PREMARIN Reviews (ESTROGENS, CONJUGATED)

Average Rating: 3.4 (505 Ratings)

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PREMARIN  (ESTROGENS, CONJUGATED):  This medication is a female hormone. It is used by women to help reduce symptoms of menopause (such as hot flashes, vaginal dryness). These symptoms are caused by the body making less estrogen. If you are using this medication to treat symptoms only in and around the vagina, products applied directly inside the vagina should be considered before medications that are taken by mouth, absorbed through the skin, or injected. Certain estrogen products may also be used by women after menopause to prevent bone loss (osteoporosis). However, there are other medications (such as raloxifene, bisphosphonates including alendronate) that are also effective in preventing bone loss and may be safer. These medications should be considered for use before estrogen treatment. Certain estrogen products may also be used by men and women to treat cancers (certain types of prostate cancer, breast cancer that has spread to other parts of the body) and by women who are not able to produce enough estrogen (for example, due to hypogonadism, primary ovarian failure).    (Sources: U.S. Centers for Medicare Services, FDA)

  

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Key to Ratings: 1=LOW (I would not recommend taking this medicine.)
5=HIGH (this medicine cured me or helped me a great deal.)

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More on PREMARIN: Reviews Summary  |  Drug Safety Information

RATING  REASONSIDE EFFECTS FOR PREMARINCOMMENTSSEXAGEDURATION/
DOSAGE
DATE ADDED
 
 3  Hot flashes Right after taking the .45 dose of Premarin, my appetite increased, I gained over 10 lbs. in the stomach, butt and thighs and no amount of exercise or diet change has helped take it off. I've been on the Premarin for 3 months and have gained 10+ lbs., my hair is breaking off and thinning and I have no energy to do much of anything. As I was a fairly active (hyperactive:) ) person before, I attribute the lethargic moods to the Premarin. If I can get past the unsightly weight gain and the thinning hair, Premarin has totally wiped out the hot flashes and sweats and that was the goal, but I am considering going off of it as the weight gain is grossing me out! F 52 3 months
10/9/2008
 4  Hysterectomy/Oophermectomy WEIGHT GAIN, sore breasts When surgical menopause hit me in the face, it was ugly. Hot flashes, night sweats, insomnia, weepiness, depression, low low body temp, constantly shiivering, just wanting to crawl out of my skin. I tried over the counter herbal remedies, nope- did not help. So I had to try Premarin or stand in front of a train, that's how awful I felt. I started on .625 of it, and felt a huge relief in a matter of days. I did notice that after a week or so, my stomach was a big bloat- like a full tick! Then my breasts were quite full (I'm basically a flatsy) they also hurt, kind of like I was going to get my period, my whole demeanor was that of PMS queen, but I knew I wasn't going to get my period, so I started to take one pill every other day, and some symptoms were alleviated. I now take .32 every other day, my hot flashes are somewhat more frequent, but the other symptoms aren't back, so that's good, I do hope this will allow me to lose the 18lbs I have gained, I eat low carb, and exercise a F 42 6 months
10/8/2008
 3  complete hysterectomy at 27 since starting the premarin at a dose of .9 mg 3 months ago i am a totally different person. i am so angry most of the time and dont know why. i have put on 10 lbs and my hair is thinning. i get really bad headaches and some times have a problem remembering things. i am not sure what to do at this point. the doctor says to give it time F 28 3 months
10/7/2008
 1  Complete Hysterectomy Dec. 22, 2006 Very painful joints and my right hip something terrible, very moody and had little patience, felt like I wasn't in control of my life. I have been off of the Premarin for almost 3 weeks and I feel better, I have very few hot flashes and seem to be happier. I started taking 1.25mg and before I quit taking it I was taking .625mg. I'm glad I quit. I had also gained weight around my middle that I am hoping to lose soon. I would not recomend this medication to anyone. F 38 20 months
9/29/2008
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 5  To stop menopause migraines at 45 I'm a DES daughter - had female problems all my life. Started getting terrible headaches at 45 -stress, divorce, weight gain etc. Doctor put me on highest dose Premarin. Now, after slowly decreasing to 0.3 a year ago (total hysterectomy + Ovaries 6 years ago) I feel and look great. I work out and hike, lift weights, would like to be 10 pounds thinner (5'9" and 155 lbs) but skin is gorgeous and hair thinning slightly but OK - cut it into a nice, young style. I am thinking of going off completely 0.3 mg daily dose but fear headaches returning and I am a writer - can't afford to miss work like I did before starting Premarin. I can take hot flashes, but not Menopause Migraines! My only sister is a year younger and has Stage 4 breast cancer...a survivor for 8 years but not athletic and not a positive thinker. I don't like paying $45 per month for Premarin but bone density scan 2 years ago and heart test last year show I am in excellent health - bones of 35 year old. Lift weights, ladies! Vaginal dryness but Astrolube solves easily. Don't want to quit Premarin if daily quality of life would decline. F 56 11 years
9/16/2008
 4  hysterectomy hot flushes I was on Premarin for 15 years, I decided to come off of it, I did it gradually, for 3 months I took one every other day, and then for another 3 months I took one every 3 days, and gradually to 1 a week until I finally stopped and it worked no more symptoms, before on premarin, I was aggressive, depressed, my stomach was bloated, I put on weight, my hair was getting thin, my legs were stiff and I was breathless, I am 65 and feel much better now that I am off of it. If you want to stop taking it, you have to do it gradually or your symptoms return with a vengeance. F 65 15 years
9/2/2008
 4  Post-Op Transgendered Woman I dont produce estrogen or testosterone. So, I only need a very low dosage..a .3 mg every other day. I have taken estradiol for 4 years, and premarin for 6 years now, and I have found that premarin is better for two reasons. Premarin is a lot more potent than estradiol, especially the "half-life", or how long it stays in your body. If my dosage isnt just right, I would have all the side effects that everyone has mentioned! I have had all those symptoms, and simply just started to do all the research, get my blood levels checked, and ween down to a lifetime, best maintenance dosage. I rated it a 4, because of two reasons. One, its more conveinent to take than estraidol is. You would have to take estradiol twice a day, because the "half-life" is only around 3 hours for estradiol, compared to around 15-20 hours for premarin. You just have to make sure to take the lowest dosage that you actually need. Premarin is potent..much more ptotent than estradiol! You will only h I have done lots and lots of research about hormones, vitamins..etc. I am a Post-Op transgendered woman..since oct. '03. I dont produce estrogen, or testosterone anymore, and my lingering amount of testosterone is constantly at around 17 ng/dl, which is very, very low for a female. So, I only need a tiny amount of premarin(estrogen) now, and its just for bone density/maintenance dosage(.3 mg every other day). There is some research that people arent doing here, and I want to explain this. First, estrogen therapy increases copper levels in the body. Estrogen, and copper levels parallel with eachother. Zinc, which is an atagonist of copper, and the opposite of copper, should be increased if on estrogen therapy!! If you are having blurry vision, joint pains, libido problems, acne breakouts, thinning hair, colds/flu..etc, its most likely because you are high on the copper side, and low on the zinc side. You should be at a level of around 12 mg of zinc, to 1 mg of copper ratio for optimum h F 40 10 years
8/9/2008
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 4  Total Hysterectomy Some depression It has been great for me my doctor had to adjust my dosing after that i have been good. F 30 4 months
7/30/2008
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 2  total hysterectomy & oophrectomy Just not myself.Tired and unmotivated. I have put on weight(5kg)which is mainly due to overeating,but I am excessively hungry.I have a constant dull headache & no libido what-so-ever.My skin feels dry & itchy and I am irritable with everything & everyone. I have tried reducing dose from 0.625 to 0.3 and also tried patches, but to no avail. Do I feel like this as a result of Premarin or the loss of my ovaries? F 55 8 months
7/24/2008
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 2  Emergency Total Hysterectomy Fluctuating weight, headaches, severe aggression, mood swings, anxiety, tearful, depression. In the year and a half since I have been taking this drug, my personality has changed considerably. I have become very aggressive to the point of losing control of my actions. This drug does not suit me, and in my opinion, has made me worse. F 36 1 years
7/17/2008
 1  Total Hysterectomy I became so nervous I constantly felt like wanting to jump right out of my skin, and on top of that I also became so angry I could have eaten people up! That's the total opposite of the kind of person that I usually am. Had to quit. Coped with hot flushes for a few years, and more recently with bone loss but, hey, it's life! I now take calcium every day, but I never feel that horrible tension and anger I felt while on this medication, so I never regretted quitting it. M 61 2 weeks
7/16/2008
 4  TAB due to borderline Ovarion Tumor Sides Effects FROM the Premarin? I have gained 20 pounds and find it hard to get off even through diet and exercise. My Cholesterol and BP are up - but this could be the weight gain. I was miserable about a month after surgery and the GYN/ONC prescribed Premarin and it was great. Going through surgical menopause while recovering from a major surgery was just not an option. I have been tapering off of the Premarin for 6 months now.Sometimes when I would lower the dosage I had minor symptoms My last dosage before quitting was .145 every other day. I have been completely off for two weeks. I have had night sweats, hot flashes and have mostly felt achy and tired. I am determined to be through with this medication- so hopefully things will settle down soon. F 46 18 months
7/13/2008
 3  Pelvic Prolapse Vaginal dryness to the point where my bladder was not supported and began to prolapse into the vagina. I am post-menopausal and had few symptoms throughout the menopausal process. After only 3 months using a weekly Premarin vaginal suppository, the health of the vaginal wall is much improved--the bladder is being supported. However, I have had a severe headache for the past 3 weeks, am anxiety-ridden, short-tempered, have leg cramps, and heart palpitations. F 60 3 months
7/8/2008
 4  Perimenopause and PMDD Tired and fatigued. Since taking Premarin, I am finding LESS hair in the shower drain. Emotionally, I feel more like my old self. The weepiness is gone and my PMDD symptoms are less. F 44 3 weeks
7/6/2008
 4  TAH & Oopherectomy 2001 @ 35yrs Hot flushes, tearfulness, forgetfulness, anger, impatience, insomnia, depression. I have had no menopausal symptoms since taking premarin but I have gained about 7lbs around my middle which won't shift, and I am beginning to get downy facial hair. My main problem is that I have been getting dreadful hemiplegic migraines since taking Premarin. I get one or two a month which is relatively few compared to some mirgaine sufferers but they are severe and I cannot function for about 24 hours afterwards. I dread travelling to other sites with work in case I get a migraine while driving. My Doctor wants me to stop HRT but I am reluctant to go back to the insomnia and depression. I honestly feel that I cannot function without HRT I have been trying Pizotifen & Propranolol along with Sumatriptan but I am still getting the migraines. Going to see Doc tomorrow about changing to an HRT patch. If that doesn't work I will stop taking HRT and see what happens. F 40 5 years
6/29/2008
 3  complete hysterectomy muscle cramps (mainly in shoulders and legs) After recently taking myself off premarin, the leg and shoulder cramps are gone. The cramping was not an immediate side effect for me. It took a while. But after the "process of elimination" theory from a couple of prescriptions that I was on Premarin seemed to be the one that was causing the severe cramps. F 51 4 years
6/19/2008
 2  Full Hysterectomy I began taking Premarin about 2 months ago, .625 and felt no change at all. Dr. increased dosage and still no results, I just picked up a new dosage of 1.25 and am now nervous after reading all your results from use. My syptoms before the drug were; weight gain, memory loss, loss of energy, syptoms of depression, inability to focus and feelings of being out of control..my doctor tells me that I will feel 100% better with this medication and can expect to lose weight and regain my past life....now i am questioning his comments? F 41 2 months
6/18/2008
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 1  Hysterectomy Horrible horrible side effects - after 2 weeks of starting on Premarin - severe joint pain, very heavy lower body feeling. After using for 2 months, I quit it, and the 3 weeks since, have had no return of hot flashes, or night sweats (yet?). I ha all of the nasty side effects - makes hot flashes seem easy in comparasin. F 51 2 months
6/17/2008
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 4  Both Ovaries Removed Slight weight gain My only complaint is slight weight gain. I have to be much more careful on what I eat than ever before. My terrible night sweats and hot flashes throughout the day are almost obsolete. My mood has been terrific. I had severe vaginal dryness but since taking the oral Premarin as well as the vaginal creme - intercourse is enjoyable again without the pain. F 30 30 days
6/14/2008
 1  HRT headache, high anxiety, suicidal/depressed thinking, crazy thinking, tingling/prickling in head and body, urine problems. F 38 2 weeks
5/26/2008

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