total hysterectomy severe itching on legs and around waistline which causes large welts. Extreme exhaustion. Some leg cramps Visited a GYN yesterday who said Premarin wasn't cause of severe itching so it was interesting to read comments from 47yr old dated 3/30/07. He suggested I switch to Estradiol and referred me to a dermatoligist. I don't know what to do! Pychologically, I feel good.....I'm just so tired and itchy. F 46 6 days
7/4/2007
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 5  yes Leg and feet pain with cramps. Swelling in the joints of the knees and ankles. Sever pain in the joints in my body especially legs. Anxiety, panic attacks. Blurred Vision. Caused Short Term Memory Loss. Heart problems such as palpatations. Weight Gain 50lbs. No matter how much I exercised and diet weight would not come off. Effected the urinary track. I have had a complete hysterectomy 6 years ago. I went off premarin on June 10, 2007. I was taking 0.625 for 6 years. I am better now. I do not have the leg and feet cramps. I have lost weight. This medication made me retain fluid. I do not have heart palpations. All the side effects have left my body. I have been off premarin going on the 3rd week. with no hot flashes. I do not take any hormones. F 45 6 years
6/26/2007
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 5  Total Hysterectomy None. When I came out of the surgery at 39, my doctor immediately put a patch on. At my follow-up apptmt the next week he prescribed 1.25. Stayed on that for a few years, gradually reduced dosage to now taking one half of .45 daily. I have had no symptoms that I think can be directly attributed to this drug. The usual aches, pains and stiffness but I think that is normal for being 54 and not very active. F 54 15 years
5/16/2007
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 2  Total hysterectomy I came to the website for answers. I have been on the medication (0.625 mg) daily for about 3 months. I've steadily put on weight, have days of being very depressed, as well as my interest in sex has vanished completely. I am off to see my doctor next week, and was wondering if others had weened themselves off this medication. I honestly cannot find a website that answers the real question of whether this medicine is doing me more harm than good. Has anyone else felt depression, weight gain and loss of sex drive? Before the medicine I had mood swings, but nothing like this. I have never experienced night sweats or hot flushed (thank goodness). F 54 3 months
4/27/2007
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 2  Hot flashes, insomnia, heart palpat Shakey, trouble concentrating,muscle twitch, nervous It didn't help with hot flashes, heart palpatations, and I still have trouble falling asleep. I took premarin for about 10 days but I have stopped taking it. F 50 10 days
4/17/2007
 1  total hysterectomy 4/06 Look at my entry on 3/25/06. I stopped taking premarin 3/25/06 and as of today 3/30, I have absolutely no more pain or spasm. Premarin was making me become a criple. I was out of work for 1 1/2 weeks. Doctors said it was this and then it was that. (they were just guessing- they didnt know) NO MORE FOR ME. If I start having night sweats, I will try Clomera patch. thanks to this website. It saved my life.. F 47
3/30/2007

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